Medical Mitogen-activated protein kinases (MAPK) Research

anti- Phospoho CDK, MAPK, GSK3, CLK, ERK1/2, JNK

ATE1 inhibits liver cancer progression through RGS5-mediated suppression of Wnt/β-catenin signaling
Ae1 Ae3 Antibody Bafilomycin A1 Bile Acid Assay Bioassay Blog cDNA Ch 223191 Choline Acetyltransferase Antibody exosome F Actin Antibody Glycodeoxycholic Acid Isotype Ldn 193189 Medium Mip 1B Mmp Activity Assay Polyclonal Ru 58841 Soft Agar Tubastatin A Uric Acid Assay Valproic Acid Sodium Salt Western Blot

ATE1 inhibits liver cancer progression through RGS5-mediated suppression of Wnt/β-catenin signaling

Arginyltransferase (ATE1) performs vital roles in lots of organic features together with cardiovascular growth, angiogenesis, adipogenesis, muscle contraction, and metastasis of most cancers. Nonetheless, the position of ATE1 in hepatocellular carcinoma (HCC) stays unknown. On this research, we discover that ATE1 performs an important position in progress and malignancy of liver most cancers.
ATE1 expression is considerably decreased in human HCC samples in comparison with regular liver tissue. Moreover, low ATE1 expression is correlated with aggressive clinicopathological options and is an unbiased poor prognostic issue for total survival and disease-free survival of HCC sufferers. Lentivirus-mediated ATE1 knockdown considerably promoted liver most cancers progress, migration and illness development in vitro and in vivo.
Opposing outcomes had been noticed when ATE1 was up-regulated. Mechanistically, ATE1 accelerated the degradation of β-catenin and inhibited Wnt signaling by regulating turnover of Regulator Of G Protein Signaling 5 (RGS5). Loss- and gain-of-function assays confirmed that RGS5 was a key effector of ATE1-mediated regulation of Wnt signaling.
Additional research indicated that RGS5 could be concerned in regulating the exercise of GSK3-β, a vital element of the cytoplasmic destruction complicated. Remedy with a GSK inhibitor (CHIR99021) cooperated with ablation of ATE1 or RGS5 overexpression to advertise Wnt/β-catenin signaling, however overexpression of ATE1 or RGS5 knockdown didn’t reverse the impact of GSK inhibitor. Implications: ATE1 inhibits liver most cancers development by suppressing Wnt/β-catenin signaling and may function a probably useful prognostic biomarker for HCC.

AGEs promote calcification of HASMCs by mediating Pi3k/AKT-GSK3β signaling

This research aimed to research the consequences of superior glycation finish merchandise (AGEs) on the calcification of human arterial easy muscle cells (HASMCs) and to discover whether or not AGEs can promote the calcification of HASMCs by activating the phosphoinositide 3-kinase (PI3K)/AKT-glycogen synthase kinase Three beta (GSK3-β) axis. Cultured HASMCs had been divided into 5 teams: clean management group, dimethyl sulfoxide (automobile) group, AGEs group, LY294002 (AKT inhibitor) group, and TWS119 (GSK3-β inhibitor) group.
Cells had been pretreated with both automobile, LY294002, or TWS119 for two hours adopted by incubation with AGEs (25 μg/mL) for five days, and the expression ranges of proteins in every group had been analyzed by western blotting. AGE therapy promoted HASMC calcification, which coincided with elevated expression of p-AKT and p-GSK3-β (serine 9).
Additionally, AGEs upregulated the expression of osteoprotegerin and bone morphogenetic protein, and these results had been suppressed by LY294002 however enhanced by TWS119. In conclusion, AGEs promote calcification of HASMCs, and this impact is ameliorated by inhibition of AKT exercise however potentiated by inhibition of GSK3-β exercise. Therefore, AGEs set off HASMC calcification by regulating PI3K/AKT-GSK3-β signaling.

