Medical Mitogen-activated protein kinases (MAPK) Research

anti- Phospoho CDK, MAPK, GSK3, CLK, ERK1/2, JNK

Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production
Ae1 Ae3 Antibody Bafilomycin A1 Bile Acid Assay Bioassay Blog Deoxycholic Acid Sodium Salt ELISA kit Epz 6438 Glycodeoxycholic Acid Hdac Activity Assay immune Isotype Ldn 193189 Medium Mip 1B Mmp Activity Assay Pamabrom 100Mg Pepstatin A peptide Phospho 4Ebp1 Ru 58841 Soft Agar Sr 9011 Trypsin Activity Assay Tubastatin A

Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production

Inflammatory bowel ailments (IBD) are prevalent and debilitating ailments; their scientific treatment is desperately unmet. Mesenchymal stem cells (MSCs) are pluripotent stem cells with a number of immunomodulatory results, that are attributed to their efficacy within the IBD rodent mannequin.
Optimization of MSC regimes in IBD is an important step for his or her additional scientific software. Wogonin is a flavonoid-like compound, which confirmed in depth immunomodulatory and adjuvant results. This analysis is aimed toward investigating whether or not and the way Wogonin boosted the therapeutic effectivity of MSCs on DSS-induced colitis.
Our outcomes confirmed that the MSC therapy with Wogonin considerably alleviated the intestinal irritation in IBD mice by elevated IL-10 expression. In vitro experiments, Wogonin clearly raised the IL-10 manufacturing and ROS ranges of MSCs in a dose-dependent method. In the meantime, western blot knowledge advised Wogonin improves the IL-10 manufacturing by inducing transcript issue HIF-1α expression by way of AKT/GSK3β sign pathway.
Lastly, the favorable results of Wogonin on MSCs have been confirmed by IL-10 blockade experiment in vivo. Collectively, our outcomes advised that Wogonin considerably elevated the IL-10 manufacturing and enhanced the therapeutic results of MSCs in DSS-induced colitis. This work advised Wogonin as a novel optimum technique for MSC scientific software.
Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production

SUMO conjugation susceptibility of Akt/protein kinase B impacts the expression of the pluripotency transcription issue Nanog in embryonic stem cells

Akt/PKB is a kinase concerned within the regulation of all kinds of cell processes. Its exercise is modulated by various post-translational modifications (PTMs). Significantly, conjugation of the small ubiquitin-related modifier (SUMO) to this kinase impacts on a number of mobile features, similar to proliferation and splicing. In embryonic stem (ES) cells, this kinase is vital for pluripotency upkeep.
Amongst different features, Akt is understood to advertise the expression of Nanog, a central pluripotency transcription issue (TF). Nonetheless, the relevance of this particular PTM of Akt has not been beforehand analyzed on this context. On this work, we examine the impact of Akt1 variants with differential SUMOylation susceptibility on the expression of Nanog.
Our outcomes exhibit that each, the Akt1 functionality of being modified by SUMO conjugation and a useful SUMO conjugase exercise are required to induce Nanog gene expression. Likewise, we discovered that the frequent oncogenic E17Okay Akt1 mutant affected Nanog expression in ES cells additionally in a SUMOylatability dependent method.
Curiously, this final result takes locations in ES cells however not in a non-pluripotent heterologous system, suggesting the presence of an important issue for this induction in ES cells. Remarkably, the 2 main candidate components to mediate this induction, GSK3-β and Tbx3, are non-essential gamers of this impact, suggesting a posh mechanism in all probability involving non-canonical pathways.
Moreover, we discovered that Akt1 subcellular distribution doesn’t depend upon its SUMOylatability, indicating that Akt localization has no affect on the impact on Nanog, and that apart from the membrane localization of E17Okay Akt mutant, SUMOylation can also be required for its hyperactivity.
Our outcomes spotlight the influence of SUMO conjugation within the operate of a kinase related for a plethora of mobile processes, together with the management of a key pluripotency TF.
Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production

