Cell Biology of Canonical Wnt Signaling

Wnt signaling has a number of capabilities past the transcriptional results of β-catenin stabilization. We evaluate current investigations that uncover new cell physiological results by means of the regulation of Wnt receptor endocytosis, Wnt-induced stabilization of proteins (Wnt-STOP), macropinocytosis, enhance in lysosomal exercise, and metabolic adjustments.

Many of those growth-promoting results of canonical Wnt happen inside minutes and are unbiased of latest protein synthesis. A key aspect is the sequestration of glycogen synthase kinase 3 (GSK3) inside multivesicular our bodies and lysosomes.

Twenty % of human proteins comprise consecutive GSK3 phosphorylation motifs, which within the absence of Wnt can kind phosphodegrons for polyubiquitination and proteasomal degradation. Wnt signaling by both the pharmacological inhibition of GSK3 or the lack of tumor-suppressor proteins, comparable to adenomatous polyposis coli (APC) and Axin1, will increase lysosomal acidification, anabolic metabolites, and macropinocytosis, which is often repressed by the GSK3-Axin1-APC destruction advanced.

The mixture of those cell physiological results drives cell development. Anticipated closing on-line publication date for the Annual Evaluate of Cell and Developmental Biology, Quantity 37 is October 2021.

Interacting Fashions of Amyloid-β and Tau Proteins: An Strategy to Determine Drug Targets in Alzheimer’s Illness

Alzheimer’s illness (AD) is the first reason for dementia affecting thousands and thousands every year internationally, although nonetheless stays incurable. This may be attributed to the lack of know-how concerning the related proteins, their mobile and molecular mechanisms, and the genesis of the illness.

The invention of medicine that earlier revolved round concentrating on the amyloid-β cascade has now been reformed with the upgraded data of the cross-seeding capability of tau protein which opens new gateways for therapeutic targets.

This text gives a complete evaluate of assorted direct and oblique connecting pathways between the 2 most important proteins concerned in growth and development of AD, enabling us to additional increase our repertoire of data concerning the etiology of AD. The present evaluate signifies the necessity for intensive analysis on this area of interest, thus appreciable advances may be made in understanding AD which finally helps to enhance the present therapeutics towards AD.

Membrane-associated RING-CH Eight capabilities as a novel PD-L1 E3 ligase to mediate PD-L1 degradation induced by EGFR inhibitors

Expression of programmed death-ligand 1 (PD-L1) on most cancers cells is a vital mechanism contributing to immunosuppression and immune escape. PD-L1 expression can also influence therapeutic outcomes of epidermal development issue receptor (EGFR)-targeted remedy (e.g., with osimertinib/AZD9291) towards EGFR mutant non-small cell lung cancers (NSCLCs) and may even be altered through the remedy albeit with largely undefined mechanisms.

This examine primarily focuses on elucidating the mechanism by which osimertinib induces PD-L1 degradation along with validating osimertinib’s impact on lowering PD-L1 expression in EGFR mutant NSCLC cells and tumors. Osimertinib and different EGFR inhibitors successfully decreased PD-L1 ranges primarily in EGFR mutant NSCLCs and xenografted tumors.

Osimertinib not solely decreased PD-L1 mRNA expression, but additionally prompted proteasomal degradation of PD-L1 protein, indicating each transcriptional and posttranslational mechanisms accounting for osimertinib-induced discount of PD-L1. Knockdown of β-TrCP or inhibition of GSK3 failed to forestall PD-L1 discount induced by osimertinib.

Fairly, knockdown of membrane-associated RING-CH 8 (MARCH8) that encodes a membrane-bound E3 ubiquitin ligase rescued osimertinib-induced PD-L1 discount. Moreover, manipulation of MARCH8 expression accordingly altered PD-L1 degradation fee. Critically, MARCH8 interacted with PD-L1 by means of its N-terminal area and likewise ubiquitinated PD-L1 in cells.

Collectively, these outcomes strongly recommend that MARCH8 is a beforehand undiscovered E3 ubiquitin ligase accountable for PD-L1 degradation together with osimertinib-induced PD-L1 degradation, establishing a novel connection between MARCH8 and PD-L1 regulation.

Implications: This examine has demonstrated new perform of MARCH8 in mediating PD-L1 degradation induced by EGFR inhibitors in NSCLC cells, establishing a novel connection between MARCH8 and PD-L1 regulation.

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by lowering Wnt/β-catenin signaling

Job syndrome is a uncommon genetic dysfunction brought on by STAT3 mutations and primarily characterised by immune dysfunction together with comorbid skeleton developmental abnormalities together with osteopenia, recurrent fracture of lengthy bones, and scoliosis.

