Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics

Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer’s therapeutics

Untangling probably the most selective kinase inhibitors by way of pharmacological intervention stays one of many difficult affairs thus far. Inaccordance to this drift, herein we describe the design and synthesis of a set of recent heterocyclic analogues consisting of 6,7 dimethyl Quinoxaline, appended to a connector, using Schiff base technique (Compounds I – IX ).
The compounds had been characterised by numerous spectroscopic strategies and the kinase inhibition assay had been carried out on few prime members of the CMGC household specifically the GSK3 b , DYRK1A and CLK1 receptors respectively, which were identified to be straight concerned in hyperphosphorylation of Tau.
Curiously the organic analysis outcomes revealed that Compounds IV & V , with bromo/chloro functionalities within the fragrant core had been advantaged of being extremely selective in the direction of the goal GSK3b over others.
To strengthen our evaluation, we adopted molecular modelling research, the place compounds IV /V had been redocked in the identical grid 4AFJ, as that of the reference ligand, 5-Aryl-4-Carboxamide-1,3-Oxazole. Surprisingly, our investigation underpined that for each the compounds IV/V, a major H-bonding existed between the designed molecules ( IV/V) and Val 135 residue within the receptor GSK3b, inline with the reference ligand. We attribute this interplay to instigate efficiency within the compounds.
Certainly the opposite non-covalent interplay, between the by-product’s fragrant nucleus and Arg 141/Thr 138 within the receptor GSK3b, might need been answerable for enhancing the selectivity within the targets. Total, we really feel that the current work depicts a logical demonstration in the direction of advantageous tuning the efficacy of the inhibitors by way of systematic adjustment of electron density at acceptable positions within the fragrant ring be it the primary quinoxaline or the opposite fragrant nucleus. Thus this pathway presents a handy technique for the event of environment friendly therapeutics for diversified neurodegenerative ailments like that of Alzheimer’s.

GSK3 as a Regulator of Cytoskeleton Structure: Penalties for Well being and Illness

Glycogen synthase kinase 3 (GSK3) was initially remoted as a vital protein in vitality metabolism. Nonetheless, subsequent research point out that GSK-Three is a multi-tasking kinase that hyperlinks quite a few signaling pathways in a cell and performs an important position within the regulation of many elements of mobile physiology.
As a regulator of actin and tubulin cytoskeleton, GSK3 influences processes of cell polarization, interplay with the extracellular matrix, and directional migration of cells and their organelles throughout the progress and growth of an animal organism. On this assessment, the roles of GSK3-cytoskeleton interactions in mind growth and pathology, migration of wholesome and most cancers cells, and in mobile trafficking of mitochondria shall be mentioned.
Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics

An Overview of the Security, Effectivity, and Sign Pathways of Stem Cell Remedy for Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune illness that impacts a number of organs and tissues. Mesenchymal stem cells (MSCs) are thought-about a great supply for autoimmune illness and hematological illness remedy. This assessment will summarize the efficacy, security, and mechanisms of MSC remedy for SLE.
MSC remedy can scale back anti-dsDNA, antinuclear antigen (ANA), proteinuria, and serum creatinine in SLE sufferers. In animal fashions of SLE, MSC remedy additionally signifies that it might scale back anti-dsDNA, ANA, proteinuria, and serum creatinine and ameliorate renal pathology.
There aren’t any severe hostile occasions, treatment-related mortality, or tumor-related occasions in SLE sufferers after stem cell therapy. MSCs can inhibit inflammatory components, equivalent to MCP-1 and HMGB-1, and inhibit inflammation-related signaling pathways, such because the NF-κB, JAK/STAT, and Akt/GSK3β signaling pathways, to alleviate the lesions in SLE.

Mitotic WNT signalling orchestrates neurogenesis within the growing neocortex

The position of WNT/β-catenin signalling in mouse neocortex growth stays ambiguous. Most research reveal that WNT/β-catenin regulates progenitor self-renewal however others counsel it could additionally promote differentiation. Right here we discover the position of WNT/STOP signalling, which stabilizes proteins throughout G2/M by inhibiting glycogen synthase kinase (GSK3)-mediated protein degradation.
We present that mice mutant for cyclin Y and cyclin Y-like 1 (Ccny/l1), key regulators of WNT/STOP signalling, show decreased neurogenesis within the growing neocortex. Particularly, basal progenitors, which exhibit delayed cell cycle development, had been drastically decreased. Ccny/l1-deficient apical progenitors present decreased uneven division attributable to a rise in apical-basal astral microtubules.
We establish the neurogenic transcription components Sox4 and Sox11 as direct GSK3 targets which are stabilized by WNT/STOP signalling in basal progenitors throughout mitosis and that promote neuron technology. Our work reveals that WNT/STOP signalling drives cortical neurogenesis and identifies mitosis as a vital part for neural progenitor destiny.

