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Cell Biology of Canonical Wnt Signaling
Lieven
- 0
Wnt signaling has a number of capabilities past the transcriptional results of β-catenin stabilization. We evaluate current investigations that uncover new cell physiological results by means of the regulation of Wnt receptor endocytosis, Wnt-induced stabilization of proteins (Wnt-STOP), macropinocytosis, enhance in lysosomal exercise, and metabolic adjustments.
Many of those growth-promoting results of canonical Wnt happen inside minutes and are unbiased of latest protein synthesis. A key aspect is the sequestration of glycogen synthase kinase 3 (GSK3) inside multivesicular our bodies and lysosomes.
Twenty % of human proteins comprise consecutive GSK3 phosphorylation motifs, which within the absence of Wnt can kind phosphodegrons for polyubiquitination and proteasomal degradation. Wnt signaling by both the pharmacological inhibition of GSK3 or the lack of tumor-suppressor proteins, comparable to adenomatous polyposis coli (APC) and Axin1, will increase lysosomal acidification, anabolic metabolites, and macropinocytosis, which is often repressed by the GSK3-Axin1-APC destruction advanced.
The mixture of those cell physiological results drives cell development. Anticipated closing on-line publication date for the Annual Evaluate of Cell and Developmental Biology, Quantity 37 is October 2021.
Interacting Fashions of Amyloid-β and Tau Proteins: An Strategy to Determine Drug Targets in Alzheimer’s Illness
Alzheimer’s illness (AD) is the first reason for dementia affecting thousands and thousands every year internationally, although nonetheless stays incurable. This may be attributed to the lack of know-how concerning the related proteins, their mobile and molecular mechanisms, and the genesis of the illness.
The invention of medicine that earlier revolved round concentrating on the amyloid-β cascade has now been reformed with the upgraded data of the cross-seeding capability of tau protein which opens new gateways for therapeutic targets.
This text gives a complete evaluate of assorted direct and oblique connecting pathways between the 2 most important proteins concerned in growth and development of AD, enabling us to additional increase our repertoire of data concerning the etiology of AD. The present evaluate signifies the necessity for intensive analysis on this area of interest, thus appreciable advances may be made in understanding AD which finally helps to enhance the present therapeutics towards AD.

Membrane-associated RING-CH Eight capabilities as a novel PD-L1 E3 ligase to mediate PD-L1 degradation induced by EGFR inhibitors
Expression of programmed death-ligand 1 (PD-L1) on most cancers cells is a vital mechanism contributing to immunosuppression and immune escape. PD-L1 expression can also influence therapeutic outcomes of epidermal development issue receptor (EGFR)-targeted remedy (e.g., with osimertinib/AZD9291) towards EGFR mutant non-small cell lung cancers (NSCLCs) and may even be altered through the remedy albeit with largely undefined mechanisms.
This examine primarily focuses on elucidating the mechanism by which osimertinib induces PD-L1 degradation along with validating osimertinib’s impact on lowering PD-L1 expression in EGFR mutant NSCLC cells and tumors. Osimertinib and different EGFR inhibitors successfully decreased PD-L1 ranges primarily in EGFR mutant NSCLCs and xenografted tumors.
Osimertinib not solely decreased PD-L1 mRNA expression, but additionally prompted proteasomal degradation of PD-L1 protein, indicating each transcriptional and posttranslational mechanisms accounting for osimertinib-induced discount of PD-L1. Knockdown of β-TrCP or inhibition of GSK3 failed to forestall PD-L1 discount induced by osimertinib.
Fairly, knockdown of membrane-associated RING-CH 8 (MARCH8) that encodes a membrane-bound E3 ubiquitin ligase rescued osimertinib-induced PD-L1 discount. Moreover, manipulation of MARCH8 expression accordingly altered PD-L1 degradation fee. Critically, MARCH8 interacted with PD-L1 by means of its N-terminal area and likewise ubiquitinated PD-L1 in cells.
Collectively, these outcomes strongly recommend that MARCH8 is a beforehand undiscovered E3 ubiquitin ligase accountable for PD-L1 degradation together with osimertinib-induced PD-L1 degradation, establishing a novel connection between MARCH8 and PD-L1 regulation.
