Cell Biology of Canonical Wnt Signaling

Cell Biology of Canonical Wnt Signaling

Wnt signaling has a number of capabilities past the transcriptional results of β-catenin stabilization. We evaluate current investigations that uncover new cell physiological results by means of the regulation of Wnt receptor endocytosis, Wnt-induced stabilization of proteins (Wnt-STOP), macropinocytosis, enhance in lysosomal exercise, and metabolic adjustments.
Many of those growth-promoting results of canonical Wnt happen inside minutes and are unbiased of latest protein synthesis. A key aspect is the sequestration of glycogen synthase kinase 3 (GSK3) inside multivesicular our bodies and lysosomes.
Twenty % of human proteins comprise consecutive GSK3 phosphorylation motifs, which within the absence of Wnt can kind phosphodegrons for polyubiquitination and proteasomal degradation. Wnt signaling by both the pharmacological inhibition of GSK3 or the lack of tumor-suppressor proteins, comparable to adenomatous polyposis coli (APC) and Axin1, will increase lysosomal acidification, anabolic metabolites, and macropinocytosis, which is often repressed by the GSK3-Axin1-APC destruction advanced.
The mixture of those cell physiological results drives cell development. Anticipated closing on-line publication date for the Annual Evaluate of Cell and Developmental Biology, Quantity 37 is October 2021.

Interacting Fashions of Amyloid-β and Tau Proteins: An Strategy to Determine Drug Targets in Alzheimer’s Illness

Alzheimer’s illness (AD) is the first reason for dementia affecting thousands and thousands every year internationally, although nonetheless stays incurable. This may be attributed to the lack of know-how concerning the related proteins, their mobile and molecular mechanisms, and the genesis of the illness.
The invention of medicine that earlier revolved round concentrating on the amyloid-β cascade has now been reformed with the upgraded data of the cross-seeding capability of tau protein which opens new gateways for therapeutic targets.
This text gives a complete evaluate of assorted direct and oblique connecting pathways between the 2 most important proteins concerned in growth and development of AD, enabling us to additional increase our repertoire of data concerning the etiology of AD. The present evaluate signifies the necessity for intensive analysis on this area of interest, thus appreciable advances may be made in understanding AD which finally helps to enhance the present therapeutics towards AD.
Cell Biology of Canonical Wnt Signaling

Membrane-associated RING-CH Eight capabilities as a novel PD-L1 E3 ligase to mediate PD-L1 degradation induced by EGFR inhibitors

Expression of programmed death-ligand 1 (PD-L1) on most cancers cells is a vital mechanism contributing to immunosuppression and immune escape. PD-L1 expression can also influence therapeutic outcomes of epidermal development issue receptor (EGFR)-targeted remedy (e.g., with osimertinib/AZD9291) towards EGFR mutant non-small cell lung cancers (NSCLCs) and may even be altered through the remedy albeit with largely undefined mechanisms.
This examine primarily focuses on elucidating the mechanism by which osimertinib induces PD-L1 degradation along with validating osimertinib’s impact on lowering PD-L1 expression in EGFR mutant NSCLC cells and tumors. Osimertinib and different EGFR inhibitors successfully decreased PD-L1 ranges primarily in EGFR mutant NSCLCs and xenografted tumors.
Osimertinib not solely decreased PD-L1 mRNA expression, but additionally prompted proteasomal degradation of PD-L1 protein, indicating each transcriptional and posttranslational mechanisms accounting for osimertinib-induced discount of PD-L1. Knockdown of β-TrCP or inhibition of GSK3 failed to forestall PD-L1 discount induced by osimertinib.
Fairly, knockdown of membrane-associated RING-CH 8 (MARCH8) that encodes a membrane-bound E3 ubiquitin ligase rescued osimertinib-induced PD-L1 discount. Moreover, manipulation of MARCH8 expression accordingly altered PD-L1 degradation fee. Critically, MARCH8 interacted with PD-L1 by means of its N-terminal area and likewise ubiquitinated PD-L1 in cells.
Collectively, these outcomes strongly recommend that MARCH8 is a beforehand undiscovered E3 ubiquitin ligase accountable for PD-L1 degradation together with osimertinib-induced PD-L1 degradation, establishing a novel connection between MARCH8 and PD-L1 regulation.
Implications: This examine has demonstrated new perform of MARCH8 in mediating PD-L1 degradation induced by EGFR inhibitors in NSCLC cells, establishing a novel connection between MARCH8 and PD-L1 regulation.

Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by lowering Wnt/β-catenin signaling

Job syndrome is a uncommon genetic dysfunction brought on by STAT3 mutations and primarily characterised by immune dysfunction together with comorbid skeleton developmental abnormalities together with osteopenia, recurrent fracture of lengthy bones, and scoliosis.
To this point, there isn’t a definitive treatment for the skeletal defects in Job syndrome, and coverings are restricted to administration of scientific signs solely. Right here, we’ve got investigated the molecular mechanism whereby Stat3 regulates skeletal growth and osteoblast differentiation.
We confirmed that eradicating Stat3 perform within the growing limb mesenchyme or osteoprogenitor cells in mice resulted in shortened and bow limbs with a number of fractures in lengthy bones that resembled the skeleton signs within the Job Syndrome.
Nevertheless, Stat3 loss didn’t alter chondrocyte differentiation and hypertrophy in embryonic growth, whereas osteoblast differentiation was severely lowered. Genome-wide transcriptome analyses in addition to biochemical and histological research confirmed that Stat3 loss resulted in down-regulation of Wnt/β-catenin signaling.
Restoration of Wnt/β-catenin signaling by injecting BIO, a small molecule inhibitor of GSK3, or crossing with a Lrp5 acquire of perform (GOF) allele, rescued the bone discount phenotypes because of Stat3 loss to an awesome extent.
These research uncover the important capabilities of Stat3 in sustaining Wnt/β-catenin signaling in early mesenchymal or osteoprogenitor cells and supply proof that bone defects within the Job Syndrome are doubtless brought on by Wnt/β-catenin signaling discount because of lowered STAT3 actions in bone growth. Enhancing Wnt/β-catenin signaling might be a therapeutic strategy to cut back bone signs of Job syndrome sufferers.

Mixture of Melatonin and Small Molecules Improved Reprogramming Neural Cell Fates by way of Autophagy Activation

Reprogramming cell fates in direction of mature cell varieties are a promising cell provide for treating degenerative illnesses. Just lately, transcription elements and a few small molecules have was spectacular modulating components for reprogramming cell fates.
Melatonin, a pineal hormone, has neuroprotective capabilities together with neural stem cell (NSC) proliferative and differentiative modulation in each embryonic and grownup mind. We developed a protocol that might be carried out within the direct reprogramming of human pores and skin fibroblast in direction of neural cells through the use of histone deacetylase (HDAC) inhibitor, glycogen synthase kinase-3 (GSK3) inhibitor (CHIR99021), c-Jun N-terminal kinase (JNK) inhibitor, rho-associated protein kinase inhibitor (Y-27632), cAMP activator, and melatonin remedy.
We discovered that melatonin enhanced neural-transcription issue genes expressions, together with brain-specific homeobox/POU area protein 2 (BRN2), Achaete-Scute Household BHLH transcription Issue 1 (ASCL1), and Myelin Transcription Issue 1 Like (MYT1L).
Melatonin additionally elevated the expression of various neural-specific proteins comparable to doublecortin (DCX), Intercourse figuring out area Y-box 2 (Sox2), and neuronal nuclei (NeuN) in contrast with different 5 small molecules (valproic acid (VPA), CHIR99021, Forskolin, 1,9 pyrazoloanthrone (SP600125), and Y-27632) mixture within the presence and absence of melatonin.

GSK3 alpha antibody

20R-2192 50 ug
EUR 337.2
Description: Rabbit polyclonal GSK3 alpha antibody

GSK3 alpha antibody

10R-1930 100 ul
EUR 483.6
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody

10R-2025 100 ul
EUR 522
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody

10R-2104 100 ul
EUR 483.6
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha Antibody

20-abx133173
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 alpha Antibody

abx010857-100ul 100 ul
EUR 493.2

GSK3 alpha Antibody

20-abx012858
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

GSK3 alpha Antibody

abx015750-100ul 100 ul
EUR 493.2

GSK3 alpha Antibody

abx015751-100ul 100 ul
EUR 493.2

GSK3 alpha Antibody

abx033883-400ul 400 ul
EUR 627.6

GSK3 alpha Antibody

abx033883-80l 80 µl
EUR 343.2

GSK3 alpha Antibody

ABF6336 100 ug
EUR 525.6

GSK3 alpha Antibody

AF7813 200ul
EUR 540

GSK3 alpha Antibody

BF0391 200ul
EUR 540

GSK3 alpha Antibody

AF6336 200ul
EUR 420

Anti-Phospho-GSK alpha (S21) antibody

STJ90282 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-GSK3alpha (S21).

