Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics

Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer’s therapeutics

Untangling probably the most selective kinase inhibitors by way of pharmacological intervention stays one of many difficult affairs thus far. Inaccordance to this drift, herein we describe the design and synthesis of a set of recent heterocyclic analogues consisting of 6,7 dimethyl Quinoxaline, appended to a connector, using Schiff base technique (Compounds I – IX ).
The compounds had been characterised by numerous spectroscopic strategies and the kinase inhibition assay had been carried out on few prime members of the CMGC household specifically the GSK3 b , DYRK1A and CLK1 receptors respectively, which were identified to be straight concerned in hyperphosphorylation of Tau.
Curiously the organic analysis outcomes revealed that Compounds IV & V , with bromo/chloro functionalities within the fragrant core had been advantaged of being extremely selective in the direction of the goal GSK3b over others.
To strengthen our evaluation, we adopted molecular modelling research, the place compounds IV /V had been redocked in the identical grid 4AFJ, as that of the reference ligand, 5-Aryl-4-Carboxamide-1,3-Oxazole. Surprisingly, our investigation underpined that for each the compounds IV/V, a major H-bonding existed between the designed molecules ( IV/V) and Val 135 residue within the receptor GSK3b, inline with the reference ligand. We attribute this interplay to instigate efficiency within the compounds.
Certainly the opposite non-covalent interplay, between the by-product’s fragrant nucleus and Arg 141/Thr 138 within the receptor GSK3b, might need been answerable for enhancing the selectivity within the targets. Total, we really feel that the current work depicts a logical demonstration in the direction of advantageous tuning the efficacy of the inhibitors by way of systematic adjustment of electron density at acceptable positions within the fragrant ring be it the primary quinoxaline or the opposite fragrant nucleus. Thus this pathway presents a handy technique for the event of environment friendly therapeutics for diversified neurodegenerative ailments like that of Alzheimer’s.

GSK3 as a Regulator of Cytoskeleton Structure: Penalties for Well being and Illness

Glycogen synthase kinase 3 (GSK3) was initially remoted as a vital protein in vitality metabolism. Nonetheless, subsequent research point out that GSK-Three is a multi-tasking kinase that hyperlinks quite a few signaling pathways in a cell and performs an important position within the regulation of many elements of mobile physiology.
As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interplay with the extracellular matrix, and directional migration of cells and their organelles throughout the progress and growth of an animal organism. On this assessment, the roles of GSK3-cytoskeleton interactions in mind growth and pathology, migration of wholesome and most cancers cells, and in mobile trafficking of mitochondria shall be mentioned.
Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics

An Overview of the Security, Effectivity, and Sign Pathways of Stem Cell Remedy for Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune illness that impacts a number of organs and tissues. Mesenchymal stem cells (MSCs) are thought-about a great supply for autoimmune illness and hematological illness remedy. This assessment will summarize the efficacy, security, and mechanisms of MSC remedy for SLE.
MSC remedy can scale back anti-dsDNA, antinuclear antigen (ANA), proteinuria, and serum creatinine in SLE sufferers. In animal fashions of SLE, MSC remedy additionally signifies that it might scale back anti-dsDNA, ANA, proteinuria, and serum creatinine and ameliorate renal pathology.
There aren’t any severe hostile occasions, treatment-related mortality, or tumor-related occasions in SLE sufferers after stem cell therapy. MSCs can inhibit inflammatory components, equivalent to MCP-1 and HMGB-1, and inhibit inflammation-related signaling pathways, such because the NF-κB, JAK/STAT, and Akt/GSK3β signaling pathways, to alleviate the lesions in SLE.

Mitotic WNT signalling orchestrates neurogenesis within the growing neocortex

The position of WNT/β-catenin signalling in mouse neocortex growth stays ambiguous. Most research reveal that WNT/β-catenin regulates progenitor self-renewal however others counsel it could additionally promote differentiation. Right here we discover the position of WNT/STOP signalling, which stabilizes proteins throughout G2/M by inhibiting glycogen synthase kinase (GSK3)-mediated protein degradation.
We present that mice mutant for cyclin Y and cyclin Y-like 1 (Ccny/l1), key regulators of WNT/STOP signalling, show decreased neurogenesis within the growing neocortex. Particularly, basal progenitors, which exhibit delayed cell cycle development, had been drastically decreased. Ccny/l1-deficient apical progenitors present decreased uneven division attributable to a rise in apical-basal astral microtubules.
We establish the neurogenic transcription components Sox4 and Sox11 as direct GSK3 targets which are stabilized by WNT/STOP signalling in basal progenitors throughout mitosis and that promote neuron technology. Our work reveals that WNT/STOP signalling drives cortical neurogenesis and identifies mitosis as a vital part for neural progenitor destiny.