Implications: This examine has demonstrated new perform of MARCH8 in mediating PD-L1 degradation induced by EGFR inhibitors in NSCLC cells, establishing a novel connection between MARCH8 and PD-L1 regulation.
Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by lowering Wnt/β-catenin signaling
Job syndrome is a uncommon genetic dysfunction brought on by STAT3 mutations and primarily characterised by immune dysfunction together with comorbid skeleton developmental abnormalities together with osteopenia, recurrent fracture of lengthy bones, and scoliosis.
To this point, there isn’t a definitive treatment for the skeletal defects in Job syndrome, and coverings are restricted to administration of scientific signs solely. Right here, we’ve got investigated the molecular mechanism whereby Stat3 regulates skeletal growth and osteoblast differentiation.
We confirmed that eradicating Stat3 perform within the growing limb mesenchyme or osteoprogenitor cells in mice resulted in shortened and bow limbs with a number of fractures in lengthy bones that resembled the skeleton signs within the Job Syndrome.
Nevertheless, Stat3 loss didn’t alter chondrocyte differentiation and hypertrophy in embryonic growth, whereas osteoblast differentiation was severely lowered. Genome-wide transcriptome analyses in addition to biochemical and histological research confirmed that Stat3 loss resulted in down-regulation of Wnt/β-catenin signaling.
Restoration of Wnt/β-catenin signaling by injecting BIO, a small molecule inhibitor of GSK3, or crossing with a Lrp5 acquire of perform (GOF) allele, rescued the bone discount phenotypes because of Stat3 loss to an awesome extent.
These research uncover the important capabilities of Stat3 in sustaining Wnt/β-catenin signaling in early mesenchymal or osteoprogenitor cells and supply proof that bone defects within the Job Syndrome are doubtless brought on by Wnt/β-catenin signaling discount because of lowered STAT3 actions in bone growth. Enhancing Wnt/β-catenin signaling might be a therapeutic strategy to cut back bone signs of Job syndrome sufferers.
Mixture of Melatonin and Small Molecules Improved Reprogramming Neural Cell Fates by way of Autophagy Activation
Reprogramming cell fates in direction of mature cell varieties are a promising cell provide for treating degenerative illnesses. Just lately, transcription elements and a few small molecules have was spectacular modulating components for reprogramming cell fates.
Melatonin, a pineal hormone, has neuroprotective capabilities together with neural stem cell (NSC) proliferative and differentiative modulation in each embryonic and grownup mind. We developed a protocol that might be carried out within the direct reprogramming of human pores and skin fibroblast in direction of neural cells through the use of histone deacetylase (HDAC) inhibitor, glycogen synthase kinase-3 (GSK3) inhibitor (CHIR99021), c-Jun N-terminal kinase (JNK) inhibitor, rho-associated protein kinase inhibitor (Y-27632), cAMP activator, and melatonin remedy.
We discovered that melatonin enhanced neural-transcription issue genes expressions, together with brain-specific homeobox/POU area protein 2 (BRN2), Achaete-Scute Household BHLH transcription Issue 1 (ASCL1), and Myelin Transcription Issue 1 Like (MYT1L).
Melatonin additionally elevated the expression of various neural-specific proteins comparable to doublecortin (DCX), Intercourse figuring out area Y-box 2 (Sox2), and neuronal nuclei (NeuN) in contrast with different 5 small molecules (valproic acid (VPA), CHIR99021, Forskolin, 1,9 pyrazoloanthrone (SP600125), and Y-27632) mixture within the presence and absence of melatonin.
