Ae1 Ae3 Antibody Bafilomycin A1 Bile Acid Assay Bioassay Blog Epz 6438 exosome F Actin Antibody Glycodeoxycholic Acid Ldn 193189 Mip 1B Mmp Activity Assay Mouse Albumin Elisa Pamabrom 100Mg Soft Agar Sr 9011 Trypsin Activity Assay Tubastatin A Uric Acid Assay
Cell Biology of Canonical Wnt Signaling
Wnt signaling has a number of capabilities past the transcriptional results of β-catenin stabilization. We evaluate current investigations that uncover new cell physiological results by means of the regulation of Wnt receptor endocytosis, Wnt-induced stabilization of proteins (Wnt-STOP), macropinocytosis, enhance in lysosomal exercise, and metabolic adjustments.
Many of those growth-promoting results of canonical Wnt happen inside minutes and are unbiased of latest protein synthesis. A key aspect is the sequestration of glycogen synthase kinase 3 (GSK3) inside multivesicular our bodies and lysosomes.
Twenty % of human proteins comprise consecutive GSK3 phosphorylation motifs, which within the absence of Wnt can kind phosphodegrons for polyubiquitination and proteasomal degradation. Wnt signaling by both the pharmacological inhibition of GSK3 or the lack of tumor-suppressor proteins, comparable to adenomatous polyposis coli (APC) and Axin1, will increase lysosomal acidification, anabolic metabolites, and macropinocytosis, which is often repressed by the GSK3-Axin1-APC destruction advanced.
The mixture of those cell physiological results drives cell development. Anticipated closing on-line publication date for the Annual Evaluate of Cell and Developmental Biology, Quantity 37 is October 2021.
Interacting Fashions of Amyloid-β and Tau Proteins: An Strategy to Determine Drug Targets in Alzheimer’s Illness
Membrane-associated RING-CH Eight capabilities as a novel PD-L1 E3 ligase to mediate PD-L1 degradation induced by EGFR inhibitors
Expression of programmed death-ligand 1 (PD-L1) on most cancers cells is a vital mechanism contributing to immunosuppression and immune escape. PD-L1 expression can also influence therapeutic outcomes of epidermal development issue receptor (EGFR)-targeted remedy (e.g., with osimertinib/AZD9291) towards EGFR mutant non-small cell lung cancers (NSCLCs) and may even be altered through the remedy albeit with largely undefined mechanisms.
This examine primarily focuses on elucidating the mechanism by which osimertinib induces PD-L1 degradation along with validating osimertinib’s impact on lowering PD-L1 expression in EGFR mutant NSCLC cells and tumors. Osimertinib and different EGFR inhibitors successfully decreased PD-L1 ranges primarily in EGFR mutant NSCLCs and xenografted tumors.
Osimertinib not solely decreased PD-L1 mRNA expression, but additionally prompted proteasomal degradation of PD-L1 protein, indicating each transcriptional and posttranslational mechanisms accounting for osimertinib-induced discount of PD-L1. Knockdown of β-TrCP or inhibition of GSK3 failed to forestall PD-L1 discount induced by osimertinib.
Fairly, knockdown of membrane-associated RING-CH 8 (MARCH8) that encodes a membrane-bound E3 ubiquitin ligase rescued osimertinib-induced PD-L1 discount. Moreover, manipulation of MARCH8 expression accordingly altered PD-L1 degradation fee. Critically, MARCH8 interacted with PD-L1 by means of its N-terminal area and likewise ubiquitinated PD-L1 in cells.
Collectively, these outcomes strongly recommend that MARCH8 is a beforehand undiscovered E3 ubiquitin ligase accountable for PD-L1 degradation together with osimertinib-induced PD-L1 degradation, establishing a novel connection between MARCH8 and PD-L1 regulation.
Implications: This examine has demonstrated new perform of MARCH8 in mediating PD-L1 degradation induced by EGFR inhibitors in NSCLC cells, establishing a novel connection between MARCH8 and PD-L1 regulation.
Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by lowering Wnt/β-catenin signaling
Job syndrome is a uncommon genetic dysfunction brought on by STAT3 mutations and primarily characterised by immune dysfunction together with comorbid skeleton developmental abnormalities together with osteopenia, recurrent fracture of lengthy bones, and scoliosis.
To this point, there isn’t a definitive treatment for the skeletal defects in Job syndrome, and coverings are restricted to administration of scientific signs solely. Right here, we’ve got investigated the molecular mechanism whereby Stat3 regulates skeletal growth and osteoblast differentiation.