To this point, there isn’t a definitive treatment for the skeletal defects in Job syndrome, and coverings are restricted to administration of scientific signs solely. Right here, we’ve got investigated the molecular mechanism whereby Stat3 regulates skeletal growth and osteoblast differentiation.

We confirmed that eradicating Stat3 perform within the growing limb mesenchyme or osteoprogenitor cells in mice resulted in shortened and bow limbs with a number of fractures in lengthy bones that resembled the skeleton signs within the Job Syndrome.

Nevertheless, Stat3 loss didn’t alter chondrocyte differentiation and hypertrophy in embryonic growth, whereas osteoblast differentiation was severely lowered. Genome-wide transcriptome analyses in addition to biochemical and histological research confirmed that Stat3 loss resulted in down-regulation of Wnt/β-catenin signaling.

Restoration of Wnt/β-catenin signaling by injecting BIO, a small molecule inhibitor of GSK3, or crossing with a Lrp5 acquire of perform (GOF) allele, rescued the bone discount phenotypes because of Stat3 loss to an awesome extent.

These research uncover the important capabilities of Stat3 in sustaining Wnt/β-catenin signaling in early mesenchymal or osteoprogenitor cells and supply proof that bone defects within the Job Syndrome are doubtless brought on by Wnt/β-catenin signaling discount because of lowered STAT3 actions in bone growth. Enhancing Wnt/β-catenin signaling might be a therapeutic strategy to cut back bone signs of Job syndrome sufferers.

Mixture of Melatonin and Small Molecules Improved Reprogramming Neural Cell Fates by way of Autophagy Activation

Reprogramming cell fates in direction of mature cell varieties are a promising cell provide for treating degenerative illnesses. Just lately, transcription elements and a few small molecules have was spectacular modulating components for reprogramming cell fates.

Melatonin, a pineal hormone, has neuroprotective capabilities together with neural stem cell (NSC) proliferative and differentiative modulation in each embryonic and grownup mind. We developed a protocol that might be carried out within the direct reprogramming of human pores and skin fibroblast in direction of neural cells through the use of histone deacetylase (HDAC) inhibitor, glycogen synthase kinase-3 (GSK3) inhibitor (CHIR99021), c-Jun N-terminal kinase (JNK) inhibitor, rho-associated protein kinase inhibitor (Y-27632), cAMP activator, and melatonin remedy.

We discovered that melatonin enhanced neural-transcription issue genes expressions, together with brain-specific homeobox/POU area protein 2 (BRN2), Achaete-Scute Household BHLH transcription Issue 1 (ASCL1), and Myelin Transcription Issue 1 Like (MYT1L).

Melatonin additionally elevated the expression of various neural-specific proteins comparable to doublecortin (DCX), Intercourse figuring out area Y-box 2 (Sox2), and neuronal nuclei (NeuN) in contrast with different 5 small molecules (valproic acid (VPA), CHIR99021, Forskolin, 1,9 pyrazoloanthrone (SP600125), and Y-27632) mixture within the presence and absence of melatonin.

GSK3 alpha Antibody
48179-100ul	SAB	100ul	EUR 333

GSK3 alpha Antibody
48179-50ul	SAB	50ul	EUR 239

GSK3 alpha antibody
10R-1930	Fitzgerald	100 ul	EUR 403
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody
10R-2025	Fitzgerald	100 ul	EUR 435
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody
10R-2104	Fitzgerald	100 ul	EUR 403
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody
70R-37447	Fitzgerald	100 ug	EUR 273
Description: Rabbit Polyclonal GSK3 alpha antibody

GSK3 alpha antibody
70R-49830	Fitzgerald	100 ul	EUR 287
Description: Purified Polyclonal GSK3 alpha antibody

GSK3 alpha antibody
70R-34164	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal GSK3 alpha antibody

GSK3 alpha Antibody
abx015750-100ul	Abbexa	100 ul	EUR 411
Shipped within 5-10 working days.

GSK3 alpha Antibody
abx015751-100ul	Abbexa	100 ul	EUR 411
Shipped within 5-10 working days.

GSK3 alpha Antibody
20-abx133173	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

GSK3 alpha Antibody
abx010857-100ul	Abbexa	100 ul	EUR 411
Shipped within 5-10 working days.

GSK3 alpha Antibody
20-abx012858	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg
Shipped within 5-10 working days.

GSK3 alpha Antibody
abx033883-400ul	Abbexa	400 ul	EUR 523
Shipped within 5-10 working days.

