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Tandem Ubiquitin Binding Entities (TUBEs) as Tools to Explore Ubiquitin-Proteasome System and PROTAC Drug Discovery
The ubiquitin proteasome system (UPS) is a fancy pathway that entails a number of enzymes and culminates within the formation of a polyubiquitin chain on a goal protein. As its significance is turning into extra evident in drug discovery, there’s a renewed curiosity in understanding the function that polyubiquitin chains play.
This has been a problem, largely because of the lack of experimental instruments for detecting the polyubiquitinated types of a protein of curiosity (POI). Tandem Ubiquitin Binding Entities (TUBEs) are engineered protein domains that bind particularly to polyubiquitin chains. These polyubiquitin affinity matrices are extremely delicate as they bind to polyubiquitin chains within the nanomolar vary.
They exist in two kinds: pan-selective TUBEs and chain-selective TUBEs. The flexibility of TUBEs to be conjugated to totally different entities is really what makes them distinctive. TUBEs are utilized in all kinds of experiments comparable to in protein pulldowns to complement for polyubiquitinated proteins. They’re an alternative choice to ubiquitin antibodies in Western blots.
Additional, TUBEs are used as seize reagents for immobilizing polyubiquitinated proteins on a microtiter plate. Using TUBEs as parts of in vitro and cell-based assays presents the distinctive function of confirming and assessing the polyubiquitination of a POI in response to inhibitors, activators, or PROTAC® molecules. Subsequently, TUBEs not solely play a giant function in finding out the usbut even have an enormous potential for rushing up the drug discovery course of.
A Novel Luminescence-Primarily based Excessive-Throughput Method for Mobile Decision of Protein Ubiquitination Utilizing Tandem Ubiquitin Binding Entities (TUBEs).
Protein turnover is extremely regulated by the posttranslational strategy of ubiquitination. Deregulation of the ubiquitin proteasome system (UPS) has been implicated in most cancers and neurodegenerative illnesses, and modulating this method has confirmed to be a viable strategy for therapeutic intervention. The event of novel applied sciences that allow high-throughput research of substrate protein ubiquitination is essential for UPS drug discovery.
Typical approaches for finding out ubiquitination both have excessive protein necessities or depend on exogenous or modified ubiquitin moieties, thus limiting their utility. As a way to circumvent these points, we developed a high-throughput live-cell assay that mixes the NanoBiT luminescence-based expertise with tandem ubiquitin binding entities (TUBEs) to resolve substrate ubiquitination.
To reveal the effectiveness and utility of this assay, we studied compound-induced ubiquitination of the G to S Part Transition 1 (GSPT1) protein. Utilizing this assay, we characterised compounds with various ranges of GSPT1 ubiquitination exercise.
This methodology gives a live-cell-based strategy for assaying substrate ubiquitination that may be tailored to review the kinetics of ubiquitin switch onto a substrate protein of curiosity. As well as, our outcomes present that this strategy is transportable for finding out the ubiquitination of goal proteins with various features.
New insights into host-parasite ubiquitin proteome dynamics in P. falciparum contaminated purple blood cells utilizing a TUBEs-MS strategy.
Malaria, attributable to Plasmodium falciparum (P. falciparum), ranks as some of the baleful infectious illnesses worldwide. New antimalarial therapies are wanted to face present or rising drug resistant strains. Protein degradation seems to play a big function through the asexual intraerythrocytic developmental cycle (IDC) of P. falciparum.
Inhibition of the ubiquitin proteasome system (UPS), a serious intracellular proteolytic pathway, successfully reduces an infection and parasite replication. P. falciparum and erythrocyte UPS coexist throughout IDC however the nature of their relationship is essentially unknown. We used an strategy primarily based on Tandem Ubiquitin-Binding Entities (TUBEs) and 1D gel electrophoresis adopted by mass spectrometry to determine main parts of the TUBEs-associated ubiquitin proteome of each host and parasite throughout ring, trophozoite and schizont levels.
Ring-exported protein (REX1), a P. falciparum protein situated in Maurer’s clefts and vital for parasite nutrient import, was discovered to succeed in a most stage of ubiquitylation in trophozoites stage. The Homo sapiens (H. sapiens) TUBEs related ubiquitin proteome decreased through the an infection, whereas the equal P. falciparum TUBEs-associated ubiquitin proteome counterpart elevated. Main mobile processes comparable to DNA restore, replication, stress response, vesicular transport and catabolic occasions look like regulated by ubiquitylation alongside the IDC P. falciparum an infection.
