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Wogonin Strengthens the Therapeutic Effects of Mesenchymal Stem Cells in DSS-Induced Colitis via Promoting IL-10 Production
Inflammatory bowel ailments (IBD) are prevalent and debilitating ailments; their scientific treatment is desperately unmet. Mesenchymal stem cells (MSCs) are pluripotent stem cells with a number of immunomodulatory results, that are attributed to their efficacy within the IBD rodent mannequin.
Optimization of MSC regimes in IBD is an important step for his or her additional scientific software. Wogonin is a flavonoid-like compound, which confirmed in depth immunomodulatory and adjuvant results. This analysis is aimed toward investigating whether or not and the way Wogonin boosted the therapeutic effectivity of MSCs on DSS-induced colitis.
Our outcomes confirmed that the MSC therapy with Wogonin considerably alleviated the intestinal irritation in IBD mice by elevated IL-10 expression. In vitro experiments, Wogonin clearly raised the IL-10 manufacturing and ROS ranges of MSCs in a dose-dependent method. In the meantime, western blot knowledge advised Wogonin improves the IL-10 manufacturing by inducing transcript issue HIF-1α expression by way of AKT/GSK3β sign pathway.
Lastly, the favorable results of Wogonin on MSCs have been confirmed by IL-10 blockade experiment in vivo. Collectively, our outcomes advised that Wogonin considerably elevated the IL-10 manufacturing and enhanced the therapeutic results of MSCs in DSS-induced colitis. This work advised Wogonin as a novel optimum technique for MSC scientific software.
SUMO conjugation susceptibility of Akt/protein kinase B impacts the expression of the pluripotency transcription issue Nanog in embryonic stem cells
Akt/PKB is a kinase concerned within the regulation of all kinds of cell processes. Its exercise is modulated by various post-translational modifications (PTMs). Significantly, conjugation of the small ubiquitin-related modifier (SUMO) to this kinase impacts on a number of mobile features, similar to proliferation and splicing. In embryonic stem (ES) cells, this kinase is vital for pluripotency upkeep.
Amongst different features, Akt is understood to advertise the expression of Nanog, a central pluripotency transcription issue (TF). Nonetheless, the relevance of this particular PTM of Akt has not been beforehand analyzed on this context. On this work, we examine the impact of Akt1 variants with differential SUMOylation susceptibility on the expression of Nanog.
Our outcomes exhibit that each, the Akt1 functionality of being modified by SUMO conjugation and a useful SUMO conjugase exercise are required to induce Nanog gene expression. Likewise, we discovered that the frequent oncogenic E17Okay Akt1 mutant affected Nanog expression in ES cells additionally in a SUMOylatability dependent method.
Curiously, this final result takes locations in ES cells however not in a non-pluripotent heterologous system, suggesting the presence of an important issue for this induction in ES cells. Remarkably, the 2 main candidate components to mediate this induction, GSK3-β and Tbx3, are non-essential gamers of this impact, suggesting a posh mechanism in all probability involving non-canonical pathways.
Moreover, we discovered that Akt1 subcellular distribution doesn’t depend upon its SUMOylatability, indicating that Akt localization has no affect on the impact on Nanog, and that apart from the membrane localization of E17Okay Akt mutant, SUMOylation can also be required for its hyperactivity.
Our outcomes spotlight the influence of SUMO conjugation within the operate of a kinase related for a plethora of mobile processes, together with the management of a key pluripotency TF.
Results of graphene on morphology, microstructure and transcriptomic profiling of Pinus tabuliformis Carr. roots
Graphene has proven nice potential for bettering progress of many vegetation, however its impact on woody vegetation stays basically unstudied. On this work, Pinus tabuliformis Carr. bare-rooted seedlings grown open air in pots have been irrigated with a graphene resolution over a focus vary of 0-50 mg/L for six months. Graphene was discovered to stimulate root progress, with a maximal impact at 25 mg/L.
