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Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer’s therapeutics
Untangling probably the most selective kinase inhibitors by way of pharmacological intervention stays one of many difficult affairs thus far. Inaccordance to this drift, herein we describe the design and synthesis of a set of recent heterocyclic analogues consisting of 6,7 dimethyl Quinoxaline, appended to a connector, using Schiff base technique (Compounds I – IX ).
The compounds had been characterised by numerous spectroscopic strategies and the kinase inhibition assay had been carried out on few prime members of the CMGC household specifically the GSK3 b , DYRK1A and CLK1 receptors respectively, which were identified to be straight concerned in hyperphosphorylation of Tau.
Curiously the organic analysis outcomes revealed that Compounds IV & V , with bromo/chloro functionalities within the fragrant core had been advantaged of being extremely selective in the direction of the goal GSK3b over others.
To strengthen our evaluation, we adopted molecular modelling research, the place compounds IV /V had been redocked in the identical grid 4AFJ, as that of the reference ligand, 5-Aryl-4-Carboxamide-1,3-Oxazole. Surprisingly, our investigation underpined that for each the compounds IV/V, a major H-bonding existed between the designed molecules ( IV/V) and Val 135 residue within the receptor GSK3b, inline with the reference ligand. We attribute this interplay to instigate efficiency within the compounds.
Certainly the opposite non-covalent interplay, between the by-product’s fragrant nucleus and Arg 141/Thr 138 within the receptor GSK3b, might need been answerable for enhancing the selectivity within the targets. Total, we really feel that the current work depicts a logical demonstration in the direction of advantageous tuning the efficacy of the inhibitors by way of systematic adjustment of electron density at acceptable positions within the fragrant ring be it the primary quinoxaline or the opposite fragrant nucleus. Thus this pathway presents a handy technique for the event of environment friendly therapeutics for diversified neurodegenerative ailments like that of Alzheimer’s.
GSK3 as a Regulator of Cytoskeleton Structure: Penalties for Well being and Illness
Glycogen synthase kinase 3 (GSK3) was initially remoted as a vital protein in vitality metabolism. Nonetheless, subsequent research point out that GSK-Three is a multi-tasking kinase that hyperlinks quite a few signaling pathways in a cell and performs an important position within the regulation of many elements of mobile physiology.
As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interplay with the extracellular matrix, and directional migration of cells and their organelles throughout the progress and growth of an animal organism. On this assessment, the roles of GSK3-cytoskeleton interactions in mind growth and pathology, migration of wholesome and most cancers cells, and in mobile trafficking of mitochondria shall be mentioned.
An Overview of the Security, Effectivity, and Sign Pathways of Stem Cell Remedy for Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune illness that impacts a number of organs and tissues. Mesenchymal stem cells (MSCs) are thought-about a great supply for autoimmune illness and hematological illness remedy. This assessment will summarize the efficacy, security, and mechanisms of MSC remedy for SLE.
MSC remedy can scale back anti-dsDNA, antinuclear antigen (ANA), proteinuria, and serum creatinine in SLE sufferers. In animal fashions of SLE, MSC remedy additionally signifies that it might scale back anti-dsDNA, ANA, proteinuria, and serum creatinine and ameliorate renal pathology.
There aren’t any severe hostile occasions, treatment-related mortality, or tumor-related occasions in SLE sufferers after stem cell therapy. MSCs can inhibit inflammatory components, equivalent to MCP-1 and HMGB-1, and inhibit inflammation-related signaling pathways, such because the NF-κB, JAK/STAT, and Akt/GSK3β signaling pathways, to alleviate the lesions in SLE.
Mitotic WNT signalling orchestrates neurogenesis within the growing neocortex
The position of WNT/β-catenin signalling in mouse neocortex growth stays ambiguous. Most research reveal that WNT/β-catenin regulates progenitor self-renewal however others counsel it could additionally promote differentiation. Right here we discover the position of WNT/STOP signalling, which stabilizes proteins throughout G2/M by inhibiting glycogen synthase kinase (GSK3)-mediated protein degradation.