Results of graphene on morphology, microstructure and transcriptomic profiling of Pinus tabuliformis Carr. roots

Graphene has proven nice potential for bettering progress of many vegetation, however its impact on woody vegetation stays basically unstudied. On this work, Pinus tabuliformis Carr. bare-rooted seedlings grown open air in pots have been irrigated with a graphene resolution over a focus vary of 0-50 mg/L for six months. Graphene was discovered to stimulate root progress, with a maximal impact at 25 mg/L.
We then investigated root microstructure and carried out transcript profiling of root supplies handled with Zero and 25 mg/L graphene. Graphene therapy resulted in plasma-wall separation and destruction of membrane integrity in root cells.
Greater than 50 thousand of differentially expressed genes (DEGs) have been obtained by RNA sequencing, amongst which 6477 may very well be annotated utilizing different plant databases. The GO enrichment evaluation and KEGG pathway evaluation of the annotated DEGs indicated that abiotic stress responses, which resemble salt stress, have been induced by graphene therapy in roots, whereas responses to biotic stimuli have been inhibited.
Quite a few metabolic processes and hormone sign transduction pathways have been altered by the therapy. The expansion promotion results of graphene could also be mediated by encouraging proline synthesis, and suppression of the expression of the auxin response gene SMALL AUXIN UP-REGULATED RNA 41 (SAUR41), PYL genes which encode ABA receptors, and GSK3 homologs.

3-hydroxyanthranic acid will increase the sensitivity of hepatocellular carcinoma to sorafenib by reducing tumor cell stemness

Sorafenib is the FDA-approved first-line goal drug for HCC sufferers. Nonetheless, sorafenib solely confers 3-5 months of survival profit with <30% of HCC sufferers. Thus, it’s essential to develop a sensitizer for hepatocellular carcinoma (HCC) to sorafenib.
Right here, we report that in consultant HCC cell strains (SMMC-7721 and PLC8024) which can be insensitive to sorafenib, 3-HAA (50 μM) considerably enhances cell sensitivity to sorafenib to an extent that would not be defined by additive results. In nude mice carrying HCC xenograft, tumor progress is inhibited by sorafenib (10 mg/kg/day) or 3-HAA (100 mg/kg/day) alone. When utilized in mixture, the therapy successfully prevents the xenograft from rising.
In a set of mechanistic experiments, we discover enhanced AKT activation and elevated proportion of CD44+CD133+ cells in sorafenib-resistant HCC cells and tissues. The proportion of CD44+CD133+ cells is decreased upon 3-HAA therapy in each cultured cells and mouse xenografts, suggesting that 3-HAA may lower the stemness of HCC. We additionally detect decreased phosphorylation of AKT, a regulator of the GSK3β/β-catenin signaling upon 3-HAA therapy.

baculoCOMPLETE protein expression kit + baculoQUANT all-in-one
400101 5 + 100 reactions
EUR 1009.89

GSK3 alpha (GSK3A) (NM_019884) Human Over-expression Lysate
E45H11030-2 each
EUR 395

GSK3 alpha (GSK3A) (NM_019884) Human Over-expression Lysate
LS002931 100ug
EUR 628
Description: Transient overexpression lysate of glycogen synthase kinase 3 alpha (GSK3A)

Human GSK3A Protein Lysate
MBS8412626-002mg 0.02mg
EUR 365

Human GSK3A Protein Lysate
MBS8412626-5x002mg 5x0.02mg
EUR 1410

GSK3 beta (GSK3B) (NM_001146156) Human Over-expression Lysate
E45H00804-2 each
EUR 395

GSK3 beta (GSK3B) (NM_002093) Human Over-expression Lysate
E45H06016-2 each
EUR 395

GSK3 beta (GSK3B) (NM_002093) Human Over-expression Lysate
LS002932 100ug
EUR 628
Description: Transient overexpression lysate of glycogen synthase kinase 3 beta (GSK3B), transcript variant 1

