ATE1 inhibits liver cancer progression through RGS5-mediated suppression of Wnt/β-catenin signaling

ATE1 inhibits liver cancer progression through RGS5-mediated suppression of Wnt/β-catenin signaling

Arginyltransferase (ATE1) performs vital roles in lots of organic features together with cardiovascular growth, angiogenesis, adipogenesis, muscle contraction, and metastasis of most cancers. Nonetheless, the position of ATE1 in hepatocellular carcinoma (HCC) stays unknown. On this research, we discover that ATE1 performs an important position in progress and malignancy of liver most cancers.
ATE1 expression is considerably decreased in human HCC samples in comparison with regular liver tissue. Moreover, low ATE1 expression is correlated with aggressive clinicopathological options and is an unbiased poor prognostic issue for total survival and disease-free survival of HCC sufferers. Lentivirus-mediated ATE1 knockdown considerably promoted liver most cancers progress, migration and illness development in vitro and in vivo.
Opposing outcomes had been noticed when ATE1 was up-regulated. Mechanistically, ATE1 accelerated the degradation of β-catenin and inhibited Wnt signaling by regulating turnover of Regulator Of G Protein Signaling 5 (RGS5). Loss- and gain-of-function assays confirmed that RGS5 was a key effector of ATE1-mediated regulation of Wnt signaling.
Additional research indicated that RGS5 could be concerned in regulating the exercise of GSK3-β, a vital element of the cytoplasmic destruction complicated. Remedy with a GSK inhibitor (CHIR99021) cooperated with ablation of ATE1 or RGS5 overexpression to advertise Wnt/β-catenin signaling, however overexpression of ATE1 or RGS5 knockdown didn’t reverse the impact of GSK inhibitor. Implications: ATE1 inhibits liver most cancers development by suppressing Wnt/β-catenin signaling and may function a probably useful prognostic biomarker for HCC.

AGEs promote calcification of HASMCs by mediating Pi3k/AKT-GSK3β signaling

This research aimed to research the consequences of superior glycation finish merchandise (AGEs) on the calcification of human arterial easy muscle cells (HASMCs) and to discover whether or not AGEs can promote the calcification of HASMCs by activating the phosphoinositide 3-kinase (PI3K)/AKT-glycogen synthase kinase Three beta (GSK3-β) axis. Cultured HASMCs had been divided into 5 teams: clean management group, dimethyl sulfoxide (automobile) group, AGEs group, LY294002 (AKT inhibitor) group, and TWS119 (GSK3-β inhibitor) group.
Cells had been pretreated with both automobile, LY294002, or TWS119 for two hours adopted by incubation with AGEs (25 μg/mL) for five days, and the expression ranges of proteins in every group had been analyzed by western blotting. AGE therapy promoted HASMC calcification, which coincided with elevated expression of p-AKT and p-GSK3-β (serine 9).
Additionally, AGEs upregulated the expression of osteoprotegerin and bone morphogenetic protein, and these results had been suppressed by LY294002 however enhanced by TWS119. In conclusion, AGEs promote calcification of HASMCs, and this impact is ameliorated by inhibition of AKT exercise however potentiated by inhibition of GSK3-β exercise. Therefore, AGEs set off HASMC calcification by regulating PI3K/AKT-GSK3-β signaling.

GSK3 Inhibitor-Induced Dentinogenesis Utilizing a Hydrogel

Small-molecule medication concentrating on glycogen synthase kinase 3 (GSK3) as inhibitors of the protein kinase exercise are capable of stimulate reparative dentine formation. To develop this method right into a viable medical therapy for uncovered pulp lesions, we synthesized a novel, small-molecule noncompetitive adenosine triphosphate (ATP) drug that may be included right into a biodegradable hydrogel for placement by syringe into the tooth.
This new drug, named NP928, belongs to the thiadiazolidinone (TDZD) household and has equal exercise to related medication of this household equivalent to tideglusib. Nonetheless, NP928 is extra water soluble than different TDZD medication, making it extra appropriate for direct supply into pulp lesions.
We have now beforehand reported that biodegradable marine collagen sponges can efficiently ship TDZD medication to pulp lesions, however this entails in-theater preparation of the fabric, which isn’t best in a medical context.
To enhance surgical dealing with and supply, right here we included NP928 right into a particularly tailor-made hydrogel that may be positioned by syringe right into a broken tooth. This hydrogel is predicated on biodegradable hyaluronic acid and might be gelled in situ upon dental blue gentle publicity, equally to different frequent dental supplies.
NP928 launched from hyaluronic acid-based hydrogels upregulated Wnt/β-catenin exercise in pulp stem cells and fostered reparative dentine formation in comparison with marine collagen sponges delivering equal concentrations of NP928. This drug-hydrogel mixture has the potential to be quickly developed right into a therapeutic process that’s amenable to normal dental follow.