GSK3 alpha Antibody
abx033883-80l	Abbexa	80 µl	EUR 286
Shipped within 5-10 working days.

GSK3 alpha Antibody
AF6336	Affbiotech	200ul	EUR 304
Description: GSK3 alpha Antibody detects endogenous levels of total GSK3 alpha.

GSK3 alpha Antibody
BF0391	Affbiotech	200ul	EUR 376
Description: GSK3 alpha antibody detects endogenous levels of total GSK3 alpha.

GSK3 alpha Antibody
AF7813	Affbiotech	200ul	EUR 376
Description: GSK3 alpha Antibody detects endogenous levels of GSK3 alpha.

GSK3 alpha Antibody
ABF6336	Lifescience Market	100 ug	EUR 438

Anti-Phospho-GSK alpha (S21) antibody
STJ90282	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-GSK3alpha (S21).

Cytokeratin (Pan-reactive) Antibody (PE)
abx140315-01mg	Abbexa	0.1 mg	EUR 523
Shipped within 5-12 working days.

Cytokeratin (Pan-reactive) Antibody (APC)
abx140316-01mg	Abbexa	0.1 mg	EUR 523
Shipped within 5-12 working days.

Cytokeratin (Pan-reactive) Antibody (Biotin)
abx140317-01mg	Abbexa	0.1 mg	EUR 425
Shipped within 5-12 working days.

Cytokeratin (Pan-reactive) Antibody (FITC)
abx140318-01mg	Abbexa	0.1 mg	EUR 467
Shipped within 5-12 working days.

anti-GSK3 alpha (6G2F1)
LF-MA30074	Abfrontier	100 ul	EUR 537
Description: Mouse Monoclonal to GSK3 alpha

anti-GSK3 alpha (9D5G1)
LF-MA30111	Abfrontier	100 ul	EUR 486
Description: Mouse Monoclonal to GSK3 alpha

anti-GSK3 alpha (6G12C2)
LF-MA30112	Abfrontier	100 ul	EUR 486
Description: Mouse Monoclonal to GSK3 alpha

Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone
CABT-B9017-05mg	Creative Diagnostics	0.5 mg	EUR 897

Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone
CABT-B9017-1mg	Creative Diagnostics	1 mg	EUR 1339

Anti-Phospho-C/EBP alpha (S21) antibody
STJ90757	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-C/EBP alpha (S21).

GSK3 alpha/beta Antibody
29039-100ul	SAB	100ul	EUR 252

GSK3 alpha/beta antibody
70R-30578	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal GSK3 alpha/beta antibody

GSK3 alpha antibody (Ser21)
70R-37089	Fitzgerald	100 ug	EUR 349
Description: Rabbit Polyclonal GSK3 alpha antibody (Ser21)

GSK3 alpha/beta antibody
70R-49831	Fitzgerald	100 ul	EUR 244
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta antibody
70R-51552	Fitzgerald	100 ul	EUR 287
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha antibody (Ser21)
70R-34163	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal GSK3 alpha antibody (Ser21)

GSK3 alpha / beta Antibody
20-abx009185	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

GSK3 alpha (pS21) Antibody
20-abx009689	Abbexa	EUR 314.00 EUR 467.00 EUR 203.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

GSK3 alpha (pS21) Antibody
abx010870-100ug	Abbexa	100 ug	EUR 439
Shipped within 5-10 working days.

GSK3 alpha Conjugated Antibody
C48179	SAB	100ul	EUR 397

GSK3 alpha/beta Antibody
AF6335	Affbiotech	200ul	EUR 304
Description: GSK3 alpha/beta Antibody detects endogenous levels of total GSK3 alpha/beta.

GSK3 alpha/beta Antibody
ABF6335	Lifescience Market	100 ug	EUR 438

Anti-Cav pan alpha antibody
STJ97558	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Cav pan alpha1 (A211).

Anti-MRP-S21 antibody
STJ94245	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to MRP-S21.

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Anti-GSK3 beta antibody
STJ99095	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to GSK3 beta.

GSK3 alpha (Phospho-Ser282) Antibody
13162-100ul	SAB	100ul	EUR 252

GSK3 alpha (Phospho-Ser282) Antibody
13162-50ul	SAB	50ul	EUR 187

GSK3 alpha (Phospho-Ser21) Antibody
20-abx012539	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg
Shipped within 5-10 working days.

Phospho-GSK3 alpha (Ser21) Antibody
AF3336	Affbiotech	200ul	EUR 304
Description: Phospho-GSK3 alpha (Ser21) Antibody detects endogenous levels of GSK3 alpha only when phosphorylated at Serine 21.