We then investigated root microstructure and carried out transcript profiling of root supplies handled with Zero and 25 mg/L graphene. Graphene therapy resulted in plasma-wall separation and destruction of membrane integrity in root cells.
Greater than 50 thousand of differentially expressed genes (DEGs) have been obtained by RNA sequencing, amongst which 6477 may very well be annotated utilizing different plant databases. The GO enrichment evaluation and KEGG pathway evaluation of the annotated DEGs indicated that abiotic stress responses, which resemble salt stress, have been induced by graphene therapy in roots, whereas responses to biotic stimuli have been inhibited.
Quite a few metabolic processes and hormone sign transduction pathways have been altered by the therapy. The expansion promotion results of graphene could also be mediated by encouraging proline synthesis, and suppression of the expression of the auxin response gene SMALL AUXIN UP-REGULATED RNA 41 (SAUR41), PYL genes which encode ABA receptors, and GSK3 homologs.
3-hydroxyanthranic acid will increase the sensitivity of hepatocellular carcinoma to sorafenib by reducing tumor cell stemness
Sorafenib is the FDA-approved first-line goal drug for HCC sufferers. Nonetheless, sorafenib solely confers 3-5 months of survival profit with <30% of HCC sufferers. Thus, it’s essential to develop a sensitizer for hepatocellular carcinoma (HCC) to sorafenib.
Right here, we report that in consultant HCC cell strains (SMMC-7721 and PLC8024) which can be insensitive to sorafenib, 3-HAA (50 μM) considerably enhances cell sensitivity to sorafenib to an extent that would not be defined by additive results. In nude mice carrying HCC xenograft, tumor progress is inhibited by sorafenib (10 mg/kg/day) or 3-HAA (100 mg/kg/day) alone. When utilized in mixture, the therapy successfully prevents the xenograft from rising.
In a set of mechanistic experiments, we discover enhanced AKT activation and elevated proportion of CD44+CD133+ cells in sorafenib-resistant HCC cells and tissues. The proportion of CD44+CD133+ cells is decreased upon 3-HAA therapy in each cultured cells and mouse xenografts, suggesting that 3-HAA may lower the stemness of HCC. We additionally detect decreased phosphorylation of AKT, a regulator of the GSK3β/β-catenin signaling upon 3-HAA therapy.
RFP expression Adenovirus, in vivo ready |
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| AVP001-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made RFP expression adenovirus, provided in PBS solution. |
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CFP expression Adenovirus, in vivo ready |
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| AVP002-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made CFP expression adenovirus, provided in PBS solution. |
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GFP expression Adenovirus, in vivo ready |
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| AVP011-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made GFP expression adenovirus, provided in PBS solution. |
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YFP expression Adenovirus, in vivo ready |
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| AVP012-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made YFP expression adenovirus, provided in PBS solution. |
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BFP expression Adenovirus, in vivo ready |
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| AVP017-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made BFP expression adenovirus, provided in PBS solution. |
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EP Reagent Biuret Reagent - 100ML |
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| 1011601 | Scientific Laboratory Supplies | 1L | EUR 59.4 |
293 Expression MAX-1 |
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| EXP-711-11 | ACROBIOSYSTEMS | 1ml | EUR 214 |
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Description: 293 Expression MAX-1 is expressed from - -. |
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PEROXIDE BLOCKING REAGENT Reagent |
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| GWB-Q00308 | GenWay Biotech | 50 ml | Ask for price |
CNGA2 Expression vector |
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| 60642 | BPS Bioscience | 20 µg | EUR 900 |
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Description: The CNGA2 expression vector is designed to express human cyclic nucleotide-gated cation channel 2 (CNGA2) in mammalian cells. |
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CNGA2 Expression vector |
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| GWB-PSFA61 | GenWay Biotech | 20ug | Ask for price |
