The novel AKT inhibitor Afuresertib suppresses human Merkel cell carcinoma MKL-1 cell growth

The novel AKT inhibitor Afuresertib suppresses human Merkel cell carcinoma MKL-1 cell growth

Merkel cell carcinoma (MCC) is a extremely aggressive neuroendocrine neoplasm of the pores and skin that’s related to exceedingly poor prognosis. The AKT/mTOR signaling pathway, which performs a pivotal function within the modulation of protein synthesis and cell survival, has been proven to be extremely necessary for Merkel cell carcinogenesis.
Within the present examine, our information point out that AKT has necessary regulatory capabilities in MCC cells and that inhibition of AKT with the novel ATP-competitive AKT inhibitor, Afuresertib, has widespread results on proliferative pathways.
Specifically, we show that remedy of MCC cells with Afuresertib led to the de-activation of mTOR and GSK3 pathway proteins whereas growing the activation of pro-apoptotic pathways via the upregulation of p16 expression and phospho-modulation of the Bcl-2-associated dying promoter. Total, Afuresertib remedy led to vital and strong inhibition of MCC cell proliferation, thus elevating intriguing questions relating to the potential efficacy of AKT inhibition for the longer term medical administration of MCCs.

An modern NRF2 nano-modulator induces lung most cancers ferroptosis and elicits an immunostimulatory tumor microenvironment

Simultaneous concentrating on of each the tumor microenvironment and most cancers cells by a single nanomedicine has not been reported up to now. Right here, we report the twin properties of zero-valent-iron nanoparticle (ZVI-NP) to induce cancer-specific cytotoxicity and anti-cancer immunity. Strategies: Most cancers-specific cytotoxicity induced by ZVI-NP was decided by MTT assay.
Mitochondria purposeful assay, immunofluorescence staining, Western blot, RT-qPCR, and ChIP-qPCR assays have been used to dissect the mechanism underlying ZVI-NP-induced ferroptotic most cancers cell dying. The therapeutic potential of ZVI-NP was evaluated in immunocompetent mice and humanized mice. Immune cell profiles of allografts and ex vivo cultured immune cells have been examined by stream cytometry evaluation, RT-qPCR assay, and immunofluorescence. 
Outcomes: ZVI-NP triggered mitochondria dysfunction, intracellular oxidative stress, and lipid peroxidation, resulting in ferroptotic dying of lung most cancers cells. Degradation of NRF2 by GSK3/β-TrCP via AMPK/mTOR activation was enhanced in such cancer-specific ferroptosis. As well as, ZVI-NP attenuated self-renewal skill of most cancers and downregulated angiogenesis-related genes.
Importantly, ZVI-NP augmented anti-tumor immunity by shifting pro-tumor M2 macrophages to anti-tumor M1, lowering the inhabitants of regulatory T cells, downregulating PD-1 and CTLA4 in CD8+ T cells to potentiate their cytolytic exercise towards most cancers cells, whereas attenuating PD-L1 expression in most cancers cells in vitro and in tumor-bearing immunocompetent mice.
Specifically, ZVI-NPs preferentially accrued in tumor and lung tissues, resulting in outstanding suppression of tumor development and metastasis. Conclusions: This dual-functional nanomedicine established an efficient technique to synergistically induce ferroptotic most cancers cell dying and reprogram the immunosuppressive microenvironment, which highlights the potential of ZVI-NP as a complicated built-in anti-cancer technique.