We confirmed that eradicating Stat3 perform within the growing limb mesenchyme or osteoprogenitor cells in mice resulted in shortened and bow limbs with a number of fractures in lengthy bones that resembled the skeleton signs within the Job Syndrome.
Nevertheless, Stat3 loss didn’t alter chondrocyte differentiation and hypertrophy in embryonic growth, whereas osteoblast differentiation was severely lowered. Genome-wide transcriptome analyses in addition to biochemical and histological research confirmed that Stat3 loss resulted in down-regulation of Wnt/β-catenin signaling.
Restoration of Wnt/β-catenin signaling by injecting BIO, a small molecule inhibitor of GSK3, or crossing with a Lrp5 acquire of perform (GOF) allele, rescued the bone discount phenotypes because of Stat3 loss to an awesome extent.
These research uncover the important capabilities of Stat3 in sustaining Wnt/β-catenin signaling in early mesenchymal or osteoprogenitor cells and supply proof that bone defects within the Job Syndrome are doubtless brought on by Wnt/β-catenin signaling discount because of lowered STAT3 actions in bone growth. Enhancing Wnt/β-catenin signaling might be a therapeutic strategy to cut back bone signs of Job syndrome sufferers.
Mixture of Melatonin and Small Molecules Improved Reprogramming Neural Cell Fates by way of Autophagy Activation
Reprogramming cell fates in direction of mature cell varieties are a promising cell provide for treating degenerative illnesses. Just lately, transcription elements and a few small molecules have was spectacular modulating components for reprogramming cell fates.
Melatonin, a pineal hormone, has neuroprotective capabilities together with neural stem cell (NSC) proliferative and differentiative modulation in each embryonic and grownup mind. We developed a protocol that might be carried out within the direct reprogramming of human pores and skin fibroblast in direction of neural cells through the use of histone deacetylase (HDAC) inhibitor, glycogen synthase kinase-3 (GSK3) inhibitor (CHIR99021), c-Jun N-terminal kinase (JNK) inhibitor, rho-associated protein kinase inhibitor (Y-27632), cAMP activator, and melatonin remedy.
We discovered that melatonin enhanced neural-transcription issue genes expressions, together with brain-specific homeobox/POU area protein 2 (BRN2), Achaete-Scute Household BHLH transcription Issue 1 (ASCL1), and Myelin Transcription Issue 1 Like (MYT1L).
Melatonin additionally elevated the expression of various neural-specific proteins comparable to doublecortin (DCX), Intercourse figuring out area Y-box 2 (Sox2), and neuronal nuclei (NeuN) in contrast with different 5 small molecules (valproic acid (VPA), CHIR99021, Forskolin, 1,9 pyrazoloanthrone (SP600125), and Y-27632) mixture within the presence and absence of melatonin.
 GSK3 alpha Antibody |
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| abx033883-80l | Abbexa | 80 µl | EUR 286 |
GSK3 alpha Antibody |
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| 48179-100ul | SAB | 100ul | EUR 333 |
GSK3 alpha Antibody |
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| 48179-50ul | SAB | 50ul | EUR 239 |
GSK3 alpha Antibody |
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| AF6336 | Affbiotech | 200ul | EUR 304 |
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Description: GSK3 alpha Antibody detects endogenous levels of total GSK3 alpha. |
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GSK3 alpha Antibody |
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| AF7813 | Affbiotech | 200ul | EUR 376 |
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Description: GSK3 alpha Antibody detects endogenous levels of GSK3 alpha. |
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GSK3 alpha Antibody |
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| BF0391 | Affbiotech | 200ul | EUR 376 |
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Description: GSK3 alpha antibody detects endogenous levels of total GSK3 alpha. |
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GSK3 alpha Antibody |
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| ABF6336 | Lifescience Market | 100 ug | EUR 438 |
 GSK3 alpha antibody |
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| 20R-1883 | Fitzgerald | 50 ug | EUR 281 |
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Description: Rabbit polyclonal GSK3 alpha antibody |
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GSK3 alpha antibody |
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| 20R-2192 | Fitzgerald | 50 ug | EUR 281 |
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Description: Rabbit polyclonal GSK3 alpha antibody |
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GSK3 alpha antibody |
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| 10R-1930 | Fitzgerald | 100 ul | EUR 403 |
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Description: Mouse monoclonal GSK3 alpha antibody |
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GSK3 alpha antibody |
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| 10R-2025 | Fitzgerald | 100 ul | EUR 435 |
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Description: Mouse monoclonal GSK3 alpha antibody |
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GSK3 alpha antibody |
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| 10R-2104 | Fitzgerald | 100 ul | EUR 403 |
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Description: Mouse monoclonal GSK3 alpha antibody |
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GSK3 alpha antibody |
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| 70R-34164 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal GSK3 alpha antibody |
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GSK3 alpha antibody |
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| 70R-49830 | Fitzgerald | 100 ul | EUR 287 |
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Description: Purified Polyclonal GSK3 alpha antibody |
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GSK3 alpha antibody |