EP Reagent Iodoplatinate Reagent - 200ML |
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| 1046300 | Scientific Laboratory Supplies | 200ML | EUR 502.2 |
LEXSYcon2.1 Expression Kit |
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| EGE-1310ble | Jena Bioscience GmbH | 1Kit | EUR 1296.1 |
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Description: for constitutive cytosolic or secretory protein expression |
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LEXSYcon2.1 Expression Kit |
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| EGE-1310bsd | Jena Bioscience GmbH | 1Kit | EUR 1296.1 |
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Description: for constitutive cytosolic or secretory protein expression |
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LEXSYcon2.1 Expression Kit |
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| EGE-1310hyg | Jena Bioscience GmbH | 1Kit | EUR 1296.1 |
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Description: for constitutive cytosolic or secretory protein expression |
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LEXSYcon2.1 Expression Kit |
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| EGE-1310neo | Jena Bioscience GmbH | 1Kit | EUR 1296.1 |
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Description: for constitutive cytosolic or secretory protein expression |
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LEXSYcon2.1 Expression Kit |
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| EGE-1310pac | Jena Bioscience GmbH | 1Kit | EUR 1296.1 |
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Description: for constitutive cytosolic or secretory protein expression |
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LEXSYcon2.1 Expression Kit |
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| EGE-1310sat | Jena Bioscience GmbH | 1Kit | EUR 1296.1 |
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Description: for constitutive cytosolic or secretory protein expression |
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pYLEX1 - Expression Vector |
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| FYY203-5MG | Yeastern Biotech | 5mg | Ask for price |
EP Reagent Molybdovanadic Reagent - 100ML |
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| 1056700 | Scientific Laboratory Supplies | 100ML | EUR 59.4 |
h OCT4 expression Adenovirus, in vivo ready |
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| AVP013-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made adenovirus express human stem cell factor, OCT4, provided in PBS solution for in vivo application. |
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h SOX2 expression Adenovirus, in vivo ready |
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| AVP014-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made adenovirus express human stem cell factor, SOX2, provided in PBS solution for in vivo application. |
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Blunt E1 Expression Kit |
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| abx098098-10rxns | Abbexa | 10 rxns | EUR 560.4 |
Blunt E2 Expression Kit |
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| abx098873-10rxns | Abbexa | 10 rxns | EUR 560.4 |
Blunt E1 Expression Kit |
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| abx098098-100l | Abbexa | 100 µl | EUR 712.5 |
Blunt E1 Expression Kit |
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| abx098098-1ml | Abbexa | 1 ml | Ask for price |
Blunt E1 Expression Kit |
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| abx098098-200l | Abbexa | 200 µl | Ask for price |
Blunt E2 Expression Kit |
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| abx098873-100l | Abbexa | 100 µl | EUR 712.5 |
Blunt E2 Expression Kit |
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| abx098873-1ml | Abbexa | 1 ml | Ask for price |
Blunt E2 Expression Kit |
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| abx098873-200l | Abbexa | 200 µl | Ask for price |
RFP expression Adenovirus |
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| AVP001 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
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Description: pre-made RFP expression adenovirus, provided in DMEM medium. |
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CFP expression Adenovirus |
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| AVP002 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
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Description: pre-made CFP expression adenovirus, provided in DMEM medium. |
