Effects of Fruquintinib on the Pluripotency Maintenance and Differentiation Potential of Mouse Embryonic Stem Cells

Effects of Fruquintinib on the Pluripotency Maintenance and Differentiation Potential of Mouse Embryonic Stem Cells

Mouse embryonic stem cells (mESCs) can keep self-renewal and differentiate into any cell kind of the three main germ layers. The vascular endothelial progress issue (VEGF) is concerned within the regulation of mESC differentiation and induces the activation of a collection of kinase responses and several other cell signaling pathways by binding to its respective transmembrane receptors, vascular endothelial progress issue receptor VEGFR1, and VEGFR2.
Fruquintinib is a selective inhibitor of VEGFRs, and we used it to research the results on the upkeep of pluripotency and differentiation potential of mESCs on this examine. Our outcomes confirmed that fruquintinib-treated cells expressed greater ranges of pluripotent markers, together with Oct4, Nanog, Sox2, and Esrrb below serum and leukemia inhibitory issue (LIF) situation, whereas the expression of phosphorylated Erk1/2 was restricted.
Mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (MEK) signaling inhibitor (PD0325901) and glycogen synthase kinase 3 (GSK3) signaling inhibitor (CHIR99021) (also referred to as 2i) allow cells to keep up naive pluripotency with LIF, and fruquintinib may promote cells to keep up naive pluripotent state even below serum/LIF situation, whereas VEGF addition limits the pluripotency traits in serum/LIF mESCs.
Moreover, fruquintinib might inhibit the three-germ layer institution in embryoid physique formation and keep the undifferentiated traits of mESCs, indicating that fruquintinib might promote the upkeep of naive pluripotency and inhibit early differentiation packages.

A Gene Expression Signature to Predict Nucleotide Excision Restore Defects and Novel Therapeutic Approaches

Nucleotide excision restore (NER) resolves DNA adducts, equivalent to these attributable to ultraviolet gentle. Poor NER (dNER) ends in the next mutation price that may predispose to most cancers growth and untimely ageing phenotypes.
Right here, we used isogenic dNER mannequin cell traces to determine a gene expression signature that may precisely predict purposeful NER capability in each cell traces and affected person samples. Critically, not one of the recognized NER poor cell traces harbored mutations in any NER genes, suggesting that the prevalence of NER defects might at present be underestimated.
Effects of Fruquintinib on the Pluripotency Maintenance and Differentiation Potential of Mouse Embryonic Stem Cells
Identification of compounds that induce the dNER gene expression signature led to the invention that NER may be functionally impaired by GSK3 inhibition, resulting in synergy when mixed with cisplatin remedy.
Moreover, we predicted and validated a number of novel medicine which are synthetically deadly with NER defects utilizing the dNER gene signature as a drug discovery platform. Taken collectively, our work supplies a dynamic predictor of NER operate that could be utilized for therapeutic stratification in addition to growth of novel organic insights in human tumors.
Effects of Fruquintinib on the Pluripotency Maintenance and Differentiation Potential of Mouse Embryonic Stem Cells

Cell floor integrin α5ß1 clustering negatively regulates receptor tyrosine kinase signaling in colorectal most cancers cells through glycogen synthase kinase 3

As a key course of throughout the tissue microenvironment, integrin signaling can affect cell purposeful responses to progress issue stimuli. We present right here that clustering of integrin α5ß1 on the plasma membrane of colorectal cancer-derived epithelial cells modulates their skill to answer stimulation by receptor tyrosine kinase (RTK)-activating progress elements EGF, NRG and HGF, via GSK3-mediated suppression of Akt pathway.
We noticed that integrin α5ß1 is misplaced from the membrane of poorly organized human colorectal tumors and that remedy with the integrin-clustering antibody P4G11 is enough to induce polarity in a mouse tumor xenograft mannequin.
Whereas including RTK progress elements (EGF, NRG and HGF) to polarized colorectal most cancers cells induced invasion and lack of monolayer formation in 2D and 3D, this pathological conduct might be blocked by P4G11. Phosphorylation of ErbB members of the family in addition to MET following EGF, NRG and HGF remedy was diminished in cells pretreated with P4G11.
Specializing in EGFR, we discovered that blockade of integrin α5ß1 elevated EGFR phosphorylation. Since exercise of a number of downstream kinase pathways have been altered by these numerous therapies, we employed computational machine studying strategies to establish crucial results. Partial least-squares discriminant evaluation recognized GSK3 as a serious regulator of EGFR pathway actions influenced by integrin α5ß1.
Furthermore, we used partial correlation evaluation to look at signaling pathway crosstalk downstream of EGF stimulation and located that integrin α5ß1 acts as a destructive regulator of the AKT signaling cascade downstream of EGFR, with GSK3 appearing as a key mediator. We experimentally validated these computational inferences by confirming that blockade of GSK3 exercise is enough to induce lack of polarity and enhance of oncogenic signaling within the colonic epithelial cells.

Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic impact

Hawthorn berry has been proved hypoglycemic impact as a result of presence of some α-glucosidase inhibitors. Herein, screening and figuring out of α-glucosidase inhibitors from hawthorn berry have been performed, and the outcomes confirmed polyphenols primarily containing quercetin (74.58%) and hyperioside (9.58%) have been chargeable for its bioactivity.
With a purpose to improve the hypoglycemic impact, the mixed glucose-lowering advanced (DEH) consisting of hawthorn polyphenols, D-chiro-inositol (DCI), and epigallocatechin gallate (EGCG) was ready, the place three elements exerted the synergistic hypoglycemic impact to boost glucose consumption and glycogen ranges and inhibit hepatic gluconeogenesis in IR-HepG2 cells.
In STZ/HFD-induced mice, DEH successfully improved insulin resistance, lowered fasting blood glucose (FBG) and hepatic gluconeogenesis, and elevated hepatic glycogen synthesis and storage through down-regulation of PI3K/Akt/FOXO1-mediated PEPCK and G6Pase and up-regulation of PI3K/Akt/GSK3-mediated GS activation within the liver. In abstract, these findings point out that DEH is a possible novel technique for the remedy of kind 2 diabetes.
PRACTICAL APPLICATIONS: Glucose-lowering advanced (DEH) with superior hypoglycemic impact, can successfully enhance the insulin resistance, cut back the fasting blood glucose, hepatic gluconeogenesis and enhance the hepatic glycogen synthesis and storage in mice, which represents a possible novel technique for the remedy of kind 2 diabetes.

Isoorientin inhibits epithelial-to-mesenchymal properties and most cancers stem-cell-like options in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis

Oral squamous cell carcinoma (OSCC) is among the many most prevalent cancers of the top and neck. This examine revealed that isoorientin attenuates OSCC cell stemness and epithelial-mesenchymal transition potential via the inhibition of JAK/sign transducer and activator of transcription 3 (STAT3) and Wnt/β-catenin signaling in cell traces. Our findings indicated that isoorientin is a possible inhibitor of β-catenin/STAT3 in vitro and in vivo.
We analyzed doable synergism between isoorientin and cisplatin in OSCC. A sulforhodamine B assay, colony formation assay, tumorsphere-formation assay, and Wnt reporter exercise assay have been used for figuring out cell invasion, cell migration, drug cytotoxicity, and cell viability with potential molecular mechanisms in vitro. Isoorientin lowered the expression of p-STAT3, β-catenin, and p-GSK3 in addition to downstream effectors TCF1/TCF7 and LEF1 and considerably lowered β-catenin colocalization within the nucleus.
Isoorientin markedly strengthened the cytotoxic results of cisplatin towards SAS and SCC-25. Due to this fact, combining isoorientin and cisplatin therapies can probably enhance the anticancer impact of cisplatin. Isoorientin inhibited the tumorigenicity and progress of OSCC via the abrogation of Wnt/β-catenin/STAT3 signaling in vivo.

GSK3 alpha Antibody

AF6336 200ul
EUR 304
Description: GSK3 alpha Antibody detects endogenous levels of total GSK3 alpha.

GSK3 alpha Antibody

BF0391 200ul
EUR 376
Description: GSK3 alpha antibody detects endogenous levels of total GSK3 alpha.

GSK3 alpha Antibody

AF7813 200ul
EUR 376
Description: GSK3 alpha Antibody detects endogenous levels of GSK3 alpha.

