Medical Mitogen-activated protein kinases (MAPK) Research

anti- Phospoho CDK, MAPK, GSK3, CLK, ERK1/2, JNK

TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state
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TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

Mouse embryonic stem cells (mESCs) might be maintained in vitro in outlined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory issue (LIF), which act synergistically to advertise self-renewal and pluripotency.
Right here, we discover that genetic deletion of the 4 genes encoding the TCF/LEF transcription elements confers mESCs with the flexibility to self-renew in N2B27 medium alone. TCF/LEF quadruple knockout (qKO) mESCs show dysregulation of a number of genes, together with Aire, Dnmt3l, and IcosL, positioned adjoining to one another inside a topologically related area (TAD).
Aire, Dnmt3l, and IcosL seem like regulated by TCF/LEF in a β-catenin unbiased method. Furthermore, downregulation of Aire and Dnmt3l in wild-type mESCs mimics the lack of TCF/LEF and will increase mESC survival within the absence of 2iL. Therefore, this research identifies TCF/LEF effectors that mediate exit from the pluripotent state.

Glycogen Synthase Kinase Three regulates the genesis of displaced retinal ganglion cells

Glycogen Synthase Kinase 3 (GSK) proteins (GSK3α and GSK3β) are key mediators of signaling pathways, with essential roles in coordinating basic organic processes throughout neural improvement. Right here we present that the whole lack of GSK3 signaling in mouse retinal progenitors results in microphthalmia with broad morphological defects. A single wild-type allele of both Gsk3α or Gsk3β is ready to rescue this phenotype.
On this genetic context, all cell sorts are current with a practical retina. Nonetheless, we unexpectedly detect a lot of cells within the inside nuclear layer expressing retinal ganglion cell (RGC)-specific markers (referred to as displaced RGCs, dRGCs) when no less than one allele of Gsk3α is expressed.
Extra dRGCs result in elevated variety of axons projecting into the ipsilateral medial terminal nucleus, an space of the mind belonging to the non-image-forming visible circuit and poorly focused by RGCs in wild-type retina. Transcriptome evaluation and optomotor response assay counsel that no less than a subset of dRGCs in Gsk3 mutant mice are direction-selective RGCs.
Our research thus uncovers a novel position of GSK3 in controlling the manufacturing of ganglion cells within the inside nuclear layer, which correspond to dRGCs, a uncommon and poorly characterised retinal cell kind.Significance StatementGlycogen Synthase Kinase 3 (GSK) proteins (Gsk3α or Gsk3β) are key mediators of signaling pathways, particularly within the central nervous system however poorly described within the retina.
Right here we present that the whole lack of GSK3 in mouse retinal progenitors results in microphthalmia. Nonetheless, when just one allele of Gsk3α or Gsk3β are current, all cell sorts are current with a practical retina.
Extra importantly, we unexpectedly uncover a novel position of GSK3 in controlling the genesis of retinal ganglion cells within the inside nuclear layer which may correspond to a uncommon and poorly characterised retinal cell kind. Subsequently, our mouse fashions probably provide a novel and highly effective mannequin system to review the visible perform of dRGCs in mammals.

P2 × 7 receptor blockade reduces Tau induced toxicity, therapeutic implications in Tauopathies

Tauopathies are neurodegenerative illnesses characterised by the presence of aberrant intraneuronal aggregates of hyperphosphorylated Tau protein. Latest research counsel that related persistent neuroinflammation could contribute to the pathological Tau dissemination. Nonetheless, the underlying molecular mechanisms stay unknown.
Since purinergic P2 × 7 receptors (P2 × 7) can sense the rise of extracellular ATP ranges related to neuroinflammation, its involvement in neurodegeneration-associated irritation was urged. We discovered a P2 × 7 upregulation in sufferers recognized with totally different tauopathies and in a tauopathy mouse mannequin, P301S mice.
In vivo pharmacological or genetic blockade of P2 × 7 reverted microglial activation in P301S mice resulting in a discount in microglial migratory, secretory, and proliferative capacities, and selling phagocytic perform. Moreover, it decreased the intraneuronal phosphorylated Tau ranges in a GSK3-dependent approach and elevated extracellular phosphorylated Tau (eTau) ranges by lowering the expression of ectoenzyme TNAP.
Accordingly, pharmacological or genetic blockade of P2 × 7 improved the mobile survival, motor and reminiscence deficits and anxiolytic profile in P301S mice. Opposite, P2 × 7 overexpression brought on a big worsening of Tau-induced toxicity and aggravated the deteriorated motor and reminiscence deficits in P301S mice. Our outcomes point out that P2 × 7 performs a deleterious position in tauopathies and counsel that its blockade could also be a promising strategy to deal with Tauopathies.