Cytokeratin (Pan-reactive) Antibody (PE)

abx140315-01mg 0.1 mg
EUR 627.6

Cytokeratin (Pan-reactive) Antibody (APC)

abx140316-01mg 0.1 mg
EUR 627.6

Cytokeratin (Pan-reactive) Antibody (Biotin)

abx140317-01mg 0.1 mg
EUR 510

Cytokeratin (Pan-reactive) Antibody (FITC)

abx140318-01mg 0.1 mg
EUR 560.4

GSK3 alpha/beta antibody

70R-49831 100 ul
EUR 292.8
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta antibody

70R-30578 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 alpha/beta antibody

GSK3 alpha antibody (Ser21)

70R-34163 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 alpha antibody (Ser21)

GSK3 alpha antibody (Ser21)

70R-37089 100 ug
EUR 418.8
Description: Rabbit Polyclonal GSK3 alpha antibody (Ser21)

GSK3 alpha/beta antibody

70R-51552 100 ul
EUR 344.4
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta Antibody

29039-100ul 100ul
EUR 302.4

GSK3 alpha / beta Antibody

20-abx009185
  • EUR 360.00
  • EUR 526.80
  • EUR 226.80
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 alpha (pS21) Antibody

20-abx009689
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 alpha (pS21) Antibody

abx010870-100ug 100 ug
EUR 526.8

GSK3 alpha/beta Antibody

ABF6335 100 ug
EUR 525.6

GSK3 alpha/ beta Antibody

DF6806 200ul
EUR 420

GSK3 alpha Conjugated Antibody

C48179 100ul
EUR 476.4

GSK3 alpha/ beta Antibody

AF6335 200ul
EUR 420

anti-GSK3 alpha (6G2F1)

LF-MA30074 100 ul
EUR 644.4
Description: Mouse Monoclonal to GSK3 alpha

anti-GSK3 alpha (9D5G1)

LF-MA30111 100 ul
EUR 583.2
Description: Mouse Monoclonal to GSK3 alpha

anti-GSK3 alpha (6G12C2)

LF-MA30112 100 ul
EUR 583.2
Description: Mouse Monoclonal to GSK3 alpha

Anti-Phospho-C/EBP alpha (S21) antibody

STJ90757 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-C/EBP alpha (S21).

Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone

CABT-B9017-05mg 0.5 mg
EUR 1076.4

Anti-Enterovirus Pan-reactive VP3 monoclonal antibody, clone

CABT-B9017-1mg 1 mg
EUR 1606.8

Anti-Cav pan alpha antibody

STJ97558 200 µl
EUR 236.4
Description: Rabbit polyclonal to Cav pan alpha1 (A211).

Anti-MRP-S21 antibody

STJ94245 200 µl
EUR 236.4
Description: Rabbit polyclonal to MRP-S21.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

GSK3 alpha (Phospho-Ser282) Antibody

13162-100ul 100ul
EUR 302.4

GSK3 alpha (Phospho-Ser282) Antibody

13162-50ul 50ul
EUR 224.4

GSK3 alpha (Phospho-Ser21) Antibody

20-abx012539
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Phospho- GSK3 alpha (Ser21) Antibody

ABF3336 100 ug
EUR 525.6

GSK3 alpha recombinant monoclonal antibody

A5830 100ul X 3
EUR 714
Description: A recombinant monoclonal antibody from rabbit against human GSK3 alpha for WB, IHC,ELISA

Phospho-GSK3 alpha (Ser282) Antibody

AF7313 200ul
EUR 540

Phospho-GSK3 alpha (Ser21) Antibody

AF3336 200ul
EUR 420

GSK3 alpha/beta Conjugated Antibody

C29039 100ul
EUR 476.4

Anti-GSK3 beta antibody

STJ99095 200 µl
EUR 236.4
Description: Mouse monoclonal to GSK3 beta.

Anti-Phospho-FYN-(S21) antibody

STJ110850 100 µl
EUR 471.6
Description: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

Anti-Ribosomal Protein S21 antibody

STJ95495 200 µl
EUR 236.4
Description: Rabbit polyclonal to Ribosomal Protein S21.