GSK3 Inhibitor-Induced Dentinogenesis Utilizing a Hydrogel

Small-molecule medication concentrating on glycogen synthase kinase 3 (GSK3) as inhibitors of the protein kinase exercise are capable of stimulate reparative dentine formation. To develop this method right into a viable medical therapy for uncovered pulp lesions, we synthesized a novel, small-molecule noncompetitive adenosine triphosphate (ATP) drug that may be included right into a biodegradable hydrogel for placement by syringe into the tooth.
This new drug, named NP928, belongs to the thiadiazolidinone (TDZD) household and has equal exercise to related medication of this household equivalent to tideglusib. Nonetheless, NP928 is extra water soluble than different TDZD medication, making it extra appropriate for direct supply into pulp lesions.
We have now beforehand reported that biodegradable marine collagen sponges can efficiently ship TDZD medication to pulp lesions, however this entails in-theater preparation of the fabric, which isn’t best in a medical context.
To enhance surgical dealing with and supply, right here we included NP928 right into a particularly tailor-made hydrogel that may be positioned by syringe right into a broken tooth. This hydrogel is predicated on biodegradable hyaluronic acid and might be gelled in situ upon dental blue gentle publicity, equally to different frequent dental supplies.
NP928 launched from hyaluronic acid-based hydrogels upregulated Wnt/β-catenin exercise in pulp stem cells and fostered reparative dentine formation in comparison with marine collagen sponges delivering equal concentrations of NP928. This drug-hydrogel mixture has the potential to be quickly developed right into a therapeutic process that’s amenable to normal dental follow.

Direct P70S6K1 inhibition to exchange dexamethasone in synergistic mixture with MCL-1 inhibition in a number of myeloma

Novel mixture therapies have markedly improved the lifespan of sufferers with a number of myeloma (MM), however drug resistance and illness relapse stay main medical issues. Dexamethasone and different glucocorticoids are a cornerstone of standard and new mixture therapies for MM, though their use is accompanied by critical unwanted side effects.
We aimed to uncover drug combos that act in synergy and, as such, enable decreased dosing whereas remaining efficient. Dexamethasone and the myeloid cell leukemia 1 (MCL-1) inhibitor S63845 (MCL-1i) proved probably the most potent mixture in our lethality display screen and induced apoptosis of human myeloma cell strains (HMCLs) that was 50% greater in contrast with an additive drug impact.
Kinome evaluation of dexamethasone-treated HMCLs revealed a discount in serine/threonine peptide phosphorylation, which was predicted to consequence from decreased Akt exercise. Biochemical methods confirmed no dexamethasone-induced results on FOXO protein or GSK3 however did present a 50% discount in P70S6K phosphorylation, downstream of the Akt-mTORC1 axis.
Changing dexamethasone by the P70S6K1 isoform-specific inhibitor PF-4708671 (S6K1i) revealed related and statistically important synergistic apoptosis of HMCLs together with MCL-1i. Apparently, apoptosis induced by the P70S6K1i and MCL-1i mixture was more-than-additive in all 9 main MM samples examined; this impact was noticed for six of 9 samples with the dexamethasone and MCL-1i mixture.

GSK3B antibody
38353-100ul 100ul
EUR 302.4

GSK3B antibody
38616 100ul
EUR 439

GSK3B antibody
38616-100ul 100ul
EUR 302.4

GSK3B Antibody
CSB-PA939628- each
EUR 402
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody
CSB-PA939628-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody
E036918 100μg/100μl
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody
E10-30705 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody
E10-30705T 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody
E10-30006 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody
E19-6806 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody
E19-7231 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B antibody
E39-03673 100ug/100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody
E93174 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody
E92081 100ul
EUR 255
Description: Available in various conjugation types.

GSK3B Antibody
E220184-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

GSK3B Antibody
E220184-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

GSK3B Antibody
BF0695-100ul 100ul
EUR 350

GSK3B Antibody
BF0695-200ul 200ul
EUR 450

GSK3B Antibody
BF0695-50ul 50ul
EUR 250

GSK3B antibody
CAF50144-100ug 100ug
EUR 312

GSK3B antibody
70R-15005 100 ul
EUR 497
Description: Rabbit polyclonal GSK3B antibody

GSK3B antibody
70R-17615 50 ul
EUR 289
Description: Rabbit polyclonal GSK3B antibody

GSK3b antibody
70R-11869 100 ug
EUR 357
Description: Rabbit polyclonal GSK3b antibody

GSK3B Antibody
1-CSB-PA009038
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

GSK3B Antibody
1-CSB-PA009963GA01HU
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  • 150ul
  • 50ul
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat, Pig. This antibody is Unconjugated. Tested in the following application: ELISA, WB

GSK3B Antibody
1-CSB-PA009963LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:500

GSK3B Antibody
1-CSB-PA002848
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

GSK3B Antibody
1-CSB-PA080166
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

GSK3B Antibody
ABD6806 100ug
EUR 325

GSK3B Antibody
ABD7231 100ug
EUR 325

Gsk3b Antibody
F44221-0.08ML 0.08 ml
EUR 140.25
Description: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).