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GFP expression Adenovirus |
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| AVP011 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
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Description: pre-made GFP expression adenovirus, provided in DMEM medium. |
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YFP expression Adenovirus |
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| AVP012 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
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Description: pre-made YFP expression adenovirus, provided in DMEM medium. |
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BFP expression Adenovirus |
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| AVP017 | GenTarget | 1x109 IFU/ml x 200ul | EUR 418.8 |
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Description: pre-made BFP expression adenovirus, provided in DMEM medium. |
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RPL21_17_477 Over-expression Lysate Product |
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| GWB-8BD971 | GenWay Biotech | 0.1 mg | Ask for price |
h LIN28 expression Adenovirus, in vivo ready |
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| AVP015-PBS | GenTarget | 1x1011 IFU/ml x 50ul | EUR 852 |
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Description: pre-made adenovirus express human stem cell factor, LIN28, provided in PBS solution for in vivo application. |
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LEXSinduce3 Expression Kit |
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| EGE-1410ble | Jena Bioscience GmbH | 1Kit | EUR 3037.6 |
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Description: for inducible cytosolic or secretory protein expression |
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LEXSinduce3 Expression Kit |
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| EGE-1410blecherry | Jena Bioscience GmbH | 1Kit | EUR 3037.6 |
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Description: for inducible cytosolic or secretory protein expression |
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LEXSinduce3 Expression Kit |
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| EGE-1410neo | Jena Bioscience GmbH | 1Kit | EUR 3037.6 |
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Description: for inducible cytosolic or secretory protein expression |
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LEXSinduce4 Expression Kit |
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| EGE-1420blecherry | Jena Bioscience GmbH | 1Kit | EUR 3037.6 |
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Description: for inducible cytosolic or secretory protein expression |
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EP Reagent Methoxyphenylacetic Reagent - 100ML |
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| 1053601 | Scientific Laboratory Supplies | 100ML | EUR 490.05 |
F7 Over-expression Lysate Product |
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| GWB-2B9655 | GenWay Biotech | 0.1 mg | Ask for price |
AR Over-expression Lysate Product |
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| GWB-524326 | GenWay Biotech | 0.1 mg | Ask for price |
MB Over-expression Lysate Product |
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| GWB-543EE8 | GenWay Biotech | 0.1 mg | Ask for price |
F8 Over-expression Lysate Product |
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| GWB-4223CC | GenWay Biotech | 0.1 mg | Ask for price |
C6 Over-expression Lysate Product |
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| GWB-4CD0B5 | GenWay Biotech | 0.1 mg | Ask for price |
T Over-expression Lysate Product |
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| GWB-4D17A7 | GenWay Biotech | 0.1 mg | Ask for price |
HP Over-expression Lysate Product |
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| GWB-19D90B | GenWay Biotech | 0.1 mg | Ask for price |
C9 Over-expression Lysate Product |
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| GWB-A98C50 | GenWay Biotech | 0.1 mg | Ask for price |
GK Over-expression Lysate Product |
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| GWB-ABEC99 | GenWay Biotech | 0.1 mg | Ask for price |
FH Over-expression Lysate Product |
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| GWB-B00EEC | GenWay Biotech | 0.1 mg | Ask for price |
C5 Over-expression Lysate Product |
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| GWB-611C50 | GenWay Biotech | 0.1 mg | Ask for price |
GK Over-expression Lysate Product |
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| GWB-799C20 | GenWay Biotech | 0.1 mg | Ask for price |
