Ae1 Ae3 Antibody Bafilomycin A1 Bile Acid Assay Bioassay Blog cDNA Choline Acetyltransferase Antibody Ldn 193189 Mouse Albumin Elisa Pamabrom 100Mg Pepstatin A Tubastatin A Uric Acid Assay Valproic Acid Sodium Salt Western Blot
Antiviral Effectivity of Favipiravir Against Peste Des Petits Ruminants Virus Is Mediated by the JAK/STAT and PI3K/AKT Pathways
Peste des petits ruminants virus (PPRV), belonging to the genus Morbillivirus within the household Paramyxoviridae, causes extreme infectious illness in small ruminants and has been quickly spreading in lots of elements of Africa, the Center East, and Asia.
Though vaccination is taken into account to be an efficient technique of controlling PPR, the heat-sensitive nature of the vaccines towards PPRV enormously limits their utility in areas with a sizzling local weather. Within the current research, we investigated the anti-PPRV results of favipiravir and sought to determine the underlying mechanisms in vitro utilizing the Vero cell line.
MTT assays, Western blotting, oblique immunofluorescence assays, virus plaque formation assays, and qRT-PCR had been used to evaluate the consequences of favipiravir on the life cycle of PPRV and the expression of RNA-dependent RNA polymerase (RdRp). Moreover, the expression ranges of JAK1, STAT1, phosphorylated (p)-STAT1, PI3K, AKT, and p-AKT, in addition to these of signaling molecules appearing downstream of the JAK/STAT and PI3K/AKT signaling pathways, had been decided by Western blotting and qRT-PCR.
The outcomes indicated that, in PPRV-infected, favipiravir-treated Vero cells, the attachment, invasion, replication, and launch of PPRV had been considerably inhibited, as was the expression of RdRp, in comparison with that in untreated PPRV-infected cells.
Moreover, in favipiravir-treated cells, the expression of JAK1 and STAT1 was downregulated, whereas that of p-STAT1 was considerably upregulated. Equally, the expression ranges of PKR, IRF9, ISG54, and MxA proteins which are related to innate antiviral exercise in host cells had been additionally markedly elevated. Furthermore, with favipiravir therapy, the expression of PI3K and p-AKT and the p-AKT/AKT ratio had been considerably decreased, whereas the expression of AKT was noticeably upregulated.
The expression of GSK3, NF-κB p65, p-NF-κB p65, and BAD was additionally elevated with favipiravir therapy, whereas the expression of CREB, p-CREB, p-GSK3, and Bcl-2 was barely decreased. As well as, all of the p-GSK3/GSK3, p-CREB/CREB, p-NF-κB/NF-κB, and p-BAD/BAD ratios had been considerably decreased in favipiravir-treated cells.
These outcomes implied that the antiviral effectivity of favipiravir towards PPRV is mediated by the JAK/STAT and PI3K/AKT pathways and that favipiravir has potential to be used as an efficient antiviral agent towards PPRV.
Glycogen synthase kinase-3β inactivation promotes cervical most cancers development, invasion, and drug resistance
Human papillomavirus (HPV) infection-dependent cervical most cancers is without doubt one of the most typical gynecological cancers and infrequently turns into aggressive, with fast proliferation, invasion/migration, and drug resistance.
Right here, 135 recent human CSCC tissue specimens, comprising: 21 adjoining normals (AN), 30 cervical-intraepithelial-neoplasia (CIN1-3 ), 45 CSCC, and 39 medicine (chemo-radiation)-resistant cervical tumor (DRCT) tissues had been included.
HPV-positive (HeLa, SiHa), HPV-negative (C33A), and cisplatin-resistant (CisR-HeLa/-SiHa/-C33A) cell strains had been used for in vitro research. HPV16/18 oncoproteins E6/E7, pERK1/2, and glycogen synthase kinase-3 (GSK3) and the matrix metalloproteinases (MMPs) MMP-9/-2 had been assessed utilizing immunohistochemistry, WB, and gelatin zymography.
HPV16/18 an infection was noticed in 16.7% of the CIN1-3 , 77.8% of the CSCC, and 89.7% of DRCT samples. Whole and inactive GSK3β expressions had been related to total CSCC development (p = 0.039 and p = 0.024, respectively) and chemoresistance (p = 0.004 and p = 0.014, respectively).
