Co-Overexpression of TWIST1-CSF1 Is a Common Event in Metastatic Oral Cancer and Drives Biologically Aggressive Phenotype

Co-Overexpression of TWIST1-CSF1 Is a Common Event in Metastatic Oral Cancer and Drives Biologically Aggressive Phenotype

Invasive oral squamous cell carcinoma (OSCC) is usually ulcerated and closely infiltrated by pro-inflammatory cells. We carried out a genome-wide profiling of tissues from OSCC sufferers (early versus superior levels) with 10 years follow-up. Co-amplification and co-overexpression of TWIST1, a transcriptional activator of epithelial-mesenchymal-transition (EMT), and colony-stimulating factor-1 (CSF1), a serious chemotactic agent for tumor-associated macrophages…

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