ATE1 inhibits liver cancer progression through RGS5-mediated suppression of Wnt/β-catenin signaling

ATE1 inhibits liver cancer progression through RGS5-mediated suppression of Wnt/β-catenin signaling

Arginyltransferase (ATE1) performs vital roles in lots of organic features together with cardiovascular growth, angiogenesis, adipogenesis, muscle contraction, and metastasis of most cancers. Nonetheless, the position of ATE1 in hepatocellular carcinoma (HCC) stays unknown. On this research, we discover that ATE1 performs an important position in progress and malignancy of liver most cancers.
ATE1 expression is considerably decreased in human HCC samples in comparison with regular liver tissue. Moreover, low ATE1 expression is correlated with aggressive clinicopathological options and is an unbiased poor prognostic issue for total survival and disease-free survival of HCC sufferers. Lentivirus-mediated ATE1 knockdown considerably promoted liver most cancers progress, migration and illness development in vitro and in vivo.
Opposing outcomes had been noticed when ATE1 was up-regulated. Mechanistically, ATE1 accelerated the degradation of β-catenin and inhibited Wnt signaling by regulating turnover of Regulator Of G Protein Signaling 5 (RGS5). Loss- and gain-of-function assays confirmed that RGS5 was a key effector of ATE1-mediated regulation of Wnt signaling.
Additional research indicated that RGS5 could be concerned in regulating the exercise of GSK3-β, a vital element of the cytoplasmic destruction complicated. Remedy with a GSK inhibitor (CHIR99021) cooperated with ablation of ATE1 or RGS5 overexpression to advertise Wnt/β-catenin signaling, however overexpression of ATE1 or RGS5 knockdown didn’t reverse the impact of GSK inhibitor. Implications: ATE1 inhibits liver most cancers development by suppressing Wnt/β-catenin signaling and may function a probably useful prognostic biomarker for HCC.

AGEs promote calcification of HASMCs by mediating Pi3k/AKT-GSK3β signaling

This research aimed to research the consequences of superior glycation finish merchandise (AGEs) on the calcification of human arterial easy muscle cells (HASMCs) and to discover whether or not AGEs can promote the calcification of HASMCs by activating the phosphoinositide 3-kinase (PI3K)/AKT-glycogen synthase kinase Three beta (GSK3-β) axis. Cultured HASMCs had been divided into 5 teams: clean management group, dimethyl sulfoxide (automobile) group, AGEs group, LY294002 (AKT inhibitor) group, and TWS119 (GSK3-β inhibitor) group.
Cells had been pretreated with both automobile, LY294002, or TWS119 for two hours adopted by incubation with AGEs (25 μg/mL) for five days, and the expression ranges of proteins in every group had been analyzed by western blotting. AGE therapy promoted HASMC calcification, which coincided with elevated expression of p-AKT and p-GSK3-β (serine 9).
Additionally, AGEs upregulated the expression of osteoprotegerin and bone morphogenetic protein, and these results had been suppressed by LY294002 however enhanced by TWS119. In conclusion, AGEs promote calcification of HASMCs, and this impact is ameliorated by inhibition of AKT exercise however potentiated by inhibition of GSK3-β exercise. Therefore, AGEs set off HASMC calcification by regulating PI3K/AKT-GSK3-β signaling.

GSK3 Inhibitor-Induced Dentinogenesis Utilizing a Hydrogel

Small-molecule medication concentrating on glycogen synthase kinase 3 (GSK3) as inhibitors of the protein kinase exercise are capable of stimulate reparative dentine formation. To develop this method right into a viable medical therapy for uncovered pulp lesions, we synthesized a novel, small-molecule noncompetitive adenosine triphosphate (ATP) drug that may be included right into a biodegradable hydrogel for placement by syringe into the tooth.
This new drug, named NP928, belongs to the thiadiazolidinone (TDZD) household and has equal exercise to related medication of this household equivalent to tideglusib. Nonetheless, NP928 is extra water soluble than different TDZD medication, making it extra appropriate for direct supply into pulp lesions.
We have now beforehand reported that biodegradable marine collagen sponges can efficiently ship TDZD medication to pulp lesions, however this entails in-theater preparation of the fabric, which isn’t best in a medical context.
To enhance surgical dealing with and supply, right here we included NP928 right into a particularly tailor-made hydrogel that may be positioned by syringe right into a broken tooth. This hydrogel is predicated on biodegradable hyaluronic acid and might be gelled in situ upon dental blue gentle publicity, equally to different frequent dental supplies.
NP928 launched from hyaluronic acid-based hydrogels upregulated Wnt/β-catenin exercise in pulp stem cells and fostered reparative dentine formation in comparison with marine collagen sponges delivering equal concentrations of NP928. This drug-hydrogel mixture has the potential to be quickly developed right into a therapeutic process that’s amenable to normal dental follow.