Small-molecule suppression of calpastatin degradation reduces neuropathology in fashions of Huntington’s illness

Mitochondrial dysfunction is a standard hallmark of neurological issues, and lowering mitochondrial harm is taken into account a promising neuroprotective therapeutic technique. Right here, we used high-throughput small molecule screening to establish CHIR99021 as a potent enhancer of mitochondrial perform.
CHIR99021 improved mitochondrial phenotypes and enhanced cell viability in a number of fashions of Huntington’s illness (HD), a deadly inherited neurodegenerative dysfunction. Notably, CHIR99201 remedy decreased HD-associated neuropathology and behavioral defects in HD mice and improved mitochondrial perform and cell survival in HD patient-derived neurons.
Unbiased of its identified inhibitory exercise towards glycogen synthase kinase 3 (GSK3), CHIR99021 remedy in HD fashions suppressed the proteasomal degradation of calpastatin (CAST), and subsequently inhibited calpain activation, a well-established effector of neural dying, and Drp1, a driver of mitochondrial fragmentation. Our outcomes established CAST-Drp1 as a druggable signaling axis in HD pathogenesis and highlighted CHIR99021 as a mitochondrial perform enhancer and a possible lead for growing HD therapies.

GSK3-Mediated Phosphorylation of DEK3 Regulates Chromatin Accessibility and Stress Tolerance in Arabidopsis

Chromatin dynamics allow the exact management of transcriptional packages. The steadiness between proscribing and opening of regulatory sequences on the DNA must be adjusted to prevailing circumstances and is fine-tuned by chromatin remodelling proteins.
DEK is an evolutionarily conserved chromatin architectural protein regulating vital chromatin-related processes. Nonetheless, the molecular hyperlink between DEK-induced chromatin reconfigurations and upstream signalling occasions stays unknown.
Right here, we present that ASKβ/AtSK31 is a salt stress-activated Glycogen Synthase Kinase 3 (GSK3) from Arabidopsis thaliana that phosphorylates DEK3. This particular phosphorylation alters nuclear DEK3 protein complicated composition, impacts nucleosome occupancy and chromatin accessibility that’s translated into adjustments in gene expression, contributing to salt stress tolerance.

GSK3 beta antibody
70R-30634 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-37442 100 ug
EUR 327.6
Description: Rabbit Polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-49832 100 ul
EUR 344.4
Description: Purified Polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-34165 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-34639 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal GSK3 beta antibody

GSK3 beta Antibody
48798-100ul 100ul
EUR 399.6

GSK3 beta Antibody
48798-50ul 50ul
EUR 286.8

GSK3 beta Antibody
ABF5016 100 ug
EUR 525.6

GSK3 beta Antibody
E38PA3978 100ul
EUR 225
Description: Available in various conjugation types.

GSK3 beta Antibody
E90064 100ul
EUR 225
Description: Available in various conjugation types.