Gsk3b Antibody
F44221-0.4ML 0.4 ml
EUR 322.15
Description: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. May phosphorylate MUC1 and decrease the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1 (By similarity).

GSK3B Antibody
F51046-0.08ML 0.08 ml
EUR 140.25
Description: GSK3B is a constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. May also mediate the development of insulin resistance by regulating activation of transcription factors. [UniProt]

GSK3B Antibody
F51046-0.4ML 0.4 ml
EUR 322.15
Description: GSK3B is a constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. May also mediate the development of insulin resistance by regulating activation of transcription factors. [UniProt]

GSK3B Antibody
GWB-MT481D 50ug Ask for price

GSK3B antibody
BF0695 100ug
EUR 355

GSK3B Antibody
MBS7136549-005mL 0.05mL
EUR 220

GSK3B Antibody
MBS7136549-01mL 0.1mL
EUR 300

GSK3B Antibody
MBS7136549-5x01mL 5x0.1mL
EUR 1350

GSK3B Antibody
MBS7131863-01mL 0.1mL
EUR 270

GSK3B Antibody
MBS7131863-5x01mL 5x0.1mL
EUR 1200

GSK3B Antibody
MBS7119532-005mg 0.05mg
EUR 150

GSK3B Antibody
MBS7119532-01mg 0.1mg
EUR 190

GSK3B Antibody
MBS7119532-5x01mg 5x0.1mg
EUR 845

GSK3B Antibody
MBS7122537-005mg 0.05mg
EUR 150

GSK3B Antibody
MBS7122537-01mg 0.1mg
EUR 190

GSK3B Antibody
MBS7122537-5x01mg 5x0.1mg
EUR 845

GSK3B Antibody
MBS7122623-005mg 0.05mg
EUR 150

GSK3B Antibody
MBS7122623-01mg 0.1mg
EUR 190

GSK3B Antibody
MBS7122623-5x01mg 5x0.1mg
EUR 845

GSK3B antibody
MBS9412683-005mL 0.05mL
EUR 300

GSK3B antibody
MBS9412683-01mL 0.1mL
EUR 390

GSK3B antibody
MBS9412683-5x01mL 5x0.1mL
EUR 1610

GSK3B antibody
MBS9410678-005mL 0.05mL
EUR 300

GSK3B antibody
MBS9410678-01mL 0.1mL
EUR 390

GSK3B antibody
MBS9410678-5x01mL 5x0.1mL
EUR 1610

GSK3B Antibody
MBS9411632-01mL 0.1mL
EUR 305

GSK3B Antibody
MBS9411632-5x01mL 5x0.1mL
EUR 1230

GSK3B antibody
MBS831019-01mL 0.1mL
EUR 810

GSK3B antibody
MBS831019-5x01mL 5x0.1mL
EUR 3505

GSK3B Antibody
MBS850776-01mg 0.1mg
EUR 305

GSK3B Antibody
MBS850776-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody
MBS850776-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody
MBS850776-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Antibody
MBS850776-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Antibody
MBS8516276-01mg 0.1mg
EUR 305

GSK3B Antibody
MBS8516276-01mLAF405L 0.1mL(AF405L)
EUR 465

GSK3B Antibody
MBS8516276-01mLAF405S 0.1mL(AF405S)
EUR 465

GSK3B Antibody
MBS8516276-01mLAF610 0.1mL(AF610)
EUR 465

GSK3B Antibody
MBS8516276-01mLAF635 0.1mL(AF635)
EUR 465

GSK3B Antibody
MBS8516665-01mg 0.1mg
EUR 305

GSK3B Antibody
MBS8516665-01mLAF405L 0.1mL(AF405L)
EUR 465

GSK3B Antibody
MBS8516665-01mLAF405S 0.1mL(AF405S)
EUR 465

GSK3B Antibody
MBS8516665-01mLAF610 0.1mL(AF610)
EUR 465

GSK3B Antibody
MBS8516665-01mLAF635 0.1mL(AF635)
EUR 465

GSK3B Antibody
MBS8503474-01mL 0.1mL
EUR 325

GSK3B Antibody
MBS8503474-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody
MBS8503474-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody
MBS8503474-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Antibody
MBS8503474-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Antibody
MBS8503766-01mL 0.1mL
EUR 325