Direct P70S6K1 inhibition to exchange dexamethasone in synergistic mixture with MCL-1 inhibition in a number of myeloma

Novel mixture therapies have markedly improved the lifespan of sufferers with a number of myeloma (MM), however drug resistance and illness relapse stay main medical issues. Dexamethasone and different glucocorticoids are a cornerstone of standard and new mixture therapies for MM, though their use is accompanied by critical unwanted side effects.
We aimed to uncover drug combos that act in synergy and, as such, enable decreased dosing whereas remaining efficient. Dexamethasone and the myeloid cell leukemia 1 (MCL-1) inhibitor S63845 (MCL-1i) proved probably the most potent mixture in our lethality display screen and induced apoptosis of human myeloma cell strains (HMCLs) that was 50% greater in contrast with an additive drug impact.
Kinome evaluation of dexamethasone-treated HMCLs revealed a discount in serine/threonine peptide phosphorylation, which was predicted to consequence from decreased Akt exercise. Biochemical methods confirmed no dexamethasone-induced results on FOXO protein or GSK3 however did present a 50% discount in P70S6K phosphorylation, downstream of the Akt-mTORC1 axis.
Changing dexamethasone by the P70S6K1 isoform-specific inhibitor PF-4708671 (S6K1i) revealed related and statistically important synergistic apoptosis of HMCLs together with MCL-1i. Apparently, apoptosis induced by the P70S6K1i and MCL-1i mixture was more-than-additive in all 9 main MM samples examined; this impact was noticed for six of 9 samples with the dexamethasone and MCL-1i mixture.

GSK3B antibody

38616-100ul 100ul
EUR 302.4

GSK3B Antibody

CSB-PA939628- each
EUR 402
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

CSB-PA939628-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

1-CSB-PA009963GA01HU
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  • 150ul
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat, Pig. This antibody is Unconjugated. Tested in the following application: ELISA, WB

GSK3B Antibody

1-CSB-PA009963LA01HU
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  • 100ug
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:500

GSK3B Antibody

E036918 100μg/100μl
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

E19-6806 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E19-7231 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E10-30006 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E10-30705 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E10-30705T 100ul
EUR 225
Description: Available in various conjugation types.

Gsk3b Antibody

F44221-0.08ML 0.08 ml
EUR 140.25
Description: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).

Gsk3b Antibody

F44221-0.4ML 0.4 ml
EUR 322.15
Description: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).

GSK3B Antibody

F51046-0.08ML 0.08 ml
EUR 140.25
Description: GSK3B is a constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. May also mediate the development of insulin resistance by regulating activation of transcription factors. [UniProt]

GSK3B Antibody

F51046-0.4ML 0.4 ml
EUR 322.15
Description: GSK3B is a constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. May also mediate the development of insulin resistance by regulating activation of transcription factors. [UniProt]

GSK3B Antibody

E220184-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

GSK3B Antibody

E220184-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

E92081 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody

E93174 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B antibody

E39-03673 100ug/100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody

1-CSB-PA002848
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  • 100ug
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

GSK3B Antibody

1-CSB-PA009038
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  • 100ug
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Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

GSK3B Antibody

36918 100ul
EUR 319

GSK3B Antibody

36918-100ul 100ul
EUR 302.4

GSK3B antibody

70R-15005 100 ul
EUR 497
Description: Rabbit polyclonal GSK3B antibody

GSK3B antibody

70R-17615 50 ul
EUR 289
Description: Rabbit polyclonal GSK3B antibody

GSK3b antibody

70R-11869 100 ug
EUR 357
Description: Rabbit polyclonal GSK3b antibody

GSK3B Antibody

BF0695 200ul
EUR 540

GSK3B Antibody

BF0695-100ul 100ul
EUR 350

GSK3B Antibody

BF0695-200ul 200ul
EUR 450

GSK3B Antibody

BF0695-50ul 50ul
EUR 250

GSK3B Antibody

ABD6806 100 ug
EUR 525.6

GSK3B Antibody

ABD7231 100 ug
EUR 525.6

GSK3B antibody

CAF50144-100ug 100ug
EUR 312

GSK3B Antibody

1-CSB-PA080166
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

GSK3B Antibody

GWB-MT481D 50ug Ask for price

GSK3A / GSK3B Antibody

20-abx328487
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  • 100 ug
  • 50 ug

