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Identification of Potential Kinase Inhibitors within the PI3K/AKT Pathway of Leishmania Species
Leishmaniasis is a public well being illness that requires the event of more practical remedies and the identification of novel molecular targets. Since blocking the PI3K/AKT pathway has been efficiently studied as an efficient anticancer technique for many years, we examined whether or not the identical method would even be possible in Leishmania on account of their excessive quantity and numerous set of annotated proteins.
Right here, we used a finest reciprocal hits protocol to establish potential protein kinase homologues in an annotated human PI3K/AKT pathway. We calculated their ligandibility primarily based on accessible bioactivity knowledge of the reported homologues and modelled their 3D buildings to estimate the druggability of their binding pockets.
The fashions have been used to run a digital screening methodology with molecular docking. We discovered and studied 5 protein kinases in 5 completely different Leishmania species, that are AKT, CDK, AMPK, mTOR and GSK3 homologues from the studied pathways.
The compounds discovered for various enzymes an
d species have been analysed and advised as start line scaffolds for the design of inhibitors. We studied the kinases’ participation in protein-protein interplay networks, and the potential deleterious results, if inhibited, have been supported with the literature.
Within the case of Leishmania GSK3, an inhibitor of its human counterpart, prioritized by our methodology, was validated in vitro to check its anti-Leishmania exercise and not directly infer the presence of the enzyme within the parasite. The evaluation contributes to bettering the information concerning the presence of comparable signalling pathways in Leishmania, in addition to the invention of compounds appearing towards any of those kinases as potential molecular targets within the parasite.
Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma
Microphthalmia-associated transcription issue (MITF) is the principal transcription issue regulating pivotal processes in melanoma cell improvement, development, survival, proliferation, differentiation and invasion. In recent times, convincing proof has been offered testifying key roles of endolysosomal cation channels, particularly TPCs and TRPMLs, in most cancers, together with breast most cancers, glioblastoma, bladder most cancers, hepatocellular carcinoma and melanoma.
On this evaluate, we offer a gene expression profile of those channels in several types of cancers and decipher their roles, particularly the roles of two-pore channel 2 (TPC2) and TRPML1 in melanocytes and melanoma. We particularly focus on the signaling cascades regulating MITF and the connection between endolysosomal cation channels, MAPK, canonical Wnt/GSK3 pathways and MITF.
Lithium as a Neuroprotective Agent for Bipolar Dysfunction: An Overview
Lithium (Li+) is a primary possibility therapy for grownup acute episodes of Bipolar Dysfunction (BD) and for the prophylaxis of recent depressed or manic episodes. Additionally it is the popular selection as upkeep therapy. Quite a few research have proven morphological abnormalities within the brains of BD sufferers, suggesting that this extremely heritable dysfunction might exhibit progressive and deleterious adjustments in mind construction.
Since therapy with Li+ ameliorates these abnormalities, it has been postulated that Li+ is a neuroprotective agent in the identical manner atypical antipsychotics are neuroprotective in sufferers identified with schizophrenia spectrum issues. Li+‘s neuroprotective properties are associated to its modulation of nerve development elements, irritation, mitochondrial operate, oxidative stress, and programmed cell dying mechanisms akin to autophagy and apoptosis.
However, it isn’t identified whether or not Li+-induced neuroprotection is said to the inhibition of its putative molecular targets in a BD episode: the enzymes inositol-monophosphatase, (IMPase), glycogen-synthase-kinase 3β (GSK3), and Protein kinase C (PKC).
Moreover, it’s unsure whether or not these neuroprotective mechanisms are correlated with Li+‘s medical efficacy in sustaining temper stability. It’s anticipated that in a close-by future, precision medication approaches will enhance analysis and broaden therapy choices. This can actually contribute to ameliorating the medical and financial burden created by this devastating temper dysfunction.
Stemness-Suppressive Impact of Bibenzyl from Dendrobium ellipsophyllum in Human Lung Most cancers Stem-Like Cells
Most cancers stem-like cells (CSCs) are key mediators driving tumor initiation, metastasis, therapeutic failure, and subsequent most cancers relapse. Thus, focusing on CSCs has not too long ago emerged as a possible technique to enhance chemotherapy. On this examine, the anticancer exercise and stemness-regulating capability of 4,5,4′-trihydroxy-3,3′-dimethoxybibenzyl (TDB), a bibenzyl extracted from Dendrobium ellipsophyllum, are revealed in CSCs of varied human lung most cancers cells.