Direct P70S6K1 inhibition to exchange dexamethasone in synergistic mixture with MCL-1 inhibition in a number of myeloma

Novel mixture therapies have markedly improved the lifespan of sufferers with a number of myeloma (MM), however drug resistance and illness relapse stay main medical issues. Dexamethasone and different glucocorticoids are a cornerstone of standard and new mixture therapies for MM, though their use is accompanied by critical unwanted side effects.
We aimed to uncover drug combos that act in synergy and, as such, enable decreased dosing whereas remaining efficient. Dexamethasone and the myeloid cell leukemia 1 (MCL-1) inhibitor S63845 (MCL-1i) proved probably the most potent mixture in our lethality display screen and induced apoptosis of human myeloma cell strains (HMCLs) that was 50% greater in contrast with an additive drug impact.
Kinome evaluation of dexamethasone-treated HMCLs revealed a discount in serine/threonine peptide phosphorylation, which was predicted to consequence from decreased Akt exercise. Biochemical methods confirmed no dexamethasone-induced results on FOXO protein or GSK3 however did present a 50% discount in P70S6K phosphorylation, downstream of the Akt-mTORC1 axis.
Changing dexamethasone by the P70S6K1 isoform-specific inhibitor PF-4708671 (S6K1i) revealed related and statistically important synergistic apoptosis of HMCLs together with MCL-1i. Apparently, apoptosis induced by the P70S6K1i and MCL-1i mixture was more-than-additive in all 9 main MM samples examined; this impact was noticed for six of 9 samples with the dexamethasone and MCL-1i mixture.

Anti-GSK3B antibody

STJ113773 100 µl
EUR 332.4
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-GSK3B antibody

STJ113841 100 µl
EUR 332.4
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-GSK3B antibody

STJ119229 100 µl
EUR 332.4

Anti-GSK3B Antibody

STJ501295 100 µg
EUR 571.2

Anti-GSK3B antibody

STJ27912 100 µl
EUR 495.6
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-GSK3B antibody

STJ23879 100 µl
EUR 332.4
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-GSK3B antibody

STJ23880 100 µl
EUR 332.4
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Anti-GSK3B Antibody (Biotin)

STJ501296 100 µg
EUR 703.2

Anti-GSK3B Antibody (FITC)

STJ501297 100 µg
EUR 703.2

anti-GSK3B (3D10)

LF-MA30340 100 ul
EUR 583.2
Description: Mouse Monoclonal to GSK3B

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Mu-48T 48T
EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Mu-96T 96T
EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Ra-48T 48T
EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Ra-96T 96T
EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Hu-48Tests 48 Tests
EUR 652.8

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Hu-96Tests 96 Tests
EUR 907.2

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Mu-48Tests 48 Tests
EUR 668.4

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Mu-96Tests 96 Tests
EUR 928.8

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-48Tests 48 Tests
EUR 699.6

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-96Tests 96 Tests
EUR 973.2

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Hu-48Tests 48 Tests
EUR 625.2

Human Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Hu-96Tests 96 Tests
EUR 867.6

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Mu-48Tests 48 Tests
EUR 639.6

Mouse Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Mu-96Tests 96 Tests
EUR 888

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-48Tests 48 Tests
EUR 668.4

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-96Tests 96 Tests
EUR 930

Anti-GSK3b (Ab-9) Antibody

A00791-1 100ul
EUR 476.4
Description: Rabbit Polyclonal GSK3b (Ab-9) Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Phospho-GSK3B-(Y216) antibody

STJ116370 100 µl
EUR 471.6
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Phospho-GSK3B-(Y216) antibody

STJ110852 100 µl
EUR 471.6
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Phospho-GSK3B-(S9) antibody

STJ22160 100 µl
EUR 471.6
Description: The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

GSK3b antibody

70R-11869 100 ug
EUR 501.6
Description: Rabbit polyclonal GSK3b antibody

GSK3B antibody

70R-17615 50 ul
EUR 522
Description: Rabbit polyclonal GSK3B antibody

GSK3B antibody

70R-15005 100 ul
EUR 470.4
Description: Rabbit polyclonal GSK3B antibody

GSK3B antibody

38353-100ul 100ul
EUR 302.4

GSK3B antibody

38616-100ul 100ul
EUR 302.4

GSK3B Antibody

36918-100ul 100ul
EUR 302.4

GSK3B antibody

10R-1862 100 ul
EUR 483.6
Description: Mouse monoclonal GSK3B antibody

GSK3B Antibody

ABD6806 100 ug
EUR 525.6

GSK3B Antibody

ABD7231 100 ug
EUR 525.6

GSK3B Antibody

BF0695 200ul
EUR 540

GSK3B Antibody

1-CSB-PA080166
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC;WB:1:1000-2000.IHC:1:200-500

