Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics

Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer’s therapeutics

Untangling probably the most selective kinase inhibitors by way of pharmacological intervention stays one of many difficult affairs thus far. Inaccordance to this drift, herein we describe the design and synthesis of a set of recent heterocyclic analogues consisting of 6,7 dimethyl Quinoxaline, appended to a connector, using Schiff base technique (Compounds I – IX ).
The compounds had been characterised by numerous spectroscopic strategies and the kinase inhibition assay had been carried out on few prime members of the CMGC household specifically the GSK3 b , DYRK1A and CLK1 receptors respectively, which were identified to be straight concerned in hyperphosphorylation of Tau.
Curiously the organic analysis outcomes revealed that Compounds IV & V , with bromo/chloro functionalities within the fragrant core had been advantaged of being extremely selective in the direction of the goal GSK3b over others.
To strengthen our evaluation, we adopted molecular modelling research, the place compounds IV /V had been redocked in the identical grid 4AFJ, as that of the reference ligand, 5-Aryl-4-Carboxamide-1,3-Oxazole. Surprisingly, our investigation underpined that for each the compounds IV/V, a major H-bonding existed between the designed molecules ( IV/V) and Val 135 residue within the receptor GSK3b, inline with the reference ligand. We attribute this interplay to instigate efficiency within the compounds.
Certainly the opposite non-covalent interplay, between the by-product’s fragrant nucleus and Arg 141/Thr 138 within the receptor GSK3b, might need been answerable for enhancing the selectivity within the targets. Total, we really feel that the current work depicts a logical demonstration in the direction of advantageous tuning the efficacy of the inhibitors by way of systematic adjustment of electron density at acceptable positions within the fragrant ring be it the primary quinoxaline or the opposite fragrant nucleus. Thus this pathway presents a handy technique for the event of environment friendly therapeutics for diversified neurodegenerative ailments like that of Alzheimer’s.

GSK3 as a Regulator of Cytoskeleton Structure: Penalties for Well being and Illness

Glycogen synthase kinase 3 (GSK3) was initially remoted as a vital protein in vitality metabolism. Nonetheless, subsequent research point out that GSK-Three is a multi-tasking kinase that hyperlinks quite a few signaling pathways in a cell and performs an important position within the regulation of many elements of mobile physiology.
As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interplay with the extracellular matrix, and directional migration of cells and their organelles throughout the progress and growth of an animal organism. On this assessment, the roles of GSK3-cytoskeleton interactions in mind growth and pathology, migration of wholesome and most cancers cells, and in mobile trafficking of mitochondria shall be mentioned.
Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics

An Overview of the Security, Effectivity, and Sign Pathways of Stem Cell Remedy for Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune illness that impacts a number of organs and tissues. Mesenchymal stem cells (MSCs) are thought-about a great supply for autoimmune illness and hematological illness remedy. This assessment will summarize the efficacy, security, and mechanisms of MSC remedy for SLE.
MSC remedy can scale back anti-dsDNA, antinuclear antigen (ANA), proteinuria, and serum creatinine in SLE sufferers. In animal fashions of SLE, MSC remedy additionally signifies that it might scale back anti-dsDNA, ANA, proteinuria, and serum creatinine and ameliorate renal pathology.
There aren’t any severe hostile occasions, treatment-related mortality, or tumor-related occasions in SLE sufferers after stem cell therapy. MSCs can inhibit inflammatory components, equivalent to MCP-1 and HMGB-1, and inhibit inflammation-related signaling pathways, such because the NF-κB, JAK/STAT, and Akt/GSK3β signaling pathways, to alleviate the lesions in SLE.

Mitotic WNT signalling orchestrates neurogenesis within the growing neocortex

The position of WNT/β-catenin signalling in mouse neocortex growth stays ambiguous. Most research reveal that WNT/β-catenin regulates progenitor self-renewal however others counsel it could additionally promote differentiation. Right here we discover the position of WNT/STOP signalling, which stabilizes proteins throughout G2/M by inhibiting glycogen synthase kinase (GSK3)-mediated protein degradation.
We present that mice mutant for cyclin Y and cyclin Y-like 1 (Ccny/l1), key regulators of WNT/STOP signalling, show decreased neurogenesis within the growing neocortex. Particularly, basal progenitors, which exhibit delayed cell cycle development, had been drastically decreased. Ccny/l1-deficient apical progenitors present decreased uneven division attributable to a rise in apical-basal astral microtubules.
We establish the neurogenic transcription components Sox4 and Sox11 as direct GSK3 targets which are stabilized by WNT/STOP signalling in basal progenitors throughout mitosis and that promote neuron technology. Our work reveals that WNT/STOP signalling drives cortical neurogenesis and identifies mitosis as a vital part for neural progenitor destiny.