Anti-Phospho-GSK3A-(S21) antibody

STJ29348 100 µl
EUR 471.6
Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.

Anti-Phospho-GSK3A-(S21) antibody

STJ22159 100 µl
EUR 471.6
Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.

GSK3 antibody

20R-1609 100 ug
EUR 807.6
Description: Rabbit polyclonal GSK3 antibody

GSK3 alpha/beta antibody (Tyr279/216)

70R-30577 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 alpha/beta antibody (Tyr279/216)

GSK3 alpha / beta (pT279 / 216) Antibody

20-abx009652
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

GSK3 alpha / beta (pY279 / 216) Antibody

20-abx119370
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

GSK3 alpha / beta (pY279 / 216) Antibody

abx010868-100ug 100 ug
EUR 526.8

Monoclonal GSK3 alpha Antibody, Clone: EP793Y

AMM05996G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Rabbit and are from clone EP793Y. This antibody is applicable in WB and IHC

Monoclonal GSK3 alpha Antibody, Clone: 9D5G1

APR12317G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 9D5G1. This antibody is applicable in WB, ICC, E

GSK3 alpha (Phospho-Ser282) Conjugated Antibody

C13162 100ul
EUR 476.4

Anti-Na+ CP type alpha-pan antibody

STJ94334 200 µl
EUR 236.4
Description: Rabbit polyclonal to Na+ CP type alpha-pan.

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma)-biotinylated

ACTB24-BTN 50 ul
EUR 489.6

Anti-RPS21/Ribosomal Protein S21 Antibody

A10068 100ul
EUR 476.4
Description: Rabbit Polyclonal RPS21/Ribosomal Protein S21 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-Phospho-GRK 1 (S21) antibody

STJ90901 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-GRK 1 (S21).

Anti-Phospho-HMG-14 (S21) antibody

STJ91313 200 µl
EUR 236.4
Description: Rabbit polyclonal to Phospho-HMG-14 (S21).

GSK3 alpha Blocking Peptide

20-abx161877
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

GSK3 alpha Blocking Peptide

AF7813-BP 1mg
EUR 234

GSK3 alpha Blocking Peptide

BF0391-BP 1mg
EUR 234

GSK3 alpha Blocking Peptide

AF6336-BP 1mg
EUR 234

Rabbit Anti-Actin (Pan, alpha, beta, gamma) IgG, aff pure

ACTB22-A 100 ug
EUR 578.4

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody

13355-100ul 100ul
EUR 399.6

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody

13355-50ul 50ul
EUR 286.8

Phospho- GSK3 alpha/ beta (Tyr279/216) Antibody

ABF3335 100 ug
EUR 525.6

Monoclonal GSK3 alpha Antibody, Clone: 6G2F1; 6G2F2

AMM02621G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 6G2F1; 6G2F2. This antibody is applicable in WB and IHC, E

Polyclonal GSK3 alpha (GSK3A) Antibody (N-term)

APR12316G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (N-term). This antibody is tested and proven to work in the following applications:

Monoclonal GSK3 alpha/beta Antibody, Clone: EP933Y

APR12318G 0.1ml
EUR 633.6
Description: A Monoclonal antibody against Human GSK3 alpha/beta. The antibodies are raised in Rabbit and are from clone EP933Y. This antibody is applicable in WB

Polyclonal GSK3 alpha (GSK3A) Antibody (C-term)

APS00025G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (C-term). This antibody is tested and proven to work in the following applications:

Phospho-GSK3 alpha/ beta (Tyr216/Tyr279) Antibody

AF3335 200ul
EUR 420

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species)

4-RAA398Ge21
  • EUR 406.80
  • EUR 4754.40
  • EUR 1146.00
  • EUR 530.40
  • EUR 303.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA)

Recombinant Antibody to Digoxin (DGX) (Pan-species)

4-RAK639Ge21
  • EUR 406.80
  • EUR 4754.40
  • EUR 1146.00
  • EUR 530.40
  • EUR 303.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Digoxin (DGX)

Anti-Phospho-GSK3 (alpha + beta) (Y216 + Y279) Rabbit Monoclonal Antibody

P03152-1 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal Phospho-GSK3 (alpha + beta) (Y216 + Y279) Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