We present that mice mutant for cyclin Y and cyclin Y-like 1 (Ccny/l1), key regulators of WNT/STOP signalling, show decreased neurogenesis within the growing neocortex. Particularly, basal progenitors, which exhibit delayed cell cycle development, had been drastically decreased. Ccny/l1-deficient apical progenitors present decreased uneven division attributable to a rise in apical-basal astral microtubules.
We establish the neurogenic transcription components Sox4 and Sox11 as direct GSK3 targets which are stabilized by WNT/STOP signalling in basal progenitors throughout mitosis and that promote neuron technology. Our work reveals that WNT/STOP signalling drives cortical neurogenesis and identifies mitosis as a vital part for neural progenitor destiny.
GSK3s: nodes of multilayer regulation of plant growth and stress responses
Glycogen synthase kinase 3 (GSK3) relations are extremely conserved serine/threonine protein kinases in eukaryotes. Not like animals, vegetation have developed with a number of homologs of GSK3s concerned in a various array of organic processes. Rising proof means that GSK3s act as signaling hubs for integrating notion and transduction of numerous indicators required for plant growth and responses to abiotic and biotic cues.
Right here we assessment current advances in understanding the molecular interactions between GSK3s and an increasing spectrum of their upstream regulators and downstream substrates in vegetation. We additional focus on how GSK3s act as key signaling nodes of multilayer regulation of plant growth and stress response by way of both being regulated on the post-translational degree or regulating their substrates by way of phosphorylation.
A GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells
Endothelin, encoded by ET1, is a vasoactive substance primarily synthesized in vascular endothelial cells (VECs). Elevation of endothelin ranges, attributable to transcriptional hyperactivation, has been noticed in a bunch of cardiovascular ailments. We now have beforehand proven that serum response issue (SRF) is a regulator of ET1 transcription in VECs.
Right here we report that angiotensin II (Ang II) induced ET1 transcription paralleled activation of glycogen synthase kinase 3 (GSK3) in cultured VECs. GSK3 knockdown or pharmaceutical inhibition attenuated Ang II induced endothelin expression.
Of curiosity, the impact of GSK3 on endothelin transcription relied on the conserved SRF motif inside the ET1 promoter. Additional evaluation revealed that GSK3 interacted with and phosphorylated SRF at serine 224. Phosphorylation of SRF by GSK3 didn’t affect its recruitment to the ET1 promoter.
As an alternative, GSK3-mediated SRF phosphorylation potentiated its interplay with MRTF-A, a key co-factor for SRF, which helped recruit the chromatin transforming protein BRG1 to the ET1 promoter leading to augmented histone H3 acetylation/H3K4 trimethylation.
 GSK3B Antibody |
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| ABD6806 | Lifescience Market | 100 ug | EUR 525.6 |
GSK3B Antibody |
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| ABD7231 | Lifescience Market | 100 ug | EUR 525.6 |
 GSK3b antibody |
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| 70R-11869 | Fitzgerald | 100 ug | EUR 357 |
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Description: Rabbit polyclonal GSK3b antibody |
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 GSK3B antibody |
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| 70R-15005 | Fitzgerald | 100 ul | EUR 497 |
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Description: Rabbit polyclonal GSK3B antibody |
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GSK3B antibody |
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| 70R-17615 | Fitzgerald | 50 ul | EUR 289 |
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Description: Rabbit polyclonal GSK3B antibody |
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GSK3B antibody |
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| 10R-1862 | Fitzgerald | 100 ul | EUR 468 |
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Description: Mouse monoclonal GSK3B antibody |
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GSK3B Antibody |
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| 36918 | SAB | 100ul | EUR 319 |
GSK3B Antibody |
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| 36918-100ul | SAB | 100ul | EUR 302.4 |
GSK3B antibody |
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| 38353 | SAB | 100ul | EUR 439 |
GSK3B antibody |
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| 38353-100ul | SAB | 100ul | EUR 302.4 |
GSK3B antibody |
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| 38616 | SAB | 100ul | EUR 439 |
GSK3B antibody |
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| 38616-100ul | SAB | 100ul | EUR 302.4 |
GSK3B Antibody |
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| CSB-PA939628- | Cusabio | each | EUR 402 |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
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GSK3B Antibody |
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| CSB-PA939628-100ul | Cusabio | 100ul | EUR 379.2 |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000 |