F9 Over-expression Lysate Product |
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| GWB-7A1142 | GenWay Biotech | 0.1 mg | Ask for price |
MB Over-expression Lysate Product |
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| GWB-DDB100 | GenWay Biotech | 0.1 mg | Ask for price |
KL Over-expression Lysate Product |
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| GWB-EF6FA2 | GenWay Biotech | 0.1 mg | Ask for price |
C2 Over-expression Lysate Product |
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| GWB-69AF56 | GenWay Biotech | 0.1 mg | Ask for price |
C7 Over-expression Lysate Product |
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| GWB-6F310B | GenWay Biotech | 0.1 mg | Ask for price |
GC Over-expression Lysate Product |
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| GWB-6FD425 | GenWay Biotech | 0.1 mg | Ask for price |
F2 Over-expression Lysate Product |
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| GWB-74B4A0 | GenWay Biotech | 0.1 mg | Ask for price |
TF Over-expression Lysate Product |
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| GWB-FDE7E0 | GenWay Biotech | 0.1 mg | Ask for price |
XG Over-expression Lysate Product |
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| GWB-C19FF5 | GenWay Biotech | 0.1 mg | Ask for price |
PC Over-expression Lysate Product |
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| GWB-C40C56 | GenWay Biotech | 0.1 mg | Ask for price |
Rac1 Expression Vector Set |
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| STA-454 | Cell Biolabs | 1 kit | EUR 1765.2 |
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Description: Rac1 Expression Vector Set contains 3 vectors: Rac wild type, T17N dominant negative mutant, and G12V constitutively active mutant. |
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RhoA Expression Vector Set |
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| STA-456 | Cell Biolabs | 1 kit | EUR 1765.2 |
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Description: RhoA Expression Vector Set contains 3 vectors: RhoA wild type, T19N dominant negative mutant, and G14V constitutively active mutant. |
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LPP Over-expression Lysate Product |
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| GWB-1EE6BD | GenWay Biotech | 0.1 mg | Ask for price |
QKI Over-expression Lysate Product |
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| GWB-2019C5 | GenWay Biotech | 0.1 mg | Ask for price |
HBB Over-expression Lysate Product |
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| GWB-2046D5 | GenWay Biotech | 0.1 mg | Ask for price |
ZAK Over-expression Lysate Product |
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| GWB-20AE0D | GenWay Biotech | 0.1 mg | Ask for price |
PF4 Over-expression Lysate Product |
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| GWB-212C3B | GenWay Biotech | 0.1 mg | Ask for price |
TFG Over-expression Lysate Product |
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| GWB-215F68 | GenWay Biotech | 0.1 mg | Ask for price |
ACE Over-expression Lysate Product |
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| GWB-21AE7F | GenWay Biotech | 0.1 mg | Ask for price |
ERH Over-expression Lysate Product |
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| GWB-220D0B | GenWay Biotech | 0.1 mg | Ask for price |
GIF Over-expression Lysate Product |
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| GWB-23C77E | GenWay Biotech | 0.1 mg | Ask for price |
PGD Over-expression Lysate Product |
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| GWB-242ED0 | GenWay Biotech | 0.1 mg | Ask for price |
GSN Over-expression Lysate Product |
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| GWB-2435DF | GenWay Biotech | 0.1 mg | Ask for price |
HLA Over-expression Lysate Product |
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| GWB-2494DC | GenWay Biotech | 0.1 mg | Ask for price |
DCX Over-expression Lysate Product |
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| GWB-24E3AD | GenWay Biotech | 0.1 mg | Ask for price |
BAX Over-expression Lysate Product |
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| GWB-250195 | GenWay Biotech | 0.1 mg | Ask for price |
SKI Over-expression Lysate Product |
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| GWB-257AA4 | GenWay Biotech | 0.1 mg | Ask for price |
AK2 Over-expression Lysate Product |
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| GWB-25961D | GenWay Biotech | 0.1 mg | Ask for price |
HLA Over-expression Lysate Product |
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| GWB-25AAC0 | GenWay Biotech | 0.1 mg | Ask for price |