GSK3 alpha Antibody

20-abx133173
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 alpha Antibody

abx033883-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

GSK3 alpha Antibody

abx033883-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

GSK3 alpha Antibody

abx010857-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

GSK3 alpha Antibody

20-abx012858
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GSK3 alpha Antibody

abx015750-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

GSK3 alpha Antibody

abx015751-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

GSK3 alpha Antibody

ABF6336 100 ug
EUR 438

GSK3 alpha antibody

70R-49830 100 ul
EUR 287
Description: Purified Polyclonal GSK3 alpha antibody

GSK3 alpha antibody

70R-37447 100 ug
EUR 273
Description: Rabbit Polyclonal GSK3 alpha antibody

GSK3 alpha antibody

70R-34164 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 alpha antibody

GSK3 alpha Antibody

48179-100ul 100ul
EUR 333

GSK3 alpha Antibody

48179-50ul 50ul
EUR 239

GSK3 alpha antibody

10R-1930 100 ul
EUR 403
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody

10R-2025 100 ul
EUR 435
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody

10R-2104 100 ul
EUR 403
Description: Mouse monoclonal GSK3 alpha antibody

GSK3 alpha antibody

20R-1883 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 alpha antibody

GSK3 alpha antibody

20R-2192 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 alpha antibody

GSK3 alpha/beta Antibody

AF6335 200ul
EUR 304
Description: GSK3 alpha/beta Antibody detects endogenous levels of total GSK3 alpha/beta.

GSK3 alpha Conjugated Antibody

C48179 100ul
EUR 397

GSK3 alpha / beta Antibody

20-abx009185
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 alpha (pS21) Antibody

20-abx009689
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 alpha (pS21) Antibody

abx010870-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

GSK3 alpha/beta Antibody

ABF6335 100 ug
EUR 438

GSK3 alpha/beta antibody

70R-49831 100 ul
EUR 244
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta antibody

70R-51552 100 ul
EUR 287
Description: Purified Polyclonal GSK3 alpha/beta antibody

GSK3 alpha antibody (Ser21)

70R-37089 100 ug
EUR 349
Description: Rabbit Polyclonal GSK3 alpha antibody (Ser21)

GSK3 alpha antibody (Ser21)

70R-34163 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 alpha antibody (Ser21)

GSK3 alpha/beta antibody

70R-30578 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 alpha/beta antibody

GSK3 alpha/beta Antibody

29039-100ul 100ul
EUR 252

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Phospho-GSK3 alpha (Ser21) Antibody

AF3336 200ul
EUR 304
Description: Phospho-GSK3 alpha (Ser21) Antibody detects endogenous levels of GSK3 alpha only when phosphorylated at Serine 21.

GSK3 alpha/beta Conjugated Antibody

C29039 100ul
EUR 397

Phospho-GSK3 alpha (Ser282) Antibody

AF7313 200ul
EUR 376
Description: Phospho-GSK3 alpha (Ser282) Antibody detects endogenous levels of GSK3 alpha only when phosphorylated at Ser282.

GSK3 alpha (Phospho-Ser21) Antibody

20-abx012539
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Phospho- GSK3 alpha (Ser21) Antibody

ABF3336 100 ug
EUR 438

GSK3 alpha recombinant monoclonal antibody

A5830 100ul X 3
EUR 595
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human GSK3 alpha for WB, IHC,ELISA

GSK3 alpha (Phospho-Ser282) Antibody

13162-100ul 100ul
EUR 252

GSK3 alpha (Phospho-Ser282) Antibody

13162-50ul 50ul
EUR 187

Anti-GSK3 beta antibody

STJ99095 200 µl
EUR 197
Description: Mouse monoclonal to GSK3 beta.

GSK3 alpha Blocking Peptide

AF6336-BP 1mg
EUR 195

GSK3 alpha Blocking Peptide

BF0391-BP 1mg
EUR 195

GSK3 alpha Blocking Peptide

AF7813-BP 1mg
EUR 195

GSK3 alpha Blocking Peptide

20-abx161877
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

anti-GSK3 beta

YF-PA12137 100 ug
EUR 403
Description: Rabbit polyclonal to GSK3 beta

anti-GSK3 beta

YF-PA23834 50 ul
EUR 334
Description: Mouse polyclonal to GSK3 beta

Monoclonal GSK3 alpha Antibody, Clone: EP793Y

AMM05996G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Rabbit and are from clone EP793Y. This antibody is applicable in WB and IHC

Monoclonal GSK3 alpha Antibody, Clone: 9D5G1

APR12317G 0.1ml
EUR 484
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 9D5G1. This antibody is applicable in WB, ICC, E

GSK3 alpha (Phospho-Ser282) Conjugated Antibody

C13162 100ul
EUR 397

GSK3 alpha / beta (pY279 / 216) Antibody

20-abx119370
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GSK3 alpha / beta (pT279 / 216) Antibody