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GSK3B Antibody |
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| 1-CSB-PA080166 | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500 |
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GSK3B Antibody |
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| 1-CSB-PA002848 | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000 |
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GSK3B Antibody |
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| 1-CSB-PA009038 | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000 |
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GSK3B Antibody |
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| 1-CSB-PA009963GA01HU | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat, Pig. This antibody is Unconjugated. Tested in the following application: ELISA, WB |
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GSK3B Antibody |
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| 1-CSB-PA009963LA01HU | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:500 |
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GSK3B Antibody |
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| E036918 | EnoGene | 100μg/100μl | EUR 255 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| BF0695 | Affbiotech | 200ul | EUR 540 |
GSK3B Antibody |
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| BF0695-100ul | Affinity Biosciences | 100ul | EUR 210 |
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Description: WB,IHC,IF/ICC,ELISA,FACS |
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GSK3B Antibody |
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| BF0695-200ul | Affinity Biosciences | 200ul | EUR 270 |
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Description: WB,IHC,IF/ICC,ELISA,FACS |
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GSK3B Antibody |
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| BF0695-50ul | Affinity Biosciences | 50ul | EUR 150 |
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Description: WB,IHC,IF/ICC,ELISA,FACS |
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GSK3B antibody |
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| CAF50144-100ug | Biomatik Corporation | 100ug | EUR 312 |
GSK3B Antibody |
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| E92081 | EnoGene | 100ul | EUR 255 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E93174 | EnoGene | 100ul | EUR 255 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E220184-1 | EnoGene | 50μg/50μl | EUR 145 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E220184-2 | EnoGene | 100μg/100μl | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E19-6806 | EnoGene | 100μg/100μl | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E19-7231 | EnoGene | 100μg/100μl | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E10-30006 | EnoGene | 100μg/100μl | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E10-30705 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| E10-30705T | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B antibody |
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| E39-03673 | EnoGene | 100ug/100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Antibody |
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| GWB-MT481D | GenWay Biotech | 50ug | Ask for price |
 GSK3b Antibody |
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| MBS5311338-01mg | MyBiosource | 0.1mg | EUR 490 |
GSK3b Antibody |
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| MBS5311338-5x01mg | MyBiosource | 5x0.1mg | EUR 2155 |
GSK3B Antibody |
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| MBS5313117-01mL | MyBiosource | 0.1mL | EUR 800 |
GSK3B Antibody |
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| MBS5313117-5x01mL | MyBiosource | 5x0.1mL | EUR 3440 |
GSK3B Antibody |
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| MBS2526368-006mL | MyBiosource | 0.06mL | EUR 180 |
GSK3B Antibody |
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| MBS2526368-012mL | MyBiosource | 0.12mL | EUR 260 |
GSK3B Antibody |
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| MBS2526368-02mL | MyBiosource | 0.2mL | EUR 405 |
GSK3B Antibody |
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| MBS2526368-5x02mL | MyBiosource | 5x0.2mL | EUR 1725 |
GSK3B Antibody |
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| MBS2526819-006mL | MyBiosource | 0.06mL | EUR 230 |
GSK3B Antibody |
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| MBS2526819-012mL | MyBiosource | 0.12mL | EUR 310 |
GSK3B Antibody |
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| MBS2526819-02mL | MyBiosource | 0.2mL | EUR 480 |
GSK3B Antibody |
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| MBS8526909-005mg | MyBiosource | 0.05mg | EUR 235 |
GSK3B Antibody |
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| MBS8526909-01mg | MyBiosource | 0.1mg | EUR 305 |
GSK3B Antibody |
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| MBS8526909-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3B Antibody |
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| MBS8526909-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3B Antibody |