Phospho-GSK3 alpha (Ser282) Antibody
AF7313	Affbiotech	200ul	EUR 376
Description: Phospho-GSK3 alpha (Ser282) Antibody detects endogenous levels of GSK3 alpha only when phosphorylated at Ser282.

GSK3 alpha/beta Conjugated Antibody
C29039	SAB	100ul	EUR 397

Phospho- GSK3 alpha (Ser21) Antibody
ABF3336	Lifescience Market	100 ug	EUR 438

GSK3 alpha recombinant monoclonal antibody
A5830	Bimake	100ul X 3	EUR 595
Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however, Show more
Description: A recombinant monoclonal antibody from rabbit against human GSK3 alpha for WB, IHC,ELISA

Anti-Phospho-FYN-(S21) antibody
STJ110850	St John's Laboratory	100 µl	EUR 393
Description: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

Anti-Phospho-GSK3A-(S21) antibody
STJ29348	St John's Laboratory	100 µl	EUR 393
Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.

Anti-Phospho-GSK3A-(S21) antibody
STJ22159	St John's Laboratory	100 µl	EUR 393
Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.

Anti-Ribosomal Protein S21 antibody
STJ95495	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Ribosomal Protein S21.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species)
4-RAA398Ge21	Cloud-Clone	EUR 339.00 EUR 3962.00 EUR 955.00 EUR 442.00 EUR 253.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA)

Recombinant Antibody to Digoxin (DGX) (Pan-species)
4-RAK639Ge21	Cloud-Clone	EUR 339.00 EUR 3962.00 EUR 955.00 EUR 442.00 EUR 253.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX)

Anti-Na+ CP type alpha-pan antibody
STJ94334	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Na+ CP type alpha-pan.

GSK3 antibody
20R-1609	Fitzgerald	100 ug	EUR 673
Description: Rabbit polyclonal GSK3 antibody

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma)-biotinylated
ACTB24-BTN	Alpha Diagnostics	50 ul	EUR 408

GSK3 alpha/beta antibody (Tyr279/216)
70R-30577	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal GSK3 alpha/beta antibody (Tyr279/216)

GSK3 alpha / beta (pT279 / 216) Antibody
20-abx009652	Abbexa	EUR 314.00 EUR 467.00 EUR 203.00	100 ul 200 ul 30 ul
Shipped within 5-10 working days.

GSK3 alpha / beta (pY279 / 216) Antibody
20-abx119370	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg
Shipped within 5-10 working days.

GSK3 alpha / beta (pY279 / 216) Antibody
abx010868-100ug	Abbexa	100 ug	EUR 439
Shipped within 5-10 working days.

Monoclonal GSK3 alpha Antibody, Clone: 9D5G1
APR12317G	Leading Biology	0.1ml	EUR 484
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 9D5G1. This antibody is applicable in WB, ICC, E

GSK3 alpha (Phospho-Ser282) Conjugated Antibody
C13162	SAB	100ul	EUR 397

Monoclonal GSK3 alpha Antibody, Clone: EP793Y
AMM05996G	Leading Biology	0.1ml	EUR 528
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Rabbit and are from clone EP793Y. This antibody is applicable in WB and IHC

Recombinant Antibody to C Reactive Protein (CRP) (Human)
4-RAA821Hu21	Cloud-Clone	EUR 339.00 EUR 3962.00 EUR 955.00 EUR 442.00 EUR 253.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Phe17~Pro224 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Human C Reactive Protein (CRP)

Anti-RPS21/Ribosomal Protein S21 Antibody
A10068	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal RPS21/Ribosomal Protein S21 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-Phospho-GRK 1 (S21) antibody
STJ90901	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-GRK 1 (S21).

Anti-Phospho-HMG-14 (S21) antibody
STJ91313	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Phospho-HMG-14 (S21).

Melanoma; Pan (Ready-To-Use)
A00134-0002	ScyTek Laboratories	2 ml	EUR 140

Melanoma; Pan (Ready-To-Use)
A00134-0007	ScyTek Laboratories	7 ml	EUR 272

Melanoma; Pan (Ready-To-Use)
A00134-0025	ScyTek Laboratories	25 ml	EUR 717

Rabbit Anti-Actin (Pan, alpha, beta, gamma) IgG, aff pure
ACTB22-A	Alpha Diagnostics	100 ug	EUR 482

