TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

Mouse embryonic stem cells (mESCs) might be maintained in vitro in outlined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory issue (LIF), which act synergistically to advertise self-renewal and pluripotency.
Right here, we discover that genetic deletion of the 4 genes encoding the TCF/LEF transcription elements confers mESCs with the flexibility to self-renew in N2B27 medium alone. TCF/LEF quadruple knockout (qKO) mESCs show dysregulation of a number of genes, together with Aire, Dnmt3l, and IcosL, positioned adjoining to one another inside a topologically related area (TAD).
Aire, Dnmt3l, and IcosL seem like regulated by TCF/LEF in a β-catenin unbiased method. Furthermore, downregulation of Aire and Dnmt3l in wild-type mESCs mimics the lack of TCF/LEF and will increase mESC survival within the absence of 2iL. Therefore, this research identifies TCF/LEF effectors that mediate exit from the pluripotent state.

Glycogen Synthase Kinase Three regulates the genesis of displaced retinal ganglion cells

Glycogen Synthase Kinase 3 (GSK) proteins (GSK3α and GSK3β) are key mediators of signaling pathways, with essential roles in coordinating basic organic processes throughout neural improvement. Right here we present that the whole lack of GSK3 signaling in mouse retinal progenitors results in microphthalmia with broad morphological defects. A single wild-type allele of both Gsk3α or Gsk3β is ready to rescue this phenotype.
On this genetic context, all cell sorts are current with a practical retina. Nonetheless, we unexpectedly detect a lot of cells within the inside nuclear layer expressing retinal ganglion cell (RGC)-specific markers (referred to as displaced RGCs, dRGCs) when no less than one allele of Gsk3α is expressed.
Extra dRGCs result in elevated variety of axons projecting into the ipsilateral medial terminal nucleus, an space of the mind belonging to the non-image-forming visible circuit and poorly focused by RGCs in wild-type retina. Transcriptome evaluation and optomotor response assay counsel that no less than a subset of dRGCs in Gsk3 mutant mice are direction-selective RGCs.
Our research thus uncovers a novel position of GSK3 in controlling the manufacturing of ganglion cells within the inside nuclear layer, which correspond to dRGCs, a uncommon and poorly characterised retinal cell kind.Significance StatementGlycogen Synthase Kinase 3 (GSK) proteins (Gsk3α or Gsk3β) are key mediators of signaling pathways, particularly within the central nervous system however poorly described within the retina.
Right here we present that the whole lack of GSK3 in mouse retinal progenitors results in microphthalmia. Nonetheless, when just one allele of Gsk3α or Gsk3β are current, all cell sorts are current with a practical retina.
Extra importantly, we unexpectedly uncover a novel position of GSK3 in controlling the genesis of retinal ganglion cells within the inside nuclear layer which may correspond to a uncommon and poorly characterised retinal cell kind. Subsequently, our mouse fashions probably provide a novel and highly effective mannequin system to review the visible perform of dRGCs in mammals.

P2 × 7 receptor blockade reduces Tau induced toxicity, therapeutic implications in Tauopathies

Tauopathies are neurodegenerative illnesses characterised by the presence of aberrant intraneuronal aggregates of hyperphosphorylated Tau protein. Latest research counsel that related persistent neuroinflammation could contribute to the pathological Tau dissemination. Nonetheless, the underlying molecular mechanisms stay unknown.
Since purinergic P2 × 7 receptors (P2 × 7) can sense the rise of extracellular ATP ranges related to neuroinflammation, its involvement in neurodegeneration-associated irritation was urged. We discovered a P2 × 7 upregulation in sufferers recognized with totally different tauopathies and in a tauopathy mouse mannequin, P301S mice.
In vivo pharmacological or genetic blockade of P2 × 7 reverted microglial activation in P301S mice resulting in a discount in microglial migratory, secretory, and proliferative capacities, and selling phagocytic perform. Moreover, it decreased the intraneuronal phosphorylated Tau ranges in a GSK3-dependent approach and elevated extracellular phosphorylated Tau (eTau) ranges by lowering the expression of ectoenzyme TNAP.
Accordingly, pharmacological or genetic blockade of P2 × 7 improved the mobile survival, motor and reminiscence deficits and anxiolytic profile in P301S mice. Opposite, P2 × 7 overexpression brought on a big worsening of Tau-induced toxicity and aggravated the deteriorated motor and reminiscence deficits in P301S mice. Our outcomes point out that P2 × 7 performs a deleterious position in tauopathies and counsel that its blockade could also be a promising strategy to deal with Tauopathies.

