Ae1 Ae3 Antibody Bafilomycin A1 Bile Acid Assay Bioassay Blog Choline Acetyltransferase Antibody Deoxycholic Acid Sodium Salt ELISA kit Epz 6438 Ldn 193189 Medium Mip 1B Mmp Activity Assay Pamabrom 100Mg Pepstatin A peptide Phospho 4Ebp1 Soft Agar Sr 9011 Trypsin Activity Assay Tubastatin A
TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state
Mouse embryonic stem cells (mESCs) might be maintained in vitro in outlined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory issue (LIF), which act synergistically to advertise self-renewal and pluripotency.
Right here, we discover that genetic deletion of the 4 genes encoding the TCF/LEF transcription elements confers mESCs with the flexibility to self-renew in N2B27 medium alone. TCF/LEF quadruple knockout (qKO) mESCs show dysregulation of a number of genes, together with Aire, Dnmt3l, and IcosL, positioned adjoining to one another inside a topologically related area (TAD).
Aire, Dnmt3l, and IcosL seem like regulated by TCF/LEF in a β-catenin unbiased method. Furthermore, downregulation of Aire and Dnmt3l in wild-type mESCs mimics the lack of TCF/LEF and will increase mESC survival within the absence of 2iL. Therefore, this research identifies TCF/LEF effectors that mediate exit from the pluripotent state.
Glycogen Synthase Kinase Three regulates the genesis of displaced retinal ganglion cells
Glycogen Synthase Kinase 3 (GSK) proteins (GSK3α and GSK3β) are key mediators of signaling pathways, with essential roles in coordinating basic organic processes throughout neural improvement. Right here we present that the whole lack of GSK3 signaling in mouse retinal progenitors results in microphthalmia with broad morphological defects. A single wild-type allele of both Gsk3α or Gsk3β is ready to rescue this phenotype.
On this genetic context, all cell sorts are current with a practical retina. Nonetheless, we unexpectedly detect a lot of cells within the inside nuclear layer expressing retinal ganglion cell (RGC)-specific markers (referred to as displaced RGCs, dRGCs) when no less than one allele of Gsk3α is expressed.
Extra dRGCs result in elevated variety of axons projecting into the ipsilateral medial terminal nucleus, an space of the mind belonging to the non-image-forming visible circuit and poorly focused by RGCs in wild-type retina. Transcriptome evaluation and optomotor response assay counsel that no less than a subset of dRGCs in Gsk3 mutant mice are direction-selective RGCs.
Our research thus uncovers a novel position of GSK3 in controlling the manufacturing of ganglion cells within the inside nuclear layer, which correspond to dRGCs, a uncommon and poorly characterised retinal cell kind.Significance StatementGlycogen Synthase Kinase 3 (GSK) proteins (Gsk3α or Gsk3β) are key mediators of signaling pathways, particularly within the central nervous system however poorly described within the retina.
Right here we present that the whole lack of GSK3 in mouse retinal progenitors results in microphthalmia. Nonetheless, when just one allele of Gsk3α or Gsk3β are current, all cell sorts are current with a practical retina.
Extra importantly, we unexpectedly uncover a novel position of GSK3 in controlling the genesis of retinal ganglion cells within the inside nuclear layer which may correspond to a uncommon and poorly characterised retinal cell kind. Subsequently, our mouse fashions probably provide a novel and highly effective mannequin system to review the visible perform of dRGCs in mammals.
P2 × 7 receptor blockade reduces Tau induced toxicity, therapeutic implications in Tauopathies
Tauopathies are neurodegenerative illnesses characterised by the presence of aberrant intraneuronal aggregates of hyperphosphorylated Tau protein. Latest research counsel that related persistent neuroinflammation could contribute to the pathological Tau dissemination. Nonetheless, the underlying molecular mechanisms stay unknown.
Since purinergic P2 × 7 receptors (P2 × 7) can sense the rise of extracellular ATP ranges related to neuroinflammation, its involvement in neurodegeneration-associated irritation was urged. We discovered a P2 × 7 upregulation in sufferers recognized with totally different tauopathies and in a tauopathy mouse mannequin, P301S mice.