The Hectd1 ubiquitin ligase is required for growth of the top mesenchyme and neural tube closure.
Closure of the cranial neural tube is determined by regular growth of the top mesenchyme. Homozygous-mutant embryos for the ENU-induced open thoughts (opm) mutation exhibit exencephaly related to defects in head mesenchyme growth and dorsal-lateral hinge level formation. The top mesenchyme in opm mutant embryos is denser than in wildtype embryos and shows an irregular mobile group.
Since cells that originate from each the cephalic paraxial mesoderm and the neural crest populate the top mesenchyme, we explored the origin of the irregular head mesenchyme. opm mutant embryos present apparently regular growth of neural crest-derived constructions. Moreover, the irregular head mesenchyme in opm mutant embryos will not be derived from the neural crest, however as an alternative expresses molecular markers of cephalic mesoderm.
We additionally report the identification of the opm mutation within the ubiquitously expressed Hectd1 E3 ubiquitin ligase. Two totally different Hectd1 alleles trigger incompletely penetrant neural tube defects in heterozygous animals, indicating that Hectd1 perform is required at a important threshold for neural tube closure. This low penetrance of neural tube defects in embryos heterozygous for Hectd1 mutations means that Hectd1 needs to be thought-about as candidate susceptibility gene in human neural tube defects.
A quick stream tube examine of fuel section H/D trade of multiply protonated ubiquitin.
An electrospray ionization (ESI)/fast-flow method has been utilized to the examine of fuel section hydrogen/deuterium (H/D) trade kinetics. Multiply charged ubiquitin ions [ubiquitin + nH](n)(+), in cost states n = 7-13, have been reacted with ND(3). The conduct of ND(3) as trade reagent is totally different from that of the beforehand studied reagents, D(2)O and CH(3)OD.
Opposite to these, the utmost variety of exchanged hydrogen atoms and the general trade fee have been noticed to extend with rising cost state of the ubiquitin ions. The outcomes are reagent-dependent as a result of the trade mechanisms are totally different for the totally different reagents. This remark is in settlement with a current conclusion by Beauchamp and colleagues that opposite to the idea usually expressed in earlier research, H/D trade kinetics could indirectly replicate ion constructions.
The outcomes for all three reagents are, nonetheless, according to observations of earlier ion mobility experiments that with rising cost state the conformers change from extra compact, partially folded constructions to elongated practically linear ones. H/D trade of (ubiquitin + 13H)(13+) with ND(3) results in two separated ion populations reflecting the potential existence of two conformers with totally different trade charges. The ions (ubiquitin + 8H)(8+) and (ubiquitin + 11H)(11+) signify {a partially} folded construction and an unfolded construction, respectively, and have been studied in better element.
The relative abundances of ions have been measured in steps of 0.5 m/z (mass-to-charge ratio), as a perform of the ND(3) stream fee. The experimental outcomes have been simulated by laptop fitted curves primarily based on a not too long ago developed algorithm. The algorithm permits the extraction of units of grouped fee constants. Eight fee fixed teams have been deduced for every of the 2 ions.