Small-molecule suppression of calpastatin degradation reduces neuropathology in fashions of Huntington’s illness

Mitochondrial dysfunction is a standard hallmark of neurological issues, and lowering mitochondrial harm is taken into account a promising neuroprotective therapeutic technique. Right here, we used high-throughput small molecule screening to establish CHIR99021 as a potent enhancer of mitochondrial perform.
CHIR99021 improved mitochondrial phenotypes and enhanced cell viability in a number of fashions of Huntington’s illness (HD), a deadly inherited neurodegenerative dysfunction. Notably, CHIR99201 remedy decreased HD-associated neuropathology and behavioral defects in HD mice and improved mitochondrial perform and cell survival in HD patient-derived neurons.
Unbiased of its identified inhibitory exercise towards glycogen synthase kinase 3 (GSK3), CHIR99021 remedy in HD fashions suppressed the proteasomal degradation of calpastatin (CAST), and subsequently inhibited calpain activation, a well-established effector of neural dying, and Drp1, a driver of mitochondrial fragmentation. Our outcomes established CAST-Drp1 as a druggable signaling axis in HD pathogenesis and highlighted CHIR99021 as a mitochondrial perform enhancer and a possible lead for growing HD therapies.

GSK3-Mediated Phosphorylation of DEK3 Regulates Chromatin Accessibility and Stress Tolerance in Arabidopsis

Chromatin dynamics allow the exact management of transcriptional packages. The steadiness between proscribing and opening of regulatory sequences on the DNA must be adjusted to prevailing circumstances and is fine-tuned by chromatin remodelling proteins.
DEK is an evolutionarily conserved chromatin architectural protein regulating vital chromatin-related processes. Nonetheless, the molecular hyperlink between DEK-induced chromatin reconfigurations and upstream signalling occasions stays unknown.
Right here, we present that ASKβ/AtSK31 is a salt stress-activated Glycogen Synthase Kinase 3 (GSK3) from Arabidopsis thaliana that phosphorylates DEK3. This particular phosphorylation alters nuclear DEK3 protein complicated composition, impacts nucleosome occupancy and chromatin accessibility that’s translated into adjustments in gene expression, contributing to salt stress tolerance.

anti-GSK3 Beta IgG2a mAb

011-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-GSK3 Beta IgG2a (monoclonal). Produced against a recombinant Xenopus laevis protein.

anti-GSK3 Beta IgG2a mAb

011-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-GSK3 Beta IgG2a (monoclonal). Produced against a recombinant Xenopus laevis protein.

GSK3 beta Antibody

AF5016 200ul
EUR 304
Description: GSK3 beta Antibody detects endogenous levels of total GSK3 beta.

GSK3 beta antibody

BF0721 200ul
EUR 376
Description: GSK3 beta mouse monoclonal antibody detects endogenous levels of total GSK3 beta.

GSK3 beta Antibody

AF7814 200ul
EUR 376
Description: GSK3 beta Antibody detects endogenous levels of GSK3 beta.

GSK3 beta Antibody

ABF5016 100 ug
EUR 438

GSK3 beta Antibody

abx449182-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GSK3 beta antibody

70R-49832 100 ul
EUR 287
Description: Purified Polyclonal GSK3 beta antibody

GSK3 beta protein

80R-4368 50 ug
EUR 349
Description: Purified Recombinant GSK3 beta protein (His tagged)

GSK3 beta antibody

70R-37442 100 ug
EUR 273
Description: Rabbit Polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-34165 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-34639 100 ug
EUR 327
Description: Purified Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-30634 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta Antibody

48798-100ul 100ul
EUR 333

GSK3 beta Antibody

48798-50ul 50ul
EUR 239

GSK3 beta antibody

10R-8595 100 ul
EUR 393
Description: Mouse monoclonal GSK3 beta antibody

GSK3 beta protein

30R-2812 10 ug
EUR 336
Description: Purified recombinant Human GSK3 beta protein

GSK3 beta antibody

20R-1878 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2124 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2187 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2452 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

Anti-GSK3 beta Rabbit Monoclonal Antibody

M00791 100ug/vial
EUR 397
Description: Rabbit Monoclonal GSK3 beta Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Rabbit Anti Gsk3 Beta (Pser9) Polyclonal Antibody

CPBT-66459RG 0.1 ml
EUR 985

GSK3 beta Blocking Peptide

AF5016-BP 1mg
EUR 195

GSK3 alpha/beta Antibody

AF6335 200ul
EUR 304
Description: GSK3 alpha/beta Antibody detects endogenous levels of total GSK3 alpha/beta.