GSK3B Antibody

CSB-PA939628-
EUR 402
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

CSB-PA939628-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

GSK3B Antibody

1-CSB-PA002848
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

GSK3B Antibody

1-CSB-PA009038
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

GSK3B Antibody

1-CSB-PA009963GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse, Rat, Pig. This antibody is Unconjugated. Tested in the following application: ELISA, WB

GSK3B Antibody

1-CSB-PA009963LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human, Mouse. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF; Recommended dilution: WB:1:2000-1:10000, IF:1:50-1:500

GSK3B Antibody

F51046-0.08ML 0.08 ml
EUR 165

GSK3B Antibody

F51046-0.4ML 0.4 ml
EUR 379

Gsk3b Antibody

F44221-0.08ML 0.08 ml
EUR 165

Gsk3b Antibody

F44221-0.4ML 0.4 ml
EUR 379

Phospho-GSK3b antibody

70R-11870 100 ug
EUR 630
Description: Rabbit polyclonal Phospho-GSK3b antibody

GSK3B (pY216) Antibody

20-abx000312
  • EUR 594.00
  • EUR 844.80
  • EUR 260.40
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3B (pY216) Antibody

20-abx123289
  • EUR 594.00
  • EUR 844.80
  • EUR 260.40
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3A / GSK3B Antibody

20-abx328487
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

GSK3B Conjugated Antibody

C36918 100ul
EUR 476.4

GSK3B Conjugated Antibody

C38353 100ul
EUR 476.4

GSK3A/GSK3B Antibody

1-CSB-PA002838
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3A/GSK3B. Recognizes GSK3A/GSK3B from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

GSK3B Polyclonal Antibody

A62706-020 20 ul
EUR 117.7

GSK3B Polyclonal Antibody

A62706-050 50 ul
EUR 302.5

GSK3B Polyclonal Antibody

A62706-100 100 ul
EUR 423.5

GSK3B Polyclonal Antibody

A62706
  • EUR 684.66
  • EUR 117.70
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72446
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72447
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72448
  • EUR 302.50
  • EUR 423.50
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72450
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody

A72446-050 50 ul
EUR 302.5

GSK3B Polyclonal Antibody

A72446-100 100 ul
EUR 423.5

GSK3B Polyclonal Antibody

A72447-050 50 ul
EUR 302.5

GSK3B Polyclonal Antibody

A72447-100 100 ul
EUR 423.5

GSK3B Polyclonal Antibody

A72448-050 50 ul
EUR 302.5

GSK3B Polyclonal Antibody

A72448-100 100 ul
EUR 423.5

GSK3B Polyclonal Antibody

A72450-050 50 ul
EUR 377.3

GSK3B Polyclonal Antibody

A72450-100 100 ul
EUR 577.5

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

GSK3B siRNA

20-abx902344
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GSK3B siRNA

20-abx918789
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GSK3B siRNA

20-abx918790
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

GSK3B Plasmid

PVT7113 2 ug
EUR 319.2

GSK3B (pS21 / 29) Antibody

abx031864-400ul 400 ul
EUR 627.6

GSK3B (pS21 / 29) Antibody

abx031864-80l 80 µl
EUR 343.2

Phospho-GSK3B (S9) Antibody

1-CSB-PA000536
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-GSK3B (S9). Recognizes Phospho-GSK3B (S9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/5000

Phospho-GSK3B (S9) Antibody

1-CSB-PA000636
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-GSK3B (S9). Recognizes Phospho-GSK3B (S9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000

GSK3B Polyclonal Conjugated Antibody

C30706 100ul
EUR 476.4

Phospho-GSK3B (Ser9) Antibody

CSB-PA166926-
EUR 402
Description: A polyclonal antibody against Phospho-GSK3B (Ser9). Recognizes Phospho-GSK3B (Ser9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

Phospho-GSK3B (Ser9) Antibody

CSB-PA166926-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-GSK3B (Ser9). Recognizes Phospho-GSK3B (Ser9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200

GSK3B (Ab-9) Antibody

CSB-PA120951-
EUR 402
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

GSK3B (Ab-9) Antibody

CSB-PA120951-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against GSK3B (Ab-9). Recognizes GSK3B (Ab-9) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