Human GSK3A Protein Lysate 20ug
IHUGSK3APLLY20UG each
EUR 213
Description: Human GSK3A Protein Lysate 20ug

EP Reagent Biuret Reagent - 100ML
1011601 1L
EUR 59.4

OCOA09277-20UG - GSK3A Protein Lysate
OCOA09277-20UG 20ug
EUR 169

PEROXIDE BLOCKING REAGENT Reagent
GWB-Q00308 50 ml Ask for price

EP Reagent Iodoplatinate Reagent - 200ML
1046300 200ML
EUR 502.2

HSPC210 (GSKIP) (NM_016472) Human Over-expression Lysate
E45H10095-2 each
EUR 395

HSPC210 (GSKIP) (NM_016472) Human Over-expression Lysate
LS051527 100ug
EUR 628
Description: Transient overexpression lysate of chromosome 14 open reading frame 129 (C14orf129)

EP Reagent Molybdovanadic Reagent - 100ML
1056700 100ML
EUR 59.4

EP Reagent Methoxyphenylacetic Reagent - 100ML
1053601 100ML
EUR 490.05

Protein expression
CRO-4-Ind each Ask for price

EP Reagent Phosphomolybdotungstic Reagent - 100ML
1065000 100ML
EUR 226.8

RFP expression Adenovirus, in vivo ready
AVP001-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made RFP expression adenovirus, provided in PBS solution.

CFP expression Adenovirus, in vivo ready
AVP002-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made CFP expression adenovirus, provided in PBS solution.

GFP expression Adenovirus, in vivo ready
AVP011-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made GFP expression adenovirus, provided in PBS solution.

YFP expression Adenovirus, in vivo ready
AVP012-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made YFP expression adenovirus, provided in PBS solution.

BFP expression Adenovirus, in vivo ready
AVP017-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made BFP expression adenovirus, provided in PBS solution.

AVIDIN/BIOTIN BLOCKING REAGENT Reagent
GWB-Q00289 30 ml Ask for price

Gordon-McLeod Reagent (Oxidase reagent)
R026-100ML 1 unit
EUR 7.76
Description: Gordon-McLeod Reagent (Oxidase reagent)

Oxidase Reagent (Gordon-Macleod Reagent)
76207 100 ml
EUR 3.38
Description: Part B

YLEX Expression Kit
FYY201-1KT 1 kit Ask for price

EP Reagent Sulfomolybdic Reagent R3 - 1L
1086500 1L
EUR 398.25

TRIpure Reagent (same as Trizol Reagent)
MBS356001-INQUIRE INQUIRE Ask for price

h OCT4 expression Adenovirus, in vivo ready
AVP013-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made adenovirus express human stem cell factor, OCT4, provided in PBS solution for in vivo application.

h SOX2 expression Adenovirus, in vivo ready
AVP014-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made adenovirus express human stem cell factor, SOX2, provided in PBS solution for in vivo application.

293 Expression MAX-1
EXP-711-11 1ml
EUR 218
Description: 293 Expression MAX-1 is expressed from - -.

h LIN28 expression Adenovirus, in vivo ready
AVP015-PBS 1x1011 IFU/ml x 50ul
EUR 455
Description: pre-made adenovirus express human stem cell factor, LIN28, provided in PBS solution for in vivo application.

Total RNA Isolation Reagent (Reagent Based)
MBS402052-100mL 100mL
EUR 235

Total RNA Isolation Reagent (Reagent Based)
MBS402052-4Reactions 4Reactions
EUR 165

CNGA2 Expression vector
60642 20 µg
EUR 900
Description: The CNGA2 expression vector is designed to express human cyclic nucleotide-gated cation channel 2 (CNGA2) in mammalian cells.

