medmk

Chimeric antigen receptor T cells

Are chimeric antigen receptor T cells (CAR-T cells) the longer term in immunotherapy for autoimmune ailments?

Goal: CAR-T cell remedy has revolutionized the remedy of oncological ailments, and potential makes use of in autoimmune ailments have just lately been described. The evaluation goals to combine the obtainable knowledge on remedy with CAR-T cells, emphasizing autoimmune ailments, to find out therapeutic advances and their potential future medical applicability in autoimmunity.

Supplies and strategies: A search was carried out in PubMed with the key phrases “Chimeric Antigen Receptor” and “CART cell”. The paperwork of curiosity had been chosen, and a crucial evaluation of the data was carried out.

Outcomes: Within the remedy of autoimmune ailments, in preclinical fashions, three completely different mobile methods have been used, which embrace Chimeric antigen receptor T cells, Chimeric autoantibody receptor T cells, and Chimeric antigen receptor in regulatory T lymphocytes. All three kinds of remedy have been efficient. The potential opposed results inside them, cytokine launch syndrome, mobile toxicity and neurotoxicity should all the time be saved in thoughts.

Conclusions: Though info in people will not be but obtainable, preclinical fashions of CAR-T cells within the remedy of autoimmune ailments present promising outcomes, in order that sooner or later, they might change into a helpful and efficient remedy within the remedy of those pathologies.

medmk
medmk

CMV Control lentiviral particles (Neo)

CMV-Null-Neo 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Neomycin marker under RSV promoter.

CMV Control lentiviral particles (Puro)

CMV-Null-Puro 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Puromycin marker under RSV promoter.

EBAG9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV694975 1.0 ug DNA
EUR 514

CMV Control lentiviral particles (GFP-Bsd)

CMV-Null-GB 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter.

CMV Control lentiviral particles (GFP-Puro)

CMV-Null-GP 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter.

CMV Control lentiviral particles (RFP-Bsd)

CMV-Null-RB 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Blasticidin fusion marker under RSV promoter.

CMV Control lentiviral particles (RFP-Puro)

CMV-Null-RP 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Puromycin fusion marker under RSV promoter.

CMV control lentivirus (Hygro)

CMV-Null-Hygro 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter.

CMV control lentivirus (Zeo)

CMV-Null-Zeo 1 x107 IFU/ml x 200ul
EUR 349
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter.

EBAG9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV709564 1.0 ug DNA
EUR 316

EBAG9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV709565 1.0 ug DNA
EUR 374

EBAG9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV709566 1.0 ug DNA
EUR 374

EBAG9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV694976 1.0 ug DNA
EUR 514

EBAG9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV694977 1.0 ug DNA
EUR 572

EBAG9 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV694978 1.0 ug DNA
EUR 572

CMV Control lentiviral particles (Bsd) in PBS

CMV-Null-Bsd-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the blasticidin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (Neo) in PBS

CMV-Null-Neo-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Neomycin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (Puro) in PBS

CMV-Null-Puro-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Puromycin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (GFP-Bsd) in PBS

CMV-Null-GB-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (GFP-Puro) in PBS

CMV-Null-GP-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (RFP-Bsd) in PBS

CMV-Null-RB-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (RFP-Puro) in PBS

CMV-Null-RP-PBS 1 x108 IFU/ml x 200ul
EUR 710
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

EBAG9 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV709567 1.0 ug DNA
EUR 316

EBAG9 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV709568 1.0 ug DNA
EUR 316

HPC1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728669 1.0 ug DNA Ask for price

HPCX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728675 1.0 ug DNA Ask for price

HPE1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728681 1.0 ug DNA Ask for price

HPFH2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728687 1.0 ug DNA Ask for price

HPLH1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728693 1.0 ug DNA Ask for price

HPP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728699 1.0 ug DNA Ask for price

HPRTP2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728705 1.0 ug DNA Ask for price

HPRTP3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728711 1.0 ug DNA Ask for price

HPRTP4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728717 1.0 ug DNA Ask for price

HPT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728723 1.0 ug DNA Ask for price

HPV6AI1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728729 1.0 ug DNA Ask for price

HPV18I1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728735 1.0 ug DNA Ask for price

HPV18I2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728741 1.0 ug DNA Ask for price

HRES1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728747 1.0 ug DNA Ask for price

HRPT1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728753 1.0 ug DNA Ask for price

HSBP1P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728771 1.0 ug DNA Ask for price

HSD3BP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728777 1.0 ug DNA Ask for price

HSD3BP2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728783 1.0 ug DNA Ask for price

HSD3BP3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728789 1.0 ug DNA Ask for price

HSD3BP4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728795 1.0 ug DNA Ask for price