Constructive correlations had been noticed, between the expression of E6 and pGSK3β expression (p = 0.013); E6 and CSCC development (p<0.0001)/ drug resistance (p = 0.0001). CisR-HeLa/-SiHa was extra depending on pGSK3β, and activation of GSK3 by SMIs (iAkt), therapy with nimbolide, or knockdown of E6/E7 decreased cisplatin-resistance and promoted apoptosis. Therefore, the activation of GSK3β with nimbolide and iAkt may be exploited for therapeutic interventions of cervical most cancers. This text is protected by copyright. All rights reserved.
G protein-coupled receptor kinase 2 is crucial to allow vasoconstrictor-mediated arterial clean muscle proliferation
Hypertension is related to elevated manufacturing and circulation of vasoconstrictors, leading to enhanced signalling by their cognate G protein-coupled receptors (GPCR). Extended vasoconstrictor GPCR signalling will increase arterial contraction and stimulates signalling pathways that promote vascular clean muscle cell (VSMC) proliferation, contributing to the event of atherosclerotic plaques, re-stenosis lesions and vascular remodelling.
GPCR signalling by phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) promotes VSMC proliferation. In VSMC, G protein-coupled receptor kinase 2 (GRK2) is thought to manage quite a few vasoconstrictor GPCRs and their downstream signalling pathways.
As GRK2 is implicated in controlling numerous elements of mobile development, we examined whether or not GRK2 might have an effect on VSMC proliferation. Utilizing two indices of cell development, we present that PI3K inhibition and depletion of GRK2 expression produced the same ablation of pro-proliferative vasoconstrictor-stimulated VSMC development.
Moreover, GRK2-knockdown ablated the sustained part of endothelin-1 and angiotensin-II-stimulated Akt phosphorylation, while the height (5 min) part was unaffected. Conversely, the GRK2 inhibitor compound 101 didn’t have an effect on vasoconstrictor-driven Akt phosphorylation.
Vasoconstrictor-stimulated phosphorylation of the Akt substrates GSK3α and GSK3β was ablated following RNAi-mediated GRK2 depletion, or after PI3K inhibition. Furthermore, GRK2 knockdown prevented endothelin-1 and angiotensin-II from rising cyclin D1 expression.
These knowledge counsel GRK2 expression is crucial to facilitate vasoconstrictor-driven VSMC proliferation by its potential to advertise environment friendly extended PI3K-Akt signalling, and thus relieve the GSK3-mediated block on cell biking. Contemplating VSMC GRK2 expression will increase early within the improvement of hypertension, this highlights the potential for GRK2 to advertise VSMC development and exacerbate hypertensive pathophysiological vascular remodelling.
Publicity to Perfluoro-Octanoic Acid Related With Upstream Uncoupling of the Insulin Signaling in Human Hepatocyte Cell Line
Perfluoro-alkyl substances (PFAS) are chemical pollution with prevalent stability and environmental persistence. Publicity to PFAS, notably perfluoro-octanoic acid (PFOA), has been related to elevated diabetes-related cardiovascular mortality in topics residing areas of excessive environmental contamination, nevertheless the precise pathogenic mechanism stays elusive.
Right here we used HepG2 cells, an in vitro mannequin of human hepatocyte, to research the potential position of PFOA publicity within the alteration of hepatic glucose metabolism. HepG2 cells had been uncovered for 24 hours to PFOA at rising focus from Zero to 1000 ng/mL after which stimulated with 100 nm Insulin (Ins).
The ensuing impact on glycogen synthesis, glucose uptake and Glut-Four glucose transporter translocation was then evaluated by, respectively, Periodic Acid Schiff (PAS) staining, 2-deoxyglucose (2-DG) uptake assay and immunofluorescence.
Publicity to PFOA was related to decreased glycogen synthesis and glucose uptake, at focus equal or higher than, respectively, 0,1 ng/mL and 10 ng/mL, with parallel impaired membrane translocation of Glut-Four upon Ins stimulation. Western blot evaluation confirmed early uncoupling of Insulin Receptor (InsR) activation from the downstream Akt and GSK3 phosphorylation.
Computational docking evaluation disclosed the potential stabilizing impact of PFOA on the advanced between InsR and GM3 ganglioside, beforehand proven to be related to the low grade persistent inflammation-related insulin resistance.