GSK3 beta Conjugated Antibody

C48798 100ul
EUR 397

GSK3 beta Blocking Peptide

AF7814-BP 1mg
EUR 195

GSK3 beta (pS9) Antibody

20-abx119160
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

20-abx119162
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GSK3 beta Blocking Peptide

20-abx162471
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

20-abx133097
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 alpha / beta Antibody

20-abx009185
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

20-abx009702
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 lpha / beta Antibody

abx010869-100ug 100 ug
EUR 425
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

abx010872-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

GSK3 alpha/beta Antibody

ABF6335 100 ug
EUR 438

GSK3 beta Antibody (APC)

abx449192-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (Biotin)

abx449193-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (FITC)

abx449194-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (HRP)

abx449195-100ug 100 ug
EUR 592
  • Shipped within 5-12 working days.

GSK3 beta Antibody (PerCP)

abx449197-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (RPE)

abx449198-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (Streptavidin)

abx449199-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 alpha/beta antibody

70R-49831 100 ul
EUR 244
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta antibody

70R-51552 100 ul
EUR 287
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 beta antibody (Ser9)

70R-37084 100 ug
EUR 349
Description: Rabbit Polyclonal GSK3 beta antibody (Ser9)

GSK3 beta antibody (Tyr216)

70R-37352 100 ug
EUR 349
Description: Rabbit Polyclonal GSK3 beta antibody (Tyr216)

GSK3 alpha/beta antibody

70R-30578 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 alpha/beta antibody

GSK3 beta antibody (Ser9)

70R-30633 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 beta antibody (Ser9)

GSK3 alpha/beta Antibody

29039-100ul 100ul
EUR 252

Anti-Phospho-GSK3 beta (Ser9) Rabbit Monoclonal Antibody

P00791-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Phospho-GSK3 beta (Ser9) Antibody. Validated in IF, IHC, ICC, WB and tested in Human.

Phospho-GSK3 beta (Ser9) Antibody

AF2016 200ul
EUR 304
Description: Phospho-GSK3 beta (Ser9) Antibody detects endogenous levels of GSK3 beta only when phosphorylated at Serine 9.

GSK3 alpha/beta Blocking Peptide

AF6335-BP 1mg
EUR 195

Polyclonal GSK3B / GSK3 Beta Antibody

AMM05221G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta . This antibody is tested and proven to work in the following applications:

GSK3 beta antibody Blocking Peptide

BF0721-BP 1mg
EUR 195

GSK3 alpha/beta Conjugated Antibody

C29039 100ul
EUR 397

Phospho-GSK3 beta (Ser25) Antibody

AF7314 200ul
EUR 376
Description: Phospho-GSK3 beta (Ser25) Antibody detects endogenous levels of GSK3 beta only when phosphorylated at Ser25.

GSK3 beta (pS9) Blocking Peptide

20-abx161635
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

GSK3 alpha / beta Blocking Peptide

20-abx062706
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Blocking Peptide

20-abx062707
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

Phospho- GSK3 beta (Ser9) Antibody

ABF2016 100 ug
EUR 438

GSK3 beta Antibody (ATTO 390)

abx449183-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (ATTO 488)

abx449184-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (ATTO 565)

abx449185-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (ATTO 594)

abx449186-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (ATTO 633)

abx449187-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (ATTO 655)

abx449188-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (ATTO 680)

abx449189-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (ATTO 700)

abx449190-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (Alkaline Phosphatase)

abx449191-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta recombinant monoclonal antibody

A5007 100ul X 3
EUR 595
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human GSK3 beta for WB, IHC, IF,ELISA

GSK3 beta (Phospho-Ser25) Antibody

13163-100ul 100ul
EUR 252

GSK3 beta (Phospho-Ser25) Antibody

13163-50ul 50ul
EUR 187

Antibody for Human GSK3 beta

SPC-758D 0.1mg
EUR 353
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is unconjugated.

Antibody for Human GSK3 beta

SPC-758D-A390 0.1mg
EUR 400
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 390.

Antibody for Human GSK3 beta

SPC-758D-A488 0.1mg
EUR 399
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 488.

Antibody for Human GSK3 beta

SPC-758D-A565 0.1mg
EUR 399
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 565.

Antibody for Human GSK3 beta

SPC-758D-A594 0.1mg
EUR 399
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 594.

Antibody for Human GSK3 beta

SPC-758D-A633 0.1mg
EUR 399
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 633.

Antibody for Human GSK3 beta

SPC-758D-A655 0.1mg
EUR 399
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 655.

Antibody for Human GSK3 beta

SPC-758D-A680 0.1mg
EUR 399
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 680.