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| MBS8526909-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3B Antibody |
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| MBS7131863-01mL | MyBiosource | 0.1mL | EUR 270 |
GSK3B Antibody |
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| MBS7131863-5x01mL | MyBiosource | 5x0.1mL | EUR 1200 |
GSK3B Antibody |
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| MBS7136549-005mL | MyBiosource | 0.05mL | EUR 220 |
GSK3B Antibody |
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| MBS7136549-01mL | MyBiosource | 0.1mL | EUR 300 |
GSK3B Antibody |
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| MBS7136549-5x01mL | MyBiosource | 5x0.1mL | EUR 1350 |
GSK3B Antibody |
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| MBS7119532-005mg | MyBiosource | 0.05mg | EUR 150 |
GSK3B Antibody |
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| MBS7119532-01mg | MyBiosource | 0.1mg | EUR 190 |
GSK3B Antibody |
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| MBS7119532-5x01mg | MyBiosource | 5x0.1mg | EUR 845 |
GSK3B Antibody |
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| MBS7122537-005mg | MyBiosource | 0.05mg | EUR 150 |
GSK3B Antibody |
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| MBS7122537-01mg | MyBiosource | 0.1mg | EUR 190 |
GSK3B Antibody |
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| MBS7122537-5x01mg | MyBiosource | 5x0.1mg | EUR 845 |
GSK3B Antibody |
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| MBS7122623-005mg | MyBiosource | 0.05mg | EUR 150 |
GSK3B Antibody |
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| MBS7122623-01mg | MyBiosource | 0.1mg | EUR 190 |
GSK3B Antibody |
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| MBS7122623-5x01mg | MyBiosource | 5x0.1mg | EUR 845 |
GSK3B Antibody |
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| MBS8503766-01mL | MyBiosource | 0.1mL | EUR 325 |
GSK3B Antibody |
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| MBS8503766-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3B Antibody |
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| MBS8503766-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3B Antibody |
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| MBS8503766-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3B Antibody |
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| MBS8503766-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3B Antibody |
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| MBS8516276-01mg | MyBiosource | 0.1mg | EUR 305 |
GSK3B Antibody |
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| MBS8516276-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
GSK3B Antibody |
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| MBS8516276-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
GSK3B Antibody |
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| MBS8516276-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
GSK3B Antibody |
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| MBS8516276-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
GSK3B Antibody |
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| MBS8516665-01mg | MyBiosource | 0.1mg | EUR 305 |
GSK3B Antibody |
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| MBS8516665-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
GSK3B Antibody |
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| MBS8516665-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
GSK3B Antibody |
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| MBS8516665-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
GSK3B Antibody |
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| MBS8516665-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
GSK3B Antibody |
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| MBS8503474-01mL | MyBiosource | 0.1mL | EUR 325 |
GSK3B Antibody |
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| MBS8503474-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3B Antibody |
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| MBS8503474-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3B Antibody |
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| MBS8503474-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3B Antibody |
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| MBS8503474-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3B Antibody |
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| MBS850776-01mg | MyBiosource | 0.1mg | EUR 305 |
GSK3B Antibody |
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| MBS850776-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3B Antibody |
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| MBS850776-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3B Antibody |
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| MBS850776-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3B Antibody |
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| MBS850776-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3B antibody |
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| MBS831019-01mL | MyBiosource | 0.1mL | EUR 810 |
GSK3B antibody |