Tube Rack |
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| BV1010-1520 | Benchmark Scientific | 1 PC | EUR 113.5 |
Tube Rack |
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| BV1010-25 | Benchmark Scientific | 1 PC | EUR 214.76 |
Tube Rack |
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| BV1010-500 | Benchmark Scientific | 1 PC | EUR 113.5 |
Drain tube |
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| 2393092 | Atto | 8unit | EUR 330 |
Tube holder |
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| R2020-0507 | Benchmark Scientific | 1 PC | EUR 132.55 |
Tube holder |
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| R2020-150 | Benchmark Scientific | 1 PC | EUR 122.03 |
Tube holder |
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| R2020-1520 | Benchmark Scientific | 1 PC | EUR 132.55 |
Tube holder |
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| R2020-500 | Benchmark Scientific | 1 PC | EUR 142.12 |
Tube holder |
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| R2020-PCR | Benchmark Scientific | 1 PC | EUR 161.26 |
Absorption Tube |
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| QAD3 | Scientific Laboratory Supplies | EACH | EUR 194.53 |
Filter Tube |
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| TUB2812 | Scientific Laboratory Supplies | PK10 | EUR 49.82 |
ubiquitin (Ubiquitin) Antibody |
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| abx022608-02ml | Abbexa | 0.2 ml | EUR 610.8 |
ubiquitin (Ubiquitin) Antibody |
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| 20-abx013245 | Abbexa |
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ubiquitin (ubiquitin) Antibody |
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| abx037750-100ug | Abbexa | 100 ug | EUR 469.2 |
ubiquitin (Ubiquitin) Antibody |
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| 20-abx444887 | Abbexa |
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ubiquitin (Ubiquitin) Antibody |
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| 20-abx444896 | Abbexa |
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ubiquitin (Ubiquitin) Antibody |
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| abx444934-100ug | Abbexa | 100 ug | EUR 427.2 |
ubiquitin (Ubiquitin) Antibody |
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| 20-abx445164 | Abbexa |
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ubiquitin (ubiquitin) Antibody |
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| abx239197-100ug | Abbexa | 100 ug | EUR 610.8 |
mini capillary tubes 1 mm pk/100 |
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| EVS1100-TUBE-1.0 | Consort | ea | EUR 78 |
mini capillary tubes 1.5 mm pk/100 |
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| EVS1100-TUBE-1.5 | Consort | ea | EUR 78 |
maxi capillary tubes 1 mm pk/100 |
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| EVS1300-TUBE-1.0 | Consort | ea | EUR 178.8 |
FlexiFuge Tube Rotor for .2mL PCR Tube Strips |
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| ARG1122 | Scientific Laboratory Supplies | EACH | EUR 159.6 |
ubiquitin (Ubiquitin) Antibody (Biotin) |
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| abx442853-200ug | Abbexa | 200 ug | EUR 744 |
ubiquitin (Ubiquitin) Antibody (Biotin) |
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| abx442862-200ug | Abbexa | 200 ug | EUR 744 |
ubiquitin (Ubiquitin) Antibody (FITC) |
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| abx443133-200ug | Abbexa | 200 ug | EUR 744 |
ubiquitin (Ubiquitin) Antibody (FITC) |
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| abx443142-200ug | Abbexa | 200 ug | EUR 744 |
ubiquitin (Ubiquitin) Antibody (HRP) |
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| abx443413-200ug | Abbexa | 200 ug | EUR 727.2 |
ubiquitin (Ubiquitin) Antibody (HRP) |
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| abx443422-200ug | Abbexa | 200 ug | EUR 727.2 |
ubiquitin (Ubiquitin) Antibody (PerCP) |
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| abx443975-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (PerCP) |
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| abx443984-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (RPE) |
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| abx444256-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (RPE) |
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| abx444265-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (Streptavidin) |
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| abx444537-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (Streptavidin) |
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| abx444546-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ALP) |
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| abx444810-100ug | Abbexa | 100 ug | EUR 477.6 |
ubiquitin (Ubiquitin) Antibody (APC) |
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| abx444814-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (Biotin) |
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| abx444818-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (FITC) |
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| abx444822-100ug | Abbexa | 100 ug | EUR 477.6 |
ubiquitin (Ubiquitin) Antibody (HRP) |
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| abx444826-100ug | Abbexa | 100 ug | EUR 477.6 |
ubiquitin (Ubiquitin) Antibody (PerCP) |
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| abx444834-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (RPE) |
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| abx444838-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (Streptavidin) |
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| abx444842-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ALP) |
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| abx447954-200ul | Abbexa | 200 ul | EUR 744 |
ubiquitin (Ubiquitin) Antibody (APC) |