Tradition with TDB (5-10 μM) strongly abolished tumor-initiating cells in lung most cancers H460, H23, and A549 cells in each anchorage-dependent and anchorage-independent colony formation assays. Via the 3D single-spheroid formation mannequin, attenuation of self-renewal capability was noticed in CSC-enriched populations handled with 1-10 μM TDB for 7 days.
Stream cytometry evaluation confirmed the attenuation of %cell overexpressing CD133, a CSC biomarker, in TDB-treated lung most cancers spheroids. TDB at 5-10 μM remarkably suppressed regulatory indicators of p-Akt/Akt, p-GSK3β/GSK3β, and β-catenin similar to the downregulated mRNA degree of stemness transcription elements together with Nanog, Oct4, and Sox2. Furthermore, the antiapoptosis Bcl-2 and Mcl-1 proteins, that are downstream molecules of Akt signaling, have been evidently decreased in CSC-enriched spheroids after tradition with TDB (1-10 μM) for 24 h.
Apparently, the diminution of Akt expression by particular siAkt successfully reversed suppressive exercise of TDB focusing on on the CSC phenotype in human lung most cancers cells. These findings present promising proof of the inhibitory impact of TDB towards lung CSCs through suppression of Akt/GSK3β/β-catenin cascade and associated proteins, which might facilitate the event of this bibenzyl pure compound as a novel CSC-targeted therapeutic method for lung most cancers therapy.
Temper Regulatory Actions of Energetic and Sham Nucleus Accumbens Deep Mind Stimulation in Antidepressant Resistant Rats
The antidepressant actions of deep mind stimulation (DBS) are related to progressive neuroadaptations throughout the temper community, modulated partly, by neurotrophic mechanisms. We investigated the antidepressant-like results of continual nucleus accumbens (NAc) DBS and its affiliation with change in glycogen synthase kinase 3 (GSK3) and mammalian goal of rapamycin (mTOR) expression within the infralimbic cortex (IL), and the dorsal (dHIP) and ventral (vHIP) subregions of the hippocampus of antidepressant resistant rats.
Antidepressant resistance was induced through each day injection of adrenocorticotropic hormone (ACTH; 100 μg/day; 15 days) and confirmed by non-response to tricyclic antidepressant therapy (imipramine, 10 mg/kg). Moveable microdevices offered steady bilateral NAc DBS (130 Hz, 200 μA, 90 μs) for 7 days. A management sham electrode group was included, along with ACTH- and saline-treated management teams.
Dwelling cage monitoring, open subject, sucrose desire, and, pressured swim behavioral checks have been carried out. Submit-mortem ranges of GSK3 and mTOR, complete and phosphorylated, have been decided with Western blot.
As beforehand reported, ACTH therapy blocked the immobility-reducing results of imipramine within the pressured swim check. In distinction, therapy with both energetic DBS or sham electrode placement within the NAc considerably lowered pressured swim immobility time in ACTH-treated animals.
This was related to elevated homecage exercise within the DBS and sham teams relative to ACTH and saline teams, nonetheless, no variations in locomotor exercise have been noticed within the open subject check, nor have been any group variations seen for sucrose consumption throughout teams.