GSK3s: nodes of multilayer regulation of plant growth and stress responses

Glycogen synthase kinase 3 (GSK3) relations are extremely conserved serine/threonine protein kinases in eukaryotes. Not like animals, vegetation have developed with a number of homologs of GSK3s concerned in a various array of organic processes. Rising proof means that GSK3s act as signaling hubs for integrating notion and transduction of numerous indicators required for plant growth and responses to abiotic and biotic cues.
Right here we assessment current advances in understanding the molecular interactions between GSK3s and an increasing spectrum of their upstream regulators and downstream substrates in vegetation. We additional focus on how GSK3s act as key signaling nodes of multilayer regulation of plant growth and stress response by way of both being regulated on the post-translational degree or regulating their substrates by way of phosphorylation.

GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells

Endothelin, encoded by ET1, is a vasoactive substance primarily synthesized in vascular endothelial cells (VECs). Elevation of endothelin ranges, attributable to transcriptional hyperactivation, has been noticed in a bunch of cardiovascular ailments. We now have beforehand proven that serum response issue (SRF) is a regulator of ET1 transcription in VECs.
Right here we report that angiotensin II (Ang II) induced ET1 transcription paralleled activation of glycogen synthase kinase 3 (GSK3) in cultured VECs. GSK3 knockdown or pharmaceutical inhibition attenuated Ang II induced endothelin expression.
Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics
Of curiosity, the impact of GSK3 on endothelin transcription relied on the conserved SRF motif inside the ET1 promoter. Additional evaluation revealed that GSK3 interacted with and phosphorylated SRF at serine 224. Phosphorylation of SRF by GSK3 didn’t affect its recruitment to the ET1 promoter.
As an alternative, GSK3-mediated SRF phosphorylation potentiated its interplay with MRTF-A, a key co-factor for SRF, which helped recruit the chromatin transforming protein BRG1 to the ET1 promoter leading to augmented histone H3 acetylation/H3K4 trimethylation.

GSK3B Antibody

36918-100ul 100ul
EUR 302.4

GSK3B antibody

38353 100ul
EUR 439

GSK3B antibody

38353-100ul 100ul
EUR 302.4

GSK3B antibody

38616 100ul
EUR 439

GSK3B antibody

38616-100ul 100ul
EUR 302.4

GSK3B Antibody

CSB-PA939628- each
EUR 402
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

CSB-PA939628-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

E036918 100μg/100μl
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

E10-30705 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E10-30705T 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E10-30006 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E19-6806 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E19-7231 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B antibody

E39-03673 100ug/100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E93174 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

E92081 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

E220184-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

GSK3B Antibody

E220184-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

BF0695 200ul
EUR 540

GSK3B Antibody

BF0695-100ul 100ul
EUR 350

GSK3B Antibody

BF0695-200ul 200ul
EUR 450

GSK3B Antibody

BF0695-50ul 50ul
EUR 250

GSK3B antibody

CAF50144-100ug 100ug
EUR 312

GSK3B antibody

70R-15005 100 ul
EUR 497
Description: Rabbit polyclonal GSK3B antibody

GSK3B antibody

70R-17615 50 ul
EUR 289
Description: Rabbit polyclonal GSK3B antibody

GSK3b antibody

70R-11869 100 ug
EUR 357
Description: Rabbit polyclonal GSK3b antibody

GSK3B Antibody

1-CSB-PA009038
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

GSK3B Antibody

1-CSB-PA009963GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat, Pig. This antibody is Unconjugated. Tested in the following application: ELISA, WB

GSK3B Antibody

1-CSB-PA009963LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:500

GSK3B Antibody

1-CSB-PA002848
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

GSK3B Antibody

1-CSB-PA080166
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  • 100ug
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

GSK3B Antibody

GWB-MT481D 50ug Ask for price

Gsk3b Antibody

F44221-0.08ML 0.08 ml
EUR 140.25
Description: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).