 Antibody) Glycogen Synthase Kinase 3 Alpha (Gsk3a) Antibody |
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| abx028353-400ul | Abbexa | 400 ul | EUR 627.6 |
 Antibody) Glycogen Synthase Kinase 3 Alpha (Gsk3a) Antibody |
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 Antibody) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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 Antibody) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| 20-abx000794 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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 Antibody) Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx130116-100l | Abbexa | 100 µl | EUR 262.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| 20-abx130116 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx130116-1ml | Abbexa | 1 ml | EUR 725 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx130116-200l | Abbexa | 200 µl | EUR 337.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| 20-abx103421 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx103421-20g | Abbexa | 20 µg | EUR 250 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| 20-abx103422 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx103422-20g | Abbexa | 20 µg | EUR 262.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx103422-50g | Abbexa | 50 µg | EUR 325 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx112807-100l | Abbexa | 100 µl | EUR 612.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| 20-abx112807 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx329707-100g | Abbexa | 100 µg | Ask for price |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| 20-abx329707 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx329707-20g | Abbexa | 20 µg | EUR 187.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx329707-50g | Abbexa | 50 µg | EUR 250 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx331993-100ul | Abbexa | 100 ul | EUR 510 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx332236-100ul | Abbexa | 100 ul | EUR 510 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| 20-abx172633 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx172633-1ml | Abbexa | 1 ml | EUR 712.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| 20-abx172634 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody |
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| abx172634-1ml | Abbexa | 1 ml | EUR 775 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx318830-100l | Abbexa | 100 µl | EUR 250 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| 20-abx318830 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx318830-50l | Abbexa | 50 µl | EUR 162.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx233672-100g | Abbexa | 100 µg | EUR 350 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx233672-100ug | Abbexa | 100 ug | EUR 577.2 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx210327-100l | Abbexa | 100 µl | EUR 350 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| 20-abx210327 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx210327-50l | Abbexa | 50 µl | EUR 250 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx210328-100l | Abbexa | 100 µl | EUR 350 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| 20-abx210328 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody |
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| abx210328-50l | Abbexa | 50 µl | EUR 250 |
 Antibody (HRP)) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP) |
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| abx316098-100g | Abbexa | 100 µg | EUR 362.5 |
 Antibody (HRP)) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP) |
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| 20-abx316098 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP) |
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| abx316098-20g | Abbexa | 20 µg | EUR 162.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (HRP) |
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| abx316098-50g | Abbexa | 50 µg | EUR 250 |
 Antibody (FITC)) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC) |
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| abx316099-100g | Abbexa | 100 µg | EUR 362.5 |
 Antibody (FITC)) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC) |
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| 20-abx316099 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC) |
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| abx316099-20g | Abbexa | 20 µg | EUR 162.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (FITC) |
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| abx316099-50g | Abbexa | 50 µg | EUR 250 |
 Antibody (Biotin)) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin) |
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| abx316100-100g | Abbexa | 100 µg | EUR 362.5 |
 Antibody (Biotin)) Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin) |
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| 20-abx316100 | Abbexa |
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Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin) |
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| abx316100-20g | Abbexa | 20 µg | EUR 162.5 |
Glycogen Synthase Kinase 3 Alpha (GSK3A) Antibody (Biotin) |
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| abx316100-50g | Abbexa | 50 µg | EUR 250 |
 Polyclonal Antibody) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody |
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| CAU27488-100ul | Biomatik Corporation | 100ul | EUR 229.4 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody |
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| CAU27488-200ul | Biomatik Corporation | 200ul | EUR 287.3 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody |
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| CAU27489-100ul | Biomatik Corporation | 100ul | EUR 217.9 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody |
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| CAU27489-200ul | Biomatik Corporation | 200ul | EUR 272.2 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody |
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| CAU27490-100ul | Biomatik Corporation | 100ul | EUR 212.2 |
Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody |
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| CAU27490-200ul | Biomatik Corporation | 200ul | EUR 265.4 |
) Glycogen Synthase Kinase 3 alpha (GSK3a) |
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| MBS6507594-01mL | MyBiosource | 0.1mL | EUR 660 |
Glycogen Synthase Kinase 3 alpha (GSK3a) |
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| MBS6507594-5x01mL | MyBiosource | 5x0.1mL | EUR 2810 |
) Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2013023-01mL | MyBiosource | 0.1mL | EUR 165 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2013023-02mL | MyBiosource | 0.2mL | EUR 200 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2013023-05mL | MyBiosource | 0.5mL | EUR 325 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2013023-1mL | MyBiosource | 1mL | EUR 395 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2013023-5mL | MyBiosource | 5mL | EUR 1075 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2028644-01mL | MyBiosource | 0.1mL | EUR 170 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2028644-02mL | MyBiosource | 0.2mL | EUR 215 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2028644-05mL | MyBiosource | 0.5mL | EUR 350 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2028644-1mL | MyBiosource | 1mL | EUR 425 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2028644-5mL | MyBiosource | 5mL | EUR 1160 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2016814-01mL | MyBiosource | 0.1mL | EUR 170 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2016814-02mL | MyBiosource | 0.2mL | EUR 205 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2016814-05mL | MyBiosource | 0.5mL | EUR 330 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2016814-1mL | MyBiosource | 1mL | EUR 405 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2016814-5mL | MyBiosource | 5mL | EUR 1100 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| PAA630Hu01 | Cloud-Clone | 100ul | EUR 221 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| PAA630Mu01 | Cloud-Clone | 100ul | EUR 227 |
Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| PAA630Ra01 | Cloud-Clone | 100ul | EUR 239 |
 Polyclonal Antibody (Rat)) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat) |
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| 4-PAA630Ra01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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 Polyclonal Antibody (Human)) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human) |
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| 4-PAA630Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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 Polyclonal Antibody (Mouse)) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse) |
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| 4-PAA630Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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-Human glycogen synthase kinase 3 alpha (GSK3A)) GSK3A (untagged)-Human glycogen synthase kinase 3 alpha (GSK3A) |
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| SC112599 | Origene Technologies GmbH | 10 µg | Ask for price |
 Polyclonal Antibody (Rat), PE) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), PE |
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| 4-PAA630Ra01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with PE. |
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) Glycogen Synthase Kinase 3 alpha, pan (GSK3a) |
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| MBS613396-01mg | MyBiosource | 0.1mg | EUR 970 |
Glycogen Synthase Kinase 3 alpha, pan (GSK3a) |
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| MBS613396-5x01mg | MyBiosource | 5x0.1mg | EUR 4210 |
 Polyclonal Antibody (Rat), APC) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), APC |
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| 4-PAA630Ra01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC. |
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 Polyclonal Antibody (Rat), Cy3) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), Cy3 |
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| 4-PAA630Ra01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Cy3. |
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 Polyclonal Antibody (Rat), HRP) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), HRP |
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| 4-PAA630Ra01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with HRP. |
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 Polyclonal Antibody (Human), PE) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), PE |
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| 4-PAA630Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with PE. |
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 Polyclonal Antibody (Mouse), PE) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), PE |
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| 4-PAA630Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with PE. |
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 Polyclonal Antibody (Rat), FITC) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), FITC |
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| 4-PAA630Ra01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with FITC. |