GSK3A/GSK3B Antibody

1-CSB-PA002838
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3A/GSK3B. Recognizes GSK3A/GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

GSK3A / GSK3B Antibody

abx328487-100g 100 µg
EUR 250

GSK3A / GSK3B Antibody

abx328487-50g 50 µg
EUR 187.5

Mouse anti GSK3b(pS9) Monoclonal Antibody

TA354463 100 µg Ask for price

Rabbit anti GSK3b(pS9) Polyclonal Antibody

TA354486 100 µg Ask for price

GSK3B (pY216) Antibody

20-abx123289
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  • 100 ul
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  • 20 ul
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GSK3B (pY216) Antibody

20-abx000312
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3B (pSer9) Antibody

abx243027-96tests 96 tests
EUR 287.5

GSK3B (pY216) Antibody

abx123289-100l 100 µl
EUR 200

GSK3B (pY216) Antibody

abx123289-1ml 1 ml
EUR 475

GSK3B (pY216) Antibody

abx123289-200l 200 µl
EUR 325

GSK3B Polyclonal Antibody

E96164 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E911360 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E911578 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody

E916868 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Conjugated Antibody

C36918 100ul
EUR 476.4

GSK3B Conjugated Antibody

C38353 100ul
EUR 476.4

GSK3B Polyclonal Antibody

A62706
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72446 50 μl
EUR 408

GSK3B Polyclonal Antibody

A72447 50 μl
EUR 408

GSK3B Polyclonal Antibody

A72448 50 μl
EUR 408

GSK3B Polyclonal Antibody

A72450 50 μl
EUR 557

Anti-GSK3 beta/GSK3B Antibody Picoband™

A00791-3 10ug
EUR 154
Description: Western blot, 0.25-0.5 μg/ml, Human;_x000D_Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Human;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Human

GSK3 beta Antibody / GSK3B

F54007-0.1ML 0.1 ml
EUR 322.15
Description: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. [UniProt]

Rabbit anti GSK3b(Paired S9) Polyclonal Antibody

TA354454 100 µg Ask for price

GSK3B (Ab-9) Antibody

CSB-PA120951- each
EUR 402
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

GSK3B (Ab-9) Antibody

CSB-PA120951-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

GSK3B (pS21 / 29) Antibody

abx031864-400ul 400 ul
EUR 627.6

GSK3B (pS21 / 29) Antibody

abx031864-80l 80 µl
EUR 343.2

GSK3B (pS21 / 29) Antibody

abx031864-400l 400 µl
EUR 525

ARP97287_P050 - GSK3B Antibody-C-terminal region

ARP97287_P050 100ul
EUR 389

ARP97287_P050-25UL - GSK3B Antibody - C-terminal region

ARP97287_P050-25UL 25ul
EUR 99

ARP54644_P050-25UL - GSK3B Antibody - C-terminal region

ARP54644_P050-25UL 25ul
EUR 99

GSK3B Antibody, HRP conjugated

1-CSB-PA009963LB01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

GSK3B Antibody, FITC conjugated

1-CSB-PA009963LC01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OAPA00251-5UG - GSK3B Antibody

OAPA00251-5UG 5ug
EUR 69

GSK3A / GSK3B (pY279 / 216) Antibody

20-abx328488
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  • 100 ug
  • 50 ug

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-100ul 100 ul
EUR 560.4

GSK3A / GSK3B (pY279 / 216) Antibody

abx328488-100g 100 µg
EUR 250

GSK3A / GSK3B (pY279 / 216) Antibody

abx328488-50g 50 µg
EUR 187.5

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-100g 100 µg Ask for price

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-20g 20 µg
EUR 412.5

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-50g 50 µg Ask for price

ARP54644_P050 - GSK3B antibody - C-terminal region (ARP54644_P050)