Gsk3b Antibody

F44221-0.4ML 0.4 ml
EUR 322.15
Description: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).

GSK3B Antibody

F51046-0.08ML 0.08 ml
EUR 140.25
Description: GSK3B is a constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. May also mediate the development of insulin resistance by regulating activation of transcription factors. [UniProt]

GSK3B Antibody

F51046-0.4ML 0.4 ml
EUR 322.15
Description: GSK3B is a constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. May also mediate the development of insulin resistance by regulating activation of transcription factors. [UniProt]

GSK3A / GSK3B Antibody

20-abx328487
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  • 100 ug
  • 50 ug

GSK3A/GSK3B Antibody

1-CSB-PA002838
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3A/GSK3B. Recognizes GSK3A/GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

GSK3A / GSK3B Antibody

abx328487-100g 100 µg
EUR 250

GSK3A / GSK3B Antibody

abx328487-50g 50 µg
EUR 187.5

Anti-GSK3 beta/GSK3B Antibody Picoband™

A00791-3 10ug
EUR 154
Description: Western blot, 0.25-0.5 μg/ml, Human;_x000D_Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Human

Mouse anti GSK3b(pS9) Monoclonal Antibody

TA354463 100 µg Ask for price

GSK3B (pY216) Antibody

20-abx123289
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  • 100 ul
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  • 20 ul
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GSK3B (pY216) Antibody

20-abx000312
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  • 100 ul
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  • 20 ul
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GSK3B (pY216) Antibody

abx123289-100l 100 µl
EUR 200

GSK3B (pY216) Antibody

abx123289-1ml 1 ml
EUR 475

GSK3B (pY216) Antibody

abx123289-200l 200 µl
EUR 325

GSK3B (pSer9) Antibody

abx243027-96tests 96 tests
EUR 287.5

GSK3B Antibody, HRP conjugated

1-CSB-PA009963LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Rabbit anti GSK3b(pS9) Polyclonal Antibody

TA354486 100 µg Ask for price

GSK3B Antibody, FITC conjugated

1-CSB-PA009963LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OAPA00251-5UG - GSK3B Antibody

OAPA00251-5UG 5ug
EUR 69

OACA03072-50UG - GSK3B Antibody

OACA03072-50UG 50ug
EUR 179

GSK3B Antibody, Biotin conjugated

1-CSB-PA009963LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OASG03249-100UL - GSK3B Antibody

OASG03249-100UL 100ul
EUR 239

OASG07740-100UL - GSK3B Antibody

OASG07740-100UL 100ul
EUR 269

OASG07741-100UL - GSK3B Antibody

OASG07741-100UL 100ul
EUR 269

OASG07742-100UL - GSK3B Antibody

OASG07742-100UL 100ul
EUR 269

OAAJ02835-100UL - GSK3B Antibody

OAAJ02835-100UL 100ul
EUR 319

OAAJ07280-100UL - GSK3B Antibody

OAAJ07280-100UL 100uL
EUR 319

OAAF01318-100UG - GSK3B Antibody

OAAF01318-100UG 100ug
EUR 329

OACA03072-100UG - GSK3B Antibody

OACA03072-100UG 100ug
EUR 319

GSK3B Polyclonal Antibody

A62706
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  • 100 µg
  • 20 ul
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  • 100 ul

GSK3B Polyclonal Antibody

E911360 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E911578 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E916868 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E96164 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Conjugated Antibody

C36918 100ul
EUR 476.4

GSK3B Conjugated Antibody

C38353 100ul
EUR 476.4

GSK3B Polyclonal Antibody

A72446 50 μl
EUR 408

GSK3B Polyclonal Antibody

A72447 50 μl
EUR 408

GSK3B Polyclonal Antibody

A72448 50 μl
EUR 408

GSK3B Polyclonal Antibody

A72450 50 μl
EUR 557

GSK3 beta Antibody / GSK3B

F54007-0.1ML 0.1 ml
EUR 322.15
Description: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. [UniProt]