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), APC
4-RAA398Ge21-APC	Cloud-Clone	EUR 484.00 EUR 5255.00 EUR 1407.00 EUR 638.00 EUR 278.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with APC.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Biotinylated
4-RAA398Ge21-Biotin	Cloud-Clone	EUR 413.00 EUR 3912.00 EUR 1090.00 EUR 526.00 EUR 262.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Biotin.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Cy3
4-RAA398Ge21-Cy3	Cloud-Clone	EUR 603.00 EUR 6965.00 EUR 1835.00 EUR 809.00 EUR 330.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Cy3.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), FITC
4-RAA398Ge21-FITC	Cloud-Clone	EUR 407.00 EUR 4224.00 EUR 1146.00 EUR 530.00 EUR 243.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with FITC.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), HRP
4-RAA398Ge21-HRP	Cloud-Clone	EUR 436.00 EUR 4571.00 EUR 1236.00 EUR 569.00 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with HRP.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), PE
4-RAA398Ge21-PE	Cloud-Clone	EUR 407.00 EUR 4224.00 EUR 1146.00 EUR 530.00 EUR 243.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with PE.

Recombinant Antibody to Digoxin (DGX) (Pan-species), APC
4-RAK639Ge21-APC	Cloud-Clone	EUR 484.00 EUR 5255.00 EUR 1407.00 EUR 638.00 EUR 278.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with APC.

Recombinant Antibody to Digoxin (DGX) (Pan-species), Biotinylated
4-RAK639Ge21-Biotin	Cloud-Clone	EUR 413.00 EUR 3912.00 EUR 1090.00 EUR 526.00 EUR 262.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Biotin.

Recombinant Antibody to Digoxin (DGX) (Pan-species), Cy3
4-RAK639Ge21-Cy3	Cloud-Clone	EUR 603.00 EUR 6965.00 EUR 1835.00 EUR 809.00 EUR 330.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Cy3.

Recombinant Antibody to Digoxin (DGX) (Pan-species), FITC
4-RAK639Ge21-FITC	Cloud-Clone	EUR 407.00 EUR 4224.00 EUR 1146.00 EUR 530.00 EUR 243.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with FITC.

Recombinant Antibody to Digoxin (DGX) (Pan-species), HRP
4-RAK639Ge21-HRP	Cloud-Clone	EUR 436.00 EUR 4571.00 EUR 1236.00 EUR 569.00 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with HRP.

Recombinant Antibody to Digoxin (DGX) (Pan-species), PE
4-RAK639Ge21-PE	Cloud-Clone	EUR 407.00 EUR 4224.00 EUR 1146.00 EUR 530.00 EUR 243.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with PE.

Anti-Phospho-GSK3 (alpha + beta) (Y216 + Y279) Rabbit Monoclonal Antibody
P03152-1	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal Phospho-GSK3 (alpha + beta) (Y216 + Y279) Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

GSK3 alpha Blocking Peptide
20-abx161877	Abbexa	EUR 272.00 EUR 411.00	1 mg 5 mg
Shipped within 5-10 working days.

GSK3 alpha Blocking Peptide
AF6336-BP	Affbiotech	1mg	EUR 195

GSK3 alpha Blocking Peptide
BF0391-BP	Affbiotech	1mg	EUR 195

GSK3 alpha Blocking Peptide
AF7813-BP	Affbiotech	1mg	EUR 195

Anti- Myosin-pan Antibody
A1213-100	Biovision		EUR 403

Anti-Keratin-pan Antibody
A05667	BosterBio	100ul	EUR 397
Description: Rabbit Polyclonal Antibody for Keratin-pan Antibody (KRT2) detection.tested for IHC, WB in Human, Mouse, Rat.

anti- Pan-PAX antibody
FNab06136	FN Test	100µg	EUR 505.25
Recommended dilution: WB: 1:500-1:2000 IP: 1:500-1:1000 IHC: 1:50-1:500 Immunogen: paired box 8 Uniprot ID: Q06710 Research Area: Cancer, Immunology, Metabolism, Developmental biology
Description: Antibody raised against Pan-PAX

anti- Pan Keratin antibody
FNab09935	FN Test	100µg	EUR 548.75
Recommended dilution: WB: 1:20000 - 1:100000 IHC: 1:500 - 1:3000 Immunogen: keratin 5 Uniprot ID: P13647 Gene ID: 3852
Description: Antibody raised against Pan Keratin

anti- Pan Keratin antibody
LSMab09935	Lifescience Market	100 ug	EUR 386

Anti-Pan-PAX antibody
PAab06136	Lifescience Market	100 ug	EUR 355

Anti-Pan-AKT antibody
STJ11100091	St John's Laboratory	100 µl	EUR 277

Anti-Pan PKC antibody
STJ119907	St John's Laboratory	100 µl	EUR 277

Anti-Periostin pan antibody
STJ120192	St John's Laboratory	100 µl	EUR 526

Anti-Pan-Keratin antibody
STJ16100232	St John's Laboratory	1 mL	EUR 290

Anti-Keratin-pan antibody
STJ96694	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Keratin-pan.