HSD3BP5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728801 1.0 ug DNA Ask for price

HSFX2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728807 1.0 ug DNA Ask for price

HSFY4P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728813 1.0 ug DNA Ask for price

HSFY5P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728819 1.0 ug DNA Ask for price

HSFY6P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728825 1.0 ug DNA Ask for price

HSFY7P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728831 1.0 ug DNA Ask for price

HSFY8P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728837 1.0 ug DNA Ask for price

HSP90AA5P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728843 1.0 ug DNA Ask for price

HSP90AA6P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728849 1.0 ug DNA Ask for price

HSP90AB5P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728855 1.0 ug DNA Ask for price

HSP90AB6P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728861 1.0 ug DNA
EUR 1790

HSPA8P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728867 1.0 ug DNA Ask for price

HSPA9P2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728873 1.0 ug DNA Ask for price

HSPD1P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728879 1.0 ug DNA Ask for price

HSPD1P2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728885 1.0 ug DNA Ask for price

HSPD1P3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728891 1.0 ug DNA Ask for price

HSPD1P4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728897 1.0 ug DNA Ask for price

HSPD1P7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728903 1.0 ug DNA Ask for price

HSPD1P8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728909 1.0 ug DNA Ask for price

HSPD1P9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728915 1.0 ug DNA
EUR 1790

HSPD1P10 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728921 1.0 ug DNA Ask for price

HSPD1P12 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728927 1.0 ug DNA Ask for price

HSPD1P15 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728933 1.0 ug DNA Ask for price

HSPE1P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728939 1.0 ug DNA Ask for price

HSPE1P2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728945 1.0 ug DNA Ask for price

HTATSF1P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728951 1.0 ug DNA Ask for price

HTC1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728957 1.0 ug DNA Ask for price

HTC2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728963 1.0 ug DNA Ask for price

HTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728969 1.0 ug DNA Ask for price

HTLVR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728975 1.0 ug DNA Ask for price

HTOR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV728981 1.0 ug DNA Ask for price

HTX2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729017 1.0 ug DNA Ask for price

HV1S Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729023 1.0 ug DNA Ask for price

HVBS7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729029 1.0 ug DNA Ask for price

HVBS8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729035 1.0 ug DNA Ask for price

HYD2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729041 1.0 ug DNA Ask for price

IBD2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729053 1.0 ug DNA Ask for price

IBD3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729059 1.0 ug DNA Ask for price

IBD4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729065 1.0 ug DNA Ask for price

IBD5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729071 1.0 ug DNA Ask for price

IBD6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729077 1.0 ug DNA Ask for price

IBD7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729083 1.0 ug DNA Ask for price

IBD8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729089 1.0 ug DNA Ask for price

IBD9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729095 1.0 ug DNA Ask for price

IBGC1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729101 1.0 ug DNA Ask for price

IBM3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729107 1.0 ug DNA Ask for price

IBTKP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729113 1.0 ug DNA Ask for price

ICCA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729119 1.0 ug DNA Ask for price

ICR1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729125 1.0 ug DNA Ask for price

ICR3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729131 1.0 ug DNA Ask for price

ICR4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729137 1.0 ug DNA Ask for price

ICR5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729143 1.0 ug DNA Ask for price

ICS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729149 1.0 ug DNA Ask for price

IDDM2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV729155 1.0 ug DNA Ask for price

Ovalbumin Antigen-Particular Activation of Human T Cell Receptor Intently Resembles Soluble Antibody Stimulation as Revealed by BOOST Phosphotyrosine Proteomics

Activation of the T cell receptor (TCR) results in a community of early signaling predominantly orchestrated by tyrosine phosphorylation in T cells. The TCR is often activated utilizing soluble anti-TCR antibodies, however this strategy will not be antigen-specific. Alternatively, activating the TCR utilizing particular antigens of a variety of binding affinities within the type of a peptide-major histocompatibility complicated (pMHC) is presumed to be extra physiological. Nonetheless, because of the lack of wide-scale phosphotyrosine (pTyr) proteomic research straight evaluating anti-TCR antibodies and pMHC, a complete definition of those activated states stays enigmatic.

Elucidation of the tyrosine phosphoproteome utilizing quantitative pTyr proteomics allows a greater understanding of the distinctive options of those activating brokers and the position of ligand binding affinity on signaling. Right here, we apply the just lately established Broad-spectrum Optimization Of Selective Triggering (BOOST) to look at perturbations in tyrosine phosphorylation of human TCR triggered by anti-TCR antibodies and pMHC. Our knowledge reveal that high-affinity ovalbumin (OVA) pMHC activation of the human TCR triggers a largely related, albeit probably stronger, pTyr-mediated signaling regulatory axis in comparison with the anti-TCR antibody. The signaling output ensuing from OVA pMHC variants correlates properly with their weaker affinities, enabling affinity-tunable management of signaling power. Collectively, we offer a framework for making use of BOOST to match pTyr-mediated signaling pathways of human T cells activated in an antigen-independent and antigen-specific method.