In vivo pharmacological or genetic blockade of P2 × 7 reverted microglial activation in P301S mice resulting in a discount in microglial migratory, secretory, and proliferative capacities, and selling phagocytic perform. Moreover, it decreased the intraneuronal phosphorylated Tau ranges in a GSK3-dependent approach and elevated extracellular phosphorylated Tau (eTau) ranges by lowering the expression of ectoenzyme TNAP.
Accordingly, pharmacological or genetic blockade of P2 × 7 improved the mobile survival, motor and reminiscence deficits and anxiolytic profile in P301S mice. Opposite, P2 × 7 overexpression brought on a big worsening of Tau-induced toxicity and aggravated the deteriorated motor and reminiscence deficits in P301S mice. Our outcomes point out that P2 × 7 performs a deleterious position in tauopathies and counsel that its blockade could also be a promising strategy to deal with Tauopathies.
Small-molecule suppression of calpastatin degradation reduces neuropathology in fashions of Huntington’s illness
Mitochondrial dysfunction is a standard hallmark of neurological issues, and lowering mitochondrial harm is taken into account a promising neuroprotective therapeutic technique. Right here, we used high-throughput small molecule screening to establish CHIR99021 as a potent enhancer of mitochondrial perform.
CHIR99021 improved mitochondrial phenotypes and enhanced cell viability in a number of fashions of Huntington’s illness (HD), a deadly inherited neurodegenerative dysfunction. Notably, CHIR99201 remedy decreased HD-associated neuropathology and behavioral defects in HD mice and improved mitochondrial perform and cell survival in HD patient-derived neurons.
Unbiased of its identified inhibitory exercise towards glycogen synthase kinase 3 (GSK3), CHIR99021 remedy in HD fashions suppressed the proteasomal degradation of calpastatin (CAST), and subsequently inhibited calpain activation, a well-established effector of neural dying, and Drp1, a driver of mitochondrial fragmentation. Our outcomes established CAST-Drp1 as a druggable signaling axis in HD pathogenesis and highlighted CHIR99021 as a mitochondrial perform enhancer and a possible lead for growing HD therapies.
GSK3-Mediated Phosphorylation of DEK3 Regulates Chromatin Accessibility and Stress Tolerance in Arabidopsis
Chromatin dynamics allow the exact management of transcriptional packages. The steadiness between proscribing and opening of regulatory sequences on the DNA must be adjusted to prevailing circumstances and is fine-tuned by chromatin remodelling proteins.
DEK is an evolutionarily conserved chromatin architectural protein regulating vital chromatin-related processes. Nonetheless, the molecular hyperlink between DEK-induced chromatin reconfigurations and upstream signalling occasions stays unknown.
Right here, we present that ASKβ/AtSK31 is a salt stress-activated Glycogen Synthase Kinase 3 (GSK3) from Arabidopsis thaliana that phosphorylates DEK3. This particular phosphorylation alters nuclear DEK3 protein complicated composition, impacts nucleosome occupancy and chromatin accessibility that’s translated into adjustments in gene expression, contributing to salt stress tolerance.