GSK3 beta antibody

70R-37442 100 ug
EUR 327.6
Description: Rabbit Polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-49832 100 ul
EUR 344.4
Description: Purified Polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-30634 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-34165 100 ug
EUR 392.4
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-34639 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal GSK3 beta antibody

GSK3 beta Antibody

48798-100ul 100ul
EUR 399.6

GSK3 beta Antibody

48798-50ul 50ul
EUR 286.8

GSK3 beta antibody

10R-8595 100 ul
EUR 471.6
Description: Mouse monoclonal GSK3 beta antibody

GSK3 beta antibody

20R-1878 50 ug
EUR 337.2
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2124 50 ug
EUR 337.2
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2187 50 ug
EUR 337.2
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2452 50 ug
EUR 337.2
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 (pS9) Antibody

20-abx000124
  • EUR 594.00
  • EUR 844.80
  • EUR 260.40
  • EUR 427.20
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

GSK3 beta Antibody

ABF5016 100 ug
EUR 525.6

GSK3 beta Antibody

abx449182-100ug 100 ug
EUR 661.2

GSK3 beta Antibody

AF7814 200ul
EUR 540

GSK3 beta antibody

BF0721 200ul
EUR 540

GSK3 beta Antibody

DF7231 200ul
EUR 420

GSK3 beta Antibody

AF5016 200ul
EUR 420

GSK3 beta Antibody

AF6658 100ul
EUR 420

GSK3? Polyclonal Antibody

ES2485-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody

ES2485-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3?/? Polyclonal Antibody

ES2486-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3?/? Polyclonal Antibody

ES2486-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody

ES2487-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody

ES2487-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody

ES5683-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody

ES5683-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody

ES8198-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

GSK3? Polyclonal Antibody

ES8198-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

Anti-GSK3 beta Rabbit Monoclonal Antibody

M00791 100ug/vial
EUR 476.4
Description: Rabbit Monoclonal GSK3 beta Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

anti-GSK3 beta

YF-PA23834 50 ul
EUR 400.8
Description: Mouse polyclonal to GSK3 beta

anti-GSK3 beta

YF-PA12137 100 ug
EUR 483.6
Description: Rabbit polyclonal to GSK3 beta

Anti-Keratin-pan Antibody

A05667 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Keratin-pan Antibody (KRT2) detection.tested for IHC, WB in Human, Mouse, Rat.

Anti- Myosin-pan Antibody

A1213-100
EUR 483.6

Anti-Pan-PAX antibody

PAab06136 100 ug
EUR 426

anti- Pan Keratin antibody

LSMab09935 100 ug
EUR 463.2

anti- Pan-PAX antibody

FNab06136 100µg
EUR 606.3
Description: Antibody raised against Pan-PAX

anti- Pan Keratin antibody

FNab09935 100µg
EUR 658.5
Description: Antibody raised against Pan Keratin

Anti-Pan-AKT antibody

STJ11100091 100 µl
EUR 332.4

Anti-Pan myristoylation antibody

STJ98665 200 µl
EUR 236.4
Description: Rabbit polyclonal to Pan myristoylation.

Anti-Pan myristoylation antibody

STJ98666 200 µl
EUR 236.4
Description: Pan myristoylation protein is encoded by the MARCKS gene which is approximately 31,6 kDa. It is localised to the cytoplasm. It is involved in the integration of energy metabolism, Fc gamma R-mediated phagocytosis, microRNAs and Ca, cAMP and lipid signalling. It is the most prominent cellular substrate for protein kinase C and is an actin filament crosslinking protein. It is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. Pan myristoylation is expressed in the nervous system, liver, lung, skin and heart. Mutations in the MARCKS gene can result in spinocerebellar ataxia and anencephaly. STJ98666 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. The antibody detects endogenous pan myristoylation protein.

Anti-Keratin-pan antibody

STJ98693 200 µl
EUR 236.4
Description: Rabbit polyclonal to Keratin-pan.

Anti-Akt (pan) antibody

STJ99073 200 µl
EUR 236.4
Description: Mouse monoclonal to Akt (pan).

Anti-Akt (pan) antibody

STJ99074 200 µl
EUR 236.4
Description: Mouse monoclonal to Akt (pan).

Anti-Keratin-pan antibody

STJ96694 200 µl
EUR 236.4
Description: Rabbit polyclonal to Keratin-pan.

Anti-MYH-pan antibody

STJ96792 200 µl
EUR 236.4
Description: Rabbit polyclonal to MYH-pan.

