Anti-alpha enolase multi-antibody specificity in human diseases. Clinical significance and molecular mechanisms

Anti-alpha enolase multi-antibody specificity in human diseases. Clinical significance and molecular mechanisms

Alpha-enolase (Eno) is an ubiquitary glycolytic enzyme taking part in a number of features that go nicely past its principal metabolic position of vitality provider throughout glycolysis. Eno is localized within the cytoplasm, but in addition expressed on the cell membrane, the place it binds plasminogen permitting its activation. Its shorter kind, within the nucleus, acts as…

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The promising effects of BMP2 transfected mesenchymal stem cells on human osteosarcoma

The promising effects of BMP2 transfected mesenchymal stem cells on human osteosarcoma

Selective concentrating on of transfected mesenchymal stem cells (MSCs) carrying particular antioncogenes to the tumor was recommended as a therapy choice. Bone morphogenetic protein-2 (BMP2) was proven to inhibit the proliferation and aggressiveness of osteosarcoma (OS) cells. Right here, we aimed to evaluate the homing effectivity of intraperitoneally administered hMSCs transfected with BMP2 to the tumoral website…

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BMP2 downregulates urokinase-type plasminogen activator via p38 MAPK: Implications in C2C12 cells myogenic differentiation

BMP2 downregulates urokinase-type plasminogen activator via p38 MAPK: Implications in C2C12 cells myogenic differentiation

Bone morphogenetic protein (BMP)2 strongly impacts the differentiation program of myoblast cells by inhibiting myogenesis and inducing osteogenic differentiation. In flip, extracellular matrix (ECM) proteinases, equivalent to urokinase-type plasminogen activator (uPA), can affect the destiny of muscle stem cells by taking part in ECM reorganization. Though each BMP2 and uPA have antagonistic roles in muscular…

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mPEG-Silane

The silane functionality in methoxy-PEG-silane allows the modification of a variety of surfaces (eg, glass, metals, particles) by PEGylation of such surfaces in a one-step process. These methoxy-PEGs are from our special PEG series, premium functional PEGs useful in various biomedical and biotechnological applications. Mole Weight: average of Mn 5,000 Polymer architecture shape: linear functionality:…

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Allium sativum Lectin (ASA)

Resume The immunomodulatory proteins present in garlic have recently been shown to be identical to the garlic lectins ASA I and ASA II [Clement F, Pramod SN, Venkatesh YP. In t. Immunopharmacol. 2010; 10: 316-324]. In this study, the stability of garlic lectins has been examined as a function of pH, temperature, and denaturants in…

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