GSK3 beta |
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| E8R1510-4 | EnoGene | 100ul | EUR 275 |
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Description: Available in various conjugation types. |
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GSK3 beta |
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| MBS8533802-01mL | MyBiosource | 0.1mL | EUR 345 |
GSK3 beta |
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| MBS8533802-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3 beta |
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| MBS8533802-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3 beta |
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| MBS8533802-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3 beta |
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| MBS8533802-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3 beta |
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| MBS8534833-01mL | MyBiosource | 0.1mL | EUR 345 |
GSK3 beta |
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| MBS8534833-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3 beta |
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| MBS8534833-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3 beta |
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| MBS8534833-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3 beta |
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| MBS8534833-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3 beta Antibody |
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| ABF5016 | Lifescience Market | 100 ug | EUR 525.6 |
GSK3 beta Antibody |
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| 48798 | SAB | 100ul | EUR 499 |
GSK3 beta Antibody |
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| 48798-100ul | SAB | 100ul | EUR 399.6 |
GSK3 beta Antibody |
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| 48798-50ul | SAB | 50ul | EUR 286.8 |
GSK3 beta antibody |
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| 70R-30634 | Fitzgerald | 100 ug | EUR 294 |
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Description: Rabbit polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 70R-34165 | Fitzgerald | 100 ug | EUR 294 |
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Description: Rabbit polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 70R-34639 | Fitzgerald | 100 ug | EUR 294 |
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Description: Purified Rabbit polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 70R-37442 | Fitzgerald | 100 ug | EUR 260 |
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Description: Rabbit Polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 70R-49832 | Fitzgerald | 100 ul | EUR 286 |
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Description: Purified Polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 10R-8595 | Fitzgerald | 100 ul | EUR 471.6 |
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Description: Mouse monoclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 20R-1878 | Fitzgerald | 50 ug | EUR 269 |
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Description: Rabbit polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 20R-2124 | Fitzgerald | 50 ug | EUR 269 |
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Description: Rabbit polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 20R-2187 | Fitzgerald | 50 ug | EUR 269 |
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Description: Rabbit polyclonal GSK3 beta antibody |
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GSK3 beta antibody |
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| 20R-2452 | Fitzgerald | 50 ug | EUR 269 |
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Description: Rabbit polyclonal GSK3 beta antibody |
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GSK3 beta Antibody |
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| AF7814 | Affbiotech | 200ul | EUR 540 |
GSK3 beta Antibody |
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| AF7814-100ul | Affinity Biosciences | 100ul | EUR 210 |
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Description: WB,ELISA(peptide) |
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GSK3 beta Antibody |
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| AF7814-200ul | Affinity Biosciences | 200ul | EUR 270 |
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Description: WB,ELISA(peptide) |
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GSK3 beta Antibody |
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| AF7814-50ul | Affinity Biosciences | 50ul | EUR 150 |
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Description: WB,ELISA(peptide) |
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GSK3 beta Antibody |
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| DF7231 | Affbiotech | 200ul | EUR 420 |
GSK3 beta Antibody |
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| DF7231-100ul | Affinity Biosciences | 100ul | EUR 168 |
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Description: WB,IF/ICC,ELISA(peptide) |
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GSK3 beta Antibody |
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| DF7231-200ul | Affinity Biosciences | 200ul | EUR 210 |
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Description: WB,IF/ICC,ELISA(peptide) |
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GSK3 beta Antibody |
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| AF5016 | Affbiotech | 200ul | EUR 420 |
GSK3 beta Antibody |
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| AF5016-100ul | Affinity Biosciences | 100ul | EUR 168 |
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Description: WB,IHC,IF/ICC,IP,ELISA(peptide) |
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GSK3 beta Antibody |
