Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways

Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways

Peste des petits ruminants virus (PPRV), belonging to the genus Morbillivirus within the household Paramyxoviridae, causes extreme infectious illness in small ruminants and has been quickly spreading in lots of elements of Africa, the Center East, and Asia.
Though vaccination is taken into account to be an efficient technique of controlling PPR, the heat-sensitive nature of the vaccines towards PPRV enormously limits their utility in areas with a sizzling local weather. Within the current research, we investigated the anti-PPRV results of favipiravir and sought to determine the underlying mechanisms in vitro utilizing the Vero cell line.
MTT assays, Western blotting, oblique immunofluorescence assays, virus plaque formation assays, and qRT-PCR had been used to evaluate the consequences of favipiravir on the life cycle of PPRV and the expression of RNA-dependent RNA polymerase (RdRp). Moreover, the expression ranges of JAK1, STAT1, phosphorylated (p)-STAT1, PI3K, AKT, and p-AKT, in addition to these of signaling molecules appearing downstream of the JAK/STAT and PI3K/AKT signaling pathways, had been decided by Western blotting and qRT-PCR.
The outcomes indicated that, in PPRV-infected, favipiravir-treated Vero cells, the attachment, invasion, replication, and launch of PPRV had been considerably inhibited, as was the expression of RdRp, in comparison with that in untreated PPRV-infected cells.
Moreover, in favipiravir-treated cells, the expression of JAK1 and STAT1 was downregulated, whereas that of p-STAT1 was considerably upregulated. Equally, the expression ranges of PKR, IRF9, ISG54, and MxA proteins which are related to innate antiviral exercise in host cells had been additionally markedly elevated. Furthermore, with favipiravir therapy, the expression of PI3K and p-AKT and the p-AKT/AKT ratio had been considerably decreased, whereas the expression of AKT was noticeably upregulated.
The expression of GSK3, NF-κB p65, p-NF-κB p65, and BAD was additionally elevated with favipiravir therapy, whereas the expression of CREB, p-CREB, p-GSK3, and Bcl-2 was barely decreased. As well as, all of the p-GSK3/GSK3, p-CREB/CREB, p-NF-κB/NF-κB, and p-BAD/BAD ratios had been considerably decreased in favipiravir-treated cells.
These outcomes implied that the antiviral effectivity of favipiravir towards PPRV is mediated by the JAK/STAT and PI3K/AKT pathways and that favipiravir has potential to be used as an efficient antiviral agent towards PPRV.

Glycogen synthase kinase-3β inactivation promotes cervical most cancers development, invasion, and drug resistance

Human papillomavirus (HPV) infection-dependent cervical most cancers is without doubt one of the most typical gynecological cancers and infrequently turns into aggressive, with fast proliferation, invasion/migration, and drug resistance.
Right here, 135 recent human CSCC tissue specimens, comprising: 21 adjoining normals (AN), 30 cervical-intraepithelial-neoplasia (CIN1-3 ), 45 CSCC, and 39 medicine (chemo-radiation)-resistant cervical tumor (DRCT) tissues had been included.
HPV-positive (HeLa, SiHa), HPV-negative (C33A), and cisplatin-resistant (CisR-HeLa/-SiHa/-C33A) cell strains had been used for in vitro research. HPV16/18 oncoproteins E6/E7, pERK1/2, and glycogen synthase kinase-3 (GSK3) and the matrix metalloproteinases (MMPs) MMP-9/-2 had been assessed utilizing immunohistochemistry, WB, and gelatin zymography.
HPV16/18 an infection was noticed in 16.7% of the CIN1-3 , 77.8% of the CSCC, and 89.7% of DRCT samples. Whole and inactive GSK3β expressions had been related to total CSCC development (p = 0.039 and p = 0.024, respectively) and chemoresistance (p = 0.004 and p = 0.014, respectively).
Constructive correlations had been noticed, between the expression of E6 and pGSK3β expression (p = 0.013); E6 and CSCC development (p<0.0001)/ drug resistance (p = 0.0001). CisR-HeLa/-SiHa was extra depending on pGSK3β, and activation of GSK3 by SMIs (iAkt), therapy with nimbolide, or knockdown of E6/E7 decreased cisplatin-resistance and promoted apoptosis. Therefore, the activation of GSK3β with nimbolide and iAkt may be exploited for therapeutic interventions of cervical most cancers. This text is protected by copyright. All rights reserved.