GSK3B Antibody, HRP conjugated

1-CSB-PA009963LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

GSK3B Antibody, FITC conjugated

1-CSB-PA009963LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

GSK3B Antibody, Biotin conjugated

1-CSB-PA009963LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against GSK3B. Recognizes GSK3B from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

GSK3 beta Antibody / GSK3B

F54007-0.1ML 0.1 ml
EUR 379

GAL Peptide

42-216P 0.1 mg
EUR 405.6
Description: (IN) GAL Peptide

Transferrin receptor 1 Peptide

43-216P 0.1 mg
EUR 405.6

PRDM16 Peptide

46-216P 0.1 mg
EUR 405.6
Description: PRDM16 / MEL1 Peptide

AGTR1 Peptide

45-216P 0.1 mg
EUR 405.6
Description: AGTR1 / AT1 Peptide

Rabbit Anti-Human GSK3B Polyclonal Antibody, Phospho-Tyr216

CPB-820RH 100 ul
EUR 670.8

Rabbit Anti-GSK3B monoclonal antibody, clone TZ13-82

DCABH-9320 100 ul
EUR 932.4

[KO Validated] GSK3B Polyclonal Antibody

30706-100ul 100ul
EUR 302.4

[KO Validated] GSK3B Polyclonal Antibody

30706-50ul 50ul
EUR 224.4

GSK3A / GSK3B (pY279 / 216) Antibody

abx333212-100ul 100 ul
EUR 560.4

GSK3A / GSK3B (pY279 / 216) Antibody

20-abx328488
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Polyclonal GSK3B / GSK3 Beta Antibody

AMM05221G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3B / GSK3 Beta . This antibody is tested and proven to work in the following applications:

Monoclonal GSK3B Antibody, Clone: 3D6B4

AMM05223G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3B. The antibodies are raised in Mouse and are from clone 3D6B4. This antibody is applicable in WB and IHC, FC, E

Antibody for Human GSK3b (pSer9)

SPC-1384D 0.1ml
EUR 424.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is unconjugated.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A390 0.1ml
EUR 481.2
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 390.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A488 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 488.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A565 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 565.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A594 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A633 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 633.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A655 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 655.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A680 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 680.

Antibody for Human GSK3b (pSer9)

SPC-1384D-A700 0.1ml
EUR 480
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to ATTO 700.

Antibody for Human GSK3b (pSer9)

SPC-1384D-ALP 0.1ml
EUR 472.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human GSK3b (pSer9)

SPC-1384D-APC 0.1ml
EUR 478.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to APC .

Antibody for Human GSK3b (pSer9)

SPC-1384D-APCCY7 0.1ml
EUR 565.2
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to APC/Cy7.

Antibody for Human GSK3b (pSer9)

SPC-1384D-BI 0.1ml
EUR 475.2
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Biotin.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY350 0.1ml
EUR 496.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 350.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY405 0.1ml
EUR 483.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 405.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY488 0.1ml
EUR 471.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 488.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY594 0.1ml
EUR 474
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-DY633 0.1ml
EUR 468
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Dylight 633.

Antibody for Human GSK3b (pSer9)

SPC-1384D-FITC 0.1ml
EUR 470.4
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to FITC.

Antibody for Human GSK3b (pSer9)

SPC-1384D-HRP 0.1ml
EUR 465.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to HRP.

Antibody for Human GSK3b (pSer9)

SPC-1384D-P594 0.1ml
EUR 488.4
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to PE/ATTO 594.

Antibody for Human GSK3b (pSer9)

SPC-1384D-PCP 0.1ml
EUR 478.8
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to PerCP.

Antibody for Human GSK3b (pSer9)

SPC-1384D-RPE 0.1ml
EUR 476.4
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to RPE .

Antibody for Human GSK3b (pSer9)

SPC-1384D-STR 0.1ml
EUR 477.6
Description: A polyclonal antibody for GSK3b (pSer9) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human GSK3b around the phosphorylation site of serine 9 (pSer9).. The Antibody is tested and validated for WB, IHC, IP assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:25-1:100); IP (Various dilutions). This GSK3b (pSer9) antibody is conjugated to Streptavidin.