GSK3 alpha antibody |
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20R-2192 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal GSK3 alpha antibody |
GSK3 alpha antibody |
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10R-1930 | Fitzgerald | 100 ul | EUR 483.6 |
Description: Mouse monoclonal GSK3 alpha antibody |
GSK3 alpha antibody |
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10R-2025 | Fitzgerald | 100 ul | EUR 522 |
Description: Mouse monoclonal GSK3 alpha antibody |
GSK3 alpha antibody |
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10R-2104 | Fitzgerald | 100 ul | EUR 483.6 |
Description: Mouse monoclonal GSK3 alpha antibody |
GSK3 alpha Antibody |
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20-abx133173 | Abbexa |
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GSK3 alpha Antibody |
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abx010857-100ul | Abbexa | 100 ul | EUR 493.2 |
GSK3 alpha Antibody |
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20-abx012858 | Abbexa |
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GSK3 alpha Antibody |
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abx015750-100ul | Abbexa | 100 ul | EUR 493.2 |
GSK3 alpha Antibody |
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abx015751-100ul | Abbexa | 100 ul | EUR 493.2 |
GSK3 alpha Antibody |
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abx033883-400ul | Abbexa | 400 ul | EUR 627.6 |
GSK3 alpha Antibody |
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abx033883-80l | Abbexa | 80 µl | EUR 343.2 |
GSK3 alpha Antibody |
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ABF6336 | Lifescience Market | 100 ug | EUR 525.6 |
GSK3 alpha Antibody |
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AF7813 | Affbiotech | 200ul | EUR 540 |
GSK3 alpha Antibody |
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BF0391 | Affbiotech | 200ul | EUR 540 |
GSK3 alpha Antibody |
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AF6336 | Affbiotech | 200ul | EUR 420 |
Anti-Phospho-GSK alpha (S21) antibody |
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STJ90282 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Phospho-GSK3alpha (S21). |
Cytokeratin (Pan-reactive) Antibody (PE) |
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abx140315-01mg | Abbexa | 0.1 mg | EUR 627.6 |
Cytokeratin (Pan-reactive) Antibody (APC) |
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abx140316-01mg | Abbexa | 0.1 mg | EUR 627.6 |
Cytokeratin (Pan-reactive) Antibody (Biotin) |
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abx140317-01mg | Abbexa | 0.1 mg | EUR 510 |
Cytokeratin (Pan-reactive) Antibody (FITC) |
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abx140318-01mg | Abbexa | 0.1 mg | EUR 560.4 |
GSK3 alpha/beta antibody |
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70R-49831 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal GSK3 alpha/beta antibody |
GSK3 alpha/beta antibody |
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70R-30578 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal GSK3 alpha/beta antibody |
GSK3 alpha antibody (Ser21) |
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70R-34163 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal GSK3 alpha antibody (Ser21) |
GSK3 alpha antibody (Ser21) |
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70R-37089 | Fitzgerald | 100 ug | EUR 418.8 |
Description: Rabbit Polyclonal GSK3 alpha antibody (Ser21) |
GSK3 alpha/beta antibody |
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70R-51552 | Fitzgerald | 100 ul | EUR 344.4 |
Description: Purified Polyclonal GSK3 alpha/beta antibody |
GSK3 alpha/beta Antibody |
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29039-100ul | SAB | 100ul | EUR 302.4 |
GSK3 alpha / beta Antibody |
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20-abx009185 | Abbexa |
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GSK3 alpha (pS21) Antibody |
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20-abx009689 | Abbexa |
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GSK3 alpha (pS21) Antibody |
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abx010870-100ug | Abbexa | 100 ug | EUR 526.8 |
GSK3 alpha/beta Antibody |
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ABF6335 | Lifescience Market | 100 ug | EUR 525.6 |
GSK3 alpha/ beta Antibody |
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DF6806 | Affbiotech | 200ul | EUR 420 |
GSK3 alpha Conjugated Antibody |
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C48179 | SAB | 100ul | EUR 476.4 |
GSK3 alpha/ beta Antibody |
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AF6335 | Affbiotech | 200ul | EUR 420 |
anti-GSK3 alpha (6G2F1) |
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LF-MA30074 | Abfrontier | 100 ul | EUR 644.4 |
Description: Mouse Monoclonal to GSK3 alpha |
anti-GSK3 alpha (9D5G1) |
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LF-MA30111 | Abfrontier | 100 ul | EUR 583.2 |
Description: Mouse Monoclonal to GSK3 alpha |
anti-GSK3 alpha (6G12C2) |
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LF-MA30112 | Abfrontier | 100 ul | EUR 583.2 |
Description: Mouse Monoclonal to GSK3 alpha |
Anti-Phospho-C/EBP alpha (S21) antibody |
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STJ90757 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Phospho-C/EBP alpha (S21). |
Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone |
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CABT-B9017-05mg | Creative Diagnostics | 0.5 mg | EUR 1076.4 |
Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone |
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CABT-B9017-1mg | Creative Diagnostics | 1 mg | EUR 1606.8 |
Anti-Cav pan alpha antibody |
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STJ97558 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Cav pan alpha1 (A211). |
Anti-MRP-S21 antibody |
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STJ94245 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to MRP-S21. |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
GSK3 alpha (Phospho-Ser282) Antibody |
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13162-100ul | SAB | 100ul | EUR 302.4 |
GSK3 alpha (Phospho-Ser282) Antibody |
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13162-50ul | SAB | 50ul | EUR 224.4 |
GSK3 alpha (Phospho-Ser21) Antibody |
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20-abx012539 | Abbexa |
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Phospho- GSK3 alpha (Ser21) Antibody |
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ABF3336 | Lifescience Market | 100 ug | EUR 525.6 |
GSK3 alpha recombinant monoclonal antibody |
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A5830 | Bimake | 100ul X 3 | EUR 714 |
Description: A recombinant monoclonal antibody from rabbit against human GSK3 alpha for WB, IHC,ELISA |
Phospho-GSK3 alpha (Ser282) Antibody |
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AF7313 | Affbiotech | 200ul | EUR 540 |
Phospho-GSK3 alpha (Ser21) Antibody |
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AF3336 | Affbiotech | 200ul | EUR 420 |
GSK3 alpha/beta Conjugated Antibody |
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C29039 | SAB | 100ul | EUR 476.4 |
Anti-GSK3 beta antibody |
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STJ99095 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to GSK3 beta. |
Anti-Phospho-FYN-(S21) antibody |
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STJ110850 | St John's Laboratory | 100 µl | EUR 471.6 |
Description: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. |
Anti-Ribosomal Protein S21 antibody |
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STJ95495 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Ribosomal Protein S21. |
Anti-Phospho-GSK3A-(S21) antibody |
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STJ29348 | St John's Laboratory | 100 µl | EUR 471.6 |
Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. |
Anti-Phospho-GSK3A-(S21) antibody |
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STJ22159 | St John's Laboratory | 100 µl | EUR 471.6 |
Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. |
GSK3 antibody |
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20R-1609 | Fitzgerald | 100 ug | EUR 807.6 |
Description: Rabbit polyclonal GSK3 antibody |
GSK3 alpha/beta antibody (Tyr279/216) |
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70R-30577 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal GSK3 alpha/beta antibody (Tyr279/216) |
GSK3 alpha / beta (pT279 / 216) Antibody |
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20-abx009652 | Abbexa |
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GSK3 alpha / beta (pY279 / 216) Antibody |
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20-abx119370 | Abbexa |
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GSK3 alpha / beta (pY279 / 216) Antibody |
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abx010868-100ug | Abbexa | 100 ug | EUR 526.8 |
Monoclonal GSK3 alpha Antibody, Clone: EP793Y |
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AMM05996G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Rabbit and are from clone EP793Y. This antibody is applicable in WB and IHC |
Monoclonal GSK3 alpha Antibody, Clone: 9D5G1 |
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APR12317G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 9D5G1. This antibody is applicable in WB, ICC, E |
GSK3 alpha (Phospho-Ser282) Conjugated Antibody |
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C13162 | SAB | 100ul | EUR 476.4 |
Anti-Na+ CP type alpha-pan antibody |
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STJ94334 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Na+ CP type alpha-pan. |
Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma)-biotinylated |
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ACTB24-BTN | Alpha Diagnostics | 50 ul | EUR 489.6 |
Anti-RPS21/Ribosomal Protein S21 Antibody |
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A10068 | BosterBio | 100ul | EUR 476.4 |
Description: Rabbit Polyclonal RPS21/Ribosomal Protein S21 Antibody. Validated in IHC and tested in Human, Mouse, Rat. |
Anti-Phospho-GRK 1 (S21) antibody |
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STJ90901 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Phospho-GRK 1 (S21). |
Anti-Phospho-HMG-14 (S21) antibody |
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STJ91313 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Phospho-HMG-14 (S21). |
GSK3 alpha Blocking Peptide |
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20-abx161877 | Abbexa |
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GSK3 alpha Blocking Peptide |