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| MBS831019-5x01mL | MyBiosource | 5x0.1mL | EUR 3505 |
GSK3B Antibody |
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| MBS9602821-005mL | MyBiosource | 0.05mL | EUR 260 |
GSK3B Antibody |
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| MBS9602821-01mL | MyBiosource | 0.1mL | EUR 325 |
GSK3B Antibody |
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| MBS9602821-02mL | MyBiosource | 0.2mL | EUR 400 |
GSK3B Antibody |
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| MBS9602821-5x02mL | MyBiosource | 5x0.2mL | EUR 1750 |
GSK3B Antibody |
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| MBS969826-005mg | MyBiosource | 0.05mg | EUR 190 |
GSK3B Antibody |
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| MBS969826-01mg | MyBiosource | 0.1mg | EUR 270 |
GSK3B Antibody |
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| MBS969826-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
GSK3B Antibody |
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| MBS9411632-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3B Antibody |
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| MBS9411632-5x01mL | MyBiosource | 5x0.1mL | EUR 1230 |
GSK3B Antibody |
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| MBS9607870-01mL | MyBiosource | 0.1mL | EUR 260 |
GSK3B Antibody |
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| MBS9607870-02mL | MyBiosource | 0.2mL | EUR 305 |
GSK3B Antibody |
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| MBS9607870-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
GSK3B antibody |
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| MBS9412683-005mL | MyBiosource | 0.05mL | EUR 300 |
GSK3B antibody |
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| MBS9412683-01mL | MyBiosource | 0.1mL | EUR 390 |
GSK3B antibody |
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| MBS9412683-5x01mL | MyBiosource | 5x0.1mL | EUR 1610 |
GSK3B antibody |
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| MBS9410678-005mL | MyBiosource | 0.05mL | EUR 300 |
GSK3B antibody |
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| MBS9410678-01mL | MyBiosource | 0.1mL | EUR 390 |
GSK3B antibody |
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| MBS9410678-5x01mL | MyBiosource | 5x0.1mL | EUR 1610 |
 GSK3A/GSK3B Antibody |
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| 1-CSB-PA002838 | Cusabio |
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Description: A polyclonal antibody against GSK3A/GSK3B. Recognizes GSK3A/GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
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 GSK3A / GSK3B Antibody |
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| abx328487-100g | Abbexa | 100 µg | EUR 250 |
GSK3A / GSK3B Antibody |
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| 20-abx328487 | Abbexa |
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GSK3A / GSK3B Antibody |
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| abx328487-50g | Abbexa | 50 µg | EUR 187.5 |
GSK3A/GSK3B Antibody |
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| MBS7122062-005mg | MyBiosource | 0.05mg | EUR 150 |
GSK3A/GSK3B Antibody |
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| MBS7122062-01mg | MyBiosource | 0.1mg | EUR 190 |
GSK3A/GSK3B Antibody |
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| MBS7122062-5x01mg | MyBiosource | 5x0.1mg | EUR 845 |
 Anti-GSK3 beta/GSK3B Antibody Picoband™ |
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| A00791-3 | BosterBio | 10ug | EUR 154 |
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Description: Western blot, 0.25-0.5 μg/ml, Human;_x000D_Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Human |
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 Monoclonal Antibody) Mouse Anti GSK3b (pS9) Monoclonal Antibody |
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| MBS460723-01mg | MyBiosource | 0.1mg | EUR 315 |
Mouse Anti GSK3b (pS9) Monoclonal Antibody |
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| MBS460723-5x01mg | MyBiosource | 5x0.1mg | EUR 1330 |
 Monoclonal Antibody) Mouse anti GSK3b(pS9) Monoclonal Antibody |
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| TA354463 | Origene Technologies GmbH | 100 µg | Ask for price |
 Polyclonal Antibody) Rabbit anti GSK3b(pS9) Polyclonal Antibody |
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| TA354486 | Origene Technologies GmbH | 100 µg | Ask for price |
 Human, Rabbit GSK3B antibody |
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| M0006 | Omnimabs | 100ul | EUR 150 |
 Antibody) GSK3B (pY216) Antibody |
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| 20-abx000312 | Abbexa |
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GSK3B (pY216) Antibody |
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| abx123289-100l | Abbexa | 100 µl | EUR 200 |
GSK3B (pY216) Antibody |
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| 20-abx123289 | Abbexa |
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GSK3B (pY216) Antibody |
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| abx123289-1ml | Abbexa | 1 ml | EUR 475 |
GSK3B (pY216) Antibody |