CNGA2 Expression vector
GWB-PSFA61 20ug Ask for price

Genomic DNA Isolation Reagent (Reagent Based)
MBS402050-100mL 100mL
EUR 255

Genomic DNA Isolation Reagent (Reagent Based)
MBS402050-4Reactions 4Reactions
EUR 185

pYLEX1 - Expression Vector
FYY203-5MG 5mg Ask for price

LEXSYcon2.1 Expression Kit
EGE-1310ble 1Kit
EUR 979.85
Description: for constitutive cytosolic or secretory protein expression

LEXSYcon2.1 Expression Kit
EGE-1310bsd 1Kit
EUR 979.85
Description: for constitutive cytosolic or secretory protein expression

LEXSYcon2.1 Expression Kit
EGE-1310hyg 1Kit
EUR 979.85
Description: for constitutive cytosolic or secretory protein expression

LEXSYcon2.1 Expression Kit
EGE-1310neo 1Kit
EUR 979.85
Description: for constitutive cytosolic or secretory protein expression

LEXSYcon2.1 Expression Kit
EGE-1310pac 1Kit
EUR 979.85
Description: for constitutive cytosolic or secretory protein expression

LEXSYcon2.1 Expression Kit
EGE-1310sat 1Kit
EUR 979.85
Description: for constitutive cytosolic or secretory protein expression

Blunt E1 Expression Kit
abx098098-100l 100 µl
EUR 712.5

Blunt E1 Expression Kit
abx098098-10rxns 10 rxns
EUR 560.4

Blunt E1 Expression Kit
abx098098-1ml 1 ml Ask for price

Blunt E1 Expression Kit
abx098098-200l 200 µl Ask for price

Blunt E2 Expression Kit
abx098873-100l 100 µl
EUR 712.5

Blunt E2 Expression Kit
abx098873-10rxns 10 rxns
EUR 560.4

Blunt E2 Expression Kit
abx098873-1ml 1 ml Ask for price

Blunt E2 Expression Kit
abx098873-200l 200 µl Ask for price

RFP expression Adenovirus
AVP001 1x109 IFU/ml x 200ul
EUR 206.5
Description: pre-made RFP expression adenovirus, provided in DMEM medium.

CFP expression Adenovirus
AVP002 1x109 IFU/ml x 200ul
EUR 206.5
Description: pre-made CFP expression adenovirus, provided in DMEM medium.

GFP expression Adenovirus
AVP011 1x109 IFU/ml x 200ul
EUR 206.5
Description: pre-made GFP expression adenovirus, provided in DMEM medium.

YFP expression Adenovirus
AVP012 1x109 IFU/ml x 200ul
EUR 206.5
Description: pre-made YFP expression adenovirus, provided in DMEM medium.

BFP expression Adenovirus
AVP017 1x109 IFU/ml x 200ul
EUR 206.5
Description: pre-made BFP expression adenovirus, provided in DMEM medium.

LEXSinduce3 Expression Kit
EGE-1410ble 1Kit
EUR 2296.43
Description: for inducible cytosolic or secretory protein expression

LEXSinduce3 Expression Kit
EGE-1410blecherry 1Kit
EUR 2296.43
Description: for inducible cytosolic or secretory protein expression

LEXSinduce3 Expression Kit
EGE-1410neo 1Kit
EUR 2296.43
Description: for inducible cytosolic or secretory protein expression

LEXSinduce4 Expression Kit
EGE-1420blecherry 1Kit
EUR 2296.43
Description: for inducible cytosolic or secretory protein expression

Rac1 Expression Vector Set
STA-454 1 kit
EUR 1765.2
Description: Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and G12V constitutively active mutant.

RhoA Expression Vector Set
STA-456 1 kit
EUR 1765.2
Description: RhoA Expression Vector Set contains 3 vectors: RhoA wild type, T19N dominant negative mutant, and G14V constitutively active mutant.

Plant Total RNA Isolation Reagent (Reagent Based)
MBS402053-100mL 100mL
EUR 245

Plant Total RNA Isolation Reagent (Reagent Based)
MBS402053-4Reactions 4Reactions
EUR 165

WB-Validated GSK3A Knockdown Cell Lysate Kit
E46C3741 kit (100 µg KD+100 µg WT)
EUR 945

OPN expression inhibitor 1
HY-146064 10 mg
EUR 2272.76
Description: OPN expression inhibitor 1 (Compound 11) is an osteopontin (OPN) expression inhibitor. OPN expression inhibitor 1 can be used for breast cancer research[1].