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AF7813-BP | Affbiotech | 1mg | EUR 234 |
GSK3 alpha Blocking Peptide |
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BF0391-BP | Affbiotech | 1mg | EUR 234 |
GSK3 alpha Blocking Peptide |
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AF6336-BP | Affbiotech | 1mg | EUR 234 |
Rabbit Anti-Actin (Pan, alpha, beta, gamma) IgG, aff pure |
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ACTB22-A | Alpha Diagnostics | 100 ug | EUR 578.4 |
GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody |
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13355-100ul | SAB | 100ul | EUR 399.6 |
GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody |
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13355-50ul | SAB | 50ul | EUR 286.8 |
Phospho- GSK3 alpha/ beta (Tyr279/216) Antibody |
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ABF3335 | Lifescience Market | 100 ug | EUR 525.6 |
Monoclonal GSK3 alpha Antibody, Clone: 6G2F1; 6G2F2 |
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AMM02621G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 6G2F1; 6G2F2. This antibody is applicable in WB and IHC, E |
Polyclonal GSK3 alpha (GSK3A) Antibody (N-term) |
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APR12316G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (N-term). This antibody is tested and proven to work in the following applications: |
Monoclonal GSK3 alpha/beta Antibody, Clone: EP933Y |
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APR12318G | Leading Biology | 0.1ml | EUR 633.6 |
Description: A Monoclonal antibody against Human GSK3 alpha/beta. The antibodies are raised in Rabbit and are from clone EP933Y. This antibody is applicable in WB |
Polyclonal GSK3 alpha (GSK3A) Antibody (C-term) |
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APS00025G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (C-term). This antibody is tested and proven to work in the following applications: |
Phospho-GSK3 alpha/ beta (Tyr216/Tyr279) Antibody |
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AF3335 | Affbiotech | 200ul | EUR 420 |
Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species) |
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4-RAA398Ge21 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA) |
Recombinant Antibody to Digoxin (DGX) (Pan-species) |
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4-RAK639Ge21 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX) |
Anti-Phospho-GSK3 (alpha + beta) (Y216 + Y279) Rabbit Monoclonal Antibody |
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P03152-1 | BosterBio | 100ug/vial | EUR 476.4 |
Description: Rabbit Monoclonal Phospho-GSK3 (alpha + beta) (Y216 + Y279) Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat. |
GSK3 beta antibody |
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70R-37442 | Fitzgerald | 100 ug | EUR 327.6 |
Description: Rabbit Polyclonal GSK3 beta antibody |
GSK3 beta antibody |
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70R-49832 | Fitzgerald | 100 ul | EUR 344.4 |
Description: Purified Polyclonal GSK3 beta antibody |
GSK3 beta antibody |
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70R-30634 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal GSK3 beta antibody |
GSK3 beta antibody |
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70R-34165 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Rabbit polyclonal GSK3 beta antibody |
GSK3 beta antibody |
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70R-34639 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Purified Rabbit polyclonal GSK3 beta antibody |
GSK3 beta Antibody |
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48798-100ul | SAB | 100ul | EUR 399.6 |
GSK3 beta Antibody |
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48798-50ul | SAB | 50ul | EUR 286.8 |
GSK3 beta antibody |
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10R-8595 | Fitzgerald | 100 ul | EUR 471.6 |
Description: Mouse monoclonal GSK3 beta antibody |
GSK3 beta antibody |
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20R-1878 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal GSK3 beta antibody |
GSK3 beta antibody |
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20R-2124 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal GSK3 beta antibody |
GSK3 beta antibody |
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20R-2187 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal GSK3 beta antibody |
GSK3 beta antibody |
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20R-2452 | Fitzgerald | 50 ug | EUR 337.2 |
Description: Rabbit polyclonal GSK3 beta antibody |
GSK3 (pS9) Antibody |
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20-abx000124 | Abbexa |
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GSK3 beta Antibody |
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ABF5016 | Lifescience Market | 100 ug | EUR 525.6 |
GSK3 beta Antibody |
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abx449182-100ug | Abbexa | 100 ug | EUR 661.2 |
GSK3 beta Antibody |
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AF7814 | Affbiotech | 200ul | EUR 540 |
GSK3 beta antibody |
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BF0721 | Affbiotech | 200ul | EUR 540 |
GSK3 beta Antibody |
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DF7231 | Affbiotech | 200ul | EUR 420 |