Anti-pan ADH antibody
STJ70639	St John's Laboratory	100 µg	EUR 359

Anti-Cytokeratin, Pan antibody
STJ180154	St John's Laboratory	0.1 ml	EUR 212

Anti-Cytokeratin, Pan antibody
STJ180390	St John's Laboratory	0.1 ml	EUR 230

Anti-cadherin-pan antibody
STJ190003	St John's Laboratory	200 µl	EUR 197
Description: Unconjugated Mouse monoclonal to cadherin-pan (AS1A23)

Anti-Collagen PAN antibody
STJ190046	St John's Laboratory	200 µl	EUR 197
Description: Unconjugated Mouse monoclonal to Collagen PAN (7B1)

Anti-PKC-pan antibody
STJ190083	St John's Laboratory	200 µl	EUR 197
Description: Unconjugated Mouse monoclonal to PKC-pan (1D2)

Anti-MYH-pan antibody
STJ96792	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to MYH-pan.

Anti-Cytokeratin (Pan) antibody
STJ97993	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Cytokeratin (Pan).

Anti-Cytokeratin (Pan) antibody
STJ97994	St John's Laboratory	100 µl	EUR 234
Description: Mouse monoclonal to Cytokeratin (Pan).

Anti-Pan myristoylation antibody
STJ98665	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Pan myristoylation.

Anti-Pan myristoylation antibody
STJ98666	St John's Laboratory	200 µl	EUR 197
Description: Pan myristoylation protein is encoded by the MARCKS gene which is approximately 31,6 kDa. It is localised to the cytoplasm. It is involved in the integration of energy metabolism, Fc gamma R-mediated phagocytosis, microRNAs and Ca, cAMP and lipid signalling. It is the most prominent cellular substrate for protein kinase C and is an actin filament crosslinking protein. It is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. Pan myristoylation is expressed in the nervous system, liver, lung, skin and heart. Mutations in the MARCKS gene can result in spinocerebellar ataxia and anencephaly. STJ98666 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. The antibody detects endogenous pan myristoylation protein.

Anti-Keratin-pan antibody
STJ98693	St John's Laboratory	200 µl	EUR 197
Description: Rabbit polyclonal to Keratin-pan.

Anti-Akt (pan) antibody
STJ99073	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Akt (pan).

Anti-Akt (pan) antibody
STJ99074	St John's Laboratory	200 µl	EUR 197
Description: Mouse monoclonal to Akt (pan).

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody
13355-100ul	SAB	100ul	EUR 333

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody
13355-50ul	SAB	50ul	EUR 239

Polyclonal GSK3 alpha (GSK3A) Antibody (C-term)
APS00025G	Leading Biology	0.1ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (C-term). This antibody is tested and proven to work in the following applications:

Phospho-GSK3 alpha/ beta (Tyr279/216) Antibody
AF3335	Affbiotech	200ul	EUR 304
Description: Phospho-GSK3 alpha/ beta (Tyr279/216) Antibody detects endogenous levels of GSK3 alpha/ beta only when phosphorylated at Tyrosine 279/216.

Polyclonal GSK3 alpha (GSK3A) Antibody (N-term)
APR12316G	Leading Biology	0.1ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (N-term). This antibody is tested and proven to work in the following applications:

Monoclonal GSK3 alpha/beta Antibody, Clone: EP933Y
APR12318G	Leading Biology	0.1ml	EUR 528
Description: A Monoclonal antibody against Human GSK3 alpha/beta. The antibodies are raised in Rabbit and are from clone EP933Y. This antibody is applicable in WB

Monoclonal GSK3 alpha Antibody, Clone: 6G2F1; 6G2F2
AMM02621G	Leading Biology	0.1ml	EUR 528
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 6G2F1; 6G2F2. This antibody is applicable in WB and IHC, E

Phospho- GSK3 alpha/ beta (Tyr279/216) Antibody
ABF3335	Lifescience Market	100 ug	EUR 438

anti-GSK3 beta
YF-PA12137	Abfrontier	100 ug	EUR 403
Description: Rabbit polyclonal to GSK3 beta

anti-GSK3 beta
YF-PA23834	Abfrontier	50 ul	EUR 334
Description: Mouse polyclonal to GSK3 beta

Anti-GSK3 beta Rabbit Monoclonal Antibody
M00791	BosterBio	100ug/vial	EUR 397
Description: Rabbit Monoclonal GSK3 beta Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Recombinant Antibody to C Reactive Protein (CRP) (Human), APC
4-RAA821Hu21-APC	Cloud-Clone	EUR 484.00 EUR 5255.00 EUR 1407.00 EUR 638.00 EUR 278.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Phe17~Pro224 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Human C Reactive Protein (CRP). This antibody is labeled with APC.