 GSK3787 |
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| MBS577288-100mg | MyBiosource | 100mg | EUR 585 |
GSK3787 |
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| MBS577288-10mg | MyBiosource | 10mg | EUR 165 |
GSK3787 |
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| MBS577288-25mg | MyBiosource | 25mg | EUR 245 |
GSK3787 |
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| MBS577288-50mg | MyBiosource | 50mg | EUR 350 |
GSK3787 |
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| MBS577288-5mg | MyBiosource | 5mg | EUR 145 |
GSK3787 |
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| MBS3602948-100mg | MyBiosource | 100mg | EUR 645 |
GSK3787 |
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| MBS3602948-10mg | MyBiosource | 10mg | EUR 225 |
GSK3787 |
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| MBS3602948-25mg | MyBiosource | 25mg | EUR 315 |
GSK3787 |
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| MBS3602948-50mg | MyBiosource | 50mg | EUR 415 |
GSK3787 |
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| MBS3602948-5mg | MyBiosource | 5mg | EUR 200 |
GSK3787 |
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| T1941-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: GSK3787 |
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GSK3787 |
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| T1941-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: GSK3787 |
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GSK3787 |
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| T1941-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: GSK3787 |
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GSK3787 |
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| T1941-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: GSK3787 |
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GSK3787 |
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| T1941-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: GSK3787 |
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) GSK163090 (GSK-163090; GSK 163090) |
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| MBS131437-100mg | MyBiosource | 100mg | EUR 1495 |
) GSK369796 (GSK-369796, GSK 369796) |
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| MBS131519-100mg | MyBiosource | 100mg | EUR 1495 |
) S/GSK1349572 (GSK1349572) |
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| E1KS2667 | EnoGene | 5mg | EUR 816 |
S/GSK1349572 (GSK1349572) |
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| MBS8506142-5mg | MyBiosource | 5mg | EUR 900 |
S/GSK1349572 (GSK1349572) |
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| MBS8506142-5x5mg | MyBiosource | 5x5mg | EUR 3900 |
) GSK269962A(GSK269962) |
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| MBS130148-100mg | MyBiosource | 100mg | EUR 1065 |
GSK269962A(GSK269962) |
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| MBS130148-500mg | MyBiosource | 500mg | EUR 2775 |
) GSK744 (S/GSK1265744) |
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| A8566-10 | ApexBio | 10 mg | EUR 60 |
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Description: Proteases|HIV Integrase |
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GSK744 (S/GSK1265744) |
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| A8566-100 | ApexBio | 100 mg | EUR 544.8 |
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Description: Proteases|HIV Integrase |
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GSK744 (S/GSK1265744) |
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| A8566-5 | ApexBio | 5 mg | EUR 40 |
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Description: Proteases|HIV Integrase |
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GSK744 (S/GSK1265744) |
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| A8566-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 84 |
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Description: Proteases|HIV Integrase |
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GSK744 (S/GSK1265744) |
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| A8566-50 | ApexBio | 50 mg | EUR 192 |
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Description: Proteases|HIV Integrase |
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GSK744 (S/GSK1265744) |
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| MBS3841321-10mg | MyBiosource | 10mg | EUR 270 |
GSK744 (S/GSK1265744) |
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| MBS3841321-5mg | MyBiosource | 5mg | EUR 190 |
GSK744 (S/GSK1265744) |
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| MBS3841321-5x10mg | MyBiosource | 5x10mg | EUR 1205 |
 Sodium salt) GSK1265744 (GSK744) Sodium salt |
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| MBS3840133-10mg | MyBiosource | 10mg | EUR 750 |
GSK1265744 (GSK744) Sodium salt |
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| MBS3840133-5mg | MyBiosource | 5mg | EUR 465 |
GSK1265744 (GSK744) Sodium salt |
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| MBS3840133-5x10mg | MyBiosource | 5x10mg | EUR 3370 |
) Cabotegravir (GSK744, GSK1265744) |
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| MBS578671-100mg | MyBiosource | 100mg | EUR 260 |
Cabotegravir (GSK744, GSK1265744) |
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| MBS578671-10mg | MyBiosource | 10mg | EUR 145 |
Cabotegravir (GSK744, GSK1265744) |
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| MBS578671-25mg | MyBiosource | 25mg | EUR 175 |
Cabotegravir (GSK744, GSK1265744) |
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| MBS578671-50mg | MyBiosource | 50mg | EUR 225 |
Cabotegravir (GSK744, GSK1265744) |
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| MBS578671-5mg | MyBiosource | 5mg | EUR 135 |
) GSK2141795 (Uprosertib, GSK795) |
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| MBS384825-10mg | MyBiosource | 10mg | EUR 230 |