ARP54644_P050 100ul
EUR 389

OACA03072-50UG - GSK3B Antibody

OACA03072-50UG 50ug
EUR 179

GSK3B Antibody, Biotin conjugated

1-CSB-PA009963LD01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

GSK3B Rabbit Polyclonal Antibody

53236 100ul
EUR 439

OASG03249-100UL - GSK3B Antibody

OASG03249-100UL 100ul
EUR 239

OAAJ02835-100UL - GSK3B Antibody

OAAJ02835-100UL 100ul
EUR 319

OAAJ07280-100UL - GSK3B Antibody

OAAJ07280-100UL 100uL
EUR 319

OAAF01318-100UG - GSK3B Antibody

OAAF01318-100UG 100ug
EUR 329

OACA03072-100UG - GSK3B Antibody

OACA03072-100UG 100ug
EUR 319

OASG07740-100UL - GSK3B Antibody

OASG07740-100UL 100ul
EUR 269

OASG07741-100UL - GSK3B Antibody

OASG07741-100UL 100ul
EUR 269

OASG07742-100UL - GSK3B Antibody

OASG07742-100UL 100ul
EUR 269

GSK3B Rabbit Polyclonal Antibody

E312222 100ug/200ul
EUR 295
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GSK3B Rabbit Polyclonal Antibody

E10G05782 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GSK3B Rabbit Polyclonal Antibody

E10G10937 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

GSK3B Rabbit Polyclonal Antibody

E10G12655 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Rabbit Anti-Human GSK3B (aa 214-218) Polyclonal Antibody

CPB-1178RH 100 ul
EUR 552

GSK3A/GSK3B (pY216 + pY279) Antibody

abx243004-96tests 96 tests
EUR 287.5

GSK3B Polyclonal Conjugated Antibody

C30706 100ul
EUR 476.4

Polyclonal GSK3B / GSK3 Beta Antibody

AMM05221G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta . This antibody is tested and proven to work in the following applications:

Antibody for Human GSK3b (pSer9)

SPC-1384D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 565.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 633.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 655.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 680.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 700.

Antibody for Human GSK3b (pSer9)

SPC-1384D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human GSK3b (pSer9)

SPC-1384D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to APC .

Antibody for Human GSK3b (pSer9)

SPC-1384D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to APC/Cy7.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY350 0.1ml
EUR 496.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 350.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY405 0.1ml
EUR 483.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 405.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 488.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY594 0.1ml
EUR 474
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY633 0.1ml
EUR 468
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 633.

Antibody for Human GSK3b (pSer9)

SPC-1384D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to HRP.

Antibody for Human GSK3b (pSer9)

SPC-1384D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to PE/ATTO 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to PerCP.

Antibody for Human GSK3b (pSer9)

SPC-1384D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to RPE .

Antibody for Human GSK3b (pSer9)

SPC-1384D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Streptavidin.

GSK3A / GSK3B (Ab-279 / 216) Antibody

abx332166-100ul 100 ul
EUR 510

GSK3A/GSK3B (Ab-279/216) Antibody

CSB-PA255909- each
EUR 402
Description: A polyclonal antibody against GSK3A/GSK3B (Ab-279/216). Recognizes GSK3A/GSK3B (Ab-279/216) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

GSK3A/GSK3B (Ab-279/216) Antibody

CSB-PA255909-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3A/GSK3B (Ab-279/216). Recognizes GSK3A/GSK3B (Ab-279/216) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Rabbit Anti-Human GSK3B Polyclonal Antibody, Phospho-Tyr216

CPB-820RH 100 ul
EUR 670.8

Mouse Monoclonal Antibody to GSK3B

sAP-1054 50ug
EUR 270

Mouse Monoclonal Antibody to GSK3B

sAP-0359 50ug
EUR 270

Anti-Glycogen synthase kinase 3 B (GSK3B) (Ser9) antibody

STJ120111 100 µl
EUR 631.2

Monoclonal GSK3B Antibody, Clone: 3D6B4

AMM05223G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3B. The antibodies are raised in Mouse and are from clone 3D6B4. This antibody is applicable in WB and IHC, FC, E

[KO Validated] GSK3B Polyclonal Antibody

30706 100ul
EUR 439

[KO Validated] GSK3B Polyclonal Antibody

30706-100ul 100ul
EUR 302.4

[KO Validated] GSK3B Polyclonal Antibody

30706-50ul 50ul
EUR 224.4

Rabbit Anti-GSK3A, GSK3B monoclonal antibody, clone TZ37-16

CABT-L635 100 ul
EUR 932.4

GSK3B Polyclonal Antibody, HRP Conjugated

A62707
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  • 100 µg
  • 50 ul
  • 100 ul

Rabbit Anti-Human GSK3B Monoclonal Antibody, Clone S10-8H9

DMAB-JX2362057 20 µL, 50 µL, 100 µL Ask for price
Description: Rabbit

GSK3B Polyclonal Antibody, FITC Conjugated

A62708
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  • 100 µg
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody, Biotin Conjugated