OPN expression inhibitor 1
T62820-10mg 10mg Ask for price
Description: OPN expression inhibitor 1

OPN expression inhibitor 1
T62820-1g 1g Ask for price
Description: OPN expression inhibitor 1

OPN expression inhibitor 1
T62820-1mg 1mg Ask for price
Description: OPN expression inhibitor 1

OPN expression inhibitor 1
T62820-50mg 50mg Ask for price
Description: OPN expression inhibitor 1

OPN expression inhibitor 1
T62820-5mg 5mg Ask for price
Description: OPN expression inhibitor 1

Cdc42 Expression Vector Set
STA-455 1 kit
EUR 1765.2
Description: Cdc42 Expression Vector Set contains 3 vectors: Cdc42 wild type, T17N dominant negative mutant, and Q61L constitutively active mutant.

Plant Genomic DNA Isolation Reagent (Reagent Based)
MBS402051-100mL 100mL
EUR 245

Plant Genomic DNA Isolation Reagent (Reagent Based)
MBS402051-4Reactions 4Reactions
EUR 165

h FAP Expression Lentivirus
LVP1307 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: FAP, containing a RFP-Blasticidin dual selection marker.

h CD1 Expression Lentivirus
LVP1320 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: CD1, containing a RFP-Blasticidin dual selection marker.

m FAP Expression Lentivirus
LVP1326 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for mouse target: FAP, containing a RFP-Blasticidin dual selection marker.

h VIM Expression Lentivirus
LVP1357 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: VIM, containing a RFP-Blasticidin dual selection marker.

h PXN Expression Lentivirus
LVP1358 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: PXN, containing a RFP-Blasticidin dual selection marker.

m CD8 Expression Lentivirus
LVP1363 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for mouse target: CD8, containing a RFP-Blasticidin dual selection marker.

h TPO Expression Lentivirus
LVP1371 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: TPO, containing a RFP-Blasticidin dual selection marker.

h WAS Expression Lentivirus
LVP1429 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: WAS, containing a RFP-Blasticidin dual selection marker.

m PGR Expression Lentivirus
LVP1455 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for mouse target: PGR containing a RFP-Blasticidin dual selection marker.

h MAG Expression Lentivirus
LVP1485 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: MAG, containing a RFP-Blasticidin dual selection marker.

h FST Expression Lentivirus
LVP1518 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express human FST gene, containing a RFP-Blasticidin dual selection marker.

h IL2 Expression Lentivirus
LVP293 1x107 IFU/ml x 200ul
EUR 276.5
Description: Lentivirus express a human IL2 gene with a Blasticidin-RFP fusion marker (Dual selection).

h ADA Expression Lentivirus
LVP923 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: ADA, containing a RFP-Blasticidin dual selection marker.

h PBK Expression Lentivirus
LVP095 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made Lentivirus express human PBK gene, carrying a RFP-Blasticidin fusion marker (Dual selection).

h IL6 Expression Lentivirus
LVP1144 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: HDAC1, containing a RFP-Blasticidin dual selection marker.

h CD4 Expression Lentivirus
LVP1152 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: CD4, containing a RFP-Blasticidin dual selection marker.

h IL4 Expression Lentivirus
LVP1161 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: IL4, containing a RFP-Blasticidin dual selection marker.

h IL7 Expression Lentivirus
LVP1162 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: IL7, containing a RFP-Blasticidin dual selection marker.

pAAV-MCS Expression Vector
MBS169528-001mg 0.01mg
EUR 695

pAAV-MCS Expression Vector
MBS169528-5x001mg 5x0.01mg
EUR 2955

pAAV-MCS Expression Vector
VPK-410 10 µg
EUR 444

FlashBAC - Baculovirus Expression System(24 reactions)
GWB-EB1FF8 Kit Ask for price