G protein-coupled receptor kinase 2 is crucial to allow vasoconstrictor-mediated arterial clean muscle proliferation

Hypertension is related to elevated manufacturing and circulation of vasoconstrictors, leading to enhanced signalling by their cognate G protein-coupled receptors (GPCR). Extended vasoconstrictor GPCR signalling will increase arterial contraction and stimulates signalling pathways that promote vascular clean muscle cell (VSMC) proliferation, contributing to the event of atherosclerotic plaques, re-stenosis lesions and vascular remodelling.
GPCR signalling by phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) promotes VSMC proliferation. In VSMC, G protein-coupled receptor kinase 2 (GRK2) is thought to manage quite a few vasoconstrictor GPCRs and their downstream signalling pathways.
As GRK2 is implicated in controlling numerous elements of mobile development, we examined whether or not GRK2 might have an effect on VSMC proliferation. Utilizing two indices of cell development, we present that PI3K inhibition and depletion of GRK2 expression produced the same ablation of pro-proliferative vasoconstrictor-stimulated VSMC development.
Moreover, GRK2-knockdown ablated the sustained part of endothelin-1 and angiotensin-II-stimulated Akt phosphorylation, while the height (5 min) part was unaffected. Conversely, the GRK2 inhibitor compound 101 didn’t have an effect on vasoconstrictor-driven Akt phosphorylation.
Vasoconstrictor-stimulated phosphorylation of the Akt substrates GSK3α and GSK3β was ablated following RNAi-mediated GRK2 depletion, or after PI3K inhibition. Furthermore, GRK2 knockdown prevented endothelin-1 and angiotensin-II from rising cyclin D1 expression.
These knowledge counsel GRK2 expression is crucial to facilitate vasoconstrictor-driven VSMC proliferation by its potential to advertise environment friendly extended PI3K-Akt signalling, and thus relieve the GSK3-mediated block on cell biking. Contemplating VSMC GRK2 expression will increase early within the improvement of hypertension, this highlights the potential for GRK2 to advertise VSMC development and exacerbate hypertensive pathophysiological vascular remodelling.

Publicity to Perfluoro-Octanoic Acid Related With Upstream Uncoupling of the Insulin Signaling in Human Hepatocyte Cell Line

Perfluoro-alkyl substances (PFAS) are chemical pollution with prevalent stability and environmental persistence. Publicity to PFAS, notably perfluoro-octanoic acid (PFOA), has been related to elevated diabetes-related cardiovascular mortality in topics residing areas of excessive environmental contamination, nevertheless the precise pathogenic mechanism stays elusive.
Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways
Right here we used HepG2 cells, an in vitro mannequin of human hepatocyte, to research the potential position of PFOA publicity within the alteration of hepatic glucose metabolism. HepG2 cells had been uncovered for 24 hours to PFOA at rising focus from Zero to 1000 ng/mL after which stimulated with 100 nm Insulin (Ins).
The ensuing impact on glycogen synthesis, glucose uptake and Glut-Four glucose transporter translocation was then evaluated by, respectively, Periodic Acid Schiff (PAS) staining, 2-deoxyglucose (2-DG) uptake assay and immunofluorescence.
Publicity to PFOA was related to decreased glycogen synthesis and glucose uptake, at focus equal or higher than, respectively, 0,1 ng/mL and 10 ng/mL, with parallel impaired membrane translocation of Glut-Four upon Ins stimulation. Western blot evaluation confirmed early uncoupling of Insulin Receptor (InsR) activation from the downstream Akt and GSK3 phosphorylation.
Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways
Computational docking evaluation disclosed the potential stabilizing impact of PFOA on the advanced between InsR and GM3 ganglioside, beforehand proven to be related to the low grade persistent inflammation-related insulin resistance.

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

20-abx210328
  • Ask for price
  • Ask for price
  • 100 ul
  • 50 ul

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx233672-100ug 100 ug
EUR 577.2

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

20-abx172633
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

20-abx172634
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx331993-100ul 100 ul
EUR 510

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx332236-100ul 100 ul
EUR 510

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

20-abx329707
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

20-abx318830
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx010871-100g 100 µg Ask for price

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx010871-10g 10 µg
EUR 350

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx010871-200g 200 µg Ask for price

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx000794-100l 100 µl
EUR 400

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx000794-20l 20 µl
EUR 175

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx000794-50l 50 µl
EUR 275

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx103421-100g 100 µg
EUR 675

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx103421-20g 20 µg
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx103421-50g 50 µg
EUR 312.5

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx103422-100g 100 µg
EUR 687.5

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx103422-20g 20 µg
EUR 262.5

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx103422-50g 50 µg
EUR 325

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx210327-100l 100 µl
EUR 350

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx210327-50l 50 µl
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx210328-100l 100 µl
EUR 350

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx210328-50l 50 µl
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx130116-100l 100 µl
EUR 262.5

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx130116-1ml 1 ml
EUR 725

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx130116-200l 200 µl
EUR 337.5

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx172633-1ml 1 ml
EUR 712.5

Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody

abx172634-1ml 1 ml
EUR 775

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx112807-100l 100 µl
EUR 612.5

