Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner

Metformin promotes anticancer activity of NK cells in a p38 MAPK dependent manner

Metformin, a drug prescribed to deal with sort 2 diabetes, has been reported to own antitumor exercise by way of immunity activation. Nevertheless, the affect of metformin on pure killer (NK) cells just isn’t totally understood. Right here, we investigated whether or not metformin exerts a potent anticancer impact by activating NK cells. The outcomes…

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Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension

Total transferrin in cerebrospinal fluid is a novel biomarker for spontaneous intracranial hypotension

Spontaneous intracranial hypotension (SIH) is attributable to cerebrospinal fluid (CSF) leakage. Sufferers with SIH expertise postural complications, nausea, and many others., attributable to CSF hypovolemia. Imaging research and scientific examinations, equivalent to radioisotope (RI) scintigraphy, are helpful for diagnosing SIH. Nonetheless, 20-30% of sufferers don’t present typical morphology and scientific check outcomes. We beforehand reported…

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Allium sativum Lectin (ASA)

Resume The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. In t. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins has been examined as a function of pH, temperature, and denaturants in…

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