FlashBAC - Baculovirus Expression System (96 reactions)
GWB-6C34E3 Kit Ask for price

FlashBAC - Baculovirus Expression System (5 reactions)
GWB-7676BB Kit Ask for price

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-25 each
EUR 992.4

ExoPure? Reagent (Overall Exosome Isolation, urine)
M1003-50 each
EUR 1083.6

h OCT4 expression Adenovirus
AVP013 1x109 IFU/ml x 200ul
EUR 206.5
Description: pre-made adenovirus express human stem cell factor, OCT4, provided in DMEM medium.

h SOX2 expression Adenovirus
AVP014 1x109 IFU/ml x 50ul
EUR 206.5
Description: pre-made adenovirus express human stem cell factor, SOX2, provided in DMEM medium.

h CBX7 Expression Lentivirus
LVP1308 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: CBX7, containing a RFP-Blasticidin dual selection marker.

h ACE2 Expression Lentivirus
LVP1310 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: ACE2, containing a RFP-Blasticidin dual selection marker.

h Rab7 Expression Lentivirus
LVP1315 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: Rab7, containing a RFP-Blasticidin dual selection marker.

h Rab5 Expression Lentivirus
LVP1316 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: Rab5, containing a RFP-Blasticidin dual selection marker.

m ASPA Expression Lentivirus
LVP1317 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for mouse target: ASPA, containing a RFP-Blasticidin dual selection marker.

h CD44 Expression Lentivirus
LVP1318 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: CD44, containing a RFP-Blasticidin dual selection marker.

h MFN2 Expression Lentivirus
LVP1327 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: MFN2, containing a RFP-Blasticidin dual selection marker.

h ANO1 Expression Lentivirus
LVP1344 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: ANO1 containing a RFP-Blasticidin dual selection marker.

h FGL2 Expression Lentivirus
LVP1346 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: FGL2, containing a RFP-Blasticidin dual selection marker.

h CCR2 Expression Lentivirus
LVP1354 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: CCR2, containing a RFP-Blasticidin dual selection marker.

h NEFL Expression Lentivirus
LVP1360 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: NEFL, containing a RFP-Blasticidin dual selection marker.

h NOS2 Expression Lentivirus
LVP1367 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: NOS2, containing a RFP-Blasticidin dual selection marker.

h BMI1 Expression Lentivirus
LVP1372 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: BMI1, containing a RFP-Blasticidin dual selection marker.

h PSCA Expression Lentivirus
LVP1374 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: PSCA, containing a RFP-Blasticidin dual selection marker.

h POLQ Expression Lentivirus
LVP1421 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: POLQ containing a RFP-Blasticidin dual selection marker.

h ARSA Expression Lentivirus
LVP1425 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: ARSA, containing a RFP-Blasticidin dual selection marker.

h IDUA Expression Lentivirus
LVP1426 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: IDUA, containing a RFP-Blasticidin dual selection marker.

h SGSH Expression Lentivirus
LVP1427 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: SGSH, containing a RFP-Blasticidin dual selection marker.

h CYBB Expression Lentivirus
LVP1430 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: CYBB, containing a RFP-Blasticidin dual selection marker.

h CAV1 Expression Lentivirus
LVP1431 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: CAV1, containing a RFP-Blasticidin dual selection marker.

m INS2 Expression Lentivirus
LVP1456 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for mouse target: INS2 containing a RFP-Blasticidin dual selection marker.

h ROR1 Expression Lentivirus
LVP1458 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: ROR1, containing a RFP-Blasticidin dual selection marker.

h DGKA Expression Lentivirus
LVP1468 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: DGKA, containing a RFP-Blasticidin dual selection marker.

h REST_HA Expression Lentivirus
LVP1475 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: REST, containing a RFP-Blasticidin dual selection marker.

h UBR7 Expression Lentivirus
LVP1483 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: UBR7, containing a RFP-Blasticidin dual selection marker.