Activation of Galanin Receptor 1 with M617 Attenuates Neuronal Apoptosis by way of ERK/GSK-3β/TIP60 Pathway After Subarachnoid Hemorrhage in Rats

Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular illness. Neuronal apoptosis performs an necessary pathological function in early mind harm after SAH. Galanin receptor 1 (GalR1) activation was not too long ago proven to be anti-apoptotic within the setting of ischemic stroke.
This examine aimed to discover the anti-neuronal apoptosis impact of GalR1 activation after SAH, in addition to the underlying mechanisms. GalR1 CRISPR and GalR1 selective agonist, M617, was administered, respectively. Extracellular-signal-regulated kinase (ERK) inhibitor (U0126) and glycogen synthase kinase 3-beta (GSK3-β) CRISPR have been administered to analyze the involvement of the ERK/GSK3-β pathway in GalR1-mediated neuroprotection after SAH.
Consequence assessments included neurobehavioral checks, western blot, and immunohistochemistry. The outcomes confirmed that endogenous ligand galanin (Gal) and GalR1 have been markedly elevated within the ipsilateral mind hemisphere at 12 h and 24 h after SAH. GalR1 have been expressed primarily in neurons, however expression was additionally noticed in some astrocytes and microglia.
GalR1 CRISPR knockdown exacerbated neurological deficits and neuronal apoptosis 24 h after SAH. Furthermore, activation of GalR1 with M617 considerably improved short- and long-term neurological deficits however decreased neuronal apoptosis after SAH.
Moreover, GalR1 activation dysregulated the protein ranges of phosphorylated ERK and GSK-3β, however downregulated the phosphorylated Tat-interactive protein 60 (TIP60) and cleaved caspase-Three at 24 h after SAH. GalR1 CRISPR, U0126, and GSK-3β CRISPR abolished the helpful results of GalR1 activation at 24 h after SAH in rats. Collectively, the current examine demonstrated that activation of GalR1 utilizing M617 attenuated neuronal apoptosis via the ERK/GSK-3β/TIP60 pathway after SAH in rats. GalR1 might function a promising therapeutic goal for SAH sufferers.

Technology and characterization of iPSC-derived renal proximal tubule-like cells with prolonged stability

The renal proximal tubule is chargeable for re-absorption of nearly all of the glomerular filtrate and its correct operate is critical for whole-body homeostasis. Getting old, sure ailments and chemical-induced toxicity are elements that contribute to proximal tubule harm and power kidney illness development.
To higher perceive these processes, it might be advantageous to generate renal tissues from human induced pluripotent stem cells (iPSC). Right here, we report the differentiation and characterization of iPSC strains into proximal tubular-like cells (PTL).
The protocol is a step sensible publicity of small molecules and development elements, together with the GSK3 inhibitor (CHIR99021), the retinoic acid receptor activator (TTNPB), FGF9 and EGF, to drive iPSC to PTL by way of cell levels representing traits of early levels of renal improvement.
Genome-wide RNA sequencing confirmed that PTL clustered inside a kidney phenotype. PTL expressed proximal tubular-specific markers, together with megalin (LRP2), confirmed a polarized phenotype, and have been conscious of parathyroid hormone.
PTL might take up albumin and exhibited ABCB1 transport exercise. The phenotype was secure for as much as 7 days and was maintained after passaging. This protocol will kind the idea of an optimized technique for molecular investigations utilizing iPSC derived PTL.

When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer’s and Huntington’s Illness

Alzheimer’s illness (AD) is a principally sporadic mind dysfunction characterised by cognitive decline ensuing from selective neurodegeneration within the hippocampus and cerebral cortex whereas Huntington’s illness (HD) is a monogenic inherited dysfunction characterised by motor abnormalities and psychiatric disturbances ensuing from selective neurodegeneration within the striatum. Though there have been quite a few medical trials for these ailments, they’ve been unsuccessful.
Analysis carried out over the previous three a long time by numerous laboratories has demonstrated that irregular actions of widespread kinases play a key function within the pathogenesis of each AD and HD in addition to a number of different neurodegenerative ailments. Distinguished amongst these kinases are glycogen synthase kinase (GSK3), p38 mitogen-activated protein kinase (MAPK) and a number of the cyclin-dependent kinases (CDKs).
After a short abstract of the molecular and cell biology of AD and HD this overview covers what is understood concerning the function of those three teams of kinases within the mind and within the pathogenesis of the 2 neurodegenerative issues.