Glycogen Synthase Kinase 3 Alpha (Gsk3a) Antibody

abx028353-400l 400 µl
EUR 518.75

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx233672-100g 100 µg
EUR 350

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx329707-100g 100 µg Ask for price

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx329707-20g 20 µg
EUR 187.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx329707-50g 50 µg
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx318830-100l 100 µl
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody

abx318830-50l 50 µl
EUR 162.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP)

20-abx316098
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP)

abx316098-100g 100 µg
EUR 362.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP)

abx316098-20g 20 µg
EUR 162.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP)

abx316098-50g 50 µg
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC)

20-abx316099
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC)

abx316099-100g 100 µg
EUR 362.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC)

abx316099-20g 20 µg
EUR 162.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC)

abx316099-50g 50 µg
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin)

20-abx316100
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin)

abx316100-100g 100 µg
EUR 362.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin)

abx316100-20g 20 µg
EUR 162.5

Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin)

abx316100-50g 50 µg
EUR 250

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody

CAU27488-100ul 100ul
EUR 229.4

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody

CAU27488-200ul 200ul
EUR 287.3

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody

CAU27489-100ul 100ul
EUR 217.9

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody

CAU27489-200ul 200ul
EUR 272.2

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody

CAU27490-100ul 100ul
EUR 212.2

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody

CAU27490-200ul 200ul
EUR 265.4

Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a)

PAA630Hu01 100ul
EUR 221

Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a)

PAA630Mu01 100ul
EUR 227

Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a)

PAA630Ra01 100ul
EUR 239

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat)

4-PAA630Ra01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a)

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human)

4-PAA630Hu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a)

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse)

4-PAA630Mu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a)

GSK3A (untagged)-Human glycogen synthase kinase 3 alpha (GSK3A)

SC112599 10 µg Ask for price

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), PE

4-PAA630Ra01-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with PE.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), APC

4-PAA630Ra01-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), Cy3

4-PAA630Ra01-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Cy3.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), HRP

4-PAA630Ra01-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with HRP.

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU54048-100ug 100ug
EUR 576.4

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU54048-1mg 1mg
EUR 2555.8

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU54048-50ug 50ug
EUR 463.1

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU41701-100ug 100ug
EUR 514.8

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU41701-1mg 1mg
EUR 2282.8

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU41701-50ug 50ug
EUR 413.6

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU41702-100ug 100ug
EUR 552.2

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU41702-1mg 1mg
EUR 2446.6

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPU41702-50ug 50ug
EUR 443.3

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPA630Hu01 10ug
EUR 167

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

4-RPA630Hu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Glycogen Synthase Kinase 3 Alpha expressed in: E.coli

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPA630Mu01 10ug
EUR 179

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

4-RPA630Mu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Glycogen Synthase Kinase 3 Alpha expressed in: E.coli

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

RPA630Ra01 10ug
EUR 187

Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a)

4-RPA630Ra01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Glycogen Synthase Kinase 3 Alpha expressed in: E.coli

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), PE

4-PAA630Hu01-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with PE.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), PE

4-PAA630Mu01-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with PE.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), FITC

4-PAA630Ra01-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with FITC.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), APC

4-PAA630Hu01-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), Cy3

4-PAA630Hu01-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Cy3.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), FITC

4-PAA630Hu01-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with FITC.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), HRP

4-PAA630Hu01-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with HRP.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), APC

4-PAA630Mu01-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), Cy3

4-PAA630Mu01-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Cy3.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), FITC

4-PAA630Mu01-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with FITC.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), HRP

4-PAA630Mu01-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with HRP.

GSK3A (GFP-tagged) - Human glycogen synthase kinase 3 alpha (GSK3A)

RG208698 10 µg Ask for price

Gsk3a (untagged) - Mouse glycogen synthase kinase 3 alpha (Gsk3a), (10ug)

MC216926 10 µg Ask for price

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

20-abx167726
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

abx167726-1ml 1 ml
EUR 225

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

abx333153-100ul 100 ul
EUR 560.4

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

20-abx329708
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

abx329708-100g 100 µg Ask for price

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

abx329708-20g 20 µg
EUR 187.5

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

abx329708-50g 50 µg
EUR 250

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

abx333153-100g 100 µg Ask for price

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

abx333153-20g 20 µg
EUR 412.5

Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody

abx333153-50g 50 µg Ask for price

Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

20-abx066875
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

20-abx066876
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

abx066875-100g 100 µg
EUR 550

Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

abx066875-10g 10 µg
EUR 212.5

Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

abx066875-50g 50 µg
EUR 387.5

Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

abx066876-100g 100 µg
EUR 587.5

Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

abx066876-10g 10 µg
EUR 225

Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein

abx066876-50g 50 µg
EUR 400

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), APC-Cy7

4-PAA630Ra01-APC-Cy7
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC-Cy7.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), Biotinylated