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| abx447955-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (Biotin) |
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| abx447956-200ul | Abbexa | 200 ul | EUR 744 |
ubiquitin (Ubiquitin) Antibody (FITC) |
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| abx447957-200ul | Abbexa | 200 ul | EUR 744 |
ubiquitin (Ubiquitin) Antibody (HRP) |
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| abx447958-200ul | Abbexa | 200 ul | EUR 727.2 |
ubiquitin (Ubiquitin) Antibody (PerCP) |
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| abx447960-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (RPE) |
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| abx447961-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (Streptavidin) |
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| abx447962-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ALP) |
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| abx442291-200ug | Abbexa | 200 ug | EUR 744 |
ubiquitin (Ubiquitin) Antibody (ALP) |
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| abx442300-200ug | Abbexa | 200 ug | EUR 744 |
ubiquitin (Ubiquitin) Antibody (APC) |
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| abx442572-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (APC) |
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| abx442581-200ug | Abbexa | 200 ug | EUR 760.8 |
Sterile Centrifuge Tube |
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| C1005-T5-ST | Benchmark Scientific | 1 PC | EUR 99.76 |
5ml Tube holder |
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| D2400-R5 | Benchmark Scientific | 1 PC | EUR 891.28 |
Digital Tube Roller |
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| abx725018-1Unitwith10Rollers | Abbexa | 1 Unit with 10 Rollers | EUR 978 |
Digital Tube Roller |
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| abx725018-1Unitwith4Rollers | Abbexa | 1 Unit with 4 Rollers | EUR 518.4 |
Digital Tube Roller |
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| abx725018-1Unitwith6Rollers | Abbexa | 1 Unit with 6 Rollers | EUR 895.2 |
Tube Tags 38x6.5mm |
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| LAB1240 | Scientific Laboratory Supplies | PK1000 | EUR 28.04 |
Lamp Fluorescent Tube |
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| LAM3218 | Scientific Laboratory Supplies | EACH | EUR 12.95 |
Tube support 1.5mL |
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| MIX1346 | Scientific Laboratory Supplies | EACH | EUR 82.08 |
Tube support 15mL |
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| MIX1348 | Scientific Laboratory Supplies | EACH | EUR 96.9 |
Tube support 50mL |
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| MIX1350 | Scientific Laboratory Supplies | EACH | EUR 96.9 |
Rubber tube replacement |
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| MIX1352 | Scientific Laboratory Supplies | EACH | EUR 53.58 |
Direct Tube Marker |
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| PCR1414 | Scientific Laboratory Supplies | EACH | EUR 6344.1 |
Paxgene Tube Kit |
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| 762165 | Scientific Laboratory Supplies | PK100 | EUR 1730.35 |
Filling Tube 190mm |
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| DEN1042 | Scientific Laboratory Supplies | EACH | EUR 40.7 |
Filling Tube 600mm |
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| DEN1044 | Scientific Laboratory Supplies | EACH | EUR 61.56 |
Eppendorf Tube Block |
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| BLO5022 | Scientific Laboratory Supplies | EACH | EUR 132.24 |
Chrom Tube Xk2620 |
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| 18100084 | Scientific Laboratory Supplies | EACH | EUR 155.04 |
Test Tube 16x100mm |
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| 3840/16X100 | Scientific Laboratory Supplies | PK100 | EUR 57.11 |
Boiling tube holder |
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| SPR4688 | Scientific Laboratory Supplies | EACH | EUR 270.18 |
Durham Tube 25x6mm |
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| TES1100 | Scientific Laboratory Supplies | PK250 | EUR 41.04 |
Durham Tube 30x6mm |
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| TES1102 | Scientific Laboratory Supplies | PK300 | EUR 27.13 |
Durham Tube 35x8mm |
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| TES1104 | Scientific Laboratory Supplies | PK250 | EUR 37.73 |
Durham Tube 50x7.5mm |
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| TES1106 | Scientific Laboratory Supplies | PK250 | EUR 47.77 |
Ubiquitin |
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| A20038 | ScyTek Laboratories | 2 ml | EUR 94.8 |
Ubiquitin |
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| A00038 | ScyTek Laboratories | 6 ml | EUR 129.6 |
Ubiquitin |
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| A00038.0025 | ScyTek Laboratories | 25 ml | EUR 261.6 |
Ubiquitin |
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| MO18001 | Neuromics | 100 ul | EUR 579.6 |
Ubiquitin |
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| MO22152 | Neuromics | 100 ul | EUR 522 |
Ubiquitin |
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| PR27083 | Neuromics | 50 ug | EUR 381.6 |
ubiquitin (Ubiquitin) Antibody (ATTO 390) |
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| abx440043-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 390) |
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| abx440052-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 390) |
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| abx444778-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 488) |
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| abx444782-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 565) |
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| abx444786-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 594) |