GSK3 beta Antibody
DF7231 100ul
EUR 280
Description: Human,Mouse,Rat

GSK3 beta Antibody
AF5016-100ul 100ul
EUR 280

GSK3 beta Antibody
AF5016-200ul 200ul
EUR 350

GSK3 beta Antibody
AF6658-100ul 100ul
EUR 280

GSK3 beta Antibody
AF6658-200ul 200ul
EUR 350

GSK3 beta Antibody
AF7814-100ul 100ul
EUR 350

GSK3 beta Antibody
AF7814-200ul 200ul
EUR 450

GSK3 beta Antibody
AF7814-50ul 50ul
EUR 250

GSK3 beta antibody
BF0721-100ul 100ul
EUR 350

GSK3 beta antibody
BF0721-200ul 200ul
EUR 450

GSK3 beta antibody
BF0721-50ul 50ul
EUR 250

GSK3 beta Antibody
AF5016 100ul
EUR 280
Description: Human,Mouse,Rat

GSK3 beta Antibody
AF6658 100ul
EUR 280
Description: Human,Mouse

GSK3 beta Antibody
AF7814 100ul
EUR 350
Description: Human,Mouse,Rat

GSK3 beta antibody
BF0721 100ul
EUR 350
Description: Human,Mouse,Rat

GSK3 beta Antibody
DF7231-100ul 100ul
EUR 280

GSK3 beta Antibody
DF7231-200ul 200ul
EUR 350

GSK3 beta Antibody
E2220014 100ug
EUR 225
Description: Available in various conjugation types.

GSK3 beta Antibody
E18-5016-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

GSK3 beta Antibody
E18-5016-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3 beta Antibody / GSK3B
F54007-0.1ML 0.1 ml
EUR 322.15
Description: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. [UniProt]

GSK3 beta protein
30R-2812 10 ug
EUR 403.2
Description: Purified recombinant Human GSK3 beta protein

GSK3 beta protein
80R-4368 50 ug
EUR 418.8
Description: Purified Recombinant GSK3 beta protein (His tagged)

GSK3 beta (pS9) Antibody
20-abx133097
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 beta (pS9) Antibody
20-abx119160
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

GSK3 beta (pS9) Antibody
20-abx119162
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

GSK3 beta Antibody (APC)
abx449192-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (HRP)
abx449195-100ug 100 ug
EUR 710.4

GSK3 beta Antibody (RPE)
abx449198-100ug 100 ug
EUR 727.2

GSK3 beta (pS9) Antibody
20-abx009702
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 beta (pS9) Antibody
abx010872-100ug 100 ug
EUR 526.8

GSK3 beta (pS9) Antibody
E38PA4424 100ul
EUR 225
Description: Available in various conjugation types.

GSK3 beta (pS9) Antibody
E38PA1513 100ul
EUR 225
Description: Available in various conjugation types.

GSK3 beta Antibody (FITC)
abx449194-100ug 100 ug
EUR 727.2

GSK3 beta antibody (Ser9)
70R-30633 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 beta antibody (Ser9)

GSK3 beta antibody (Ser9)
70R-37084 100 ug
EUR 418.8
Description: Rabbit Polyclonal GSK3 beta antibody (Ser9)

GSK3 beta Antibody (PerCP)
abx449197-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (Biotin)
abx449193-100ug 100 ug
EUR 727.2

GSK3 beta antibody (Tyr216)
70R-37352 100 ug
EUR 418.8
Description: Rabbit Polyclonal GSK3 beta antibody (Tyr216)

GSK3 beta Conjugated Antibody
C48798 100ul
EUR 476.4

GSK3 beta Antibody (Streptavidin)
abx449199-100ug 100 ug
EUR 727.2

GSK3 lpha / beta Antibody
abx010869-100ug 100 ug
EUR 510

GSK3 alpha/beta Antibody
29039-100ul 100ul
EUR 302.4

GSK3 alpha/beta antibody
70R-30578 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta antibody
70R-51552 100 ul
EUR 344.4
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta antibody
70R-49831 100 ul
EUR 292.8
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta Antibody
ABF6335 100 ug
EUR 525.6

GSK3 alpha / beta Antibody
20-abx009185
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 alpha/beta Antibody
E38PA1512 100ul
EUR 225
Description: Available in various conjugation types.