GSK3s: nodes of multilayer regulation of plant growth and stress responses

Glycogen synthase kinase 3 (GSK3) relations are extremely conserved serine/threonine protein kinases in eukaryotes. Not like animals, vegetation have developed with a number of homologs of GSK3s concerned in a various array of organic processes. Rising proof means that GSK3s act as signaling hubs for integrating notion and transduction of numerous indicators required for plant growth and responses to abiotic and biotic cues.
Right here we assessment current advances in understanding the molecular interactions between GSK3s and an increasing spectrum of their upstream regulators and downstream substrates in vegetation. We additional focus on how GSK3s act as key signaling nodes of multilayer regulation of plant growth and stress response by way of both being regulated on the post-translational degree or regulating their substrates by way of phosphorylation.

GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells

Endothelin, encoded by ET1, is a vasoactive substance primarily synthesized in vascular endothelial cells (VECs). Elevation of endothelin ranges, attributable to transcriptional hyperactivation, has been noticed in a bunch of cardiovascular ailments. We now have beforehand proven that serum response issue (SRF) is a regulator of ET1 transcription in VECs.
Right here we report that angiotensin II (Ang II) induced ET1 transcription paralleled activation of glycogen synthase kinase 3 (GSK3) in cultured VECs. GSK3 knockdown or pharmaceutical inhibition attenuated Ang II induced endothelin expression.
Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics
Of curiosity, the impact of GSK3 on endothelin transcription relied on the conserved SRF motif inside the ET1 promoter. Additional evaluation revealed that GSK3 interacted with and phosphorylated SRF at serine 224. Phosphorylation of SRF by GSK3 didn’t affect its recruitment to the ET1 promoter.
As an alternative, GSK3-mediated SRF phosphorylation potentiated its interplay with MRTF-A, a key co-factor for SRF, which helped recruit the chromatin transforming protein BRG1 to the ET1 promoter leading to augmented histone H3 acetylation/H3K4 trimethylation.

GSK3B Antibody

36918 100ul
EUR 319

GSK3B Antibody

36918-100ul 100ul
EUR 302.4

GSK3B antibody

70R-17615 50 ul
EUR 289
Description: Rabbit polyclonal GSK3B antibody

GSK3b antibody

70R-11869 100 ug
EUR 357
Description: Rabbit polyclonal GSK3b antibody

GSK3B antibody

70R-15005 100 ul
EUR 497
Description: Rabbit polyclonal GSK3B antibody

GSK3B Antibody

ABD6806 100 ug
EUR 525.6

GSK3B Antibody

ABD7231 100 ug
EUR 525.6

GSK3B antibody

10R-1862 100 ul
EUR 468
Description: Mouse monoclonal GSK3B antibody

GSK3B Antibody

1-CSB-PA002848
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

GSK3B Antibody

BF0695 200ul
EUR 540

GSK3B Antibody

BF0695-100ul 100ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA,FACS

GSK3B Antibody

BF0695-200ul 200ul
EUR 270
Description: WB,IHC,IF/ICC,ELISA,FACS

GSK3B Antibody

BF0695-50ul 50ul
EUR 150
Description: WB,IHC,IF/ICC,ELISA,FACS

GSK3B Antibody

1-CSB-PA009963GA01HU
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat, Pig. This antibody is Unconjugated. Tested in the following application: ELISA, WB

GSK3B Antibody

1-CSB-PA009963LA01HU
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:500

GSK3B Antibody

1-CSB-PA009038
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

GSK3B antibody

CAF50144-100ug 100ug
EUR 312

GSK3B Antibody

1-CSB-PA080166
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

GSK3B Antibody

CSB-PA939628- each
EUR 402
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

CSB-PA939628-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

GWB-MT481D 50ug Ask for price

GSK3B Antibody

E036918 100μg/100μl
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

E10-30006 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E10-30705 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E10-30705T 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E220184-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

GSK3B Antibody

E220184-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B antibody

E39-03673 100ug/100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E19-6806 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E19-7231 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E92081 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