GSK3 beta Antibody |
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AF5016 | Affbiotech | 200ul | EUR 420 |
GSK3 beta Antibody |
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AF6658 | Affbiotech | 100ul | EUR 420 |
GSK3? Polyclonal Antibody |
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ES2485-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA |
GSK3? Polyclonal Antibody |
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ES2485-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA |
GSK3?/? Polyclonal Antibody |
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ES2486-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
GSK3?/? Polyclonal Antibody |
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ES2486-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
GSK3? Polyclonal Antibody |
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ES2487-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA |
GSK3? Polyclonal Antibody |
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ES2487-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA |
GSK3? Polyclonal Antibody |
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ES5683-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
GSK3? Polyclonal Antibody |
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ES5683-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
GSK3? Polyclonal Antibody |
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ES8198-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC |
GSK3? Polyclonal Antibody |
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ES8198-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC |
Anti-GSK3 beta Rabbit Monoclonal Antibody |
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M00791 | BosterBio | 100ug/vial | EUR 476.4 |
Description: Rabbit Monoclonal GSK3 beta Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat. |
anti-GSK3 beta |
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YF-PA23834 | Abfrontier | 50 ul | EUR 400.8 |
Description: Mouse polyclonal to GSK3 beta |
anti-GSK3 beta |
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YF-PA12137 | Abfrontier | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal to GSK3 beta |
Anti-Keratin-pan Antibody |
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A05667 | BosterBio | 100ul | EUR 476.4 |
Description: Rabbit Polyclonal Antibody for Keratin-pan Antibody (KRT2) detection.tested for IHC, WB in Human, Mouse, Rat. |
Anti- Myosin-pan Antibody |
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A1213-100 | Biovision | EUR 483.6 |
Anti-Pan-PAX antibody |
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PAab06136 | Lifescience Market | 100 ug | EUR 426 |
anti- Pan Keratin antibody |
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LSMab09935 | Lifescience Market | 100 ug | EUR 463.2 |
anti- Pan-PAX antibody |
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FNab06136 | FN Test | 100µg | EUR 606.3 |
Description: Antibody raised against Pan-PAX |
anti- Pan Keratin antibody |
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FNab09935 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against Pan Keratin |
Anti-Pan-AKT antibody |
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STJ11100091 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Pan myristoylation antibody |
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STJ98665 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Pan myristoylation. |
Anti-Pan myristoylation antibody |
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STJ98666 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Pan myristoylation protein is encoded by the MARCKS gene which is approximately 31,6 kDa. It is localised to the cytoplasm. It is involved in the integration of energy metabolism, Fc gamma R-mediated phagocytosis, microRNAs and Ca, cAMP and lipid signalling. It is the most prominent cellular substrate for protein kinase C and is an actin filament crosslinking protein. It is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. Pan myristoylation is expressed in the nervous system, liver, lung, skin and heart. Mutations in the MARCKS gene can result in spinocerebellar ataxia and anencephaly. STJ98666 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. The antibody detects endogenous pan myristoylation protein. |
Anti-Keratin-pan antibody |
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STJ98693 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Keratin-pan. |
Anti-Akt (pan) antibody |
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STJ99073 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to Akt (pan). |
Anti-Akt (pan) antibody |
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STJ99074 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Mouse monoclonal to Akt (pan). |
Anti-Keratin-pan antibody |
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STJ96694 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to Keratin-pan. |
Anti-MYH-pan antibody |
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STJ96792 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to MYH-pan. |
Anti-Cytokeratin (Pan) antibody |
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STJ97993 | St John's Laboratory | 100 µl | EUR 280.8 |
Description: Mouse monoclonal to Cytokeratin (Pan). |
Anti-Cytokeratin (Pan) antibody |
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STJ97994 | St John's Laboratory | 100 µl | EUR 280.8 |