JUN Over-expression Lysate Product |
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| GWB-25E290 | GenWay Biotech | 0.1 mg | Ask for price |
ID3 Over-expression Lysate Product |
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| GWB-25FB29 | GenWay Biotech | 0.1 mg | Ask for price |
HLA Over-expression Lysate Product |
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| GWB-26D380 | GenWay Biotech | 0.1 mg | Ask for price |
GAA Over-expression Lysate Product |
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| GWB-275951 | GenWay Biotech | 0.1 mg | Ask for price |
HLA Over-expression Lysate Product |
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| GWB-2813E2 | GenWay Biotech | 0.1 mg | Ask for price |
CKB Over-expression Lysate Product |
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| GWB-282F50 | GenWay Biotech | 0.1 mg | Ask for price |
NPS Over-expression Lysate Product |
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| GWB-2858B7 | GenWay Biotech | 0.1 mg | Ask for price |
ECD Over-expression Lysate Product |
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| GWB-28A800 | GenWay Biotech | 0.1 mg | Ask for price |
HLX Over-expression Lysate Product |
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| GWB-29D927 | GenWay Biotech | 0.1 mg | Ask for price |
NF2 Over-expression Lysate Product |
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| GWB-2A2667 | GenWay Biotech | 0.1 mg | Ask for price |
RAX Over-expression Lysate Product |
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| GWB-2A5892 | GenWay Biotech | 0.1 mg | Ask for price |
SDS Over-expression Lysate Product |
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| GWB-2A7E33 | GenWay Biotech | 0.1 mg | Ask for price |
PTN Over-expression Lysate Product |
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| GWB-2A9C7B | GenWay Biotech | 0.1 mg | Ask for price |
FAU Over-expression Lysate Product |
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| GWB-2AD0E3 | GenWay Biotech | 0.1 mg | Ask for price |
BMF Over-expression Lysate Product |
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| GWB-2BEE00 | GenWay Biotech | 0.1 mg | Ask for price |
NOG Over-expression Lysate Product |
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| GWB-2BF6EB | GenWay Biotech | 0.1 mg | Ask for price |
GSS Over-expression Lysate Product |
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| GWB-2C1A43 | GenWay Biotech | 0.1 mg | Ask for price |
MIF Over-expression Lysate Product |
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| GWB-2D4830 | GenWay Biotech | 0.1 mg | Ask for price |
TXN Over-expression Lysate Product |
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| GWB-2DEFC9 | GenWay Biotech | 0.1 mg | Ask for price |
F11 Over-expression Lysate Product |
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| GWB-2E15A7 | GenWay Biotech | 0.1 mg | Ask for price |
MAX Over-expression Lysate Product |
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| GWB-2E2D42 | GenWay Biotech | 0.1 mg | Ask for price |
CRK Over-expression Lysate Product |
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| GWB-306905 | GenWay Biotech | 0.1 mg | Ask for price |
GH1 Over-expression Lysate Product |
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| GWB-4F3DD0 | GenWay Biotech | 0.1 mg | Ask for price |
IVD Over-expression Lysate Product |
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| GWB-4F555F | GenWay Biotech | 0.1 mg | Ask for price |
SLA Over-expression Lysate Product |
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| GWB-4F6FFE | GenWay Biotech | 0.1 mg | Ask for price |
AK4 Over-expression Lysate Product |
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| GWB-4FADC0 | GenWay Biotech | 0.1 mg | Ask for price |
BRE Over-expression Lysate Product |
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| GWB-4FC6EC | GenWay Biotech | 0.1 mg | Ask for price |
MOS Over-expression Lysate Product |
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| GWB-503237 | GenWay Biotech | 0.1 mg | Ask for price |
ERF Over-expression Lysate Product |
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| GWB-5242BB | GenWay Biotech | 0.1 mg | Ask for price |
HFE Over-expression Lysate Product |
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| GWB-5243B9 | GenWay Biotech | 0.1 mg | Ask for price |
TEK Over-expression Lysate Product |
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| GWB-533C4C | GenWay Biotech | 0.1 mg | Ask for price |
MIA Over-expression Lysate Product |
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| GWB-534100 | GenWay Biotech | 0.1 mg | Ask for price |
IDE Over-expression Lysate Product |