GSK3 alpha/ beta Antibody
DF6806 100ul
EUR 280
Description: Human,Mouse,Rat

GSK3 alpha/ beta Antibody
AF6335-100ul 100ul
EUR 280

GSK3 alpha/ beta Antibody
AF6335-200ul 200ul
EUR 350

GSK3 alpha/ beta Antibody
DF6806-100ul 100ul
EUR 280

GSK3 alpha/ beta Antibody
DF6806-200ul 200ul
EUR 350

GSK3 alpha/ beta Antibody
AF6335 100ul
EUR 280
Description: Human,Mouse,Rat,Monkey

GSK3 alpha/beta Antibody
E18-6335-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

GSK3 alpha/beta Antibody
E18-6335-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Rabbit Anti Gsk3 Beta (Pser9) Polyclonal Antibody
CPBT-66459RG 0.1 ml
EUR 1182

GSK3 beta Antibody (ATTO 390)
abx449183-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (ATTO 488)
abx449184-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (ATTO 565)
abx449185-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (ATTO 594)
abx449186-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (ATTO 633)
abx449187-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (ATTO 655)
abx449188-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (ATTO 680)
abx449189-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (ATTO 700)
abx449190-100ug 100 ug
EUR 727.2

GSK3 beta Rabbit pAb
E2380655 100ul
EUR 225
Description: Available in various conjugation types.

GSK3 beta Rabbit mAb
E2R22868 100μl
EUR 225
Description: Available in various conjugation types.

Antibody for Human GSK3 beta
SPC-758D 0.1mg
EUR 423.6
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is unconjugated.

Antibody for Human GSK3 beta
SPC-758D-A390 0.1mg
EUR 480
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 390.

Antibody for Human GSK3 beta
SPC-758D-A488 0.1mg
EUR 478.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 488.

Antibody for Human GSK3 beta
SPC-758D-A565 0.1mg
EUR 478.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 565.

Antibody for Human GSK3 beta
SPC-758D-A594 0.1mg
EUR 478.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 594.

Antibody for Human GSK3 beta
SPC-758D-A633 0.1mg
EUR 478.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 633.

Antibody for Human GSK3 beta
SPC-758D-A655 0.1mg
EUR 478.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 655.

Antibody for Human GSK3 beta
SPC-758D-A680 0.1mg
EUR 478.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 680.

Antibody for Human GSK3 beta
SPC-758D-A700 0.1mg
EUR 478.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to ATTO 700.

Antibody for Human GSK3 beta
SPC-758D-ALP 0.1mg
EUR 471.6
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Alkaline Phosphatase.

Antibody for Human GSK3 beta
SPC-758D-APC 0.1mg
EUR 477.6
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to APC .

Antibody for Human GSK3 beta
SPC-758D-APCCY7 0.1mg
EUR 564
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to APC/Cy7.

Antibody for Human GSK3 beta
SPC-758D-BI 0.1mg
EUR 474
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Biotin.

Antibody for Human GSK3 beta
SPC-758D-DY350 0.1mg
EUR 495.6
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 350.

Antibody for Human GSK3 beta
SPC-758D-DY405 0.1mg
EUR 482.4
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 405.

Antibody for Human GSK3 beta
SPC-758D-DY488 0.1mg
EUR 470.4
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 488.

Antibody for Human GSK3 beta
SPC-758D-DY594 0.1mg
EUR 472.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 594.

Antibody for Human GSK3 beta
SPC-758D-DY633 0.1mg
EUR 466.8
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Dylight 633.

Antibody for Human GSK3 beta
SPC-758D-FITC 0.1mg
EUR 469.2
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to FITC.

Antibody for Human GSK3 beta
SPC-758D-HRP 0.1mg
EUR 464.4
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to HRP.

Antibody for Human GSK3 beta
SPC-758D-P594 0.1mg
EUR 487.2
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to PE/ATTO 594.

Antibody for Human GSK3 beta
SPC-758D-PCP 0.1mg
EUR 477.6
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to PerCP.

Antibody for Human GSK3 beta
SPC-758D-RPE 0.1mg
EUR 475.2
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to RPE .