E93174 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

MBS5313117-01mL 0.1mL
EUR 800

GSK3B Antibody

MBS5313117-5x01mL 5x0.1mL
EUR 3440

GSK3b Antibody

MBS5311338-01mg 0.1mg
EUR 490

GSK3b Antibody

MBS5311338-5x01mg 5x0.1mg
EUR 2155

GSK3B Antibody

MBS2526368-006mL 0.06mL
EUR 180

GSK3B Antibody

MBS2526368-012mL 0.12mL
EUR 260

GSK3B Antibody

MBS2526368-02mL 0.2mL
EUR 405

GSK3B Antibody

MBS2526368-5x02mL 5x0.2mL
EUR 1725

GSK3B Antibody

MBS2526819-006mL 0.06mL
EUR 230

GSK3B Antibody

MBS2526819-012mL 0.12mL
EUR 310

GSK3B Antibody

MBS2526819-02mL 0.2mL
EUR 480

GSK3B Antibody

MBS7131863-01mL 0.1mL
EUR 270

GSK3B Antibody

MBS7131863-5x01mL 5x0.1mL
EUR 1200

GSK3B Antibody

MBS7122537-005mg 0.05mg
EUR 150

GSK3B Antibody

MBS7122537-01mg 0.1mg
EUR 190

GSK3B Antibody

MBS7122537-5x01mg 5x0.1mg
EUR 845

GSK3B Antibody

MBS7122623-005mg 0.05mg
EUR 150

GSK3B Antibody

MBS7122623-01mg 0.1mg
EUR 190

GSK3B Antibody

MBS7122623-5x01mg 5x0.1mg
EUR 845

GSK3B Antibody

MBS7119532-005mg 0.05mg
EUR 150

GSK3B Antibody

MBS7119532-01mg 0.1mg
EUR 190

GSK3B Antibody

MBS7119532-5x01mg 5x0.1mg
EUR 845

GSK3B Antibody

MBS7136549-005mL 0.05mL
EUR 220

GSK3B Antibody

MBS7136549-01mL 0.1mL
EUR 300

GSK3B Antibody

MBS7136549-5x01mL 5x0.1mL
EUR 1350

GSK3B Antibody

MBS9607870-01mL 0.1mL
EUR 260

GSK3B Antibody

MBS9607870-02mL 0.2mL
EUR 305

GSK3B Antibody

MBS9607870-5x02mL 5x0.2mL
EUR 1220

GSK3B Antibody

MBS9602821-005mL 0.05mL
EUR 260

GSK3B Antibody

MBS9602821-01mL 0.1mL
EUR 325

GSK3B Antibody

MBS9602821-02mL 0.2mL
EUR 400

GSK3B Antibody

MBS9602821-5x02mL 5x0.2mL
EUR 1750

GSK3B Antibody

MBS969826-005mg 0.05mg
EUR 190

GSK3B Antibody

MBS969826-01mg 0.1mg
EUR 270

GSK3B Antibody

MBS969826-5x01mg 5x0.1mg
EUR 1205

GSK3B Antibody

MBS8503474-01mL 0.1mL
EUR 325

GSK3B Antibody

MBS8503474-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody

MBS8503474-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody

MBS8503474-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Antibody

MBS8503474-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Antibody

MBS850776-01mg 0.1mg
EUR 305

GSK3B Antibody

MBS850776-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody

MBS850776-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody

MBS850776-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Antibody

MBS850776-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Antibody

MBS8516276-01mg 0.1mg
EUR 305

GSK3B Antibody

MBS8516276-01mLAF405L 0.1mL(AF405L)
EUR 465

GSK3B Antibody

MBS8516276-01mLAF405S 0.1mL(AF405S)
EUR 465

GSK3B Antibody

MBS8516276-01mLAF610 0.1mL(AF610)
EUR 465

GSK3B Antibody

MBS8516276-01mLAF635 0.1mL(AF635)
EUR 465

GSK3B antibody

MBS831019-01mL 0.1mL
EUR 810

GSK3B antibody

MBS831019-5x01mL 5x0.1mL
EUR 3505

GSK3B Antibody

MBS8503766-01mL 0.1mL
EUR 325

GSK3B Antibody

MBS8503766-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody

MBS8503766-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody

MBS8503766-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Antibody

MBS8503766-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Antibody

MBS8516665-01mg 0.1mg
EUR 305

GSK3B Antibody

MBS8516665-01mLAF405L 0.1mL(AF405L)
EUR 465

GSK3B Antibody

MBS8516665-01mLAF405S 0.1mL(AF405S)
EUR 465

GSK3B Antibody

MBS8516665-01mLAF610 0.1mL(AF610)
EUR 465

GSK3B Antibody

MBS8516665-01mLAF635 0.1mL(AF635)
EUR 465

GSK3B Antibody

MBS8526909-005mg 0.05mg
EUR 235

GSK3B Antibody