4-PAA630Ra01-Biotin
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Biotin.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3A) CLIA Kit

abx197051-96tests 96 tests
EUR 990

Rat Glycogen Synthase Kinase 3 alpha (GSK3a) CLIA Kit

20-abx491794
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Glycogen Synthase Kinase 3 Alpha (GSK3A) CLIA Kit

abx197051-100l 100 µl Ask for price

Rat Glycogen Synthase Kinase 3 Alpha (GSK3A) CLIA Kit

abx197051-50l 50 µl
EUR 618.75

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), APC-Cy7

4-PAA630Hu01-APC-Cy7
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC-Cy7.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA630Mu01-APC-Cy7
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC-Cy7.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), Biotinylated

4-PAA630Hu01-Biotin
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Biotin.

Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), Biotinylated

4-PAA630Mu01-Biotin
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Biotin.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx256173-96tests 96 tests
EUR 801.6

Rat Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx573249-96tests 96 tests
EUR 801.6

Rat Glycogen Synthase Kinase 3 alpha (GSK3a) ELISA Kit

20-abx155612
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Dog Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx355435-96tests 96 tests
EUR 1111.2

Pig Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx360633-96tests 96 tests
EUR 990

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

DLR-GSK3a-Ra 96T
EUR 454
Description: tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

DLR-GSK3a-Ra-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

DLR-GSK3a-Ra-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

EKU04521-48T 48T
EUR 542.78

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

EKU04521-5x96T 5x96T
EUR 3683.15

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

EKU04521-96T 96T
EUR 775.4

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

EKN45632-48T 48T
EUR 370.02

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

EKN45632-5x96T 5x96T
EUR 2510.85

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

EKN45632-96T 96T
EUR 528.6

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

DL-GSK3a-Ra 96T
EUR 432
Description: tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

EK14378 96Т
EUR 768

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RDR-GSK3a-Ra-48T 48T
EUR 465.47
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RDR-GSK3a-Ra-48Tests 48 Tests
EUR 640.8

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RDR-GSK3a-Ra-96T 96T
EUR 664.97
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RDR-GSK3a-Ra-96Tests 96 Tests
EUR 890.4

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RD-GSK3a-Ra-48T 48T
EUR 443.3
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RD-GSK3a-Ra-48Tests 48 Tests
EUR 613.2

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RD-GSK3a-Ra-96T 96T
EUR 633.3
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

RD-GSK3a-Ra-96Tests 96 Tests
EUR 850.8

ELISA Kit for Glycogen Synthase Kinase 3 Alpha (GSK3a)

SEA630Hu 96Т
EUR 630

ELISA Kit for Glycogen Synthase Kinase 3 Alpha (GSK3a)

SEA630Ra 96Т
EUR 684

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

SEA630Ra-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

SEA630Ra-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

SEA630Ra-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

SEA630Ra-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) ELISA Kit

4-SEA630Ra
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Glycogen Synthase Kinase 3 alpha (GSK3a) ELISA Kit

abx155612-1mg 1 mg
EUR 675

Rat Glycogen Synthase Kinase 3 alpha (GSK3a) ELISA Kit

abx155612-5mg 5 mg
EUR 3212.5

Dog Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx355435-1096tests 10 × 96 tests Ask for price

Dog Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx355435-596tests 5 × 96 tests
EUR 743.75

Pig Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx360633-100g 100 µg Ask for price

Pig Glycogen Synthase Kinase 3 Alpha (GSK3A) ELISA Kit

abx360633-50g 50 µg
EUR 743.75

Gsk3a (GFP-tagged) - Mouse glycogen synthase kinase 3 alpha (Gsk3a), (10ug)

MG227461 10 µg Ask for price

Gsk3a (Myc-DDK-tagged) - Mouse glycogen synthase kinase 3 alpha (Gsk3a)

MR227461 10 µg Ask for price

GSK3A (Myc-DDK-tagged)-Human glycogen synthase kinase 3 alpha (GSK3A)

RC208698 10 µg Ask for price

Human Glycogen Synthase Kinase 3 Alpha (GSK3a) CLIA Kit

abx197049-96tests 96 tests
EUR 990

Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) CLIA Kit

abx197050-96tests 96 tests
EUR 990

Human Glycogen Synthase Kinase 3 alpha (GSK3a) CLIA Kit

20-abx491793
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Glycogen Synthase Kinase 3 Alpha (GSK3a) CLIA Kit

abx197049-100l 100 µl Ask for price
Constantly, long run therapy with glucosyl-ceramide synthase inhibitor PDMP was in a position to largely restore glycogen synthesis, glucose uptake and Glut-Four translocation upon Ins stimulation in HepG2 uncovered to PFOA. Our knowledge help a novel pathogenic mechanism linking publicity to PFOA to derangement of hepatocyte cell metabolism.

Leave a Reply

Your email address will not be published. Required fields are marked *