GSK2141795 (Uprosertib, GSK795) |
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| MBS384825-25mg | MyBiosource | 25mg | EUR 335 |
GSK2141795 (Uprosertib, GSK795) |
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| MBS384825-5mg | MyBiosource | 5mg | EUR 170 |
GSK2141795 (Uprosertib, GSK795) |
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| MBS384825-5x25mg | MyBiosource | 5x25mg | EUR 1490 |
 GSK1292263 |
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| A8439-10 | ApexBio | 10 mg | EUR 112 |
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Description: GPCR/G protein|Free Fatty Acid Receptors |
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GSK1292263 |
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| A8439-200 | ApexBio | 200 mg | EUR 1128 |
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Description: GPCR/G protein|Free Fatty Acid Receptors |
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GSK1292263 |
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| A8439-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 184 |
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Description: GPCR/G protein|Free Fatty Acid Receptors |
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GSK1292263 |
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| A8439-50 | ApexBio | 50 mg | EUR 376 |
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Description: GPCR/G protein|Free Fatty Acid Receptors |
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 GSK2126458 |
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| A8556-10 | ApexBio | 10 mg | EUR 132 |
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Description: PI3K/Akt/mTOR Signaling|mTOR |
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GSK2126458 |
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| A8556-5 | ApexBio | 5 mg | EUR 44 |
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Description: PI3K/Akt/mTOR Signaling|mTOR |
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GSK2126458 |
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| A8556-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 104 |
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Description: PI3K/Akt/mTOR Signaling|mTOR |
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GSK2126458 |
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| A8556-50 | ApexBio | 50 mg | EUR 369.6 |
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Description: PI3K/Akt/mTOR Signaling|mTOR |
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 GSK3179106 |
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| 555258 | MedKoo Biosciences | 50.0mg | EUR 550 |
 GSK3117391 |
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| 555376 | MedKoo Biosciences | 100.0mg | EUR 950 |
 GSK3039294 |
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| 555377 | MedKoo Biosciences | 50.0mg | EUR 450 |
 GSK1940029 |
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| 555378 | MedKoo Biosciences | 5.0mg | EUR 80 |
 GSK2814338 |
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| 555379 | MedKoo Biosciences | 50.0mg | EUR 450 |
 GSK2292767 |
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| 522376 | MedKoo Biosciences | 5.0mg | EUR 380 |
 GSK2245035 |
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| 522629 | MedKoo Biosciences | 1.0mg | EUR 280 |
 GSK2981278 |
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| 526931 | MedKoo Biosciences | 10.0mg | EUR 90 |
 GSK2982772 |
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| 530503 | MedKoo Biosciences | 50.0mg | EUR 550 |
 GSK2193874 |
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| 531870 | MedKoo Biosciences | 5.0mg | EUR 240 |
 GSK-2830371 |
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| 540187 | MedKoo Biosciences | 10.0mg | EUR 270 |
 GSK2334470 |
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| 406156 | MedKoo Biosciences | 25.0mg | EUR 450 |
 GSK2656157 |
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| 406230 | MedKoo Biosciences | 10.0mg | EUR 110 |
 GSK2606414 |
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| 406393 | MedKoo Biosciences | 10.0mg | EUR 90 |
 GSK-1292263 |
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| 500890 | MedKoo Biosciences | 10.0mg | EUR 150 |
 GSK2838232 |
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| 510350 | MedKoo Biosciences | 5.0mg | EUR 90 |
 GSK2795039 |
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| 565076 | MedKoo Biosciences | 50.0mg | EUR 450 |
 GSK1349572 |
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| 2288-25 | Biovision | each | EUR 1070.4 |
GSK1349572 |
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| 2288-5 | Biovision | each | EUR 314.4 |
 GSK2636771 |
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| 2793-25 | Biovision | each | EUR 705.6 |
GSK2636771 |
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| 2793-5 | Biovision | each | EUR 222 |
 GSK-1059615 |
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| 9450-25 | Biovision | each | EUR 652.8 |
GSK-1059615 |
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| 9450-5 | Biovision | each | EUR 210 |
 GSK-2656157 |
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| 9466-25 | Biovision | each | EUR 705.6 |
GSK-2656157 |
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| 9466-5 | Biovision | each | EUR 222 |
 GSK-2606414 |
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| 9467-25 | Biovision | each | EUR 757.2 |
GSK-2606414 |
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| 9467-5 | Biovision | each | EUR 235.2 |
 GSK2879552 |
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| 206158 | MedKoo Biosciences | 25.0mg | EUR 250 |
 GSK2194069 |
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| 206467 | MedKoo Biosciences | 10.0mg | EUR 320 |
 GSK-3326595 |
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| 206819 | MedKoo Biosciences | 10.0mg | EUR 150 |