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| abx444790-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 633) |
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| abx444794-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 655) |
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| abx444798-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 680) |
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| abx444802-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 700) |
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| abx444806-100ug | Abbexa | 100 ug | EUR 493.2 |
ubiquitin (Ubiquitin) Antibody (ATTO 390) |
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| abx447946-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 488) |
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| abx447947-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 565) |
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| abx447948-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 594) |
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| abx447949-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 633) |
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| abx447950-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 655) |
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| abx447951-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 680) |
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| abx447952-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 700) |
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| abx447953-200ul | Abbexa | 200 ul | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 488) |
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| abx440324-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 488) |
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| abx440333-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 565) |
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| abx440605-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 565) |
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| abx440614-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 594) |
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| abx440886-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 594) |
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| abx440895-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 633) |
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| abx441167-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 633) |
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| abx441176-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 655) |
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| abx441448-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 655) |
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| abx441457-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 680) |
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| abx441729-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 680) |
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| abx441738-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 700) |
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| abx442010-200ug | Abbexa | 200 ug | EUR 760.8 |
ubiquitin (Ubiquitin) Antibody (ATTO 700) |
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| abx442019-200ug | Abbexa | 200 ug | EUR 760.8 |
Test Tube Rack Holder (for 50 Ml Test Tube Racks) |
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| 480169 | Scientific Laboratory Supplies | EACH | EUR 53.35 |
Fallopian tube disease spectrum (fallopian tube cancer progression) tissue array |
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| UTE601 | TissueArray | each | EUR 306 |
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Description: Fallopian tube disease spectrum (fallopian tube cancer progression) tissue array, including pathology grade, TNM and clinical stage, 30 cases/60 cores |
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mini tube gel insert |
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| EVS1100-TUBEINSERT | Consort | ea | EUR 493.2 |
maxi tube gel insert |
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| EVS1300-TUBEINSERT | Consort | ea | EUR 604.8 |
PIPET CONTROLLER SILICONE TUBE |
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| 357483 | CORNING | 1/pk | EUR 51.6 |
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Description: Falcon Liquid Handling Equipment; Falcon Pipet Controllers and Accessories |
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Tubulin Epsilon (TUBe) Antibody |
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| 20-abx101415 | Abbexa |
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Tubulin Epsilon (TUBe) Antibody |
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| 20-abx128096 | Abbexa |
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Tube Holder Set (Small |
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| MSS-1100 | Spherotech | mL | EUR 176.4 |
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Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
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Recombinant Tubulin Epsilon (TUBe) |
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| 4-RPE719Hu01 | Cloud-Clone |
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Description: Recombinant Human Tubulin Epsilon expressed in: E.coli |
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Recombinant Tubulin Epsilon (TUBe) |
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| 4-RPE719Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Tubulin Epsilon expressed in: E.coli |
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Microcentrifuge Tube 1.5mL (Axygen) |
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| TUBE1.5AX-S | Next Advance | 500box | EUR 255.6 |