20-abx009652
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 alpha / beta (pY279 / 216) Antibody

abx010868-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

GSK3 alpha/beta antibody (Tyr279/216)

70R-30577 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 alpha/beta antibody (Tyr279/216)

GSK3 antibody

20R-1609 100 ug
EUR 673
Description: Rabbit polyclonal GSK3 antibody

GSK3 alpha/beta Blocking Peptide

AF6335-BP 1mg
EUR 195

GSK3 alpha (pS21) Blocking Peptide

20-abx062705
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

GSK3 alpha / beta Blocking Peptide

20-abx062706
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

GSK3 alpha protein (GST Fusion)

80R-2554 100 ug
EUR 247
Description: Purified recombinant Human GSK3 alpha-GST Fusion protein

Anti-Phospho-GSK3 (alpha + beta) (Y216 + Y279) Rabbit Monoclonal Antibody

P03152-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Phospho-GSK3 (alpha + beta) (Y216 + Y279) Antibody. Validated in IP, IF, WB and tested in Human, Mouse, Rat.

anti-GSK3 β (AF12E8)

LF-MA0315 100 ul
EUR 334
Description: Mouse monoclonal to GSK3 β

Anti-GSK3 beta (1H3)

YF-MA10388 100 ug
EUR 363
Description: Mouse monoclonal to GSK3 beta

Phospho-GSK3 alpha/ beta (Tyr279/216) Antibody

AF3335 200ul
EUR 304
Description: Phospho-GSK3 alpha/ beta (Tyr279/216) Antibody detects endogenous levels of GSK3 alpha/ beta only when phosphorylated at Tyrosine 279/216.

Polyclonal GSK3 alpha (GSK3A) Antibody (C-term)

APS00025G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (C-term). This antibody is tested and proven to work in the following applications:

Monoclonal GSK3 alpha Antibody, Clone: 6G2F1; 6G2F2

AMM02621G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human GSK3 alpha. The antibodies are raised in Mouse and are from clone 6G2F1; 6G2F2. This antibody is applicable in WB and IHC, E

Polyclonal GSK3 alpha (GSK3A) Antibody (N-term)

APR12316G 0.1ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human GSK3 alpha (GSK3A) (N-term). This antibody is tested and proven to work in the following applications:

Monoclonal GSK3 alpha/beta Antibody, Clone: EP933Y

APR12318G 0.1ml
EUR 528
Description: A Monoclonal antibody against Human GSK3 alpha/beta. The antibodies are raised in Rabbit and are from clone EP933Y. This antibody is applicable in WB

Phospho- GSK3 alpha/ beta (Tyr279/216) Antibody

ABF3335 100 ug
EUR 438

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody

13355-100ul 100ul
EUR 333

GSK3(alpha+beta)(Phospho-Y216+Y279) Antibody

13355-50ul 50ul
EUR 239

Anti-GSK3 beta Rabbit Monoclonal Antibody

M00791 100ug/vial
EUR 397
Description: Rabbit Monoclonal GSK3 beta Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

GSK3

EF016956 96 Tests
EUR 689

Gsk3

EF012988 96 Tests
EUR 689

GSK3

EF014015 96 Tests
EUR 689

GSK3

EF000406 96 Tests
EUR 689

GSK3

EF006886 96 Tests
EUR 689

Phospho-GSK3 alpha (Ser21) Blocking Peptide

AF3336-BP 1mg
EUR 195

Phospho-GSK3 alpha (Ser282) Blocking Peptide

AF7313-BP 1mg
EUR 195

[KO Validated] GSK3 alpha Rabbit mAb

A19060-100ul 100 ul
EUR 410

[KO Validated] GSK3 alpha Rabbit mAb

A19060-200ul 200 ul
EUR 571

[KO Validated] GSK3 alpha Rabbit mAb

A19060-20ul 20 ul
EUR 221

[KO Validated] GSK3 alpha Rabbit mAb

A19060-50ul 50 ul
EUR 287

GSK3 beta Antibody

AF5016 200ul
EUR 304
Description: GSK3 beta Antibody detects endogenous levels of total GSK3 beta.

GSK3 beta antibody

BF0721 200ul
EUR 376
Description: GSK3 beta mouse monoclonal antibody detects endogenous levels of total GSK3 beta.