Rat Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7251608-96StripWells 96-Strip-Wells
EUR 690

Rat Glycogen synthase kinase-3 beta ELISA Kit

EK4490 96 tests
EUR 579

Rat Glycogen synthase kinase-3 beta ELISA Kit

MBS2881213-10x96StripWells 10x96-Strip-Wells
EUR 4080

Rat Glycogen synthase kinase-3 beta ELISA Kit

MBS2881213-48StripWells 48-Strip-Wells
EUR 390

Rat Glycogen synthase kinase-3 beta ELISA Kit

MBS2881213-5x96StripWells 5x96-Strip-Wells
EUR 2220

Rat Glycogen synthase kinase-3 beta ELISA Kit

MBS2881213-96StripWells 96-Strip-Wells
EUR 520

Rat Glycogen synthase kinase-3 beta ELISA Kit

MBS9428316-5x96Tests 5x96Tests
EUR 2740

Rat Glycogen synthase kinase-3 beta ELISA Kit

MBS9428316-96Tests 96Tests
EUR 600

Rat Glycogen Synthase Kinase 3 Beta ELISA Kit (GSK3b)

RK03701 96 Tests
EUR 625.2

Rat GSK3b(Glycogen Synthase Kinase 3 Beta) ELISA Kit

ELK6544-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GSK3b. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GSK3b. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat GSK3b, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat GSK3b in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat GSK3b(Glycogen Synthase Kinase 3 Beta) ELISA Kit

ELK6544-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat GSK3b. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat GSK3b. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat GSK3b, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat GSK3b in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat GSK3b (Glycogen Synthase Kinase 3 Beta) ELISA Kit

MBS8805521-10x96StripWells 10x96-Strip-Wells
EUR 3130

Rat GSK3b (Glycogen Synthase Kinase 3 Beta) ELISA Kit

MBS8805521-48StripWells 48-Strip-Wells
EUR 350

Rat GSK3b (Glycogen Synthase Kinase 3 Beta) ELISA Kit

MBS8805521-5x96StripWells 5x96-Strip-Wells
EUR 1710

Rat GSK3b (Glycogen Synthase Kinase 3 Beta) ELISA Kit

MBS8805521-96StripWells 96-Strip-Wells
EUR 445

Rat Gsk3b/ Glycogen synthase kinase-3 beta ELISA Kit

E0421Ra 1 Kit
EUR 557
Description: 2.7.11.1,Factor A,Serine/threonine-protein kinase GSK3B,FA

Rat GSK3β(Glycogen synthase kinase-3 beta) ELISA Kit

EKF60666-48T 48T
EUR 396.9

Rat GSK3β(Glycogen synthase kinase-3 beta) ELISA Kit

EKF60666-5x96T 5x96T
EUR 2693.25

Rat GSK3β(Glycogen synthase kinase-3 beta) ELISA Kit

EKF60666-96T 96T
EUR 567

Rat GSK3β(Glycogen synthase kinase-3 beta) ELISA Kit

ER0060 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml

Rat Gsk3b / Glycogen synthase kinase-3 beta ELISA Kit

E2298r 96T
EUR 796

Rat Glycogen Synthase Kinase 3 Beta (GSK3B) ELISA Kit

abx573569-96tests 96 tests
EUR 801.6

Rat Glycogen Synthase Kinase 3 beta (GSK3b) ELISA Kit

20-abx155613
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Ra 96T
EUR 499
Description: tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Ra-48T 48T
EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DLR-GSK3b-Ra-96T 96T
EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3β) Elisa kit

EK720562 96 Wells
EUR 0.58

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

EKU04523-48T 48T
EUR 603.26

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

EKU04523-5x96T 5x96T
EUR 4093.55

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

EKU04523-96T 96T
EUR 861.8

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

EKN45634-48T 48T
EUR 410.83

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

EKN45634-5x96T 5x96T
EUR 2787.78

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

EKN45634-96T 96T
EUR 586.9

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

DL-GSK3b-Ra 96T
EUR 475
Description: tissue homogenates, cell lysates or other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