Antibody for Human GSK3 beta

SPC-758D-A700 0.1mg
EUR 399
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 700.

Antibody for Human GSK3 beta

SPC-758D-ALP 0.1mg
EUR 393
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Alkaline Phosphatase.

Antibody for Human GSK3 beta

SPC-758D-APC 0.1mg
EUR 398
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to APC .

Antibody for Human GSK3 beta

SPC-758D-APCCY7 0.1mg
EUR 470
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to APC/Cy7.

Antibody for Human GSK3 beta

SPC-758D-BI 0.1mg
EUR 395
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Biotin.

Antibody for Human GSK3 beta

SPC-758D-DY350 0.1mg
EUR 413
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 350.

Antibody for Human GSK3 beta

SPC-758D-DY405 0.1mg
EUR 402
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 405.

Antibody for Human GSK3 beta

SPC-758D-DY488 0.1mg
EUR 392
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 488.

Antibody for Human GSK3 beta

SPC-758D-DY594 0.1mg
EUR 394
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 594.

Antibody for Human GSK3 beta

SPC-758D-DY633 0.1mg
EUR 389
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 633.

Antibody for Human GSK3 beta

SPC-758D-FITC 0.1mg
EUR 391
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to FITC.

Antibody for Human GSK3 beta

SPC-758D-HRP 0.1mg
EUR 387
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to HRP.

Antibody for Human GSK3 beta

SPC-758D-P594 0.1mg
EUR 406
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to PE/ATTO 594.

Antibody for Human GSK3 beta

SPC-758D-PCP 0.1mg
EUR 398
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to PerCP.

Antibody for Human GSK3 beta

SPC-758D-RPE 0.1mg
EUR 396
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to RPE .

Antibody for Human GSK3 beta

SPC-758D-STR 0.1mg
EUR 397
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Streptavidin.

Antibody for Human GSK3 beta

SPC-758S 0.012mg
EUR 65
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is unconjugated.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

anti-GSK3 β (AF12E8)

LF-MA0315 100 ul
EUR 334
Description: Mouse monoclonal to GSK3 β

anti-GSK3 alpha (6G2F1)

LF-MA30074 100 ul
EUR 537
Description: Mouse Monoclonal to GSK3 alpha

anti-GSK3 alpha (9D5G1)

LF-MA30111 100 ul
EUR 486
Description: Mouse Monoclonal to GSK3 alpha

anti-GSK3 alpha (6G12C2)

LF-MA30112 100 ul
EUR 486
Description: Mouse Monoclonal to GSK3 alpha

Phospho-GSK3 beta (Ser9) Blocking Peptide

AF2016-BP 1mg
EUR 195

GSK3 beta (Phospho-Ser25) Conjugated Antibody

C13163 100ul
EUR 397

Phospho-GSK3 beta (Ser25) Blocking Peptide

AF7314-BP 1mg
EUR 195

GSK3 alpha / beta (pY279 / 216) Antibody

20-abx119370
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GSK3 alpha / beta (pT279 / 216) Antibody

20-abx009652
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 alpha / beta (pY279 / 216) Antibody

abx010868-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

GSK3 beta Antibody (PE/ATTO 594)

abx449196-100ug 100 ug
EUR 620
  • Shipped within 5-12 working days.

GSK3 alpha/beta antibody (Tyr279/216)

70R-30577 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 alpha/beta antibody (Tyr279/216)

GSK3 beta(Phospho-Ser 9) Antibody

13356-100ul 100ul
EUR 333

GSK3 beta(Phospho-Ser 9) Antibody

13356-50ul 50ul
EUR 239

GSK3

EF016956 96 Tests
EUR 689

Gsk3

EF012988 96 Tests
EUR 689

GSK3

EF014015 96 Tests
EUR 689

GSK3

EF000406 96 Tests
EUR 689

GSK3

EF006886 96 Tests
EUR 689

Anti-Phospho-GSK3 (alpha + beta) (Y216 + Y279) Rabbit Monoclonal Antibody

P03152-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Phospho-GSK3 (alpha + beta) (Y216 + Y279) Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

Anti-GSK3 alpha/GSK3A Antibody

A03152-2 100ug/vial
EUR 294

Phospho-GSK3 alpha/ beta (Tyr279/216) Antibody

AF3335 200ul
EUR 304
Description: Phospho-GSK3 alpha/ beta (Tyr279/216) Antibody detects endogenous levels of GSK3 alpha/ beta only when phosphorylated at Tyrosine 279/216.