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 Polyclonal Antibody (Human), APC) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), APC |
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| 4-PAA630Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC. |
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 Polyclonal Antibody (Human), Cy3) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), Cy3 |
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| 4-PAA630Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Cy3. |
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 Polyclonal Antibody (Human), FITC) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), FITC |
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| 4-PAA630Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with FITC. |
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 Polyclonal Antibody (Human), HRP) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), HRP |
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| 4-PAA630Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with HRP. |
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 Polyclonal Antibody (Mouse), APC) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), APC |
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| 4-PAA630Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC. |
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 Polyclonal Antibody (Mouse), Cy3) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), Cy3 |
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| 4-PAA630Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Cy3. |
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 Polyclonal Antibody (Mouse), FITC) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), FITC |
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| 4-PAA630Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with FITC. |
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 Polyclonal Antibody (Mouse), HRP) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), HRP |
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| 4-PAA630Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with HRP. |
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) Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2028945-001mg | MyBiosource | 0.01mg | EUR 175 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
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| MBS2028945-005mg | MyBiosource | 0.05mg | EUR 320 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2028945-01mg | MyBiosource | 0.1mg | EUR 490 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2028945-02mg | MyBiosource | 0.2mg | EUR 595 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2028945-05mg | MyBiosource | 0.5mg | EUR 1130 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018243-001mg | MyBiosource | 0.01mg | EUR 165 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018243-005mg | MyBiosource | 0.05mg | EUR 295 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018243-01mg | MyBiosource | 0.1mg | EUR 440 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018243-02mg | MyBiosource | 0.2mg | EUR 535 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018243-05mg | MyBiosource | 0.5mg | EUR 1020 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018527-001mg | MyBiosource | 0.01mg | EUR 170 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018527-005mg | MyBiosource | 0.05mg | EUR 305 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018527-01mg | MyBiosource | 0.1mg | EUR 470 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018527-02mg | MyBiosource | 0.2mg | EUR 570 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2018527-05mg | MyBiosource | 0.5mg | EUR 1085 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU54048-100ug | Biomatik Corporation | 100ug | EUR 576.4 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU54048-1mg | Biomatik Corporation | 1mg | EUR 2555.8 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU54048-50ug | Biomatik Corporation | 50ug | EUR 463.1 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU41701-100ug | Biomatik Corporation | 100ug | EUR 514.8 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU41701-1mg | Biomatik Corporation | 1mg | EUR 2282.8 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU41701-50ug | Biomatik Corporation | 50ug | EUR 413.6 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU41702-100ug | Biomatik Corporation | 100ug | EUR 552.2 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU41702-1mg | Biomatik Corporation | 1mg | EUR 2446.6 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPU41702-50ug | Biomatik Corporation | 50ug | EUR 443.3 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPA630Hu01 | Cloud-Clone | 10ug | EUR 167 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| 4-RPA630Hu01 | Cloud-Clone |
|
|
|
Description: Recombinant Human Glycogen Synthase Kinase 3 Alpha expressed in: E.coli |
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Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPA630Mu01 | Cloud-Clone | 10ug | EUR 179 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| 4-RPA630Mu01 | Cloud-Clone |
|
|
|
Description: Recombinant Mouse Glycogen Synthase Kinase 3 Alpha expressed in: E.coli |
|||
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| RPA630Ra01 | Cloud-Clone | 10ug | EUR 187 |
Recombinant Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| 4-RPA630Ra01 | Cloud-Clone |
|
|
|
Description: Recombinant Rat Glycogen Synthase Kinase 3 Alpha expressed in: E.coli |
|||
 - Human glycogen synthase kinase 3 alpha (GSK3A)) GSK3A (GFP-tagged) - Human glycogen synthase kinase 3 alpha (GSK3A) |
|||
| RG208698 | Origene Technologies GmbH | 10 µg | Ask for price |
 - Mouse glycogen synthase kinase 3 alpha (Gsk3a), (10ug)) Gsk3a (untagged) - Mouse glycogen synthase kinase 3 alpha (Gsk3a), (10ug) |