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| AF5016-200ul | Affinity Biosciences | 200ul | EUR 210 |
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Description: WB,IHC,IF/ICC,IP,ELISA(peptide) |
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GSK3 beta Antibody |
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| abx449182-100ug | Abbexa | 100 ug | EUR 661.2 |
GSK3 beta Antibody |
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| abx449182-1096tests | Abbexa | 10 × 96 tests | Ask for price |
GSK3 beta Antibody |
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| abx449182-596tests | Abbexa | 5 × 96 tests | Ask for price |
GSK3 beta Antibody |
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| abx449182-96tests | Abbexa | 96 tests | EUR 550 |
GSK3 beta antibody |
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| BF0721 | Affbiotech | 200ul | EUR 540 |
GSK3 beta antibody |
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| BF0721-100ul | Affinity Biosciences | 100ul | EUR 210 |
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Description: WB,IHC,IF/ICC,IF |
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GSK3 beta antibody |
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| BF0721-200ul | Affinity Biosciences | 200ul | EUR 270 |
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Description: WB,IHC,IF/ICC,IF |
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GSK3 beta antibody |
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| BF0721-50ul | Affinity Biosciences | 50ul | EUR 150 |
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Description: WB,IHC,IF/ICC,IF |
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GSK3 beta Antibody |
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| AF6658 | Affbiotech | 100ul | EUR 420 |
GSK3 beta Antibody |
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| AF6658-100ul | Affinity Biosciences | 100ul | EUR 168 |
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Description: WB,IF/ICC,ELISA(peptide) |
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GSK3 beta Antibody |
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| AF6658-200ul | Affinity Biosciences | 200ul | EUR 210 |
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Description: WB,IF/ICC,ELISA(peptide) |
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GSK3 beta Antibody |
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| E90064 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3 beta Antibody |
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| E38PA3978 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3 beta Antibody |
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| E2220014 | EnoGene | 100ug | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3 beta Antibody |
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| E18-5016-1 | EnoGene | 50μg/50μl | EUR 145 |
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Description: Available in various conjugation types. |
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GSK3 beta Antibody |
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| E18-5016-2 | EnoGene | 100μg/100μl | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3 beta antibody |
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| MBS5309465-005mg | MyBiosource | 0.05mg | EUR 485 |
GSK3 beta antibody |
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| MBS5309465-5x005mg | MyBiosource | 5x0.05mg | EUR 2045 |
GSK3 beta antibody |
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| MBS5309611-005mg | MyBiosource | 0.05mg | EUR 485 |
GSK3 beta antibody |
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| MBS5309611-5x005mg | MyBiosource | 5x0.05mg | EUR 2045 |
GSK3 beta antibody |
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| MBS5309646-005mg | MyBiosource | 0.05mg | EUR 485 |
GSK3 beta antibody |
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| MBS5309646-5x005mg | MyBiosource | 5x0.05mg | EUR 2045 |
GSK3 beta antibody |
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| MBS5309797-005mg | MyBiosource | 0.05mg | EUR 485 |
GSK3 beta antibody |
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| MBS5309797-5x005mg | MyBiosource | 5x0.05mg | EUR 2045 |
GSK3 beta Antibody |
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| MBS5314452-01mL | MyBiosource | 0.1mL | EUR 535 |
GSK3 beta Antibody |
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| MBS5314452-5x01mL | MyBiosource | 5x0.1mL | EUR 2270 |
GSK3 beta Antibody |
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| MBS5313784-01mg | MyBiosource | 0.1mg | EUR 420 |
GSK3 beta Antibody |
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| MBS5313784-5x01mg | MyBiosource | 5x0.1mg | EUR 1740 |
GSK3 beta Antibody |
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| MBS541779-01mg | MyBiosource | 0.1mg | EUR 445 |
GSK3 beta Antibody |
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| MBS541779-5x01mg | MyBiosource | 5x0.1mg | EUR 1855 |
GSK3 beta Antibody |
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| MBS8001075-01mg | MyBiosource | 0.1mg | EUR 515 |
GSK3 beta Antibody |
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| MBS8001075-5x01mg | MyBiosource | 5x0.1mg | EUR 1780 |
GSK3 beta Antibody |
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| MBS8500032-01mg | MyBiosource | 0.1mg | EUR 305 |
GSK3 beta Antibody |
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| MBS8500032-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3 beta Antibody |
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| MBS8500032-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3 beta Antibody |
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| MBS8500032-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3 beta Antibody |