GSK3B (Ab-9) Antibody

CSB-PA120951- each
EUR 402
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

GSK3B (Ab-9) Antibody

CSB-PA120951-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

GSK3B (pS21 / 29) Antibody

abx031864-400ul 400 ul
EUR 627.6

GSK3B (pS21 / 29) Antibody

abx031864-80l 80 µl
EUR 343.2

GSK3B (pS21 / 29) Antibody

abx031864-400l 400 µl
EUR 525

Rabbit Anti-Human GSK3B (aa 214-218) Polyclonal Antibody

CPB-1178RH 100 ul
EUR 552

Rabbit anti GSK3b(Paired S9) Polyclonal Antibody

TA354454 100 µg Ask for price

Monoclonal GSK3B Antibody, Clone: 3D6B4

AMM05223G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3B. The antibodies are raised in Mouse and are from clone 3D6B4. This antibody is applicable in WB and IHC, FC, E

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-100ul 100 ul
EUR 560.4

GSK3A / GSK3B (pY279 / 216) Antibody

20-abx328488
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  • 100 ug
  • 50 ug

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-100g 100 µg Ask for price

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-20g 20 µg
EUR 412.5

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-50g 50 µg Ask for price

GSK3A / GSK3B (pY279 / 216) Antibody

abx328488-100g 100 µg
EUR 250

GSK3A / GSK3B (pY279 / 216) Antibody

abx328488-50g 50 µg
EUR 187.5

GSK3B Rabbit Polyclonal Antibody

53236 100ul
EUR 439

GSK3B Rabbit Polyclonal Antibody

E312222 100ug/200ul
EUR 295
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GSK3B Rabbit Polyclonal Antibody

E10G10937 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GSK3B Rabbit Polyclonal Antibody

E10G12655 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GSK3B Rabbit Polyclonal Antibody

E10G05782 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GSK3A/GSK3B (pY216 + pY279) Antibody

abx243004-96tests 96 tests
EUR 287.5

Polyclonal Mouse Gsk3b Antibody (N-term)

APR04027G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Mouse Gsk3b (N-term). This antibody is tested and proven to work in the following applications:

Polyclonal GSK3B / GSK3 Beta Antibody

AMM05221G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta . This antibody is tested and proven to work in the following applications:

GSK3B Polyclonal Conjugated Antibody

C30706 100ul
EUR 476.4

GSK3A / GSK3B (Ab-279 / 216) Antibody

abx332166-100ul 100 ul
EUR 510

GSK3A/GSK3B (Ab-279/216) Antibody

CSB-PA255909- each
EUR 402
Description: A polyclonal antibody against GSK3A/GSK3B (Ab-279/216). Recognizes GSK3A/GSK3B (Ab-279/216) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GSK3A/GSK3B (Ab-279/216) Antibody

CSB-PA255909-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3A/GSK3B (Ab-279/216). Recognizes GSK3A/GSK3B (Ab-279/216) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Antibody for Human GSK3b (pSer9)

SPC-1384D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 565.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 633.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 655.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 680.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 700.

Antibody for Human GSK3b (pSer9)

SPC-1384D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human GSK3b (pSer9)

SPC-1384D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to APC .

Antibody for Human GSK3b (pSer9)

SPC-1384D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to APC/Cy7.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY350 0.1ml
EUR 496.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 350.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY405 0.1ml
EUR 483.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 405.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 488.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY594 0.1ml
EUR 474
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY633 0.1ml
EUR 468
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 633.

Antibody for Human GSK3b (pSer9)

SPC-1384D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to HRP.

Antibody for Human GSK3b (pSer9)

SPC-1384D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to PE/ATTO 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to PerCP.

Antibody for Human GSK3b (pSer9)

SPC-1384D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to RPE .

Antibody for Human GSK3b (pSer9)

SPC-1384D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Streptavidin.

ARP97287_P050 - GSK3B Antibody-C-terminal region

ARP97287_P050 100ul
EUR 389

OAGA08182-100UL - GSK3B Antibody (Phospho-Ser9)

OAGA08182-100UL 100ul
EUR 369

OASG03245-100UL - GSK3B Antibody (Phospho-Ser9)

OASG03245-100UL 100ul
EUR 239

OASG03246-100UL - GSK3B Antibody (Phospho-Ser9)

OASG03246-100UL 100ul
EUR 239

Mouse Monoclonal Antibody to GSK3B

sAP-1054 50ug
EUR 270

Mouse Monoclonal Antibody to GSK3B

sAP-0359 50ug
EUR 270

OAEC00270-50UG - GSK3B Antibody (Phospho-Tyr216)

OAEC00270-50UG 50ug
EUR 369

OABF00015-100UL - GSK3B Antibody (OABF00015-100UL)