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| 70R-37447 | Fitzgerald | 100 ug | EUR 273 |
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Description: Rabbit Polyclonal GSK3 alpha antibody |
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 antibody) Anti-Phospho-GSK alpha (S21) antibody |
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| STJ90282 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Phospho-GSK3alpha (S21). |
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 Antibody (APC)) Cytokeratin (Pan-reactive) Antibody (APC) |
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| abx140316-01mg | Abbexa | 0.1 mg | EUR 523 |
 Antibody (Biotin)) Cytokeratin (Pan-reactive) Antibody (Biotin) |
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| abx140317-01mg | Abbexa | 0.1 mg | EUR 425 |
 Antibody (FITC)) Cytokeratin (Pan-reactive) Antibody (FITC) |
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| abx140318-01mg | Abbexa | 0.1 mg | EUR 467 |
 Antibody (PE)) Cytokeratin (Pan-reactive) Antibody (PE) |
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| abx140315-01mg | Abbexa | 0.1 mg | EUR 523 |
 Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone |
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| CABT-B9017-05mg | Creative Diagnostics | 0.5 mg | EUR 897 |
Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone |
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| CABT-B9017-1mg | Creative Diagnostics | 1 mg | EUR 1339 |
 Anti-Cav pan alpha antibody |
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| STJ97558 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Cav pan alpha1 (A211). |
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) anti-GSK3 alpha (6G2F1) |
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| LF-MA30074 | Abfrontier | 100 ul | EUR 537 |
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Description: Mouse Monoclonal to GSK3 alpha |
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) anti-GSK3 alpha (9D5G1) |
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| LF-MA30111 | Abfrontier | 100 ul | EUR 486 |
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Description: Mouse Monoclonal to GSK3 alpha |
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) anti-GSK3 alpha (6G12C2) |
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| LF-MA30112 | Abfrontier | 100 ul | EUR 486 |
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Description: Mouse Monoclonal to GSK3 alpha |
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 antibody) Anti-Phospho-C/EBP alpha (S21) antibody |
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| STJ90757 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Phospho-C/EBP alpha (S21). |
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 GSK3 alpha/beta Antibody |
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| 29039-100ul | SAB | 100ul | EUR 252 |
 GSK3 alpha / beta Antibody |
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| 20-abx009185 | Abbexa |
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 Antibody) GSK3 alpha (pS21) Antibody |
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| 20-abx009689 | Abbexa |
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GSK3 alpha (pS21) Antibody |
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| abx010870-100ug | Abbexa | 100 ug | EUR 439 |
 GSK3 alpha Conjugated Antibody |
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| C48179 | SAB | 100ul | EUR 397 |
GSK3 alpha/beta Antibody |
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| AF6335 | Affbiotech | 200ul | EUR 304 |
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Description: GSK3 alpha/beta Antibody detects endogenous levels of total GSK3 alpha/beta. |
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GSK3 alpha/beta Antibody |
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| ABF6335 | Lifescience Market | 100 ug | EUR 438 |
 GSK3 alpha/beta antibody |
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| 70R-30578 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal GSK3 alpha/beta antibody |
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) GSK3 alpha antibody (Ser21) |
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| 70R-34163 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal GSK3 alpha antibody (Ser21) |
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GSK3 alpha/beta antibody |
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| 70R-49831 | Fitzgerald | 100 ul | EUR 244 |
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Description: Purified Polyclonal GSK3 alpha/beta antibody |
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GSK3 alpha/beta antibody |
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| 70R-51552 | Fitzgerald | 100 ul | EUR 287 |
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Description: Purified Polyclonal GSK3 alpha/beta antibody |
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GSK3 alpha antibody (Ser21) |
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| 70R-37089 | Fitzgerald | 100 ug | EUR 349 |
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Description: Rabbit Polyclonal GSK3 alpha antibody (Ser21) |
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 Anti-MRP-S21 antibody |
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| STJ94245 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to MRP-S21. |
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 Rabbit Polyclonal antibody Anti-CRBN |
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| Anti-CRBN | ImmunoStep | 50 µg | EUR 349 |
 Anti-GSK3 beta antibody |
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| STJ99095 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Mouse monoclonal to GSK3 beta. |
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 Antibody) GSK3 alpha (Phospho-Ser282) Antibody |
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| 13162-100ul | SAB | 100ul | EUR 252 |
GSK3 alpha (Phospho-Ser282) Antibody |