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| abx123289-200l | Abbexa | 200 µl | EUR 325 |
 Antibody) GSK3B (pSer9) Antibody |
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| abx243027-96tests | Abbexa | 96 tests | EUR 287.5 |
 GSK3B Antibody, HRP conjugated |
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| 1-CSB-PA009963LB01HU | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
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 GSK3B Antibody; HRP conjugated |
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| MBS7005440-005mg | MyBiosource | 0.05mg | EUR 190 |
GSK3B Antibody; HRP conjugated |
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| MBS7005440-01mg | MyBiosource | 0.1mg | EUR 270 |
GSK3B Antibody; HRP conjugated |
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| MBS7005440-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
 GSK3B Antibody HRP Conjugated |
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| MBS9459703-01mL | MyBiosource | 0.1mL | EUR 595 |
GSK3B Antibody HRP Conjugated |
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| MBS9459703-5x01mL | MyBiosource | 5x0.1mL | EUR 2525 |
 GSK3B Antibody, FITC conjugated |
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| 1-CSB-PA009963LC01HU | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
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 GSK3B Antibody; FITC conjugated |
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| MBS7005054-005mg | MyBiosource | 0.05mg | EUR 190 |
GSK3B Antibody; FITC conjugated |
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| MBS7005054-01mg | MyBiosource | 0.1mg | EUR 270 |
GSK3B Antibody; FITC conjugated |
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| MBS7005054-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
 OAPA00251-5UG - GSK3B Antibody |
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| OAPA00251-5UG | Aviva Systems Biology | 5ug | EUR 69 |
 OACA03072-50UG - GSK3B Antibody |
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| OACA03072-50UG | Aviva Systems Biology | 50ug | EUR 179 |
 GSK3B Antibody, Biotin conjugated |
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| 1-CSB-PA009963LD01HU | Cusabio |
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
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 GSK3B Antibody; Biotin conjugated |
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| MBS7002577-005mg | MyBiosource | 0.05mg | EUR 190 |
GSK3B Antibody; Biotin conjugated |
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| MBS7002577-01mg | MyBiosource | 0.1mg | EUR 270 |
GSK3B Antibody; Biotin conjugated |
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| MBS7002577-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
 OAAF01318-100UG - GSK3B Antibody |
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| OAAF01318-100UG | Aviva Systems Biology | 100ug | EUR 329 |
 OAAJ02835-100UL - GSK3B Antibody |
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| OAAJ02835-100UL | Aviva Systems Biology | 100ul | EUR 319 |
 OAAJ07280-100UL - GSK3B Antibody |
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| OAAJ07280-100UL | Aviva Systems Biology | 100uL | EUR 319 |
 OACA03072-100UG - GSK3B Antibody |
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| OACA03072-100UG | Aviva Systems Biology | 100ug | EUR 319 |
 OASG03249-100UL - GSK3B Antibody |
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| OASG03249-100UL | Aviva Systems Biology | 100ul | EUR 239 |
 OASG07740-100UL - GSK3B Antibody |
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| OASG07740-100UL | Aviva Systems Biology | 100ul | EUR 269 |
 OASG07741-100UL - GSK3B Antibody |
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| OASG07741-100UL | Aviva Systems Biology | 100ul | EUR 269 |
 OASG07742-100UL - GSK3B Antibody |
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| OASG07742-100UL | Aviva Systems Biology | 100ul | EUR 269 |
 GSK3B Polyclonal Antibody |
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| A72446 | EpiGentek |
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GSK3B Polyclonal Antibody |
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| A72447 | EpiGentek |
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GSK3B Polyclonal Antibody |
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| A72448 | EpiGentek |
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GSK3B Polyclonal Antibody |
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| A72450 | EpiGentek |
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GSK3B Polyclonal Antibody |
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| A62706 | EpiGentek |
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 GSK3B Conjugated Antibody |
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| C36918 | SAB | 100ul | EUR 476.4 |
GSK3B Conjugated Antibody |
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| C38353 | SAB | 100ul | EUR 476.4 |
GSK3B Polyclonal Antibody |
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| MBS127965-002mL | MyBiosource | 0.02mL | EUR 220 |
GSK3B Polyclonal Antibody |
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| MBS127965-005mL | MyBiosource | 0.05mL | EUR 295 |
GSK3B Polyclonal Antibody |