Antibody for Human GSK3 beta
SPC-758D-STR 0.1mg
EUR 476.4
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is conjugated to Streptavidin.

Antibody for Human GSK3 beta
SPC-758S 0.012mg
EUR 78
Description: A polyclonal antibody for GSK3 beta from Human | Mouse. The antibody is produced in rabbit after immunization with human synthetic peptide from the N-terminal of Human GSK3 beta (aa. 1-100). The Antibody is tested and validated for WB, IHC assays with the following recommended dilutions: WB (1:1000); IHC (1:50). This GSK3 beta antibody is unconjugated.

Polyclonal GSK3B / GSK3 Beta Antibody
AMM05221G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta . This antibody is tested and proven to work in the following applications:

Phospho- GSK3 beta (Ser9) Antibody
ABF2016 100 ug
EUR 525.6

GSK3 beta Blocking Peptide
AF7814-BP 1mg
EUR 234

GSK3 beta Blocking Peptide
AF5016-BP 1mg
EUR 234

GSK3 beta Blocking Peptide
20-abx162471
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

GSK3 beta (Phospho-Ser25) Antibody
13163-100ul 100ul
EUR 302.4

GSK3 beta (Phospho-Ser25) Antibody
13163-50ul 50ul
EUR 224.4

GSK3 beta antibody Blocking Peptide
BF0721-BP 1mg
EUR 234

GSK3 beta Antibody (Alkaline Phosphatase)
abx449191-100ug 100 ug
EUR 727.2

GSK3 beta Antibody (PE/ATTO 594)
abx449196-100ug 100 ug
EUR 744

GSK3 beta recombinant monoclonal antibody
A5007 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human GSK3 beta for WB, IHC, IF,ELISA

Mouse Anti Human GSK3 Beta Monoclonal Clone 2C6
IMSAMLGSK3B2C6C120UL each
EUR 260
Description: Mouse Anti Human GSK3 Beta Monoclonal Clone 2C6

Mouse Anti Human GSK3 Beta Monoclonal Clone 4C3
IMSAMLGSK3B4C3C120UL each
EUR 260
Description: Mouse Anti Human GSK3 Beta Monoclonal Clone 4C3

Mouse Anti Human GSK3 Beta Monoclonal Clone 4D2
IMSAMLGSK3B4D2C120UL each
EUR 260
Description: Mouse Anti Human GSK3 Beta Monoclonal Clone 4D2

GSK3 alpha/beta Conjugated Antibody
C29039 100ul
EUR 476.4

GSK3 beta(Phospho-Ser 9) Antibody
13356-100ul 100ul
EUR 399.6

GSK3 beta(Phospho-Ser 9) Antibody
13356-50ul 50ul
EUR 286.8

GSK3 beta (pS9) Blocking Peptide
20-abx062707
  • EUR 376.80
  • EUR 610.80
  • 1 mg
  • 5 mg

GSK3 beta (pS9) Blocking Peptide
20-abx161635
  • EUR 376.80
  • EUR 610.80
  • 1 mg
  • 5 mg

GSK3 alpha / beta (pY279 / 216) Antibody
20-abx119370
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

GSK3 alpha / beta (pT279 / 216) Antibody
20-abx009652
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 alpha / beta (pY279 / 216) Antibody
abx010868-100ug 100 ug
EUR 526.8

GSK3 alpha/beta (pY279/216) Antibody
E38PA3233 100ul
EUR 225
Description: Available in various conjugation types.

GSK3 alpha/beta Rabbit mAb
E2R22884 100ul
EUR 255
Description: Available in various conjugation types.