EK14381 96Т
EUR 768

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

SED317Ra-10x96wellstestplate 10x96-wells test plate
EUR 6149.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

SED317Ra-1x48wellstestplate 1x48-wells test plate
EUR 611.57
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

SED317Ra-1x96wellstestplate 1x96-wells test plate
EUR 822.24
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

SED317Ra-5x96wellstestplate 5x96-wells test plate
EUR 3340.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

4-SED317Ra
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Glycogen Synthase Kinase 3 Beta (GSK3b) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-48T 48T
EUR 512.09
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-48Tests 48 Tests
EUR 699.6

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-96T 96T
EUR 731.54
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RDR-GSK3b-Ra-96Tests 96 Tests
EUR 973.2

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-48T 48T
EUR 487.7
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-48Tests 48 Tests
EUR 668.4

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-96T 96T
EUR 696.7
Description: tissue homogenates, cell lysates and other biological fluids.

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

RD-GSK3b-Ra-96Tests 96 Tests
EUR 930

Rat Glycogen Synthase Kinase 3 beta (GSK3b) ELISA Kit

abx155613-100g 100 µg
EUR 662.5

Rat Glycogen Synthase Kinase 3 beta (GSK3b) ELISA Kit

abx155613-1mg 1 mg
EUR 5962.5

Rat Glycogen Synthase Kinase 3 beta (GSK3b) ELISA Kit

abx155613-200g 200 µg
EUR 3150

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2020422-10x96StripWells 10x96-Strip-Wells
EUR 5705

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2020422-24StripWells 24-Strip-Wells
EUR 380

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2020422-48StripWells 48-Strip-Wells
EUR 575

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2020422-5x96StripWells 5x96-Strip-Wells
EUR 3125

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2020422-96StripWells 96-Strip-Wells
EUR 775

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS453773-10x96StripWells 10x96-Strip-Wells
EUR 5375

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS453773-48StripWells 48-Strip-Wells
EUR 470

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS453773-5x96StripWells 5x96-Strip-Wells
EUR 2760

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS453773-96StripWells 96-Strip-Wells
EUR 620

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS459737-10x96Tests 10x96Tests
EUR 5615

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS459737-48Tests 48Tests
EUR 485

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS459737-5x96Tests 5x96Tests
EUR 2875

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS459737-96Tests 96Tests
EUR 645

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2705041-10x96StripWells 10x96-Strip-Wells
EUR 3390

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2705041-24StripWells 24-Strip-Wells
EUR 260

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2705041-48StripWells 48-Strip-Wells
EUR 350

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2705041-5x96StripWells 5x96-Strip-Wells
EUR 1760

Rat Glycogen Synthase Kinase 3 Beta (GSK3b) ELISA Kit

MBS2705041-96StripWells 96-Strip-Wells
EUR 445

Rat Glycogen synthase kinase-3 beta(GSK3B) Elisa Kit

EK721647 96 Wells
EUR 0.64

Rat Glycogen synthase kinase-3 beta(GSK3B) ELISA kit

CSB-EL009963RA-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Rat Glycogen synthase kinase-3 beta (GSK3B) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Glycogen synthase kinase-3 beta(GSK3B) ELISA kit

1-CSB-EL009963RA
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Glycogen synthase kinase-3 beta(GSK3B) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Glycogen synthase kinase-3 beta,Gsk3b ELISA Kit