GSK3 beta Antibody

AF7814 200ul
EUR 376
Description: GSK3 beta Antibody detects endogenous levels of GSK3 beta.

GSK3? Polyclonal Antibody

ES2485-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody

ES2485-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3?/? Polyclonal Antibody

ES2486-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3?/? Polyclonal Antibody

ES2486-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against GSK3?/? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody

ES2487-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody

ES2487-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IP, WB, ELISA

GSK3? Polyclonal Antibody

ES5683-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody

ES5683-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

GSK3? Polyclonal Antibody

ES8198-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

GSK3? Polyclonal Antibody

ES8198-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against GSK3? from Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC

GSK3 (pS9) Antibody

20-abx000124
  • EUR 495.00
  • EUR 704.00
  • EUR 217.00
  • EUR 356.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

GSK3 beta Antibody

ABF5016 100 ug
EUR 438

GSK3 beta Antibody

abx449182-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

GSK3 beta antibody

70R-49832 100 ul
EUR 287
Description: Purified Polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-37442 100 ug
EUR 273
Description: Rabbit Polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-34165 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-34639 100 ug
EUR 327
Description: Purified Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

70R-30634 100 ug
EUR 327
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta Antibody

48798-100ul 100ul
EUR 333

GSK3 beta Antibody

48798-50ul 50ul
EUR 239

GSK3 beta antibody

10R-8595 100 ul
EUR 393
Description: Mouse monoclonal GSK3 beta antibody

GSK3 beta antibody

20R-1878 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2124 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2187 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

GSK3 beta antibody

20R-2452 50 ug
EUR 281
Description: Rabbit polyclonal GSK3 beta antibody

anti-GSK3 Beta IgG2a mAb

011-A-01mg 0,1 mg
EUR 267.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-GSK3 Beta IgG2a (monoclonal). Produced against a recombinant Xenopus laevis protein.

anti-GSK3 Beta IgG2a mAb

011-A-1000ug 1000 ug
EUR 1282.5
  • Category: Antibody, Signal Transduction Antibodies, mAb
Description: anti-GSK3 Beta IgG2a (monoclonal). Produced against a recombinant Xenopus laevis protein.

GSK3(alpha+beta)(Phospho-Y216+Y279) Conjugated Antibody

C13355 100ul
EUR 397

Rabbit Anti Gsk3 Beta (Pser9) Polyclonal Antibody

CPBT-66459RG 0.1 ml
EUR 985

GSK3 alpha / beta (pY279 / 216) Blocking Peptide

20-abx062127
  • EUR 314.00
  • EUR 509.00
  • 1 mg
  • 5 mg
  • Shipped within 5-10 working days.

Phospho-GSK3 (alpha+beta)(Y216+Y279) recombinant monoclonal antibody

A5960 100ul X 3
EUR 681
  • Comparisons between Mnoclonal, Polyclonal and Recombinant antibodies and their benefits: Regular monoclonal antibodies have higher purity, better specificity and less lot-to-lot variations than polyclonal antibodies. Recombinant antibodies, however,
  • Show more
Description: A recombinant monoclonal antibody from rabbit against human Phospho-GSK3 (alpha+beta)(Y216+Y279) for WB,ELISA

GSK3 beta Conjugated Antibody

C48798 100ul
EUR 397

GSK3? (2C6) Monoclonal Antibody

EM1283-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against GSK3? (2C6) from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

GSK3? (2C6) Monoclonal Antibody

EM1283-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against GSK3? (2C6) from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IHC

GSK3 beta (pS9) Antibody

20-abx119160
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

20-abx119162
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

20-abx133097
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

20-abx009702
  • EUR 314.00
  • EUR 467.00
  • EUR 203.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

GSK3 lpha / beta Antibody

abx010869-100ug 100 ug
EUR 425
  • Shipped within 5-10 working days.

GSK3 beta (pS9) Antibody

abx010872-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

GSK3 beta Antibody (APC)

abx449192-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.

GSK3 beta Antibody (Biotin)

abx449193-100ug 100 ug
EUR 606
  • Shipped within 5-12 working days.
Thus, isoorientin disrupted the β-catenin signaling pathway via the inactivation of STAT3 signaling. In conclusion, focusing on OSCC-SC-mediated stemness with isoorientin to eradicate OSCC-SCs could also be an efficient technique for stopping relapse and metastasis of OSCC and offering long-term survival advantages.

Leave a Reply

Your email address will not be published. Required fields are marked *