Polyclonal GSK3B / GSK3 Beta Antibody (C-Terminus)

AMM05222G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta (C-Terminus). This antibody is tested and proven to work in the following applications:

Monoclonal GSK3 alpha/beta Antibody, Clone: EP933Y

APR12318G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human GSK3 alpha/beta. The antibodies are raised in Rabbit and are from clone EP933Y. This antibody is applicable in WB

GSK3 beta(Phospho-Ser 9) Conjugated Antibody

C13356 100ul
EUR 397

GSK3 alpha / beta (pY279 / 216) Blocking Peptide

20-abx062127
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

Phospho- GSK3 alpha/ beta (Tyr279/216) Antibody

ABF3335 100 ug
EUR 438

Phospho-GSK3 beta (Ser9) recombinant monoclonal antibody

A5961 100ul X 3
EUR 681
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human Phospho-GSK3 beta (Ser9) for IF, IHC, WB,ELISA

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody

13355-100ul 100ul
EUR 333

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody

13355-50ul 50ul
EUR 239

GSK3 antibody

20R-1609 100 ug
EUR 673
Description: Rabbit polyclonal GSK3 antibody

Phospho-GSK3 alpha/ beta (Tyr279/216) Blocking Peptide

AF3335-BP 1mg
EUR 195

Monoclonal GSK3 beta Antibody Phospho (pS9), Clone: EPR2286Y

AMM05220G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human GSK3 beta Phospho (pS9). The antibodies are raised in Rabbit and are from clone EPR2286Y. This antibody is applicable in WB and IHC

Chicken GSK3-Beta Interaction Protein (GSKIP) ELISA Kit

abx555355-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

Human GSK3-Beta Interaction Protein (GSKIP) ELISA Kit

abx555562-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Rat GSK3-Beta Interaction Protein (GSKIP) ELISA Kit

abx555578-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Mouse GSK3-Beta Interaction Protein (GSKIP) ELISA Kit

abx555638-96tests 96 tests
EUR 739
  • Shipped within 5-12 working days.

Cow GSK3-Beta Interaction Protein (GSKIP) ELISA Kit

abx555788-96tests 96 tests
EUR 911
  • Shipped within 5-12 working days.

GSK3(alpha+beta)(Phospho-Y216+Y279) Conjugated Antibody

C13355 100ul
EUR 397

Rat Gskip/ GSK3-beta interaction protein ELISA Kit

E0422Ra 1 Kit
EUR 646

Mouse Gskip/ GSK3-beta interaction protein ELISA Kit

E0634Mo 1 Kit
EUR 632

ELISA kit for Rat GSK3-beta interaction protein

EK3727 96 tests
EUR 670
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat GSK3-beta interaction protein in samples from serum, plasma, tissue homogenates and other biological fluids.

Human GSKIP/ GSK3-beta interaction protein ELISA Kit

E1066Hu 1 Kit
EUR 605

Mouse GSK3- beta interaction protein, Gskip ELISA KIT

ELI-08777m 96 Tests
EUR 865

Bovine GSK3- beta interaction protein, GSKIP ELISA KIT

ELI-27494b 96 Tests
EUR 928

Human GSK3- beta interaction protein, GSKIP ELISA KIT

ELI-27905h 96 Tests
EUR 824

Chicken GSK3- beta interaction protein, GSKIP ELISA KIT

ELI-31338c 96 Tests
EUR 928

Rat GSK3- beta interaction protein, Gskip ELISA KIT

ELI-31339r 96 Tests
EUR 886

GSK3 Beta Colorimetric Cell-Based ELISA Kit (OKAG00757)

OKAG00757 96 Wells
EUR 596
Description: Description of target: ;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Phospho-GSK3 (alpha+beta)(Y216+Y279) recombinant monoclonal antibody

A5960 100ul X 3
EUR 681
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human Phospho-GSK3 (alpha+beta)(Y216+Y279) for WB,ELISA

GSK3 Alpha/ Beta Colorimetric Cell-Based ELISA Kit (OKAG00756)

OKAG00756 96 Wells
EUR 596
Description: Description of target: ;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

GSK3 alpha Antibody

AF6336 200ul
EUR 304
Description: GSK3 alpha Antibody detects endogenous levels of total GSK3 alpha.

GSK3 alpha Antibody

BF0391 200ul
EUR 376
Description: GSK3 alpha antibody detects endogenous levels of total GSK3 alpha.
These findings reveal that DEK3 phosphorylation is essential for chromatin perform and mobile stress response and supply a mechanistic instance of how GSK3-based signalling is straight linked to chromatin, facilitating a transcriptional response.

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