YLA0074RA-48T 48T Ask for price

Rat Glycogen synthase kinase-3 beta,Gsk3b ELISA Kit

YLA0074RA-96T 96T Ask for price

Rat Glycogen synthase kinase-3 beta,Gsk3b ELISA KIT

ELI-07359r 96tests
EUR 756

Rat Glycogen synthase kinase-3 beta,Gsk3b ELISA KIT

E0989Ra-1096T 10*96T
EUR 4122

Rat Glycogen synthase kinase-3 beta,Gsk3b ELISA KIT

E0989Ra-48wells 48 wells
EUR 300

Rat Glycogen synthase kinase-3 beta,Gsk3b ELISA KIT

E0989Ra-596T 5*96T
EUR 2061

Rat Glycogen synthase kinase-3 beta,Gsk3b ELISA KIT

E0989Ra-96wells 96 wells
EUR 458

Rat Glycogen synthase kinase-3 beta(GSK3B) ELISA Kit

QY-E11753 96T
EUR 448.8

Rat Glycogen synthase kinase-3 beta (GSK3B) ELISA Kit

RK14462 96T
EUR 280

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS9304668-10x96StripWells 10x96-Strip-Wells
EUR 6725

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS9304668-48StripWells 48-Strip-Wells
EUR 550

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS9304668-5x96StripWells 5x96-Strip-Wells
EUR 3420

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS9304668-96StripWells 96-Strip-Wells
EUR 765

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS165423-10x96StripWells 10x96-Strip-Wells
EUR 3955

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS165423-48StripWells 48-Strip-Wells
EUR 305

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS165423-5x96StripWells 5x96-Strip-Wells
EUR 2005

Rat Glycogen synthase kinase-3 beta, Gsk3b ELISA Kit

MBS165423-96StripWells 96-Strip-Wells
EUR 475

Rat Glycogen synthase kinase-3 beta (GSK3B) ELISA Kit

MBS284677-10x96StripWells 10x96-Strip-Wells
EUR 6255

Rat Glycogen synthase kinase-3 beta (GSK3B) ELISA Kit

MBS284677-48StripWells 48-Strip-Wells
EUR 445

Rat Glycogen synthase kinase-3 beta (GSK3B) ELISA Kit

MBS284677-5x96StripWells 5x96-Strip-Wells
EUR 3290

Rat Glycogen synthase kinase-3 beta (GSK3B) ELISA Kit

MBS284677-96StripWells 96-Strip-Wells
EUR 730

Cat Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS048790-INQUIRE INQUIRE Ask for price

ELISA kit for Rat GSK3b (Glycogen Synthase Kinase 3 Beta)

ELK6544 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Glycogen Synthase Kinase 3 Beta from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Fish Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS088973-INQUIRE INQUIRE Ask for price

Cavy Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS108365-INQUIRE INQUIRE Ask for price

Duck Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS065253-INQUIRE INQUIRE Ask for price

Goat Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS084548-INQUIRE INQUIRE Ask for price

Goat Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7245893-10x96StripWells 10x96-Strip-Wells
EUR 5685

Goat Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7245893-48StripWells 48-Strip-Wells
EUR 485

Goat Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7245893-5x96StripWells 5x96-Strip-Wells
EUR 3020

Goat Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7245893-96StripWells 96-Strip-Wells
EUR 690

ELISA kit for Rat Glycogen synthase kinase 3 beta (GSK3B)  Kit

KTE101131-48T 48T
EUR 424.8
Description: Quantitative sandwich ELISA for measuring Rat Glycogen synthase kinase 3 beta (GSK3B)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Glycogen synthase kinase 3 beta (GSK3B)  Kit

KTE101131-5platesof96wells 5 plates of 96 wells
EUR 2702.4
Description: Quantitative sandwich ELISA for measuring Rat Glycogen synthase kinase 3 beta (GSK3B)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Glycogen synthase kinase 3 beta (GSK3B)  Kit

KTE101131-96T 96T
EUR 686.4
Description: Quantitative sandwich ELISA for measuring Rat Glycogen synthase kinase 3 beta (GSK3B)  Kit in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS096386-10x96StripWells 10x96-Strip-Wells
EUR 6725

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS096386-48StripWells 48-Strip-Wells
EUR 550

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS096386-5x96StripWells 5x96-Strip-Wells
EUR 3420

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS096386-96StripWells 96-Strip-Wells
EUR 765