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| MBS8500032-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3 beta Antibody |
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| MBS8511731-005mg | MyBiosource | 0.05mg | EUR 235 |
GSK3 beta Antibody |
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| MBS8511731-01mg | MyBiosource | 0.1mg | EUR 305 |
GSK3 beta Antibody |
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| MBS8511731-01mLAF405M | MyBiosource | 0.1mL(AF405M) | EUR 465 |
GSK3 beta Antibody |
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| MBS8511731-01mLAF546 | MyBiosource | 0.1mL(AF546) | EUR 465 |
GSK3 beta Antibody |
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| MBS8511731-01mLAF750 | MyBiosource | 0.1mL(AF750) | EUR 465 |
GSK3 beta antibody |
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| MBS838553-INQUIRE | MyBiosource | INQUIRE | Ask for price |
GSK3 beta Antibody |
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| MBS8582263-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3 beta Antibody |
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| MBS8582263-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
GSK3 beta Antibody |
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| MBS8582263-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
GSK3 beta Antibody |
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| MBS8582263-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
GSK3 beta Antibody |
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| MBS8582263-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
GSK3 beta Antibody |
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| MBS858475-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3 beta Antibody |
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| MBS858475-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 565 |
GSK3 beta Antibody |
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| MBS858475-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 565 |
GSK3 beta Antibody |
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| MBS858475-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 565 |
GSK3 beta Antibody |
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| MBS858475-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 565 |
GSK3 beta Antibody |
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| MBS9504150-005mL | MyBiosource | 0.05mL | EUR 285 |
GSK3 beta Antibody |
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| MBS9504150-01mL | MyBiosource | 0.1mL | EUR 385 |
GSK3 beta Antibody |
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| MBS9504150-5x01mL | MyBiosource | 5x0.1mL | EUR 1590 |
GSK3 beta Antibody |
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| MBS9601273-01mL | MyBiosource | 0.1mL | EUR 260 |
GSK3 beta Antibody |
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| MBS9601273-02mL | MyBiosource | 0.2mL | EUR 305 |
GSK3 beta Antibody |
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| MBS9601273-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
GSK3 beta Antibody |
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| MBS9613679-01mL | MyBiosource | 0.1mL | EUR 260 |
GSK3 beta Antibody |
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| MBS9613679-02mL | MyBiosource | 0.2mL | EUR 305 |
GSK3 beta Antibody |
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| MBS9613679-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
GSK3 beta Antibody |
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| MBS9611102-005mL | MyBiosource | 0.05mL | EUR 245 |
GSK3 beta Antibody |
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| MBS9611102-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3 beta Antibody |
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| MBS9611102-02mL | MyBiosource | 0.2mL | EUR 365 |
GSK3 beta Antibody |
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| MBS9611102-5x02mL | MyBiosource | 5x0.2mL | EUR 1495 |
GSK3 beta Antibody |
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| MBS9435624-005mL | MyBiosource | 0.05mL | EUR 325 |
GSK3 beta Antibody |
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| MBS9435624-01mL | MyBiosource | 0.1mL | EUR 435 |
GSK3 beta Antibody |
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| MBS9435624-5x01mL | MyBiosource | 5x0.1mL | EUR 1810 |
Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D | Stressmarq | 0.1mg | EUR 330 |
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Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is unconjugated. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-A390 | Stressmarq | 0.1mg | EUR 384 |
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Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 390. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-A488 | Stressmarq | 0.1mg | EUR 383 |
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Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 488. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-A594 | Stressmarq | 0.1mg | EUR 383 |
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Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 594. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-ALP | Stressmarq | 0.1mg | EUR 376 |
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Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Alkaline Phosphatase. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-APC | Stressmarq | 0.1mg | EUR 382 |
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Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to APC . |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-BI | Stressmarq | 0.1mg | EUR 378 |
|
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Biotin. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-FITC | Stressmarq | 0.1mg | EUR 374 |