MBS8526909-01mg 0.1mg
EUR 305

GSK3B Antibody

MBS8526909-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody

MBS8526909-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody

MBS8526909-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B antibody

MBS9412683-005mL 0.05mL
EUR 300

GSK3B antibody

MBS9412683-01mL 0.1mL
EUR 390

GSK3B antibody

MBS9412683-5x01mL 5x0.1mL
EUR 1610

GSK3B antibody

MBS9410678-005mL 0.05mL
EUR 300

GSK3B antibody

MBS9410678-01mL 0.1mL
EUR 390

GSK3B antibody

MBS9410678-5x01mL 5x0.1mL
EUR 1610

GSK3B Antibody

MBS9411632-01mL 0.1mL
EUR 305

GSK3B Antibody

MBS9411632-5x01mL 5x0.1mL
EUR 1230

GSK3A/GSK3B Antibody

1-CSB-PA002838
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  • 50ug
  • 100ug
Description: A polyclonal antibody against GSK3A/GSK3B. Recognizes GSK3A/GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

GSK3A / GSK3B Antibody

abx328487-100g 100 µg
EUR 250

GSK3A / GSK3B Antibody

20-abx328487
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  • 50 ug
  • 100 ug

GSK3A / GSK3B Antibody

abx328487-50g 50 µg
EUR 187.5

GSK3A/GSK3B Antibody

MBS7122062-005mg 0.05mg
EUR 150

GSK3A/GSK3B Antibody

MBS7122062-01mg 0.1mg
EUR 190

GSK3A/GSK3B Antibody

MBS7122062-5x01mg 5x0.1mg
EUR 845

Anti-GSK3 beta/GSK3B Antibody Picoband™

A00791-3 10ug
EUR 154
Description: Western blot, 0.25-0.5 μg/ml, Human;_x000D_Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Human

Mouse Anti GSK3b (pS9) Monoclonal Antibody

MBS460723-01mg 0.1mg
EUR 315

Mouse Anti GSK3b (pS9) Monoclonal Antibody

MBS460723-5x01mg 5x0.1mg
EUR 1330

Mouse anti GSK3b(pS9) Monoclonal Antibody

TA354463 100 µg Ask for price

Rabbit anti GSK3b(pS9) Polyclonal Antibody

TA354486 100 µg Ask for price

Human, Rabbit GSK3B antibody

M0006 100ul
EUR 150

GSK3B (pY216) Antibody

20-abx000312
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  • 20 ul
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GSK3B (pSer9) Antibody

abx243027-96tests 96 tests
EUR 287.5

GSK3B (pY216) Antibody

abx123289-100l 100 µl
EUR 200

GSK3B (pY216) Antibody

20-abx123289
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  • 20 ul
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GSK3B (pY216) Antibody

abx123289-1ml 1 ml
EUR 475

GSK3B (pY216) Antibody

abx123289-200l 200 µl
EUR 325

GSK3B Antibody, HRP conjugated

1-CSB-PA009963LB01HU
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  • 50ug
  • 100ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

GSK3B Antibody; HRP conjugated

MBS7005440-005mg 0.05mg
EUR 190

GSK3B Antibody; HRP conjugated

MBS7005440-01mg 0.1mg
EUR 270

GSK3B Antibody; HRP conjugated

MBS7005440-5x01mg 5x0.1mg
EUR 1205

GSK3B Antibody HRP Conjugated

MBS9459703-01mL 0.1mL
EUR 595

GSK3B Antibody HRP Conjugated

MBS9459703-5x01mL 5x0.1mL
EUR 2525

GSK3B Antibody, FITC conjugated

1-CSB-PA009963LC01HU
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  • 50ug
  • 100ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

GSK3B Antibody; FITC conjugated

MBS7005054-005mg 0.05mg
EUR 190

GSK3B Antibody; FITC conjugated

MBS7005054-01mg 0.1mg
EUR 270

GSK3B Antibody; FITC conjugated

MBS7005054-5x01mg 5x0.1mg
EUR 1205

OAPA00251-5UG - GSK3B Antibody

OAPA00251-5UG 5ug
EUR 69

OACA03072-50UG - GSK3B Antibody

OACA03072-50UG 50ug
EUR 179

GSK3B Antibody, Biotin conjugated

1-CSB-PA009963LD01HU
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  • 50ug
  • 100ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