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| 13162-50ul | SAB | 50ul | EUR 187 |
 Antibody) GSK3 alpha (Phospho-Ser21) Antibody |
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| 20-abx012539 | Abbexa |
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 GSK3 alpha/beta Conjugated Antibody |
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| C29039 | SAB | 100ul | EUR 397 |
 Antibody) Phospho-GSK3 alpha (Ser282) Antibody |
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| AF7313 | Affbiotech | 200ul | EUR 376 |
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Description: Phospho-GSK3 alpha (Ser282) Antibody detects endogenous levels of GSK3 alpha only when phosphorylated at Ser282. |
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 Antibody) Phospho- GSK3 alpha (Ser21) Antibody |
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| ABF3336 | Lifescience Market | 100 ug | EUR 438 |
 GSK3 alpha recombinant monoclonal antibody |
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| A5830 | Bimake | 100ul X 3 | EUR 595 |
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Description: A recombinant monoclonal antibody from rabbit against human GSK3 alpha for WB, IHC,ELISA |
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 Antibody) Phospho-GSK3 alpha (Ser21) Antibody |
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| AF3336 | Affbiotech | 200ul | EUR 304 |
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Description: Phospho-GSK3 alpha (Ser21) Antibody detects endogenous levels of GSK3 alpha only when phosphorylated at Serine 21. |
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 antibody) Anti-Phospho-GSK3A-(S21) antibody |
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| STJ29348 | St John's Laboratory | 100 µl | EUR 393 |
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Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. |
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Anti-Phospho-GSK3A-(S21) antibody |
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| STJ22159 | St John's Laboratory | 100 µl | EUR 393 |
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Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. |
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 antibody) Anti-Phospho-FYN-(S21) antibody |
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| STJ110850 | St John's Laboratory | 100 µl | EUR 393 |
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Description: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. |
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 Anti-Ribosomal Protein S21 antibody |
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| STJ95495 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Ribosomal Protein S21. |
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 (Pan-species)) Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species) |
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| 4-RAA398Ge21 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA) |
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 (Pan-species)) Recombinant Antibody to Digoxin (DGX) (Pan-species) |
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| 4-RAK639Ge21 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX) |
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 Anti-Na+ CP type alpha-pan antibody |
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| STJ94334 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Na+ CP type alpha-pan. |
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-biotinylated) Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma)-biotinylated |
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| ACTB24-BTN | Alpha Diagnostics | 50 ul | EUR 408 |
 GSK3 antibody |
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| 20R-1609 | Fitzgerald | 100 ug | EUR 673 |
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Description: Rabbit polyclonal GSK3 antibody |
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 Monoclonal GSK3 alpha Antibody, Clone: EP793Y |
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| AMM05996G | Leading Biology | 0.1ml | EUR 528 |
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Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Rabbit and are from clone EP793Y. This antibody is applicable in WB and IHC |
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 Monoclonal GSK3 alpha Antibody, Clone: 9D5G1 |
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| APR12317G | Leading Biology | 0.1ml | EUR 484 |
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Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 9D5G1. This antibody is applicable in WB, ICC, E |
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 Antibody) GSK3 alpha / beta (pY279 / 216) Antibody |
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| 20-abx119370 | Abbexa |
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 Antibody) GSK3 alpha / beta (pT279 / 216) Antibody |
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| 20-abx009652 | Abbexa |
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GSK3 alpha / beta (pY279 / 216) Antibody |
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| abx010868-100ug | Abbexa | 100 ug | EUR 439 |
 Conjugated Antibody) GSK3 alpha (Phospho-Ser282) Conjugated Antibody |
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| C13162 | SAB | 100ul | EUR 397 |
) GSK3 alpha/beta antibody (Tyr279/216) |
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| 70R-30577 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal GSK3 alpha/beta antibody (Tyr279/216) |
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 (Human)) Recombinant Antibody to C Reactive Protein (CRP) (Human) |
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| 4-RAA821Hu21 | Cloud-Clone |
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Description: A Recombinant antibody against Human C Reactive Protein (CRP) |
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) Melanoma; Pan (Ready-To-Use) |