GSK3 alpha/beta antibody (Tyr279/216)
70R-30577 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 alpha/beta antibody (Tyr279/216)

GSK3 beta (Phospho-Ser25) Conjugated Antibody
C13163 100ul
EUR 476.4

Polyclonal GSK3B / GSK3 Beta Antibody (C-Terminus)
AMM05222G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta (C-Terminus). This antibody is tested and proven to work in the following applications:

GSK3 alpha / beta Blocking Peptide
20-abx062706
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

GSK3 alpha/beta Blocking Peptide
AF6335-BP 1mg
EUR 234

GSK3 beta(Phospho-Ser 9) Conjugated Antibody
C13356 100ul
EUR 476.4

Phospho- GSK3 alpha/ beta (Tyr279/216) Antibody
ABF3335 100 ug
EUR 525.6

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody
13355-100ul 100ul
EUR 399.6

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody
13355-50ul 50ul
EUR 286.8

Monoclonal GSK3 alpha/beta Antibody, Clone: EP933Y
APR12318G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3 alpha/beta. The antibodies are raised in Rabbit and are from clone EP933Y. This antibody is applicable in WB

anti-GSK3 beta
YF-PA23834 50 ul
EUR 400.8
Description: Mouse polyclonal to GSK3 beta

anti-GSK3 beta
YF-PA12137 100 ug
EUR 483.6
Description: Rabbit polyclonal to GSK3 beta

Monoclonal GSK3 beta Antibody Phospho (pS9), Clone: EPR2286Y
AMM05220G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3 beta Phospho (pS9). The antibodies are raised in Rabbit and are from clone EPR2286Y. This antibody is applicable in WB and IHC

GSK3 alpha / beta (pY279 / 216) Blocking Peptide
20-abx062127
  • EUR 376.80
  • EUR 610.80
  • 1 mg
  • 5 mg

Rat GSK3- beta interaction protein, Gskip ELISA KIT
ELI-31339r 96 Tests
EUR 1063.2

Mouse GSK3- beta interaction protein, Gskip ELISA KIT
ELI-08777m 96 Tests
EUR 1038

Human GSK3- beta interaction protein, GSKIP ELISA KIT
ELI-27905h 96 Tests
EUR 988.8

Bovine GSK3- beta interaction protein, GSKIP ELISA KIT
ELI-27494b 96 Tests
EUR 1113.6

Chicken GSK3- beta interaction protein, GSKIP ELISA KIT
ELI-31338c 96 Tests
EUR 1113.6

GSK3(alpha+beta)(Phospho-Y216+Y279) Conjugated Antibody
C13355 100ul
EUR 476.4

GSK3 Beta Colorimetric Cell-Based ELISA Kit (OKAG00757)
OKAG00757 96 Wells
EUR 715.2
Description: Description of target: ;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

Anti-GSK3 beta (1H3)
YF-MA10388 100 ug
EUR 435.6
Description: Mouse monoclonal to GSK3 beta

Anti-GSK3 beta Antibody
R1510-4 100ul
EUR 189
Description: Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer’s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer’s disease.

Anti-GSK3 beta antibody
STJ99095 200 µl
EUR 236.4
Description: Mouse monoclonal to GSK3 beta.

Monoclonal GSK3 Antibody alpha/beta Phospho (pY279)/(pY216), Clone: EPR933Y
AMM05997G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3 alpha/beta Phospho (pY279)/(pY216). The antibodies are raised in Rabbit and are from clone EPR933Y. This antibody is applicable in WB and IHC

anti-GSK3 Beta IgG2a mAb
011-A-01mg 0,1 mg
EUR 321
Description: anti-GSK3 Beta IgG2a (monoclonal). Produced against a recombinant Xenopus laevis protein.

anti-GSK3 Beta IgG2a mAb
011-A-1000ug 1000 ug
EUR 1539
Description: anti-GSK3 Beta IgG2a (monoclonal). Produced against a recombinant Xenopus laevis protein.

GSK3 Alpha/ Beta Colorimetric Cell-Based ELISA Kit (OKAG00756)
OKAG00756 96 Wells
EUR 715.2
Description: Description of target: ;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:
These findings reveal that DEK3 phosphorylation is essential for chromatin perform and mobile stress response and supply a mechanistic instance of how GSK3-based signalling is straight linked to chromatin, facilitating a transcriptional response.
Tags:
Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways
Unravelling the selectivity of 6,7 dimethyl Quinoxaline analogues for kinase inhibition: An Insight towards the development of Alzheimer's therapeutics

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