Recombinant Antibody to C Reactive Protein (CRP) (Human), Biotinylated
4-RAA821Hu21-Biotin	Cloud-Clone	EUR 413.00 EUR 3912.00 EUR 1090.00 EUR 526.00 EUR 262.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Phe17~Pro224 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Human C Reactive Protein (CRP). This antibody is labeled with Biotin.

Recombinant Antibody to C Reactive Protein (CRP) (Human), Cy3
4-RAA821Hu21-Cy3	Cloud-Clone	EUR 603.00 EUR 6965.00 EUR 1835.00 EUR 809.00 EUR 330.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Phe17~Pro224 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Human C Reactive Protein (CRP). This antibody is labeled with Cy3.

Recombinant Antibody to C Reactive Protein (CRP) (Human), FITC
4-RAA821Hu21-FITC	Cloud-Clone	EUR 407.00 EUR 4224.00 EUR 1146.00 EUR 530.00 EUR 243.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Phe17~Pro224 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Human C Reactive Protein (CRP). This antibody is labeled with FITC.

Recombinant Antibody to C Reactive Protein (CRP) (Human), HRP
4-RAA821Hu21-HRP	Cloud-Clone	EUR 436.00 EUR 4571.00 EUR 1236.00 EUR 569.00 EUR 258.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Phe17~Pro224 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Human C Reactive Protein (CRP). This antibody is labeled with HRP.

Recombinant Antibody to C Reactive Protein (CRP) (Human), PE
4-RAA821Hu21-PE	Cloud-Clone	EUR 407.00 EUR 4224.00 EUR 1146.00 EUR 530.00 EUR 243.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Phe17~Pro224 Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Human C Reactive Protein (CRP). This antibody is labeled with PE.

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG-Cy3 conjugate
ACTB24-Cy3	Alpha Diagnostics	100 ul	EUR 408

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG-FITC conjugate
ACTB24-FITC	Alpha Diagnostics	100 ul	EUR 408

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG, aff pure
ACTB24-M	Alpha Diagnostics	100 ug	EUR 482

GSK3 beta antibody
20R-1878	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
20R-2124	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
20R-2187	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
20R-2452	Fitzgerald	50 ug	EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-30634	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
10R-8595	Fitzgerald	100 ul	EUR 393
Description: Mouse monoclonal GSK3 beta antibody

GSK3 beta Antibody
48798-100ul	SAB	100ul	EUR 333

GSK3 beta Antibody
48798-50ul	SAB	50ul	EUR 239

GSK3 beta antibody
70R-34639	Fitzgerald	100 ug	EUR 327
Description: Purified Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-37442	Fitzgerald	100 ug	EUR 273
Description: Rabbit Polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-49832	Fitzgerald	100 ul	EUR 287
Description: Purified Polyclonal GSK3 beta antibody

GSK3 beta antibody
70R-34165	Fitzgerald	100 ug	EUR 327
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta Antibody
AF5016	Affbiotech	200ul	EUR 304
Description: GSK3 beta Antibody detects endogenous levels of total GSK3 beta.

GSK3 beta antibody
BF0721	Affbiotech	200ul	EUR 376
Description: GSK3 beta mouse monoclonal antibody detects endogenous levels of total GSK3 beta.

GSK3 beta Antibody
abx449182-100ug	Abbexa	100 ug	EUR 551
Shipped within 5-12 working days.

GSK3 beta Antibody
AF7814	Affbiotech	200ul	EUR 376
Description: GSK3 beta Antibody detects endogenous levels of GSK3 beta.

GSK3 beta Antibody
ABF5016	Lifescience Market	100 ug	EUR 438

GSK3 (pS9) Antibody
20-abx000124	Abbexa	EUR 495.00 EUR 704.00 EUR 217.00 EUR 356.00	100 ul 200 ul 20 ul 50 ul
Shipped within 5-10 working days.