GSK3B Polyclonal Antibody, HRP Conjugated

A62707-050 50 ul
EUR 302.5

GSK3B Polyclonal Antibody, HRP Conjugated

A62707-100 100 ul
EUR 423.5

GSK3B Polyclonal Antibody, FITC Conjugated

A62708-050 50 ul
EUR 302.5

GSK3B Polyclonal Antibody, FITC Conjugated

A62708-100 100 ul
EUR 423.5

GSK3B Polyclonal Antibody, Biotin Conjugated

A62709-050 50 ul
EUR 302.5

GSK3B Polyclonal Antibody, Biotin Conjugated

A62709-100 100 ul
EUR 423.5

GSK3B Polyclonal Antibody, HRP Conjugated

A62707
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody, FITC Conjugated

A62708
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

GSK3B Polyclonal Antibody, Biotin Conjugated

A62709
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Phospho-GSK3B-S9 Polyclonal Antibody

A72451
  • EUR 341.00
  • EUR 518.10
  • 50 ul
  • 100 ul

Phospho-GSK3B-Y216 Polyclonal Antibody

A72452
  • EUR 341.00
  • EUR 518.10
  • 50 ul
  • 100 ul

Phospho-GSK3B-S9 Polyclonal Antibody

A72451-050 50 ul
EUR 341

Phospho-GSK3B-S9 Polyclonal Antibody

A72451-100 100 ul
EUR 518.1

Phospho-GSK3B-Y216 Polyclonal Antibody

A72452-050 50 ul
EUR 341

Phospho-GSK3B-Y216 Polyclonal Antibody

A72452-100 100 ul
EUR 518.1

GSK3B Rabbit mAb

A10877-100ul 100 ul
EUR 460.8

GSK3B Rabbit mAb

A10877-200ul 200 ul
EUR 664.8

GSK3B Rabbit mAb

A10877-20ul 20 ul Ask for price

GSK3B Rabbit mAb

A10877-50ul 50 ul
EUR 318

GSK3B Rabbit pAb

A11360-100ul 100 ul
EUR 369.6

GSK3B Rabbit pAb

A11360-200ul 200 ul
EUR 550.8

GSK3B Rabbit pAb

A11360-20ul 20 ul
EUR 219.6

GSK3B Rabbit pAb

A11360-50ul 50 ul
EUR 267.6

GSK3B Rabbit pAb

A11578-100ul 100 ul
EUR 369.6

GSK3B Rabbit pAb

A11578-200ul 200 ul
EUR 550.8

GSK3B Rabbit pAb

A11578-20ul 20 ul
EUR 219.6

GSK3B Rabbit pAb

A11578-50ul 50 ul
EUR 267.6

GSK3b Blocking Peptide

33R-10782 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GSK3b antibody, catalog no. 70R-11869

GSK3B Rabbit pAb

A2081-100ul 100 ul
EUR 369.6

GSK3B Rabbit pAb

A2081-200ul 200 ul
EUR 550.8

GSK3B Rabbit pAb

A2081-20ul 20 ul
EUR 219.6

GSK3B Rabbit pAb

A2081-50ul 50 ul
EUR 267.6

GSK3B Rabbit pAb

A3174-100ul 100 ul
EUR 369.6

GSK3B Rabbit pAb

A3174-200ul 200 ul
EUR 550.8

GSK3B Rabbit pAb

A3174-20ul 20 ul
EUR 219.6

GSK3B Rabbit pAb

A3174-50ul 50 ul
EUR 267.6

GSK3B Rabbit pAb

A16868-100ul 100 ul
EUR 369.6

GSK3B Rabbit pAb

A16868-200ul 200 ul
EUR 550.8

GSK3B Rabbit pAb

A16868-20ul 20 ul
EUR 219.6

GSK3B Rabbit pAb

A16868-50ul 50 ul
EUR 267.6

GSK3B Blocking Peptide

BF0695-BP 1mg
EUR 234

GSK3B Blocking Peptide

DF7231-BP 1mg
EUR 234

GSK3B cloning plasmid

CSB-CL009963HU-10ug 10ug
EUR 568.8
Description: A cloning plasmid for the GSK3B gene.

Recombinant Human GSK3B

P0221 100ug
EUR 626.83
Description: Recombinant Human protein for GSK3B

pT7- His- GSK3B

PVT10128 2 ug
EUR 361.2

Rabbit Anti-Human GSK3B (aa 214-218) Polyclonal Antibody

CPB-1178RH 100 ul
EUR 552

Rabbit Anti-GSK3A, GSK3B monoclonal antibody, clone TZ37-16

CABT-L635 100 ul
EUR 932.4

Anti-Glycogen synthase kinase 3 B (GSK3B) (Ser9) antibody

STJ120111 100 µl
EUR 631.2

GSK3A / GSK3B (Ab-279 / 216) Antibody

abx332166-100ul 100 ul
EUR 510
Toxicity on stem and progenitor cell subsets remained minimal. Mixed, our outcomes present a powerful rationale for mixture remedies utilizing the P70S6K inhibitor in MM. Direct and particular inhibition of P70S6K may present an answer for sufferers ineligible or insensitive to dexamethasone or different glucocorticoids.

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