A62709
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  • 100 µg
  • 50 ul
  • 100 ul

Rabbit anti Glycogen Synthase Kinase 3b (GSK3b) Polyclonal Antibody

TA354389 100 µg Ask for price

Phospho-GSK3A/GSK3B (Y279/216) Antibody

1-CSB-PA000535
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  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-GSK3A/GSK3B (Y279/216). Recognizes Phospho-GSK3A/GSK3B (Y279/216) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

Phospho-GSK3A/GSK3B (Tyr279/216) Antibody

CSB-PA575559- each
EUR 402
Description: A polyclonal antibody against Phospho-GSK3A/GSK3B (Tyr279/216). Recognizes Phospho-GSK3A/GSK3B (Tyr279/216) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

Phospho-GSK3A/GSK3B (Tyr279/216) Antibody

CSB-PA575559-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-GSK3A/GSK3B (Tyr279/216). Recognizes Phospho-GSK3A/GSK3B (Tyr279/216) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

OAEC01479-100UG - GSK3b (Ab-9) Antibody

OAEC01479-100UG 100ug
EUR 369

Polyclonal Mouse Gsk3b Antibody (N-term)

APR04027G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Mouse Gsk3b (N-term). This antibody is tested and proven to work in the following applications:

OASG03245-100UL - GSK3B Antibody (Phospho-Ser9)

OASG03245-100UL 100ul
EUR 239

OASG03246-100UL - GSK3B Antibody (Phospho-Ser9)

OASG03246-100UL 100ul
EUR 239

OAGA08182-100UL - GSK3B Antibody (Phospho-Ser9)

OAGA08182-100UL 100ul
EUR 369

Polyclonal GSK3B / GSK3 Beta Antibody (C-Terminus)

AMM05222G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta (C-Terminus). This antibody is tested and proven to work in the following applications:

GSK3B / GSK3 Beta Rabbit Polyclonal (pSer9) Antibody

TA317698 50 µg Ask for price

OAEC00270-50UG - GSK3B Antibody (Phospho-Tyr216)

OAEC00270-50UG 50ug
EUR 369

GSK3 beta (GSK3B) rabbit polyclonal antibody, Purified

AP22887PU-N 50 µg Ask for price

OABF00015-100UL - GSK3B Antibody (OABF00015-100UL)

OABF00015-100UL 100ul
EUR 409

glycogen synthase kinase 3 beta (GSK3B) Antibody

E301022 100ug/200ul
EUR 275
Description: Available in various conjugation types.

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx318062
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx328988
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  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx329709
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  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx332790-100ul 100 ul
EUR 510

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx330217
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  • 100 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx332014-100ul 100 ul
EUR 510

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx037712-100ug 100 ug
EUR 469.2

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx172635
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  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx172636
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  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx176674
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Glycogen Synthase Kinase 3 Beta (GSK3b) Antibody

20-abx176675
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  • 1 mg
  • 200 ug

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx125048
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  • 100 ul
  • 200 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx125336
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  • 100 ul
  • 200 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx125917
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  • 100 ul
  • 200 ul
  • 20 ul
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Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233673-100ug 100 ug
EUR 577.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233674-100ug 100 ug
EUR 577.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233675-100ug 100 ug
EUR 661.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx233676-100ug 100 ug
EUR 610.8

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx224101-100ug 100 ug
EUR 493.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx112808
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  • 150 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx147405-100ug 100 ug
EUR 526.8

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx004714
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx010856-100ul 100 ul
EUR 493.2

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx001694
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

20-abx002277
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Glycogen Synthase Kinase 3 Beta (Gsk3b) Antibody

abx028354-400ul 400 ul
EUR 627.6

Glycogen Synthase Kinase 3 Beta (Gsk3b) Antibody

abx028354-80l 80 µl
EUR 343.2

Rabbit polyclonal Mouse Gsk3b Antibody (N-term)

TA324570 400 µl Ask for price

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx002277-100l 100 µl
EUR 475

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx002277-20l 20 µl
EUR 200

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx002277-50l 50 µl
EUR 325

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx004714-100l 100 µl
EUR 400

Glycogen Synthase Kinase 3 Beta (GSK3B) Antibody

abx004714-20l 20 µl
EUR 175
Toxicity on stem and progenitor cell subsets remained minimal. Mixed, our outcomes present a powerful rationale for mixture remedies utilizing the P70S6K inhibitor in MM. Direct and particular inhibition of P70S6K may present an answer for sufferers ineligible or insensitive to dexamethasone or different glucocorticoids.

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