Human Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS104711-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS104711-48StripWells 48-Strip-Wells
EUR 550

Human Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS104711-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS104711-96StripWells 96-Strip-Wells
EUR 765

Horse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS108074-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS108074-48StripWells 48-Strip-Wells
EUR 550

Horse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS108074-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS108074-96StripWells 96-Strip-Wells
EUR 765

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099740-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099740-48StripWells 48-Strip-Wells
EUR 550

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099740-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099740-96StripWells 96-Strip-Wells
EUR 765

Camel Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS094208-10x96StripWells 10x96-Strip-Wells
EUR 6725

Camel Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS094208-48StripWells 48-Strip-Wells
EUR 550

Camel Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS094208-5x96StripWells 5x96-Strip-Wells
EUR 3420

Camel Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS094208-96StripWells 96-Strip-Wells
EUR 765

Goose Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS065492-INQUIRE INQUIRE Ask for price

Human Glycogen Synthase Kinase 3 beta ELISA Kit

MBS7253535-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human Glycogen Synthase Kinase 3 beta ELISA Kit

MBS7253535-48StripWells 48-Strip-Wells
EUR 485

Human Glycogen Synthase Kinase 3 beta ELISA Kit

MBS7253535-5x96StripWells 5x96-Strip-Wells
EUR 3020

Human Glycogen Synthase Kinase 3 beta ELISA Kit

MBS7253535-96StripWells 96-Strip-Wells
EUR 690

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7247868-10x96StripWells 10x96-Strip-Wells
EUR 5685

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7247868-48StripWells 48-Strip-Wells
EUR 485

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7247868-5x96StripWells 5x96-Strip-Wells
EUR 3020

Sheep Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7247868-96StripWells 96-Strip-Wells
EUR 690

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS728557-10x96StripWells 10x96-Strip-Wells
EUR 5685

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS728557-48StripWells 48-Strip-Wells
EUR 485

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS728557-5x96StripWells 5x96-Strip-Wells
EUR 3020

Mouse Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS728557-96StripWells 96-Strip-Wells
EUR 690

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS088155-10x96StripWells 10x96-Strip-Wells
EUR 6725

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS088155-48StripWells 48-Strip-Wells
EUR 550

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS088155-5x96StripWells 5x96-Strip-Wells
EUR 3420

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS088155-96StripWells 96-Strip-Wells
EUR 765

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS091538-10x96StripWells 10x96-Strip-Wells
EUR 6725

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS091538-48StripWells 48-Strip-Wells
EUR 550

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS091538-5x96StripWells 5x96-Strip-Wells
EUR 3420

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS091538-96StripWells 96-Strip-Wells
EUR 765

Donkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS047733-INQUIRE INQUIRE Ask for price

Rabbit Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS050565-INQUIRE INQUIRE Ask for price

Pigeon Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS081789-INQUIRE INQUIRE Ask for price

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS082923-10x96StripWells 10x96-Strip-Wells
EUR 6725

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS082923-48StripWells 48-Strip-Wells
EUR 550

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS082923-5x96StripWells 5x96-Strip-Wells
EUR 3420

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS082923-96StripWells 96-Strip-Wells
EUR 765

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7209416-10x96StripWells 10x96-Strip-Wells
EUR 5685

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7209416-48StripWells 48-Strip-Wells
EUR 485

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7209416-5x96StripWells 5x96-Strip-Wells
EUR 3020

Bovine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7209416-96StripWells 96-Strip-Wells
EUR 690

Rabbit Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7242050-10x96StripWells 10x96-Strip-Wells
EUR 5685

Rabbit Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7242050-48StripWells 48-Strip-Wells
EUR 485

Rabbit Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7242050-5x96StripWells 5x96-Strip-Wells
EUR 3020

Rabbit Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7242050-96StripWells 96-Strip-Wells
EUR 690

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7225926-10x96StripWells 10x96-Strip-Wells
EUR 5685