Description: Mouse monoclonal to Cytokeratin (Pan). |
Anti-Pan PKC antibody |
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STJ119907 | St John's Laboratory | 100 µl | EUR 332.4 |
Anti-Periostin pan antibody |
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STJ120192 | St John's Laboratory | 100 µl | EUR 631.2 |
Anti-Pan-Keratin antibody |
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STJ16100232 | St John's Laboratory | 1 mL | EUR 348 |
Anti-Cytokeratin, Pan antibody |
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STJ180154 | St John's Laboratory | 0.1 ml | EUR 254.4 |
Anti-Cytokeratin, Pan antibody |
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STJ180390 | St John's Laboratory | 0.1 ml | EUR 276 |
Anti-cadherin-pan antibody |
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STJ190003 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Unconjugated Mouse monoclonal to cadherin-pan (AS1A23) |
Anti-Collagen PAN antibody |
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STJ190046 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Unconjugated Mouse monoclonal to Collagen PAN (7B1) |
Anti-PKC-pan antibody |
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STJ190083 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Unconjugated Mouse monoclonal to PKC-pan (1D2) |
Anti-pan ADH antibody |
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STJ70639 | St John's Laboratory | 100 µg | EUR 430.8 |
Recombinant Antibody to C Reactive Protein (CRP) (Human) |
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4-RAA821Hu21 | Cloud-Clone |
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Description: A Recombinant antibody against Human C Reactive Protein (CRP) |
Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG-Cy3 conjugate |
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ACTB24-Cy3 | Alpha Diagnostics | 100 ul | EUR 489.6 |
Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG-FITC conjugate |
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ACTB24-FITC | Alpha Diagnostics | 100 ul | EUR 489.6 |
Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG, aff pure |
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ACTB24-M | Alpha Diagnostics | 100 ug | EUR 578.4 |
OR Antibody |
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44609-100ul | SAB | 100ul | EUR 302.4 |
OR Antibody |
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44609-50ul | SAB | 50ul | EUR 224.4 |
OR Antibody |
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ABD10250 | Lifescience Market | 100 ug | EUR 525.6 |
OR Antibody |
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20-abx217389 | Abbexa |
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OR Antibody |
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DF10250 | Affbiotech | 200ul | EUR 420 |
MRP-S21 Polyclonal Antibody |
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41179-100ul | SAB | 100ul | EUR 302.4 |
MRP-S21 Polyclonal Antibody |
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41179-50ul | SAB | 50ul | EUR 224.4 |
MRP-S21 Polyclonal Antibody |
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ABP51848-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90 |
MRP-S21 Polyclonal Antibody |
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ABP51848-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90 |
MRP-S21 Polyclonal Antibody |
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ABP51848-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90 |
Polyclonal GSK3A Antibody (S21) |
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APR12320G | Leading Biology | 0.1ml | EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3A (S21). This antibody is tested and proven to work in the following applications: |
Phospho-GSK3A (S21) Antibody |
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1-CSB-PA000534 | Cusabio |
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Description: A polyclonal antibody against Phospho-GSK3A (S21). Recognizes Phospho-GSK3A (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000 |
Phospho-CEBPA (S21) Antibody |
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1-CSB-PA000685 | Cusabio |
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Description: A polyclonal antibody against Phospho-CEBPA (S21). Recognizes Phospho-CEBPA (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000 |
Phospho-GRK1 (S21) Antibody |
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1-CSB-PA040218 | Cusabio |
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Description: A polyclonal antibody against Phospho-GRK1 (S21). Recognizes Phospho-GRK1 (S21) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000 |
Phospho-HMGN1 (S21) Antibody |
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1-CSB-PA009215 | Cusabio |
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Description: A polyclonal antibody against Phospho-HMGN1 (S21). Recognizes Phospho-HMGN1 (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000 |
MRP-S21 Polyclonal Antibody |
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ES2847-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against MRP-S21 from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
MRP-S21 Polyclonal Antibody |
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ES2847-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against MRP-S21 from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