h MMP1 Expression Lentivirus
LVP1516 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express human MMP1 gene, containing a RFP-Blasticidin dual selection marker.

h BDNF Expression Lentivirus
LVP1520 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express human BDNF gene, containing a RFP-Blasticidin dual selection marker.

m CCL5 Expression Lentivirus
LVP1619 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express mouse CCL5 gene, containing a RFP-Blasticidin dual selection marker.

h TET2 Expression Lentivirus
LVP875 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made lentivirus express human target: TET2 (tet methylcytosine dioxygenase 2). It contains a RFP-Blasticidin dual selection marker.

h TET3 Expression Lentivirus
LVP876 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for expressing human target: TET3 (tet methylcytosine dioxygenase 3), [alternative names: hCG_40738]. The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_001287491.1 . It also contains a RFP-Blasticidin dual selection marker.

h CDR1 Expression Lentivirus
LVP917 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: CDR1, containing a RFP-Blasticidin dual selection marker.

h CD47 Expression Lentivirus
LVP918 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CD47, containing a RFP-Blasticidin dual selection marker.

h ESR1 Expression Lentivirus
LVP924 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: ESR1, containing a RFP-Blasticidin dual selection marker.

r Syn1 Expression Lentivirus
LVP925 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for rat target: Syn1, containing a RFP-Blasticidin dual selection marker.

h NME4 Expression Lentivirus
LVP932 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: NME4, containing a RFP-Blasticidin dual selection marker.

h EGFR Expression Lentivirus
LVP1142 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made over-expression lentivirus for human target: EGFR, containing a RFP-Blasticidin dual selection marker.

h CD8a Expression Lentivirus
LVP1151 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made over-expression lentivirus for human target: CD8a, containing a RFP-Blasticidin dual selection marker.

h PIGF Expression Lentivirus
LVP1154 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: PIGF, containing a RFP-Blasticidin dual selection marker.

h BRAF Expression Lentivirus
LVP1156 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: BRAF, containing a RFP-Blasticidin dual selection marker.

h ROS1 Expression Lentivirus
LVP1158 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: ROS1, containing a RFP-Blasticidin dual selection marker.

h CD3E Expression Lentivirus
LVP1163 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: IL7, containing a RFP-Blasticidin dual selection marker.

h KLK3 Expression Lentivirus
LVP1171 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: KLK3, containing a RFP-Blasticidin dual selection marker.

h NEK6 Expression Lentivirus
LVP1182 1x107 IFU/ml x 200ul
EUR 541.2
Description: Pre-made over-expression lentivirus for human target: NEK6, containing a RFP-Blasticidin dual selection marker.

h NEK7 Expression Lentivirus
LVP1183 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: NEK7, containing a RFP-Blasticidin dual selection marker.

h STM2 Expression Lentivirus
LVP1210 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: STM2, containing a RFP-Blasticidin dual selection marker.

H-Ras Expression Vector Set
STA-457 1 kit
EUR 1765.2
Description: H-Ras Expression Vector Set contains 3 vectors: H-Ras wild type, T19N dominant negative mutant, and G12V constitutively active mutant.

h LIN28 expression Adenovirus
AVP015 1x109 IFU/ml x 200ul
EUR 206.5
Description: pre-made adenovirus express human stem cell factor, LIN28, provided in DMEM medium.

h FADS2 Expression Lentivirus
LVP1319 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: FADS2, containing a RFP-Blasticidin dual selection marker.

h OVOL2 Expression Lentivirus
LVP1322 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: OVOL2, containing a RFP-Blasticidin dual selection marker.

h APOA1 Expression Lentivirus
LVP1324 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: APOA1, containing a RFP-Blasticidin dual selection marker.

h SOX10 Expression Lentivirus
LVP1325 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: SOX10, containing a RFP-Blasticidin dual selection marker.

h P2RY1 Expression Lentivirus
LVP1328 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: P2RY1, containing a RFP-Blasticidin dual selection marker.