|||
| MC216926 | Origene Technologies GmbH | 10 µg | Ask for price |
 Antibody) Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| abx329708-100g | Abbexa | 100 µg | Ask for price |
Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| 20-abx329708 | Abbexa |
|
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Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| abx329708-20g | Abbexa | 20 µg | EUR 187.5 |
Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| abx329708-50g | Abbexa | 50 µg | EUR 250 |
Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| abx333153-100g | Abbexa | 100 µg | Ask for price |
Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| abx333153-100ul | Abbexa | 100 ul | EUR 560.4 |
Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| abx333153-20g | Abbexa | 20 µg | EUR 412.5 |
Glycogen Synthase Kinase 3 Alpha Phospho-Ser21 (GSK3A pS21) Antibody |
|||
| abx333153-50g | Abbexa | 50 µg | Ask for price |
 Antibody Pair Kit (with Standard)) Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099221-10x96Tests | MyBiosource | 10x96Tests | EUR 1445 |
Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099221-10x96TestsMBS2090685AbPairsSupportPack110x96Tests | MyBiosource | 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests) | EUR 1570 |
Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099221-5x96Tests | MyBiosource | 5x96Tests | EUR 915 |
Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099221-5x96TestsMBS2090685AbPairsSupportPack15x96Tests | MyBiosource | 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests) | EUR 990 |
 Antibody Pair Kit (with Standard)) Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099219-10x96Tests | MyBiosource | 10x96Tests | EUR 1340 |
Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099219-10x96TestsMBS2090685AbPairsSupportPack110x96Tests | MyBiosource | 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests) | EUR 1465 |
Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099219-5x96Tests | MyBiosource | 5x96Tests | EUR 855 |
Human Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099219-5x96TestsMBS2090685AbPairsSupportPack15x96Tests | MyBiosource | 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests) | EUR 925 |
 Antibody Pair Kit (with Standard)) Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099220-10x96Tests | MyBiosource | 10x96Tests | EUR 1515 |
Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099220-10x96TestsMBS2090685AbPairsSupportPack110x96Tests | MyBiosource | 10x96Tests+MBS2090685(AbPairsSupportPack1,10x96Tests) | EUR 1640 |
Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099220-5x96Tests | MyBiosource | 5x96Tests | EUR 960 |
Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a) Antibody Pair Kit (with Standard) |
|||
| MBS2099220-5x96TestsMBS2090685AbPairsSupportPack15x96Tests | MyBiosource | 5x96Tests+MBS2090685(AbPairsSupportPack1,5x96Tests) | EUR 1035 |
 Polyclonal Antibody (Rat), Biotinylated) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), Biotinylated |
|||
| 4-PAA630Ra01-Biotin | Cloud-Clone |
|
|
|
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Biotin. |
|||
 Polyclonal Antibody (Rat), APC-Cy7) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Rat), APC-Cy7 |
|||
| 4-PAA630Ra01-APC-Cy7 | Cloud-Clone |
|
|
|
Description: A Rabbit polyclonal antibody against Rat Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with APC-Cy7. |
|||
) Glycogen Synthase Kinase 3 alpha, beta (GSK3a/b) |
|||
| MBS632730-10Blots | MyBiosource | 10Blots | EUR 665 |
Glycogen Synthase Kinase 3 alpha, beta (GSK3a/b) |
|||
| MBS632730-5x10Blots | MyBiosource | 5x10Blots | EUR 2830 |
Glycogen Synthase Kinase 3 alpha, beta (GSK3a/b) |
|||
| MBS609175-01mL | MyBiosource | 0.1mL | EUR 690 |
Glycogen Synthase Kinase 3 alpha, beta (GSK3a/b) |
|||
| MBS609175-5x01mL | MyBiosource | 5x0.1mL | EUR 2955 |
 Protein) Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein |
|||
| 20-abx167726 | Abbexa |
|
|
Rat Glycogen Synthase Kinase 3 Alpha (GSK3a) Protein |
|||
| abx167726-1ml | Abbexa | 1 ml | EUR 225 |
 Polyclonal Antibody (Human), Biotinylated) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Human), Biotinylated |
|||
| 4-PAA630Hu01-Biotin | Cloud-Clone |
|
|
|
Description: A Rabbit polyclonal antibody against Human Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Biotin. |
|||
 Polyclonal Antibody (Mouse), Biotinylated) Glycogen Synthase Kinase 3 Alpha (GSK3a) Polyclonal Antibody (Mouse), Biotinylated |
|||
| 4-PAA630Mu01-Biotin | Cloud-Clone |
|
|
|
Description: A Rabbit polyclonal antibody against Mouse Glycogen Synthase Kinase 3 Alpha (GSK3a). This antibody is labeled with Biotin. |
|||
) PE-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045243-01mL | MyBiosource | 0.1mL | EUR 250 |
PE-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045243-02mL | MyBiosource | 0.2mL | EUR 325 |
PE-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045243-05mL | MyBiosource | 0.5mL | EUR 600 |
PE-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045243-1mL | MyBiosource | 1mL | EUR 735 |
PE-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045243-5mL | MyBiosource | 5mL | EUR 2105 |
) APC-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045244-01mL | MyBiosource | 0.1mL | EUR 250 |
APC-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045244-02mL | MyBiosource | 0.2mL | EUR 325 |
APC-Linked Polyclonal Antibody to Glycogen Synthase Kinase 3 Alpha (GSK3a) |
|||
| MBS2045244-05mL | MyBiosource | 0.5mL | EUR 600 |
Constantly, long run therapy with glucosyl-ceramide synthase inhibitor PDMP was in a position to largely restore glycogen synthesis, glucose uptake and Glut-Four translocation upon Ins stimulation in HepG2 uncovered to PFOA. Our knowledge help a novel pathogenic mechanism linking publicity to PFOA to derangement of hepatocyte cell metabolism.
