
Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study
Lieven
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T Regulatory Cells in Rheumatoid Arthritis with Reference to Anti-Citrullinated Peptide Antibody and TNF–alpha Inhibitor Remedy
T regulatory cells (Tregs) performs an essential position in sustaining self-tolerance and stopping autoimmune illnesses by inhibiting proliferation and cytokine manufacturing of self-reactive T cells. Controversy was reported relating to the frequency of CD4+CD25+ Tregs within the peripheral circulation of rheumatoid arthritis (RA) sufferers in comparison with regular controls. Additionally, some confirmed that remedy with TNF-α inhibitor restored the capability of Tregs.
This work aimed to review Tregs within the peripheral blood of RA sufferers versus management along with these on TNF-α inhibitor remedy in comparison with those that haven’t obtained it and to correlate with standing of anti-cyclic citrullinated peptide antibody (ACPA). Two teams of RA sufferers had been studied; one on TNF-α inhibitor remedy and the opposite not. Moreover, age-matched apparently wholesome controls had been studied.
The share of CD4+CD25+ T cells within the whole lymphocytic cell inhabitants was decided by circulate cytometry evaluation whereas ACPA focus was measured by a second-generation peptide-based ELISA. Imply stage of Tregs was considerably decrease within the studied RA sufferers in comparison with the management group. Sufferers in early illness (0-5 years) had low imply Tregs share in comparison with sufferers with lengthy length of illness (> 10 years) (P=0.044).
Sufferers on TNF-α blocker remedy had elevated Tregs share relative to sufferers on methotrexate (MTX) (P=0.022) and different therapies. No impact of gender or age was discovered on Tregs ranges. In RA sufferers, 85.4% had been ACPA seropositive and 65.9% of seropositive sufferers have focus of > 100U/ml. The imply Treg share was considerably decrease in ACPA seronegative group in comparison with the seropositive group (P=0.013).
In conclusion, the studied RA sufferers have low Treg, and TNF-α blocker remedy elevated its quantity, in comparison with different therapies.
The Efficacy of Medium- to Lengthy-term Anti-TNF–α Antibody-based Upkeep Remedy in Behçet’s Illness Sufferers with Intestinal Lesions
Neurological Opposed Results Related to anti-TNF Alpha Antibodies in Pediatric Inflammatory Bowel Illnesses.
Fast temporal enchancment of pembrolizumab-induced pneumonitis utilizing the anti-TNF–α antibody infliximab.
TNF alpha antibody |
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10R-10252 | Fitzgerald | 50 ul | EUR 262.8 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-2119 | Fitzgerald | 100 ul | EUR 457.2 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-2976 | Fitzgerald | 100 ug | EUR 318 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-2986 | Fitzgerald | 100 ug | EUR 318 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-3098 | Fitzgerald | 100 ug | EUR 488.4 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-3099 | Fitzgerald | 100 ug | EUR 488.4 |
Description: Mouse monoclonal HBxAg antibody |
TNF alpha antibody |
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10R-6647 | Fitzgerald | 50 ug | EUR 184.8 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-6648 | Fitzgerald | 50 ug | EUR 184.8 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-6649 | Fitzgerald | 50 ug | EUR 184.8 |
Description: Armenian Hamster monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-7734 | Fitzgerald | 500 ug | EUR 678 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-8493 | Fitzgerald | 100 ul | EUR 471.6 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-T114a | Fitzgerald | 500 ug | EUR 249.6 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-T131a | Fitzgerald | 1 mg | EUR 586.8 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-T131b | Fitzgerald | 1 mg | EUR 536.4 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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10R-T131c | Fitzgerald | 1 mg | EUR 586.8 |
Description: Mouse monoclonal TNF alpha antibody |
TNF alpha antibody |
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20R-TG002 | Fitzgerald | 50 ug | EUR 327.6 |
Description: Goat polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-TG001 | Fitzgerald | 100 ug | EUR 392.4 |
Description: Affinity purified Goat polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-TG009 | Fitzgerald | 50 ug | EUR 327.6 |
Description: Affinity purified Goat polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-TR007X | Fitzgerald | 100 ug | EUR 392.4 |
Description: Affinity purified Rabbit polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-TR008 | Fitzgerald | 50 ug | EUR 392.4 |
Description: Affinity purified Rabbit polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-TR020 | Fitzgerald | 50 ug | EUR 327.6 |
Description: Affinity purified Rabbit polyclonal TNF alpha antibody |
TNF alpha Antibody |
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AF7014 | Affbiotech | 200ul | EUR 540 |
TNF alpha antibody |
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70R-11582 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-11583 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-11584 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-13663 | Fitzgerald | 100 ug | EUR 457.2 |
Description: Affinity purified Rabbit polyclonal TNF alpha antibody |
TNF alpha antibody |
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70R-50493 | Fitzgerald | 100 ul | EUR 292.8 |
Description: Purified Polyclonal TNF alpha antibody |
TNF alpha Antibody |
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48136-100ul | SAB | 100ul | EUR 399.6 |
TNF alpha Antibody |
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48136-50ul | SAB | 50ul | EUR 286.8 |
TNF alpha Antibody |
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DF6080 | Affbiotech | 200ul | EUR 420 |
TNF alpha antibody |
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PAab09822 | Lifescience Market | 100 ug | EUR 463.2 |
TNF alpha Antibody |
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R32668 | NSJ Bioreagents | 100ug | EUR 356.15 |
Description: TNFa (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. And this cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Moreover, this cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
Tnf alpha Antibody |
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RQ5771 | NSJ Bioreagents | 100 ug | EUR 356.15 |
Description: TNF alpha (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
TNF alpha Antibody |
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RQ4613 | NSJ Bioreagents | 100ug | EUR 356.15 |
Description: TNF (Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
TNF alpha Antibody |
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V3719-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
Description: This mAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex. |
TNF alpha Antibody |
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V3719-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
Description: This mAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex. |