Anti-Cytokeratin (Pan) antibody

STJ97993 100 µl
EUR 280.8
Description: Mouse monoclonal to Cytokeratin (Pan).

Anti-Cytokeratin (Pan) antibody

STJ97994 100 µl
EUR 280.8
Description: Mouse monoclonal to Cytokeratin (Pan).

Anti-Pan PKC antibody

STJ119907 100 µl
EUR 332.4

Anti-Periostin pan antibody

STJ120192 100 µl
EUR 631.2

Anti-Pan-Keratin antibody

STJ16100232 1 mL
EUR 348

Anti-Cytokeratin, Pan antibody

STJ180154 0.1 ml
EUR 254.4

Anti-Cytokeratin, Pan antibody

STJ180390 0.1 ml
EUR 276

Anti-cadherin-pan antibody

STJ190003 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to cadherin-pan (AS1A23)

Anti-Collagen PAN antibody

STJ190046 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to Collagen PAN (7B1)

Anti-PKC-pan antibody

STJ190083 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to PKC-pan (1D2)

Anti-pan ADH antibody

STJ70639 100 µg
EUR 430.8

Recombinant Antibody to C Reactive Protein (CRP) (Human)

4-RAA821Hu21
  • EUR 406.80
  • EUR 4754.40
  • EUR 1146.00
  • EUR 530.40
  • EUR 303.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Human C Reactive Protein (CRP)

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG-Cy3 conjugate

ACTB24-Cy3 100 ul
EUR 489.6

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG-FITC conjugate

ACTB24-FITC 100 ul
EUR 489.6

Mouse Monoclonal Anti-Actin (Pan, alpha, beta, gamma) IgG, aff pure

ACTB24-M 100 ug
EUR 578.4

OR Antibody

44609-100ul 100ul
EUR 302.4

OR Antibody

44609-50ul 50ul
EUR 224.4

OR Antibody

ABD10250 100 ug
EUR 525.6

OR Antibody

20-abx217389
  • EUR 510.00
  • EUR 410.40
  • 100 ug
  • 50 ug

OR Antibody

DF10250 200ul
EUR 420

MRP-S21 Polyclonal Antibody

41179-100ul 100ul
EUR 302.4

MRP-S21 Polyclonal Antibody

41179-50ul 50ul
EUR 224.4

MRP-S21 Polyclonal Antibody

ABP51848-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90

MRP-S21 Polyclonal Antibody

ABP51848-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90

MRP-S21 Polyclonal Antibody

ABP51848-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of MRP-S21 from Human, Mouse, Rat, Monkey. This MRP-S21 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human MRP-S21 at AA range: 10-90

Polyclonal GSK3A Antibody (S21)

APR12320G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3A (S21). This antibody is tested and proven to work in the following applications:

Phospho-GSK3A (S21) Antibody

1-CSB-PA000534
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-GSK3A (S21). Recognizes Phospho-GSK3A (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IP, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IP:2-5ug/mglysate.ELISA:1/20000

Phospho-CEBPA (S21) Antibody

1-CSB-PA000685
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-CEBPA (S21). Recognizes Phospho-CEBPA (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-GRK1 (S21) Antibody

1-CSB-PA040218
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-GRK1 (S21). Recognizes Phospho-GRK1 (S21) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-HMGN1 (S21) Antibody

1-CSB-PA009215
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-HMGN1 (S21). Recognizes Phospho-HMGN1 (S21) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

MRP-S21 Polyclonal Antibody

ES2847-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against MRP-S21 from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

MRP-S21 Polyclonal Antibody

ES2847-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against MRP-S21 from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

GSK3(alpha+beta)(Phospho-Y216+Y279) Conjugated Antibody

C13355 100ul
EUR 476.4

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), APC

4-RAA398Ge21-APC
  • EUR 580.80
  • EUR 6306.00
  • EUR 1688.40
  • EUR 765.60
  • EUR 333.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with APC.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Biotinylated

4-RAA398Ge21-Biotin
  • EUR 495.60
  • EUR 4694.40
  • EUR 1308.00
  • EUR 631.20
  • EUR 314.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Biotin.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), Cy3

4-RAA398Ge21-Cy3
  • EUR 723.60
  • EUR 8358.00
  • EUR 2202.00
  • EUR 970.80
  • EUR 396.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with Cy3.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), FITC

4-RAA398Ge21-FITC
  • EUR 488.40
  • EUR 5068.80
  • EUR 1375.20
  • EUR 636.00
  • EUR 291.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with FITC.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), HRP

4-RAA398Ge21-HRP
  • EUR 523.20
  • EUR 5485.20
  • EUR 1483.20
  • EUR 682.80
  • EUR 309.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with HRP.