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Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to FITC. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-HRP | Stressmarq | 0.1mg | EUR 370 |
|
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to HRP. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-PCP | Stressmarq | 0.1mg | EUR 382 |
|
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to PerCP. |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758D-RPE | Stressmarq | 0.1mg | EUR 380 |
|
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to RPE . |
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Rabbit Anti-Human GSK3 beta Polyclonal |
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| SPC-758S | Stressmarq | 0.012mg | EUR 44 |
|
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is unconjugated. |
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GSK3 beta mAb |
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| MBS435309-005mL | MyBiosource | 0.05mL | EUR 415 |
GSK3 beta mAb |
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| MBS435309-01mL | MyBiosource | 0.1mL | EUR 660 |
GSK3 beta mAb |
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| MBS435309-5x01mL | MyBiosource | 5x0.1mL | EUR 2655 |
GSK3 beta Antibody (PE) |
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| abx449198-1096tests | Abbexa | 10 × 96 tests | Ask for price |
GSK3 beta Antibody (PE) |
|||
| abx449198-596tests | Abbexa | 5 × 96 tests | Ask for price |
GSK3 beta Antibody (PE) |
|||
| abx449198-96tests | Abbexa | 96 tests | EUR 600 |
GSK3 beta (pS9) Antibody |
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| 20-abx009702 | Abbexa |
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GSK3 beta (pS9) Antibody |
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| abx010872-100ug | Abbexa | 100 ug | EUR 526.8 |
GSK3 beta (pS9) Antibody |
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| abx119160-100l | Abbexa | 100 µl | EUR 312.5 |
GSK3 beta (pS9) Antibody |
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| 20-abx119160 | Abbexa |
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GSK3 beta (pS9) Antibody |
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| abx119160-20l | Abbexa | 20 µl | EUR 43.75 |
GSK3 beta (pS9) Antibody |
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| abx119160-50l | Abbexa | 50 µl | EUR 237.5 |
GSK3 beta (pS9) Antibody |
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| abx119162-100l | Abbexa | 100 µl | EUR 312.5 |
GSK3 beta (pS9) Antibody |
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| 20-abx119162 | Abbexa |
|
|
GSK3 beta (pS9) Antibody |
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| abx119162-20l | Abbexa | 20 µl | EUR 43.75 |
GSK3 beta (pS9) Antibody |
|||
| abx119162-50l | Abbexa | 50 µl | EUR 237.5 |
GSK3 beta (pS9) Antibody |
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| 20-abx133097 | Abbexa |
|
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GSK3 beta Antibody (APC) |
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| abx449192-100ug | Abbexa | 100 ug | EUR 727.2 |
GSK3 beta Antibody (APC) |
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| abx449192-1096tests | Abbexa | 10 × 96 tests | Ask for price |
GSK3 beta Antibody (APC) |
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| abx449192-596tests | Abbexa | 5 × 96 tests | Ask for price |
GSK3 beta Antibody (APC) |
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| abx449192-96tests | Abbexa | 96 tests | EUR 612.5 |
GSK3 beta Antibody (HRP) |
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| abx449195-100ug | Abbexa | 100 ug | EUR 710.4 |
GSK3 beta Antibody (HRP) |
|||
| abx449195-1096tests | Abbexa | 10 × 96 tests | Ask for price |
GSK3 beta Antibody (HRP) |
|||
| abx449195-596tests | Abbexa | 5 × 96 tests | Ask for price |
GSK3 beta Antibody (HRP) |
|||
| abx449195-96tests | Abbexa | 96 tests | EUR 600 |
GSK3 beta Antibody (RPE) |
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| abx449198-100ug | Abbexa | 100 ug | EUR 727.2 |
GSK3 beta (pS9) Antibody |
|||
| E38PA4424 | EnoGene | 100ul | EUR 225 |
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Description: Available in various conjugation types. |
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GSK3 beta (pS9) Antibody |
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| E38PA1513 | EnoGene | 100ul | EUR 225 |
|
Description: Available in various conjugation types. |
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GSK3 beta Antibody: HRP |
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| MBS8001088-01mg | MyBiosource | 0.1mg | EUR 555 |
GSK3 beta Antibody: HRP |
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| MBS8001088-5x01mg | MyBiosource | 5x0.1mg | EUR 1965 |
GSK3 beta Antibody: RPE |
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| MBS8001091-01mg | MyBiosource | 0.1mg | EUR 565 |
GSK3 beta Antibody: RPE |
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| MBS8001091-5x01mg | MyBiosource | 5x0.1mg | EUR 2005 |
GSK3 beta (pS9) Antibody |
|||
| MBS8580646-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3 beta (pS9) Antibody |
|||
| MBS8580646-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
GSK3 beta (pS9) Antibody |
|||
| MBS8580646-01mLAF405S | MyBiosource | 0.1mL(AF405S) | EUR 465 |
GSK3 beta (pS9) Antibody |
|||
| MBS8580646-01mLAF610 | MyBiosource | 0.1mL(AF610) | EUR 465 |
GSK3 beta (pS9) Antibody |
|||
| MBS8580646-01mLAF635 | MyBiosource | 0.1mL(AF635) | EUR 465 |
GSK3 beta (pS9) Antibody |
|||
| MBS8582501-01mL | MyBiosource | 0.1mL | EUR 305 |
GSK3 beta (pS9) Antibody |
|||
| MBS8582501-01mLAF405L | MyBiosource | 0.1mL(AF405L) | EUR 465 |
These findings reveal that DEK3 phosphorylation is essential for chromatin perform and mobile stress response and supply a mechanistic instance of how GSK3-based signalling is straight linked to chromatin, facilitating a transcriptional response.