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| MBS127965-01mL | MyBiosource | 0.1mL | EUR 430 |
GSK3B Polyclonal Antibody |
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| MBS127965-02mL | MyBiosource | 0.2mL | EUR 600 |
GSK3B Polyclonal Antibody |
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| MBS127965-5x02mL | MyBiosource | 5x0.2mL | EUR 2525 |
GSK3B Polyclonal Antibody |
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| MBS127304-002mL | MyBiosource | 0.02mL | EUR 200 |
GSK3B Polyclonal Antibody |
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| MBS127304-005mL | MyBiosource | 0.05mL | EUR 255 |
GSK3B Polyclonal Antibody |
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| MBS127304-01mL | MyBiosource | 0.1mL | EUR 345 |
GSK3B Polyclonal Antibody |
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| MBS127304-02mL | MyBiosource | 0.2mL | EUR 545 |
GSK3B Polyclonal Antibody |
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| MBS127304-5x02mL | MyBiosource | 5x0.2mL | EUR 2265 |
GSK3B Polyclonal Antibody |
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| E911360 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Polyclonal Antibody |
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| E911578 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Polyclonal Antibody |
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| E916868 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Polyclonal Antibody |
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| E96164 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3B Polyclonal Antibody |
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| MBS2520732-002mL | MyBiosource | 0.02mL | EUR 135 |
GSK3B Polyclonal Antibody |
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| MBS2520732-006mL | MyBiosource | 0.06mL | EUR 180 |
GSK3B Polyclonal Antibody |
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| MBS2520732-012mL | MyBiosource | 0.12mL | EUR 255 |
GSK3B Polyclonal Antibody |
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| MBS2520732-02mL | MyBiosource | 0.2mL | EUR 400 |
GSK3B Polyclonal Antibody |
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| MBS2520732-5x02mL | MyBiosource | 5x0.2mL | EUR 1715 |
GSK3B Polyclonal Antibody |
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| MBS2547907-006mL | MyBiosource | 0.06mL | EUR 180 |
GSK3B Polyclonal Antibody |
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| MBS2547907-012mL | MyBiosource | 0.12mL | EUR 260 |
GSK3B Polyclonal Antibody |
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| MBS2547907-02mL | MyBiosource | 0.2mL | EUR 405 |
GSK3B Polyclonal Antibody |
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| MBS2547907-5x02mL | MyBiosource | 5x0.2mL | EUR 1725 |
GSK3B Polyclonal Antibody |
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| MBS2566238-006mL | MyBiosource | 0.06mL | EUR 190 |
GSK3B Polyclonal Antibody |
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| MBS2566238-012mL | MyBiosource | 0.12mL | EUR 265 |
GSK3B Polyclonal Antibody |
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| MBS2566238-02mL | MyBiosource | 0.2mL | EUR 415 |
GSK3B Polyclonal Antibody |
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| MBS2566238-5x02mL | MyBiosource | 5x0.2mL | EUR 1835 |
GSK3B Polyclonal Antibody |
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| MBS8566844-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3B Polyclonal Antibody |
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| MBS8566844-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS8566844-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS8566844-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS8566844-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS8566893-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3B Polyclonal Antibody |
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| MBS8566893-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS8566893-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS8566893-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS8566893-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3B Polyclonal Antibody |
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| MBS9126031-002mL | MyBiosource | 0.02mL | EUR 200 |
GSK3B Polyclonal Antibody |
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| MBS9126031-005mL | MyBiosource | 0.05mL | EUR 255 |
GSK3B Polyclonal Antibody |
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| MBS9126031-01mL | MyBiosource | 0.1mL | EUR 345 |
GSK3B Polyclonal Antibody |
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| MBS9126031-02mL | MyBiosource | 0.2mL | EUR 545 |
GSK3B Polyclonal Antibody |
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| MBS9126031-5x02mL | MyBiosource | 5x0.2mL | EUR 2265 |
Constantly, over-expression of a constitutively energetic GSK enhanced Ang II-induced ET1 transcription and knockdown of both MRTF-A or BRG1 abrogated the enhancement of ET1 transcription. In conclusion, our information spotlight a beforehand unrecognized mechanism that contributes to the transcriptional regulation of endothelin. Concentrating on this GSK3-SRF axis could yield novel approaches within the intervention of cardiovascular ailments.