h TUSC2 Expression Lentivirus
LVP1343 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: TUSC2, containing a RFP-Blasticidin dual selection marker.

h NLRP3 Expression Lentivirus
LVP1350 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: NLRP3, containing a RFP-Blasticidin dual selection marker.

h CCL19 Expression Lentivirus
LVP1353 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: CCL19, containing a RFP-Blasticidin dual selection marker.

h Sirt2 Expression Lentivirus
LVP1373 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: Sirt2, containing a RFP-Blasticidin dual selection marker.

h EPCAM Expression Lentivirus
LVP1375 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: EPCAM, containing a RFP-Blasticidin dual selection marker.

h PDE6B Expression Lentivirus
LVP1423 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: PDE6B, containing a RFP-Blasticidin dual selection marker.

h ABCA4 Expression Lentivirus
LVP1424 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: ABCA4, containing a RFP-Blasticidin dual selection marker.

h NAGLU Expression Lentivirus
LVP1428 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: NAGLU, containing a RFP-Blasticidin dual selection marker.

h ACOD1 Expression Lentivirus
LVP1432 1x10^7 IFU/ml x 200ul
EUR 276.5
Description: Over-expression lentivirus for human target: ACOD1, containing a RFP-Blasticidin dual selection marker.

h SIRPA Expression Lentivirus
LVP1459 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: SIRPA, containing a RFP-Blasticidin dual selection marker.

h RIOK1 Expression Lentivirus
LVP1469 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: RIOK1, containing a RFP-Blasticidin dual selection marker.

h HDAC8 Expression Lentivirus
LVP1482 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: HDAC8, containing a RFP-Blasticidin dual selection marker.

h CD226 Expression Lentivirus
LVP1484 1x10^7 IFU/ml x 200ul
EUR 346.5
Description: Pre-made over-expression lentivirus for human target: CD226, containing a RFP-Blasticidin dual selection marker.

h TAOK1 Expression Lentivirus
LVP1509 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express human TAOK1 gene, containing a RFP-Blasticidin dual selection marker.

h CD155 Expression Lentivirus
LVP1512 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express human CD155 gene, containing a RFP-Blasticidin dual selection marker.

h GSTA1 Expression Lentivirus
LVP1514 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express human GSTA1 gene, containing a RFP-Blasticidin dual selection marker.

h GSTA2 Expression Lentivirus
LVP1515 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express human GSTA2 gene, containing a RFP-Blasticidin dual selection marker.

m CXCL9 Expression Lentivirus
LVP1620 1x10^8 IFU/ml x 200ul
EUR 455
Description: Pre-made lentivirus express mouse CXCL9 gene, containing a RFP-Blasticidin dual selection marker.

h TACC3 Expression Lentivirus
LVP594 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made optional inducible lentiviral particles for expressing human target: h TACC3 (alternative name: ERIC-1; ERIC1). The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_006342.2. Particles also contains a RFP-Blasticidin dual selection marker.

h GPNMB Expression Lentivirus
LVP921 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: GPNMB, containing a RFP-Blasticidin dual selection marker.

h DECR1 Expression Lentivirus
LVP927 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: DECR1, containing a RFP-Blasticidin dual selection marker.

h DECR2 Expression Lentivirus
LVP928 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: DECR2, containing a RFP-Blasticidin dual selection marker.

h NMRK1 Expression Lentivirus
LVP930 1x107 IFU/ml x 200ul
EUR 276.5
Description: Pre-made over-expression lentivirus for human target: NMRK1, containing a RFP-Blasticidin dual selection marker.
The AKT activator SC79 prompts GSK3 β/β-catenin signaling whereas the Wnt inhibitor XAV-939 abolishes 3-HAA inhibition of HCC progress in vitro and in mice. The present examine demonstrates that 3-HAA sensitizes HCC cells to sorafenib by lowering tumor stemness, suggesting it’s a promising molecule for HCC remedy.
Tags:
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
Cell Biology of Canonical Wnt Signaling

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