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| GWB-5367D7 | GenWay Biotech | 0.1 mg | Ask for price |
AFP Over-expression Lysate Product |
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| GWB-536D51 | GenWay Biotech | 0.1 mg | Ask for price |
RDX Over-expression Lysate Product |
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| GWB-53CF80 | GenWay Biotech | 0.1 mg | Ask for price |
ILK Over-expression Lysate Product |
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| GWB-54E227 | GenWay Biotech | 0.1 mg | Ask for price |
SFN Over-expression Lysate Product |
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| GWB-55C5F7 | GenWay Biotech | 0.1 mg | Ask for price |
BPI Over-expression Lysate Product |
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| GWB-55FF0C | GenWay Biotech | 0.1 mg | Ask for price |
MAX Over-expression Lysate Product |
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| GWB-56E43C | GenWay Biotech | 0.1 mg | Ask for price |
TAZ Over-expression Lysate Product |
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| GWB-572853 | GenWay Biotech | 0.1 mg | Ask for price |
MLN Over-expression Lysate Product |
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| GWB-576AA3 | GenWay Biotech | 0.1 mg | Ask for price |
CA2 Over-expression Lysate Product |
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| GWB-578B82 | GenWay Biotech | 0.1 mg | Ask for price |
GIP Over-expression Lysate Product |
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| GWB-57B640 | GenWay Biotech | 0.1 mg | Ask for price |
MKX Over-expression Lysate Product |
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| GWB-57FD34 | GenWay Biotech | 0.1 mg | Ask for price |
FAS Over-expression Lysate Product |
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| GWB-586DE6 | GenWay Biotech | 0.1 mg | Ask for price |
ADK Over-expression Lysate Product |
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| GWB-590E04 | GenWay Biotech | 0.1 mg | Ask for price |
CAT Over-expression Lysate Product |
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| GWB-59B4AF | GenWay Biotech | 0.1 mg | Ask for price |
AES Over-expression Lysate Product |
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| GWB-5A4211 | GenWay Biotech | 0.1 mg | Ask for price |
GRP Over-expression Lysate Product |
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| GWB-5A56CC | GenWay Biotech | 0.1 mg | Ask for price |
C8A Over-expression Lysate Product |
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| GWB-5AD920 | GenWay Biotech | 0.1 mg | Ask for price |
ME2 Over-expression Lysate Product |
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| GWB-5B40C3 | GenWay Biotech | 0.1 mg | Ask for price |
TTK Over-expression Lysate Product |
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| GWB-5B4DBF | GenWay Biotech | 0.1 mg | Ask for price |
HGF Over-expression Lysate Product |
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| GWB-5CC3A0 | GenWay Biotech | 0.1 mg | Ask for price |
XDH Over-expression Lysate Product |
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| GWB-5CD953 | GenWay Biotech | 0.1 mg | Ask for price |
DES Over-expression Lysate Product |
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| GWB-5E571D | GenWay Biotech | 0.1 mg | Ask for price |
BTD Over-expression Lysate Product |
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| GWB-103751 | GenWay Biotech | 0.1 mg | Ask for price |
GPT Over-expression Lysate Product |
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| GWB-103C17 | GenWay Biotech | 0.1 mg | Ask for price |
TOX Over-expression Lysate Product |
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| GWB-10886C | GenWay Biotech | 0.1 mg | Ask for price |
CPO Over-expression Lysate Product |
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| GWB-118B1B | GenWay Biotech | 0.1 mg | Ask for price |
SHE Over-expression Lysate Product |
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| GWB-11CBF7 | GenWay Biotech | 0.1 mg | Ask for price |
IL2 Over-expression Lysate Product |
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| GWB-123508 | GenWay Biotech | 0.1 mg | Ask for price |
OGN Over-expression Lysate Product |
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| GWB-132F6D | GenWay Biotech | 0.1 mg | Ask for price |
NF2 Over-expression Lysate Product |
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| GWB-14BDEE | GenWay Biotech | 0.1 mg | Ask for price |
PTS Over-expression Lysate Product |
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| GWB-153D07 | GenWay Biotech | 0.1 mg | Ask for price |
CRX Over-expression Lysate Product |