GSK3? Polyclonal Antibody
ES8198-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

GSK3? Polyclonal Antibody
ES8198-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

GSK3? Polyclonal Antibody
ES5683-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody
ES5683-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody
ES2485-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody
ES2485-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3?/? Polyclonal Antibody
ES2486-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3?/? Polyclonal Antibody
ES2486-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody
ES2487-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody
ES2487-50ul	ELK Biotech	50ul	EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), APC-Cy7
4-RAA398Ge21-APC-Cy7	Cloud-Clone	EUR 848.00 EUR 10390.00 EUR 2695.00 EUR 1156.00 EUR 437.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with APC-Cy7.

Recombinant Antibody to Digoxin (DGX) (Pan-species), APC-Cy7
4-RAK639Ge21-APC-Cy7	Cloud-Clone	EUR 848.00 EUR 10390.00 EUR 2695.00 EUR 1156.00 EUR 437.00	100ul 10ml 1ml 200ul 20ul
Sequence of the immunogen: Inquire for antigen sequence. Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with APC-Cy7.

dsDNA-cellulose (affinity support) (for removing autoantibodies to dsDNA or DNA-binding proteins)
DNAD15-AS	Alpha Diagnostics	100 mg	EUR 225

ssDNA-cellulose (affinity support) (for removing autoantibodies to ssDNA or DNA-binding proteins)
DNAS25-AS	Alpha Diagnostics	100 mg	EUR 225

OR Antibody
44609-100ul	SAB	100ul	EUR 252

OR Antibody
44609-50ul	SAB	50ul	EUR 187

OR Antibody
DF10250	Affbiotech	200ul	EUR 304
Description: OR Antibody detects endogenous levels of total OR.

OR Antibody
20-abx217389	Abbexa	EUR 425.00 EUR 342.00	100 ug 50 ug
Shipped within 5-10 working days.

OR Antibody
ABD10250	Lifescience Market	100 ug	EUR 438

MRP-S21 Polyclonal Antibody
41179-100ul	SAB	100ul	EUR 252

MRP-S21 Polyclonal Antibody
41179-50ul	SAB	50ul	EUR 187

Phospho-CEBPA (S21) Antibody
1-CSB-PA000685	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Form: Liquid Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against Phospho-CEBPA (S21). Recognizes Phospho-CEBPA (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-GSK3A (S21) Antibody
1-CSB-PA000534	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Form: Liquid Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against Phospho-GSK3A (S21). Recognizes Phospho-GSK3A (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

Phospho-GRK1 (S21) Antibody
1-CSB-PA040218	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Form: Liquid Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against Phospho-GRK1 (S21). Recognizes Phospho-GRK1 (S21) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Polyclonal GSK3A Antibody (S21)
APR12320G	Leading Biology	0.1ml	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3A (S21). This antibody is tested and proven to work in the following applications:

Phospho-HMGN1 (S21) Antibody
1-CSB-PA009215	Cusabio	EUR 222.00 EUR 195.00	100ug 50ug
Form: Liquid Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against Phospho-HMGN1 (S21). Recognizes Phospho-HMGN1 (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

MRP-S21 Polyclonal Antibody
ABP51848-003ml	Abbkine	0.03ml	EUR 158
Immunogen information: Synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90 Applications tips:
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90

MRP-S21 Polyclonal Antibody
ABP51848-01ml	Abbkine	0.1ml	EUR 289
Immunogen information: Synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90 Applications tips:
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90

MRP-S21 Polyclonal Antibody
ABP51848-02ml	Abbkine	0.2ml	EUR 414
Immunogen information: Synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90 Applications tips:
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90

MRP-S21 Polyclonal Antibody
ES2847-100ul	ELK Biotech	100ul	EUR 279
Description: A Rabbit Polyclonal antibody against MRP-S21 from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

A noticeable upregulation of autophagy proteins (microtubule-associated protein 1A/1B-light chain 3 (LC3) and Beclin-1) had been seen within the melatonin remedy through the induction interval whereas these had been reverted within the presence of L-leucine, an autophagy inhibitor. As well as, the expression of NeuN was additionally considerably lowered by L-leucine. Collectively, our findings revealed an activation of autophagy throughout neural induction; melatonin enhanced reprogramming effectivity for neuron induction by means of the modulation of autophagy activation.

Tags: destination vector egfp c1 eyfp sequence lenticrispr v2 p3xflag cmv 10 pacyc184 pcmv flag pcmv vsv g pcr2 1 sequence pcr2 1 topo vector pcr2 1 vector pdest pdisplay pet19b petduet vector pexpress pfgc5941 plko 1 vector plko tet on pproex prset vector psicheck2 pspax2 puc19 invitrogen sv40 promoter sequence yfp