GSK3B Antibody
MBS8503766-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody
MBS8503766-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody
MBS8503766-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Antibody
MBS8503766-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Antibody
MBS8526909-005mg 0.05mg
EUR 235

GSK3B Antibody
MBS8526909-01mg 0.1mg
EUR 305

GSK3B Antibody
MBS8526909-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Antibody
MBS8526909-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Antibody
MBS8526909-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Antibody
MBS2526819-006mL 0.06mL
EUR 230

GSK3B Antibody
MBS2526819-012mL 0.12mL
EUR 310

GSK3B Antibody
MBS2526819-02mL 0.2mL
EUR 480

GSK3B Antibody
MBS2526368-006mL 0.06mL
EUR 180

GSK3B Antibody
MBS2526368-012mL 0.12mL
EUR 260

GSK3B Antibody
MBS2526368-02mL 0.2mL
EUR 405

GSK3B Antibody
MBS2526368-5x02mL 5x0.2mL
EUR 1725

GSK3b Antibody
MBS5311338-01mg 0.1mg
EUR 490

GSK3b Antibody
MBS5311338-5x01mg 5x0.1mg
EUR 2155

GSK3B Antibody
MBS5313117-01mL 0.1mL
EUR 800

GSK3B Antibody
MBS5313117-5x01mL 5x0.1mL
EUR 3440

GSK3B Antibody
MBS9602821-005mL 0.05mL
EUR 260

GSK3B Antibody
MBS9602821-01mL 0.1mL
EUR 325

GSK3B Antibody
MBS9602821-02mL 0.2mL
EUR 400

GSK3B Antibody
MBS9602821-5x02mL 5x0.2mL
EUR 1750

GSK3B Antibody
MBS9607870-01mL 0.1mL
EUR 260

GSK3B Antibody
MBS9607870-02mL 0.2mL
EUR 305

GSK3B Antibody
MBS9607870-5x02mL 5x0.2mL
EUR 1220

GSK3B Antibody
MBS969826-005mg 0.05mg
EUR 190

GSK3B Antibody
MBS969826-01mg 0.1mg
EUR 270

GSK3B Antibody
MBS969826-5x01mg 5x0.1mg
EUR 1205

Mouse anti GSK3b(pS9) Monoclonal Antibody
TA354463 100 µg Ask for price

Mouse Anti GSK3b (pS9) Monoclonal Antibody
MBS460723-01mg 0.1mg
EUR 315

Mouse Anti GSK3b (pS9) Monoclonal Antibody
MBS460723-5x01mg 5x0.1mg
EUR 1330

Rabbit anti GSK3b(pS9) Polyclonal Antibody
TA354486 100 µg Ask for price

GSK3A / GSK3B Antibody
20-abx328487
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  • 100 ug
  • 50 ug

GSK3A/GSK3B Antibody
1-CSB-PA002838
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  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3A/GSK3B. Recognizes GSK3A/GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

GSK3A / GSK3B Antibody
abx328487-100g 100 µg
EUR 250

GSK3A / GSK3B Antibody
abx328487-50g 50 µg
EUR 187.5

GSK3A/GSK3B Antibody
MBS7122062-005mg 0.05mg
EUR 150

GSK3A/GSK3B Antibody
MBS7122062-01mg 0.1mg
EUR 190

GSK3A/GSK3B Antibody
MBS7122062-5x01mg 5x0.1mg
EUR 845

GSK3B (pY216) Antibody
20-abx123289
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3B (pY216) Antibody
20-abx000312
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  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3B (pY216) Antibody
abx123289-100l 100 µl
EUR 200

GSK3B (pY216) Antibody
abx123289-1ml 1 ml
EUR 475

GSK3B (pY216) Antibody
abx123289-200l 200 µl
EUR 325

GSK3B (pSer9) Antibody
abx243027-96tests 96 tests
EUR 287.5

GSK3B Polyclonal Antibody
A62706
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  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody
E911360 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody
E911578 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody
E916868 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Polyclonal Antibody
E96164 100ul
EUR 225
Description: Available in various conjugation types.