 GSK3145095 |
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| 207094 | MedKoo Biosciences | 100.0mg | EUR 2250 |
 GSK1070916 |
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| 205477 | MedKoo Biosciences | 5.0mg | EUR 270 |
 GSK-2256098 |
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| 205482 | MedKoo Biosciences | 5.0mg | EUR 90 |
 GSK1059615 |
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| 205739 | MedKoo Biosciences | 5.0mg | EUR 120 |
GSK2636771 |
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| 205844 | MedKoo Biosciences | 25.0mg | EUR 150 |
 GSK-1120212 |
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| 1960-1 | Biovision | each | EUR 164.4 |
GSK-1120212 |
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| 1960-5 | Biovision | each | EUR 464.4 |
 GSK-2126458 |
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| 1961-1 | Biovision | each | EUR 189.6 |
GSK-2126458 |
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| 1961-5 | Biovision | each | EUR 574.8 |
 Gsk1120212 |
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| 20-abx182481 | Abbexa |
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GSK2606414 |
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| A3448-10 | ApexBio | 10 mg | EUR 120 |
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Description: Cell Cycle/Checkpoint|PERK |
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GSK2606414 |
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| A3448-200 | ApexBio | 200 mg | EUR 720 |
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Description: Cell Cycle/Checkpoint|PERK |
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GSK2606414 |
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| A3448-5 | ApexBio | 5 mg | EUR 80 |
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Description: Cell Cycle/Checkpoint|PERK |
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GSK2606414 |
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| A3448-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 84 |
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Description: Cell Cycle/Checkpoint|PERK |
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GSK2606414 |
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| A3448-50 | ApexBio | 50 mg | EUR 320 |
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Description: Cell Cycle/Checkpoint|PERK |
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 S/GSK1349572 |
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| A4074-10 | ApexBio | 10 mg | EUR 134.4 |
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Description: Microbiology & Virology|HIV#Proteases|HIV Integrase |
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S/GSK1349572 |
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| A4074-100 | ApexBio | 100 mg | EUR 752.8 |
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Description: Microbiology & Virology|HIV#Proteases|HIV Integrase |
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S/GSK1349572 |
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| A4074-5 | ApexBio | 5 mg | EUR 92.8 |
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Description: Microbiology & Virology|HIV#Proteases|HIV Integrase |
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S/GSK1349572 |
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| A4074-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 81.6 |
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Description: Microbiology & Virology|HIV#Proteases|HIV Integrase |
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S/GSK1349572 |
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| A4074-50 | ApexBio | 50 mg | EUR 486.4 |
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Description: Microbiology & Virology|HIV#Proteases|HIV Integrase |
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GSK1070916 |
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| A4127-10 | ApexBio | 10 mg | EUR 212 |
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Description: Cell Cycle/Checkpoint|Aurora Kinase#Chromatin/Epigenetics|Aurora Kinase |
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GSK1070916 |
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| A4127-100 | ApexBio | 100mg | EUR 1124.8 |
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Description: Cell Cycle/Checkpoint|Aurora Kinase#Chromatin/Epigenetics|Aurora Kinase |
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GSK1070916 |
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| A4127-200 | ApexBio | 200 mg | EUR 1720 |
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Description: Cell Cycle/Checkpoint|Aurora Kinase#Chromatin/Epigenetics|Aurora Kinase |
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GSK1070916 |
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| A4127-5 | ApexBio | 5 mg | EUR 131.2 |
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Description: Cell Cycle/Checkpoint|Aurora Kinase#Chromatin/Epigenetics|Aurora Kinase |
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GSK1070916 |
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| A4127-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 268.8 |
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Description: GSK1070916 is a potent and selective inhibitor of Aurora B/C Kinase with Ki values of 0.38nM and 1.5nM, respectively [1]. |
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GSK1070916 |
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| A4127-50 | ApexBio | 50 mg | EUR 688 |
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Description: Cell Cycle/Checkpoint|Aurora Kinase#Chromatin/Epigenetics|Aurora Kinase |
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 GSK2830371 |
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| 2578-1 | Biovision | each | EUR 170.4 |
GSK2830371 |
