Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3β, and PFKfβ3 in 3T3-L1 adipocyte cells.
Klotho is taken into account as an anti-aging issue inducing insulin resistance and concerned in sort 2 diabetes. Nevertheless, mechanisms by which klotho induces insulin resistance stay to be understood. Thus, on this examine, we aimed to judge doable interference factors of klotho with insulin signaling pathways in 3T3-L1 adipocyte cells by specializing in phosphorylation…Read More
Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice.
Overexpression of FGF receptor 3 (FGFR3) is implicated within the growth of t(4;14)-positive a number of myeloma. Whereas FGFR3 is steadily overexpressed and/or activated via mutations in bladder most cancers, the purposeful significance of FGFR3 and its potential as a particular therapeutic goal on this illness haven’t been elucidated in vivo. Right here we report…Read More
Hippeastrum hybrid Lectin (HHL)
Product name Hybrid Hippeastrum Lectin Full Product Name Hybrid Hippeastrum Lectin (HHL, Lectin Amaryllis, AL) (Biotin) Purity / Purification Degree in Molecular Biology Shape / Format Supplied as a powder in 10 mM HEPES, pH 7.5, 0.15 M sodium chloride, 0.08% sodium azide. Reconstitute with 1 ml of dH2O. Labeled with biotin. Preparation and storage…Read More