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7225926-48StripWells 48-Strip-Wells
EUR 485

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7225926-5x96StripWells 5x96-Strip-Wells
EUR 3020

Canine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7225926-96StripWells 96-Strip-Wells
EUR 690

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7250761-10x96StripWells 10x96-Strip-Wells
EUR 5685

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7250761-48StripWells 48-Strip-Wells
EUR 485

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7250761-5x96StripWells 5x96-Strip-Wells
EUR 3020

Monkey Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7250761-96StripWells 96-Strip-Wells
EUR 690

Human Glycogen synthase kinase-3 beta ELISA Kit

EK4488 96 tests
EUR 497

Mouse Glycogen synthase kinase-3 beta ELISA Kit

EK4489 96 tests
EUR 579

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS763250-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS763250-48StripWells 48-Strip-Wells
EUR 340

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS763250-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS763250-96StripWells 96-Strip-Wells
EUR 455

Mouse Glycogen synthase kinase-3 beta ELISA Kit

MBS2887455-10x96StripWells 10x96-Strip-Wells
EUR 4080

Mouse Glycogen synthase kinase-3 beta ELISA Kit

MBS2887455-48StripWells 48-Strip-Wells
EUR 390

Mouse Glycogen synthase kinase-3 beta ELISA Kit

MBS2887455-5x96StripWells 5x96-Strip-Wells
EUR 2220

Mouse Glycogen synthase kinase-3 beta ELISA Kit

MBS2887455-96StripWells 96-Strip-Wells
EUR 520

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS2883314-10x96StripWells 10x96-Strip-Wells
EUR 3290

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS2883314-48StripWells 48-Strip-Wells
EUR 340

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS2883314-5x96StripWells 5x96-Strip-Wells
EUR 1800

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS2883314-96StripWells 96-Strip-Wells
EUR 435

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS9428314-5x96Tests 5x96Tests
EUR 2420

Human Glycogen synthase kinase-3 beta ELISA Kit

MBS9428314-96Tests 96Tests
EUR 530

Mouse Glycogen synthase kinase-3 beta ELISA Kit

MBS9428315-5x96Tests 5x96Tests
EUR 2740

Mouse Glycogen synthase kinase-3 beta ELISA Kit

MBS9428315-96Tests 96Tests
EUR 600

Porcine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS100323-10x96StripWells 10x96-Strip-Wells
EUR 6725

Porcine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS100323-48StripWells 48-Strip-Wells
EUR 550

Porcine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS100323-5x96StripWells 5x96-Strip-Wells
EUR 3420

Porcine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS100323-96StripWells 96-Strip-Wells
EUR 765

Hamster Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099673-10x96StripWells 10x96-Strip-Wells
EUR 6725

Hamster Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099673-48StripWells 48-Strip-Wells
EUR 550

Hamster Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099673-5x96StripWells 5x96-Strip-Wells
EUR 3420

Hamster Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS099673-96StripWells 96-Strip-Wells
EUR 765

Chicken Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS067453-INQUIRE INQUIRE Ask for price

Chicken Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7237191-10x96StripWells 10x96-Strip-Wells
EUR 5685

Chicken Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7237191-48StripWells 48-Strip-Wells
EUR 485

Chicken Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7237191-5x96StripWells 5x96-Strip-Wells
EUR 3020

Chicken Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7237191-96StripWells 96-Strip-Wells
EUR 690

Porcine Glycogen Synthase Kinase 3 Beta ELISA Kit

MBS7226342-10x96StripWells 10x96-Strip-Wells
EUR 5685
The potential of concentrating on GSK3, p38 MAPK and CDKS as efficient therapeutics can be mentioned as is a short dialogue on the utilization of not too long ago developed medicine that concurrently goal two or all three of those teams of kinases. Multi-kinase inhibitors both by themselves or together with methods at present getting used corresponding to immunotherapy or secretase inhibitors for AD and knockdown for HD might characterize a simpler therapeutic strategy for these deadly neurodegenerative ailments.

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