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| 2578-5 | Biovision | each | EUR 496.8 |
 GSK-3484862 |
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| 462425 | MedKoo Biosciences | 10.0mg | EUR 430 |
 GSK2850163 |
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| 462577 | MedKoo Biosciences | 5.0mg | EUR 260 |
 GSK2881078 |
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| C4768-10 | ApexBio | 10 mg | EUR 144 |
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Description: Endocrinology and Hormones|Androgen Receptor |
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GSK2881078 |
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| C4768-25 | ApexBio | 25 mg | EUR 284.8 |
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Description: Endocrinology and Hormones|Androgen Receptor |
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GSK2881078 |
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| C4768-5 | ApexBio | 5 mg | EUR 88 |
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Description: Endocrinology and Hormones|Androgen Receptor |
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 GSK2269557 |
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| C5012-10 | ApexBio | 10 mg | EUR 378.4 |
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Description: PI3K/Akt/mTOR Signaling|PI3K |
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GSK2269557 |
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| C5012-25 | ApexBio | 25 mg | EUR 828 |
|
Description: PI3K/Akt/mTOR Signaling|PI3K |
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GSK2269557 |
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| C5012-5 | ApexBio | 5 mg | EUR 212.8 |
|
Description: PI3K/Akt/mTOR Signaling|PI3K |
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GSK2838232 |
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| B5818-10 | ApexBio | 10 mg | EUR 661.6 |
|
Description: Microbiology & Virology|HIV |
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GSK2838232 |
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| B5818-100 | ApexBio | 100 mg | EUR 2778.4 |
|
Description: Microbiology & Virology|HIV |
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GSK2838232 |
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| B5818-5 | ApexBio | 5 mg | EUR 463.2 |
|
Description: Microbiology & Virology|HIV |
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GSK2838232 |
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| B5818-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 1024.8 |
|
Description: GSK2838232 is an HIV-1 maturation inhibitor [1] [2]. HIV-1 maturation inhibitors disrupt the cleavage of the HIV-1 gag protein immediate precursor by the enzyme HIV-1 protease. |
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GSK2838232 |
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| B5818-50 | ApexBio | 50 mg | EUR 1984.8 |
|
Description: Microbiology & Virology|HIV |
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GSK2879552 |
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| B5879-25 | ApexBio | 25 mg | EUR 208 |
|
Description: Chromatin/Epigenetics|Histone Demethylases |
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GSK2879552 |
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| B5879-5 | ApexBio | 5 mg | EUR 69.6 |
|
Description: Chromatin/Epigenetics|Histone Demethylases |
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GSK2879552 |
|||
| B5879-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 80.8 |
|
Description: Chromatin/Epigenetics|Histone Demethylases |
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GSK2194069 |
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| B8005-5 | ApexBio | 5 mg | EUR 289.2 |
|
Description: IC50: 7.7 nMGSK 2194069 is a potent human fatty acid synthase inhibitor. Human fatty acid synthase (hFAS) is a multifunctional enzyme solely responsible for the de novo synthesis of long chain fatty acids. |
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 GSK2330672 |
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| B8327-1 | ApexBio | 1mg | EUR 132.8 |
GSK2330672 |
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| B8327-10 | ApexBio | 10mg | EUR 661.6 |
GSK2330672 |
|||
| B8327-100 | ApexBio | 100mg | EUR 2778.4 |
GSK2330672 |
|||
| B8327-5 | ApexBio | 5mg | EUR 397.6 |
GSK2330672 |
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| B8327-50 | ApexBio | 50mg | EUR 1984.8 |
GSK2981278 |
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| C3707-10 | ApexBio | 10 mg | EUR 160 |
|
Description: Tyrosine Kinase|ROR |
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GSK2981278 |
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| C3707-25 | ApexBio | 25 mg | EUR 296 |
|
Description: Tyrosine Kinase|ROR |
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GSK2981278 |
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| C3707-5 | ApexBio | 5 mg | EUR 104 |
|
Description: Tyrosine Kinase|ROR |
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 GSK-2334470 |
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| B1555-25 | Biovision | each | EUR 907.2 |
GSK-2334470 |
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| B1555-5 | Biovision | each | EUR 274.8 |
GSK-1292263 |
|||
| B1556-25 | Biovision | each | EUR 907.2 |
GSK-1292263 |
|||
| B1556-5 | Biovision | each | EUR 274.8 |
The antidepressant-like actions of NAc DBS and sham electrode placements have been related to a rise in ranges of IL and vHIP phospho-GSK3β and phospho-mTOR, nonetheless, no variations in these protein ranges have been noticed within the dHIP area.
These knowledge recommend that early response to electrode placement within the NAc, no matter whether or not energetic DBS or sham, has antidepressant-like results within the ACTH-model of antidepressant resistance related to distal upregulation of phospho-GSK3β and phospho-mTOR within the IL and vHIP areas of the temper community.