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Description: Screw-cap tubes, 1.5 mL, Axygen brand, with caps for use in microcentrifuge style Bullet Blenders with a "W" in the serial number. Sterile, RNase & DNase free. |
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wl tube 6 w |
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| VLT6-WL | Consort | ea | EUR 87.6 |
wl tube 8 w |
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| VLT8-WL | Consort | ea | EUR 87.6 |
Tube Tags 12.5x24mm Medium |
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| LAB1230 | Scientific Laboratory Supplies | PK1000 | EUR 43.89 |
Multi-use Milling Tube |
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| MIL2212 | Scientific Laboratory Supplies | EACH | EUR 290.7 |
Trayster Tube Insert TR1 |
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| MIX1042 | Scientific Laboratory Supplies | EACH | EUR 58.14 |
Trayster Tube Insert TR2 |
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| MIX1044 | Scientific Laboratory Supplies | EACH | EUR 58.14 |
Trayster Tube Insert TR3 |
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| MIX1046 | Scientific Laboratory Supplies | EACH | EUR 58.14 |
Trayster Tube Insert TR4 |
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| MIX1048 | Scientific Laboratory Supplies | EACH | EUR 58.14 |
Digital Tube Rocker 230V |
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| MIX1138 | Scientific Laboratory Supplies | EACH | EUR 978.12 |
Multi tube digital vortex |
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| MIX1252 | Scientific Laboratory Supplies | EACH | EUR 527.82 |
Double Tier Tube Platform |
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| MIX1282 | Scientific Laboratory Supplies | EACH | EUR 94.62 |
Tube Rocker Stacking Bars |
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| MIX1286 | Scientific Laboratory Supplies | EACH | EUR 66.12 |
Horizontal 50mL Tube Holder |
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| MIX5088 | Scientific Laboratory Supplies | EACH | EUR 144.78 |
Small Ampoule Tube Head |
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| MIX5100 | Scientific Laboratory Supplies | EACH | EUR 249.66 |
Genie Tube Inserts Assorted |
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| MIX5120 | Scientific Laboratory Supplies | PK4 | EUR 87.78 |
BenchMixer XL Multi-Tube |
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| MIX7240 | Scientific Laboratory Supplies | EACH | EUR 3690.18 |
Techne Tube Small FHB32 |
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| OVE3010 | Scientific Laboratory Supplies | EACH | EUR 160.74 |
Techne Tube Large FHB11 |
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| OVE3011 | Scientific Laboratory Supplies | EACH | EUR 175.56 |
Techne Tube Large FHB12 |
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| OVE3012 | Scientific Laboratory Supplies | EACH | EUR 206.34 |
Techne 15ml Tube Holder |
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| OVE3019 | Scientific Laboratory Supplies | EACH | EUR 394.44 |
Techne 50ml Tube Holder |
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| OVE3021 | Scientific Laboratory Supplies | EACH | EUR 291.84 |
Techne Tube Large FHB16 |
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| OVE3022 | Scientific Laboratory Supplies | EACH | EUR 206.34 |
Techne Tube Small FHB36 |
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| OVE3024 | Scientific Laboratory Supplies | EACH | EUR 157.32 |
Techne Tube Mini FHB41 |
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| OVE3026 | Scientific Laboratory Supplies | PK4 | EUR 206.34 |
Microcapillary tube Drummond Microcaps |
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| P1924-1PAK | Scientific Laboratory Supplies | PK100 | EUR 31.35 |
Tube rack round floating |
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| R7901-5EA | Scientific Laboratory Supplies | PK5 | EUR 22.49 |
Tube Rack EPS 100x1.5ml |
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| RAC0410 | Scientific Laboratory Supplies | PK10 | EUR 82.08 |
Melting Point Tube 75x1.35mm |
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| HAE3151 | Scientific Laboratory Supplies | PK1000 | EUR 112.06 |
Capillary Tube 100x1.35mm Pipette |
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| HAE3152 | Scientific Laboratory Supplies | PK1000 | EUR 46.06 |
Cristaseal Capillary Tube Sealant |
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| HAE3160 | Scientific Laboratory Supplies | PK10 | EUR 39.9 |
Bridge for 15ml tube |
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| HOM2650 | Scientific Laboratory Supplies | EACH | EUR 306.66 |
Bridge for 50ml tube |
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| HOM2654 | Scientific Laboratory Supplies | EACH | EUR 306.66 |
Tube Holder 5/15mL |
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| E5353040148 | Scientific Laboratory Supplies | EACH | EUR 100.32 |
Tube Holder 25/50mL |
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| E5353040156 | Scientific Laboratory Supplies | EACH | EUR 100.32 |
Oil Centrifuge Tube 100ml |
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| F87990 | Scientific Laboratory Supplies | PK2 | EUR 135.27 |
LowProfile 5ml2D WhitePatch Tube |
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| SAM0200 | Scientific Laboratory Supplies | PK240 | EUR 633.84 |
LowProfile 5ml WhitePatch Tube |
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| SAM0204 | Scientific Laboratory Supplies | PK240 | EUR 442.32 |
IKA Test Tube Attachment |
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| SHA2002 | Scientific Laboratory Supplies | EACH | EUR 560.88 |
Tube Marker Ribbon White |
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| PCR1416 | Scientific Laboratory Supplies | EACH | EUR 136.8 |
These fee constants correspond to 32 and 44 H/D exchanges for the 8+ and 11+ charged ions, respectively. The outcomes point out increased particular person charges for many of the exchanged atoms within the 11+ ion in comparison with the 8+ ion.