GSK3s: nodes of multilayer regulation of plant growth and stress responses

Glycogen synthase kinase 3 (GSK3) relations are extremely conserved serine/threonine protein kinases in eukaryotes. Not like animals, vegetation have developed with a number of homologs of GSK3s concerned in a various array of organic processes. Rising proof means that GSK3s act as signaling hubs for integrating notion and transduction of numerous indicators required for plant growth and responses to abiotic and biotic cues.
Right here we assessment current advances in understanding the molecular interactions between GSK3s and an increasing spectrum of their upstream regulators and downstream substrates in vegetation. We additional focus on how GSK3s act as key signaling nodes of multilayer regulation of plant growth and stress response by way of both being regulated on the post-translational degree or regulating their substrates by way of phosphorylation.

GSK3-SRF Axis Mediates Angiotensin II Induced Endothelin Transcription in Vascular Endothelial Cells

Endothelin, encoded by ET1, is a vasoactive substance primarily synthesized in vascular endothelial cells (VECs). Elevation of endothelin ranges, attributable to transcriptional hyperactivation, has been noticed in a bunch of cardiovascular ailments. We now have beforehand proven that serum response issue (SRF) is a regulator of ET1 transcription in VECs.
Right here we report that angiotensin II (Ang II) induced ET1 transcription paralleled activation of glycogen synthase kinase 3 (GSK3) in cultured VECs. GSK3 knockdown or pharmaceutical inhibition attenuated Ang II induced endothelin expression.
Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics
Of curiosity, the impact of GSK3 on endothelin transcription relied on the conserved SRF motif inside the ET1 promoter. Additional evaluation revealed that GSK3 interacted with and phosphorylated SRF at serine 224. Phosphorylation of SRF by GSK3 didn’t affect its recruitment to the ET1 promoter.
As an alternative, GSK3-mediated SRF phosphorylation potentiated its interplay with MRTF-A, a key co-factor for SRF, which helped recruit the chromatin transforming protein BRG1 to the ET1 promoter leading to augmented histone H3 acetylation/H3K4 trimethylation.

anti- GSK3B antibody

FNab03674 100µg
EUR 505.25
Description: Antibody raised against GSK3B

anti- GSK3B antibody

FNab03675 100µg
EUR 585
Description: Antibody raised against GSK3B

anti- GSK3B antibody

FNab03676 100µg
EUR 548.75
Description: Antibody raised against GSK3B

Anti-GSK3B antibody

PAab03673 100 ug
EUR 355

Anti-GSK3B antibody

PAab03674 100 ug
EUR 355

Anti-GSK3B antibody

PAab03675 100 ug
EUR 412

Anti-GSK3B antibody

PAab03676 100 ug
EUR 386

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-GSK3B Antibody (Biotin)

STJ501296 100 µg
EUR 586

Anti-GSK3B Antibody (FITC)

STJ501297 100 µg
EUR 586

anti-GSK3B (3D10)

LF-MA30340 100 ul
EUR 486
Description: Mouse Monoclonal to GSK3B

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Hu-48Tests 48 Tests
EUR 521

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Hu-96Tests 96 Tests
EUR 723

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Mu-48Tests 48 Tests
EUR 533

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Mu-96Tests 96 Tests
EUR 740

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-48Tests 48 Tests
EUR 557

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-96Tests 96 Tests
EUR 775

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Mu-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Mu-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Hu-48Tests 48 Tests
EUR 544

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Hu-96Tests 96 Tests
EUR 756

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Mu-48Tests 48 Tests
EUR 557

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Mu-96Tests 96 Tests
EUR 774

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-48Tests 48 Tests
EUR 583

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-96Tests 96 Tests
EUR 811

Anti-Phospho-GSK3B-(S9) antibody

STJ22160 100 µl
EUR 393
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Phospho-GSK3B-(Y216) antibody

STJ116370 100 µl
EUR 393
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Phospho-GSK3B-(Y216) antibody

STJ110852 100 µl
EUR 393
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-GSK3b (Ab-9) Antibody

A00791-1 100ul
EUR 397
Description: Rabbit Polyclonal GSK3b (Ab-9) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

GSK3B Antibody

1-CSB-PA009038
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

GSK3B Antibody

1-CSB-PA009963GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat, Pig. This antibody is Unconjugated. Tested in the following application: ELISA, WB

GSK3B Antibody

1-CSB-PA009963LA01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:500

GSK3B Antibody

1-CSB-PA002848
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

GSK3B Antibody

1-CSB-PA080166
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

GSK3B Antibody

CSB-PA939628-
EUR 335
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

CSB-PA939628-100ul 100ul
EUR 316
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

36918-100ul 100ul
EUR 252

GSK3B antibody

38353-100ul 100ul
EUR 252

GSK3B antibody

38616-100ul 100ul
EUR 252

GSK3B Antibody

ABD6806 100 ug
EUR 438

GSK3B Antibody

ABD7231 100 ug
EUR 438

GSK3B Antibody

DF7231 200ul
EUR 304
Description: GSK3B Antibody detects endogenous levels of total GSK3B.