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| A00134-0002 | ScyTek Laboratories | 2 ml | EUR 140 |
Melanoma; Pan (Ready-To-Use) |
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| A00134-0007 | ScyTek Laboratories | 7 ml | EUR 272 |
Melanoma; Pan (Ready-To-Use) |
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| A00134-0025 | ScyTek Laboratories | 25 ml | EUR 717 |
 Anti-RPS21/Ribosomal Protein S21 Antibody |
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| A10068 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal RPS21/Ribosomal Protein S21 Antibody. Validated in IHC and tested in Human, Mouse, Rat. |
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 antibody) Anti-Phospho-HMG-14 (S21) antibody |
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| STJ91313 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Phospho-HMG-14 (S21). |
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 antibody) Anti-Phospho-GRK 1 (S21) antibody |
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| STJ90901 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Phospho-GRK 1 (S21). |
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 IgG, aff pure) Rabbit Anti-Actin (Pan, alpha, beta, gamma) IgG, aff pure |
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| ACTB22-A | Alpha Diagnostics | 100 ug | EUR 482 |
 (Pan-species), APC) Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), APC |
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| 4-RAA398Ge21-APC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with APC. |
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 (Pan-species), Biotinylated) Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Biotinylated |
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| 4-RAA398Ge21-Biotin | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Biotin. |
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 (Pan-species), Cy3) Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Cy3 |
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| 4-RAA398Ge21-Cy3 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Cy3. |
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 (Pan-species), FITC) Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), FITC |
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| 4-RAA398Ge21-FITC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with FITC. |
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 (Pan-species), HRP) Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), HRP |
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| 4-RAA398Ge21-HRP | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with HRP. |
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 (Pan-species), PE) Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), PE |
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| 4-RAA398Ge21-PE | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with PE. |
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 (Pan-species), APC) Recombinant Antibody to Digoxin (DGX) (Pan-species), APC |
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| 4-RAK639Ge21-APC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with APC. |
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 (Pan-species), Biotinylated) Recombinant Antibody to Digoxin (DGX) (Pan-species), Biotinylated |
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| 4-RAK639Ge21-Biotin | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Biotin. |
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 (Pan-species), Cy3) Recombinant Antibody to Digoxin (DGX) (Pan-species), Cy3 |
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| 4-RAK639Ge21-Cy3 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Cy3. |
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 (Pan-species), FITC) Recombinant Antibody to Digoxin (DGX) (Pan-species), FITC |
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| 4-RAK639Ge21-FITC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with FITC. |
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 (Pan-species), HRP) Recombinant Antibody to Digoxin (DGX) (Pan-species), HRP |
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| 4-RAK639Ge21-HRP | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with HRP. |
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 (Pan-species), PE) Recombinant Antibody to Digoxin (DGX) (Pan-species), PE |
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| 4-RAK639Ge21-PE | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with PE. |
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 Anti-Pan PKC antibody |
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| STJ119907 | St John's Laboratory | 100 µl | EUR 277 |
 Anti-Periostin pan antibody |
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| STJ120192 | St John's Laboratory | 100 µl | EUR 526 |
 Anti-Pan-Keratin antibody |
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| STJ16100232 | St John's Laboratory | 1 mL | EUR 290 |
 Anti-Cytokeratin, Pan antibody |
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| STJ180154 | St John's Laboratory | 0.1 ml | EUR 212 |
Anti-Cytokeratin, Pan antibody |
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| STJ180390 | St John's Laboratory | 0.1 ml | EUR 230 |
 Anti-cadherin-pan antibody |
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| STJ190003 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Unconjugated Mouse monoclonal to cadherin-pan (AS1A23) |
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A noticeable upregulation of autophagy proteins (microtubule-associated protein 1A/1B-light chain 3 (LC3) and Beclin-1) had been seen within the melatonin remedy through the induction interval whereas these had been reverted within the presence of L-leucine, an autophagy inhibitor. As well as, the expression of NeuN was additionally considerably lowered by L-leucine. Collectively, our findings revealed an activation of autophagy throughout neural induction; melatonin enhanced reprogramming effectivity for neuron induction by means of the modulation of autophagy activation.