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| GWB-372B50 | GenWay Biotech | 0.1 mg | Ask for price |
FST Over-expression Lysate Product |
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| GWB-3758FE | GenWay Biotech | 0.1 mg | Ask for price |
PNN Over-expression Lysate Product |
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| GWB-379ABB | GenWay Biotech | 0.1 mg | Ask for price |
CRK Over-expression Lysate Product |
|||
| GWB-37B7E4 | GenWay Biotech | 0.1 mg | Ask for price |
B2M Over-expression Lysate Product |
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| GWB-39B4E3 | GenWay Biotech | 0.1 mg | Ask for price |
NGB Over-expression Lysate Product |
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| GWB-39F54D | GenWay Biotech | 0.1 mg | Ask for price |
KIN Over-expression Lysate Product |
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| GWB-3ABEBE | GenWay Biotech | 0.1 mg | Ask for price |
OXT Over-expression Lysate Product |
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| GWB-3B1FD3 | GenWay Biotech | 0.1 mg | Ask for price |
PXK Over-expression Lysate Product |
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| GWB-3C8EA1 | GenWay Biotech | 0.1 mg | Ask for price |
ALB Over-expression Lysate Product |
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| GWB-3E03B0 | GenWay Biotech | 0.1 mg | Ask for price |
IL9 Over-expression Lysate Product |
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| GWB-3E3A84 | GenWay Biotech | 0.1 mg | Ask for price |
HLA Over-expression Lysate Product |
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| GWB-3E6FB0 | GenWay Biotech | 0.1 mg | Ask for price |
SPR Over-expression Lysate Product |
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| GWB-3FACD1 | GenWay Biotech | 0.1 mg | Ask for price |
SPN Over-expression Lysate Product |
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| GWB-404D95 | GenWay Biotech | 0.1 mg | Ask for price |
AIP Over-expression Lysate Product |
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| GWB-40DF2C | GenWay Biotech | 0.1 mg | Ask for price |
CSK Over-expression Lysate Product |
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| GWB-415B1A | GenWay Biotech | 0.1 mg | Ask for price |
WT1 Over-expression Lysate Product |
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| GWB-41C1E8 | GenWay Biotech | 0.1 mg | Ask for price |
C8B Over-expression Lysate Product |
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| GWB-41E9AB | GenWay Biotech | 0.1 mg | Ask for price |
HDC Over-expression Lysate Product |
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| GWB-4302B9 | GenWay Biotech | 0.1 mg | Ask for price |
TNF Over-expression Lysate Product |
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| GWB-448BBB | GenWay Biotech | 0.1 mg | Ask for price |
PNP Over-expression Lysate Product |
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| GWB-4538EC | GenWay Biotech | 0.1 mg | Ask for price |
MUT Over-expression Lysate Product |
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| GWB-455C37 | GenWay Biotech | 0.1 mg | Ask for price |
CFP Over-expression Lysate Product |
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| GWB-4575E9 | GenWay Biotech | 0.1 mg | Ask for price |
HPN Over-expression Lysate Product |
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| GWB-4602DE | GenWay Biotech | 0.1 mg | Ask for price |
C1D Over-expression Lysate Product |
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| GWB-461FBD | GenWay Biotech | 0.1 mg | Ask for price |
PIP Over-expression Lysate Product |
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| GWB-4782A0 | GenWay Biotech | 0.1 mg | Ask for price |
SF1 Over-expression Lysate Product |
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| GWB-47A9D3 | GenWay Biotech | 0.1 mg | Ask for price |
DDO Over-expression Lysate Product |
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| GWB-481A81 | GenWay Biotech | 0.1 mg | Ask for price |
LYZ Over-expression Lysate Product |
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| GWB-4830E7 | GenWay Biotech | 0.1 mg | Ask for price |
PAM Over-expression Lysate Product |
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| GWB-48AFF2 | GenWay Biotech | 0.1 mg | Ask for price |
DCN Over-expression Lysate Product |
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| GWB-4AB343 | GenWay Biotech | 0.1 mg | Ask for price |
The AKT activator SC79 prompts GSK3 β/β-catenin signaling whereas the Wnt inhibitor XAV-939 abolishes 3-HAA inhibition of HCC progress in vitro and in mice. The present examine demonstrates that 3-HAA sensitizes HCC cells to sorafenib by lowering tumor stemness, suggesting it’s a promising molecule for HCC remedy.