GSK3B Antibody

BF0695 200ul
EUR 376
Description: GSK3B antibody detects endogenous levels of total GSK3B.

GSK3B antibody

10R-1862 100 ul
EUR 403
Description: Mouse monoclonal GSK3B antibody

GSK3B antibody

70R-17615 50 ul
EUR 435
Description: Rabbit polyclonal GSK3B antibody

GSK3b antibody

70R-11869 100 ug
EUR 418
Description: Rabbit polyclonal GSK3b antibody

GSK3B antibody

70R-15005 100 ul
EUR 392
Description: Rabbit polyclonal GSK3B antibody

GSK3A/GSK3B Antibody

1-CSB-PA002838
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3A/GSK3B. Recognizes GSK3A/GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

GSK3B (pY216) Antibody

20-abx123289
  • EUR 495.00
  • EUR 704.00
  • EUR 217.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3B (pY216) Antibody

20-abx000312
  • EUR 495.00
  • EUR 704.00
  • EUR 217.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3B Polyclonal Antibody

A62706 100 µg
EUR 570.55
Description: reagents widely cited

GSK3A / GSK3B Antibody

20-abx328487
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

GSK3B Conjugated Antibody

C36918 100ul
EUR 397

GSK3B Conjugated Antibody

C38353 100ul
EUR 397

Phospho-GSK3b antibody

70R-11870 100 ug
EUR 525
Description: Rabbit polyclonal Phospho-GSK3b antibody

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

GSK3B siRNA

20-abx918789
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

GSK3B siRNA

20-abx918790
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

GSK3B siRNA

20-abx902344
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

GSK3B Plasmid

PVT7113 2 ug
EUR 266

Phospho-GSK3B (S9) Antibody

1-CSB-PA000536
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-GSK3B (S9). Recognizes Phospho-GSK3B (S9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/5000

Phospho-GSK3B (S9) Antibody

1-CSB-PA000636
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-GSK3B (S9). Recognizes Phospho-GSK3B (S9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

GSK3B Antibody, HRP conjugated

1-CSB-PA009963LB01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

GSK3B Antibody, FITC conjugated

1-CSB-PA009963LC01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

GSK3B Antibody, Biotin conjugated

1-CSB-PA009963LD01HU
  • EUR 317.00
  • EUR 335.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

GSK3B (Ab-9) Antibody

CSB-PA120951-
EUR 335
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

GSK3B (Ab-9) Antibody

CSB-PA120951-100ul 100ul
EUR 316
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

Phospho-GSK3B (Ser9) Antibody

CSB-PA166926-
EUR 335
Description: A polyclonal antibody against Phospho-GSK3B (Ser9). Recognizes Phospho-GSK3B (Ser9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

Phospho-GSK3B (Ser9) Antibody

CSB-PA166926-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-GSK3B (Ser9). Recognizes Phospho-GSK3B (Ser9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

GSK3B (pS21 / 29) Antibody

abx031864-400ul 400 ul
EUR 523

GSK3B (pS21 / 29) Antibody

abx031864-80l 80 µl
EUR 286

GSK3B Polyclonal Conjugated Antibody

C30706 100ul
EUR 397

Rabbit Anti-GSK3B monoclonal antibody, clone TZ13-82

DCABH-9320 100 ul
EUR 777

Rabbit Anti-Human GSK3B Polyclonal Antibody, Phospho-Tyr216

CPB-820RH 100 ul
EUR 559

Anti-Glycogen synthase kinase 3 B (GSK3B) (Ser9) antibody

STJ120111 100 µl
EUR 526

Rabbit Anti-GSK3A, GSK3B monoclonal antibody, clone TZ37-16

CABT-L635 100 ul
EUR 777

Rabbit Anti-Human GSK3B (aa 214-218) Polyclonal Antibody

CPB-1178RH 100 ul
EUR 460

Antibody for Human GSK3b (pSer9)

SPC-1384D 0.1ml
EUR 354
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is unconjugated.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A390 0.1ml
EUR 401
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 390.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A488 0.1ml
EUR 400
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 488.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A565 0.1ml
EUR 400
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 565.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A594 0.1ml
EUR 400
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A633 0.1ml
EUR 400
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 633.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A655 0.1ml
EUR 400
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 655.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A680 0.1ml
EUR 400
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 680.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A700 0.1ml
EUR 400
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 700.
Constantly, over-expression of a constitutively energetic GSK enhanced Ang II-induced ET1 transcription and knockdown of both MRTF-A or BRG1 abrogated the enhancement of ET1 transcription. In conclusion, our information spotlight a beforehand unrecognized mechanism that contributes to the transcriptional regulation of endothelin. Concentrating on this GSK3-SRF axis could yield novel approaches within the intervention of cardiovascular ailments.

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