OABF00015-100UL 100ul
EUR 409

[KO Validated] GSK3B Polyclonal Antibody

30706 100ul
EUR 439

[KO Validated] GSK3B Polyclonal Antibody

30706-100ul 100ul
EUR 302.4

[KO Validated] GSK3B Polyclonal Antibody

30706-50ul 50ul
EUR 224.4

Rabbit Anti-Human GSK3B Polyclonal Antibody, Phospho-Tyr216

CPB-820RH 100 ul
EUR 670.8

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx112808
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx125048
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx125336
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx125917
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx147405-100ug 100 ug
EUR 526.8

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx037712-100ug 100 ug
EUR 469.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx002277
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx004714
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx010856-100ul 100 ul
EUR 493.2

Glycogen Synthase Kinase 3 Beta (Gsk3b) Antibody

abx028354-400ul 400 ul
EUR 627.6

Glycogen Synthase Kinase 3 Beta (Gsk3b) Antibody

abx028354-80l 80 µl
EUR 343.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx001694
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233673-100ug 100 ug
EUR 577.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233674-100ug 100 ug
EUR 577.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233675-100ug 100 ug
EUR 661.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233676-100ug 100 ug
EUR 610.8

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx172635
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx172636
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  • Ask for price
  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx224101-100ug 100 ug
EUR 493.2

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx176674
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  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx176675
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  • Ask for price
  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx332014-100ul 100 ul
EUR 510

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx332790-100ul 100 ul
EUR 510

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx328988
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  • Ask for price
  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx329709
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  • Ask for price
  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx330217
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  • Ask for price
  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx318062
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  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

glycogen synthase kinase 3 beta (GSK3B) Antibody

E301022 100ug/200ul
EUR 275
Description: Available in various conjugation types.

Rabbit polyclonal Mouse Gsk3b Antibody (N-term)

TA324570 400 µl Ask for price

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx004714-100l 100 µl
EUR 400

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx004714-20l 20 µl
EUR 175

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx004714-50l 50 µl
EUR 275

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx001694-100l 100 µl
EUR 400

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx001694-20l 20 µl
EUR 175

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx001694-50l 50 µl
EUR 275

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx002277-100l 100 µl
EUR 475

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx002277-20l 20 µl
EUR 200

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx002277-50l 50 µl
EUR 325

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx010856-100g 100 µg Ask for price

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx010856-10g 10 µg
EUR 362.5

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx010856-200g 200 µg Ask for price

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx172635-1ml 1 ml
EUR 787.5

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx172636-1ml 1 ml
EUR 850

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx176674-1096tests 10 × 96 tests
EUR 750

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx176674-596tests 5 × 96 tests
EUR 337.5

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx176674-96tests 96 tests
EUR 275

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx176675-1096tests 10 × 96 tests
EUR 812.5

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx176675-596tests 5 × 96 tests
EUR 362.5

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

abx176675-96tests 96 tests
EUR 287.5

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx112808-100l 100 µl
EUR 612.5

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx037712-96tests 96 tests
EUR 337.5

Glycogen Synthase Kinase 3 Beta (Gsk3b) Antibody

abx028354-400l 400 µl
EUR 518.75

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx125917-100l 100 µl
EUR 175

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx125917-1ml 1 ml
EUR 400

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx125917-200l 200 µl
EUR 275

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx125918-100l 100 µl
EUR 175

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx125918-1ml 1 ml
EUR 400

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx125918-200l 200 µl
EUR 275

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx224101-100l 100 µl Ask for price

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx224101-200l 200 µl Ask for price

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx224101-50l 50 µl
EUR 362.5

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233673-100g 100 µg
EUR 350

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233674-100g 100 µg
EUR 350

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233675-100g 100 µg
EUR 350

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233676-100g 100 µg
EUR 350

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx376355-96tests 96 tests
EUR 225

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx329709-100g 100 µg Ask for price

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx329709-20g 20 µg
EUR 187.5
Constantly, over-expression of a constitutively energetic GSK enhanced Ang II-induced ET1 transcription and knockdown of both MRTF-A or BRG1 abrogated the enhancement of ET1 transcription. In conclusion, our information spotlight a beforehand unrecognized mechanism that contributes to the transcriptional regulation of endothelin. Concentrating on this GSK3-SRF axis could yield novel approaches within the intervention of cardiovascular ailments.

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