GSK3(alpha+beta)(Phospho-Y216+Y279) Conjugated Antibody |
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C13355 | SAB | 100ul | EUR 476.4 |
Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), APC |
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4-RAA398Ge21-APC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with APC. |
Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Biotinylated |
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4-RAA398Ge21-Biotin | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Biotin. |
Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Cy3 |
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4-RAA398Ge21-Cy3 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Cy3. |
Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), FITC |
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4-RAA398Ge21-FITC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with FITC. |
Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), HRP |
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4-RAA398Ge21-HRP | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with HRP. |
Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), PE |
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4-RAA398Ge21-PE | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with PE. |
Recombinant Antibody to Digoxin (DGX) (Pan-species), APC |
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4-RAK639Ge21-APC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with APC. |
Recombinant Antibody to Digoxin (DGX) (Pan-species), Biotinylated |
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4-RAK639Ge21-Biotin | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Biotin. |
Recombinant Antibody to Digoxin (DGX) (Pan-species), Cy3 |
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4-RAK639Ge21-Cy3 | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Cy3. |
Recombinant Antibody to Digoxin (DGX) (Pan-species), FITC |
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4-RAK639Ge21-FITC | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with FITC. |
Recombinant Antibody to Digoxin (DGX) (Pan-species), HRP |
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4-RAK639Ge21-HRP | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with HRP. |
Recombinant Antibody to Digoxin (DGX) (Pan-species), PE |
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4-RAK639Ge21-PE | Cloud-Clone |
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Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with PE. |
Coating Antibody or Protein stabilizer solution (10X) |
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PRTS-100 | Alpha Diagnostics | 100 ml | EUR 343.2 |
GSK3 alpha (pS21) Blocking Peptide |
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20-abx062705 | Abbexa |
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GSK3 alpha / beta Blocking Peptide |
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20-abx062706 | Abbexa |
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GSK3 alpha protein (GST Fusion) |
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80R-2554 | Fitzgerald | 100 ug | EUR 296.4 |
Description: Purified recombinant Human GSK3 alpha-GST Fusion protein |
GSK3 alpha/beta Blocking Peptide |
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AF6335-BP | Affbiotech | 1mg | EUR 234 |
Melanoma; Pan (Ready-To-Use) |
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A00134-0002 | ScyTek Laboratories | 2 ml | EUR 168 |
Melanoma; Pan (Ready-To-Use) |
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A00134-0007 | ScyTek Laboratories | 7 ml | EUR 326.4 |
Melanoma; Pan (Ready-To-Use) |
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A00134-0025 | ScyTek Laboratories | 25 ml | EUR 860.4 |
Rabbit Anti-AQP1-AQP9 Antiserum (25 ul each of AQP1-9) |
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AQP19-PAN-S | Alpha Diagnostics | 25 ul x9 | EUR 1074 |
Actin (Pan, alpha, beta, gamma) Control/blocking peptide |
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ACTB22-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rabbit Anti-AQP1-AQP6 IgG (25 ug each of AQP1-6) aff pure |
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AQP16-PAN-A | Alpha Diagnostics | 25 ul x 6 | EUR 578.4 |
Rabbit Anti-AQP1-AQP6 Antiserum (25 ul each of AQP1-6) neat serum |
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AQP16-PAN-S | Alpha Diagnostics | 25 ul x 6 | EUR 548.4 |
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A noticeable upregulation of autophagy proteins (microtubule-associated protein 1A/1B-light chain 3 (LC3) and Beclin-1) had been seen within the melatonin remedy through the induction interval whereas these had been reverted within the presence of L-leucine, an autophagy inhibitor. As well as, the expression of NeuN was additionally considerably lowered by L-leucine. Collectively, our findings revealed an activation of autophagy throughout neural induction; melatonin enhanced reprogramming effectivity for neuron induction by means of the modulation of autophagy activation.
Tags: destination vector egfp c1 eyfp sequence lenticrispr v2 p3xflag cmv 10 pacyc184 pcmv flag pcmv vsv g pcr2 1 sequence pcr2 1 topo vector pcr2 1 vector pdest pdisplay pet19b petduet vector pexpress pfgc5941 plko 1 vector plko tet on pproex prset vector psicheck2 pspax2 puc19 invitrogen sv40 promoter sequence yfp