Recombinant Antibody to Dehydroepiandrosterone (DHEA) (Pan-species), PE

4-RAA398Ge21-PE
  • EUR 488.40
  • EUR 5068.80
  • EUR 1375.20
  • EUR 636.00
  • EUR 291.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Dehydroepiandrosterone (DHEA). This antibody is labeled with PE.

Recombinant Antibody to Digoxin (DGX) (Pan-species), APC

4-RAK639Ge21-APC
  • EUR 580.80
  • EUR 6306.00
  • EUR 1688.40
  • EUR 765.60
  • EUR 333.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with APC.

Recombinant Antibody to Digoxin (DGX) (Pan-species), Biotinylated

4-RAK639Ge21-Biotin
  • EUR 495.60
  • EUR 4694.40
  • EUR 1308.00
  • EUR 631.20
  • EUR 314.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Biotin.

Recombinant Antibody to Digoxin (DGX) (Pan-species), Cy3

4-RAK639Ge21-Cy3
  • EUR 723.60
  • EUR 8358.00
  • EUR 2202.00
  • EUR 970.80
  • EUR 396.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with Cy3.

Recombinant Antibody to Digoxin (DGX) (Pan-species), FITC

4-RAK639Ge21-FITC
  • EUR 488.40
  • EUR 5068.80
  • EUR 1375.20
  • EUR 636.00
  • EUR 291.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with FITC.

Recombinant Antibody to Digoxin (DGX) (Pan-species), HRP

4-RAK639Ge21-HRP
  • EUR 523.20
  • EUR 5485.20
  • EUR 1483.20
  • EUR 682.80
  • EUR 309.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with HRP.

Recombinant Antibody to Digoxin (DGX) (Pan-species), PE

4-RAK639Ge21-PE
  • EUR 488.40
  • EUR 5068.80
  • EUR 1375.20
  • EUR 636.00
  • EUR 291.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Pan-species Digoxin (DGX). This antibody is labeled with PE.

Coating Antibody or Protein stabilizer solution (10X)

PRTS-100 100 ml
EUR 343.2

GSK3 alpha (pS21) Blocking Peptide

20-abx062705
  • EUR 376.80
  • EUR 610.80
  • 1 mg
  • 5 mg

GSK3 alpha / beta Blocking Peptide

20-abx062706
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

GSK3 alpha protein (GST Fusion)

80R-2554 100 ug
EUR 296.4
Description: Purified recombinant Human GSK3 alpha-GST Fusion protein

GSK3 alpha/beta Blocking Peptide

AF6335-BP 1mg
EUR 234

Melanoma; Pan (Ready-To-Use)

A00134-0002 2 ml
EUR 168

Melanoma; Pan (Ready-To-Use)

A00134-0007 7 ml
EUR 326.4

Melanoma; Pan (Ready-To-Use)

A00134-0025 25 ml
EUR 860.4

Rabbit Anti-AQP1-AQP9 Antiserum (25 ul each of AQP1-9)

AQP19-PAN-S 25 ul x9
EUR 1074

Actin (Pan, alpha, beta, gamma) Control/blocking peptide

ACTB22-P 100 ug
EUR 196.8

Rabbit Anti-AQP1-AQP6 IgG (25 ug each of AQP1-6) aff pure

AQP16-PAN-A 25 ul x 6
EUR 578.4

Rabbit Anti-AQP1-AQP6 Antiserum (25 ul each of AQP1-6) neat serum

AQP16-PAN-S 25 ul x 6
EUR 548.4
A noticeable upregulation of autophagy proteins (microtubule-associated protein 1A/1B-light chain 3 (LC3) and Beclin-1) had been seen within the melatonin remedy through the induction interval whereas these had been reverted within the presence of L-leucine, an autophagy inhibitor. As well as, the expression of NeuN was additionally considerably lowered by L-leucine. Collectively, our findings revealed an activation of autophagy throughout neural induction; melatonin enhanced reprogramming effectivity for neuron induction by means of the modulation of autophagy activation.

Leave a Reply

Your email address will not be published. Required fields are marked *