GSK3B Conjugated Antibody
C36918 100ul
EUR 476.4

GSK3B Conjugated Antibody
C38353 100ul
EUR 476.4

GSK3B Polyclonal Antibody
MBS127304-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody
MBS127304-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody
MBS127304-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody
MBS127304-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody
MBS127304-5x02mL 5x0.2mL
EUR 2265

GSK3B Polyclonal Antibody
MBS127965-002mL 0.02mL
EUR 220

GSK3B Polyclonal Antibody
MBS127965-005mL 0.05mL
EUR 295

GSK3B Polyclonal Antibody
MBS127965-01mL 0.1mL
EUR 430

GSK3B Polyclonal Antibody
MBS127965-02mL 0.2mL
EUR 600

GSK3B Polyclonal Antibody
MBS127965-5x02mL 5x0.2mL
EUR 2525

GSK3B Polyclonal Antibody
A72446 50 μl
EUR 408

GSK3B Polyclonal Antibody
A72447 50 μl
EUR 408

GSK3B Polyclonal Antibody
A72448 50 μl
EUR 408

GSK3B Polyclonal Antibody
A72450 50 μl
EUR 557

GSK3B Polyclonal Antibody
MBS8571509-01mL 0.1mL
EUR 305

GSK3B Polyclonal Antibody
MBS8571509-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Polyclonal Antibody
MBS8571509-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Polyclonal Antibody
MBS8571509-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Polyclonal Antibody
MBS8571509-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Polyclonal Antibody
MBS9140997-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody
MBS9140997-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody
MBS9140997-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody
MBS9140997-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody
MBS9140997-5x02mL 5x0.2mL
EUR 2265

GSK3B Polyclonal Antibody
MBS9131456-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody
MBS9131456-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody
MBS9131456-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody
MBS9131456-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody
MBS9131456-5x02mL 5x0.2mL
EUR 2265

GSK3B Polyclonal Antibody
MBS9131576-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody
MBS9131576-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody
MBS9131576-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody
MBS9131576-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody
MBS9131576-5x02mL 5x0.2mL
EUR 2265

GSK3B Polyclonal Antibody
MBS9126031-002mL 0.02mL
EUR 200

GSK3B Polyclonal Antibody
MBS9126031-005mL 0.05mL
EUR 255

GSK3B Polyclonal Antibody
MBS9126031-01mL 0.1mL
EUR 345

GSK3B Polyclonal Antibody
MBS9126031-02mL 0.2mL
EUR 545

GSK3B Polyclonal Antibody
MBS9126031-5x02mL 5x0.2mL
EUR 2265

GSK3B Polyclonal Antibody
MBS8572783-01mL 0.1mL
EUR 305

GSK3B Polyclonal Antibody
MBS8572783-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Polyclonal Antibody
MBS8572783-01mLAF405S 0.1mL(AF405S)
EUR 565

GSK3B Polyclonal Antibody
MBS8572783-01mLAF610 0.1mL(AF610)
EUR 565

GSK3B Polyclonal Antibody
MBS8572783-01mLAF635 0.1mL(AF635)
EUR 565

GSK3B Polyclonal Antibody
MBS8566844-01mL 0.1mL
EUR 305

GSK3B Polyclonal Antibody
MBS8566844-01mLAF405L 0.1mL(AF405L)
EUR 565

GSK3B Polyclonal Antibody
MBS8566844-01mLAF405S 0.1mL(AF405S)
EUR 565
Toxicity on stem and progenitor cell subsets remained minimal. Mixed, our outcomes present a powerful rationale for mixture remedies utilizing the P70S6K inhibitor in MM. Direct and particular inhibition of P70S6K may present an answer for sufferers ineligible or insensitive to dexamethasone or different glucocorticoids.
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Cell Biology of Canonical Wnt Signaling
The novel AKT inhibitor Afuresertib suppresses human Merkel cell carcinoma MKL-1 cell growth

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