GSK3B Antibody; Biotin conjugated

MBS7002577-005mg 0.05mg
EUR 190

GSK3B Antibody; Biotin conjugated

MBS7002577-01mg 0.1mg
EUR 270

GSK3B Antibody; Biotin conjugated

MBS7002577-5x01mg 5x0.1mg
EUR 1205

OAAF01318-100UG - GSK3B Antibody

OAAF01318-100UG 100ug
EUR 329

OAAJ02835-100UL - GSK3B Antibody

OAAJ02835-100UL 100ul
EUR 319

OAAJ07280-100UL - GSK3B Antibody

OAAJ07280-100UL 100uL
EUR 319

OASG07740-100UL - GSK3B Antibody

OASG07740-100UL 100ul
EUR 269

OASG07741-100UL - GSK3B Antibody

OASG07741-100UL 100ul
EUR 269

OASG07742-100UL - GSK3B Antibody

OASG07742-100UL 100ul
EUR 269

OASG03249-100UL - GSK3B Antibody

OASG03249-100UL 100ul
EUR 239

OACA03072-100UG - GSK3B Antibody

OACA03072-100UG 100ug
EUR 319

GSK3B Polyclonal Antibody

A62706
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72446
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  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72447
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  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72448
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  • 50 ul
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GSK3B Polyclonal Antibody

A72450
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  • 50 ul
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GSK3B Conjugated Antibody

C36918 100ul
EUR 476.4

GSK3B Conjugated Antibody

C38353 100ul
EUR 476.4

GSK3B Polyclonal Antibody

MBS127304-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody

MBS127304-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody

MBS127304-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody

MBS127304-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody

MBS127304-5x02mL 5x0.2mL
EUR 2265

GSK3B Polyclonal Antibody

MBS127965-002mL 0.02mL
EUR 220

GSK3B Polyclonal Antibody

MBS127965-005mL 0.05mL
EUR 295

GSK3B Polyclonal Antibody

MBS127965-01mL 0.1mL
EUR 430

GSK3B Polyclonal Antibody

MBS127965-02mL 0.2mL
EUR 600

GSK3B Polyclonal Antibody

MBS127965-5x02mL 5x0.2mL
EUR 2525

GSK3B Polyclonal Antibody

E911360 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E911578 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E916868 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E96164 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

MBS2566238-006mL 0.06mL
EUR 190

GSK3B Polyclonal Antibody

MBS2566238-012mL 0.12mL
EUR 265

GSK3B Polyclonal Antibody

MBS2566238-02mL 0.2mL
EUR 415

GSK3B Polyclonal Antibody

MBS2566238-5x02mL 5x0.2mL
EUR 1835

GSK3B Polyclonal Antibody

MBS2547907-006mL 0.06mL
EUR 180

GSK3B Polyclonal Antibody

MBS2547907-012mL 0.12mL
EUR 260

GSK3B Polyclonal Antibody

MBS2547907-02mL 0.2mL
EUR 405

GSK3B Polyclonal Antibody

MBS2547907-5x02mL 5x0.2mL
EUR 1725

GSK3B Polyclonal Antibody

MBS2520732-002mL 0.02mL
EUR 135

GSK3B Polyclonal Antibody

MBS2520732-006mL 0.06mL
EUR 180

GSK3B Polyclonal Antibody

MBS2520732-012mL 0.12mL
EUR 255

GSK3B Polyclonal Antibody

MBS2520732-02mL 0.2mL
EUR 400

GSK3B Polyclonal Antibody

MBS2520732-5x02mL 5x0.2mL
EUR 1715

GSK3B Polyclonal Antibody

MBS8572783-01mL 0.1mL
EUR 305

GSK3B Polyclonal Antibody

MBS8572783-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Polyclonal Antibody

MBS8572783-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Polyclonal Antibody

MBS8572783-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Polyclonal Antibody

MBS8572783-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Polyclonal Antibody

MBS9126031-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody

MBS9126031-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody

MBS9126031-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody

MBS9126031-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody

MBS9126031-5x02mL 5x0.2mL
EUR 2265

GSK3B Polyclonal Antibody

MBS9131456-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody

MBS9131456-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody

MBS9131456-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody

MBS9131456-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody

MBS9131456-5x02mL 5x0.2mL
EUR 2265
Constantly, over-expression of a constitutively energetic GSK enhanced Ang II-induced ET1 transcription and knockdown of both MRTF-A or BRG1 abrogated the enhancement of ET1 transcription. In conclusion, our information spotlight a beforehand unrecognized mechanism that contributes to the transcriptional regulation of endothelin. Concentrating on this GSK3-SRF axis could yield novel approaches within the intervention of cardiovascular ailments.

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