Bilateral anterior cerebral artery occlusion following CD19- and BCMA-targeted chimeric antigen receptor T-cell remedy for a myeloma affected person

Chimeric antigen receptor T (CAR-T)-cell remedy is a promising remedy for relapsed/refractory a number of myeloma (RRMM). In our earlier report, CD19- and BCMA-targeted CAR-T co-administration was related to a excessive response fee. Though cytokine launch syndrome (CRS) and neurotoxicity are frequent problems following CAR-T remedy, cerebral infarction isn’t reported as a CAR-T-related complication. We reported a 73-year-old feminine MM affected person who acquired CD19- and BCMA-targeted CAR-T for refractory illness.

Her illness responded to CAR-T remedy, however she developed neurological signs following CRS. Cranial CT and MRI demonstrated a number of cerebral infarctions and bilateral anterior cerebral artery (ACA) occlusion. We recommend that cerebral infarction apart from CAR-T-related neurotoxicity is the underlying explanation for irregular neuropsychological signs, and diagnostic imaging exams must be actively carried out to exclude ischemic cerebrovascular occasions.

The Intracellular Area of CD40 is a Potent Costimulatory Aspect in Chimeric Antigen Receptors

The costimulatory domains integrated into second-generation and third-generation chimeric antigen receptors (CARs) strongly affect CAR-T-cell operate. Right here, we explored second-generation and third-generation CARs harboring the signaling area of the CD40 receptor as a brand new costimulatory component compared with related CARs carrying the 4-1BB area. In CARs of each generations, CD40 was stronger than 4-1BB in triggering the NF-κB signaling pathway.

In human T cells from 2 donors, CD40 was akin to 4-1BB in upregulating costimulatory and activation markers, inducing proinflammatory cytokine secretion and mediating goal cell killing. Apparently, variations within the response sample of T cells from the two donors with respect to CD40 and 4-1BB had been evident. We conclude that in human T cells, the CD40 signaling area is a potent costimulatory component in each second-generation and third-generation CARs.

A Systematic Evaluation of the Function of Chimeric Antigen Receptor T (CAR-T) Cell Remedy within the Remedy of Strong Tumors

Chimeric antigen receptor T (CAR-T) cell remedy makes use of sufferers’ personal T lymphocytes which might be engineered to assault most cancers cells. It’s Meals and Drug Administration (FDA)-approved in numerous hematological malignancies and at the moment being evaluated in stable cancers in early part research. We did a scientific evaluation consisting of 15 potential medical trials (n=159) evaluating CAR-T cells in stable cancers. Early part trials confirmed promising response charges in ovarian epithelial most cancers (100%), human epidermal development issue receptor 2 (HER2)-positive sarcoma (67%), epidermal development issue receptor (EGFR)-positive biliary tract most cancers (65%), superior gastric/pancreatic most cancers (82%), hepatocellular carcinoma (67%), and colorectal most cancers (70%).

The median total response throughout all malignancies was 62% (vary 17%-100%). Median progression-free survival and total survival weren’t reached in most trials. Cytokine launch syndrome was seen in just one affected person with cholangiocarcinoma who acquired EGFR-specific CAR-T cell remedy. Though survival knowledge continues to be not mature, CAR-T cell remedy in stable malignancies did present encouraging response charges and was well-tolerated.

Variations in lymphoma sufferers between chimeric antigen receptor T-cell remedy trials and the overall inhabitants

Chimeric antigen receptor (CAR)-T cell therapies seem to be promising remedies for non-Hodgkin’s and B-cell lymphoma. Nonetheless, a number of CAR-T therapies authorised by the US Meals and Drug Administration have solely been examined for efficacy in comparatively few single-arm medical trials with small pattern sizes. We sought to look at the variations between sufferers in these trials and the overall inhabitants of sufferers with non-Hodgkin’s and B-cell lymphoma. 5 hundred and twenty-two sufferers from 15 CAR-T trials present in a scientific evaluation and 417,492 sufferers from the Surveillance, Epidemiology, and Finish Outcomes (SEER) Program database had been in contrast.

CAR-T examine members seemed to be youthful (46.7% beneath 70 years outdated vs. 42.2%), extra male (68.0% vs. 55.7%), and adopted for a shorter time period in comparison with sufferers within the SEER inhabitants (imply [M] 45.6 months, 95% confidence interval [CI] 17.7 to 63.three months follow-up vs. M 57.1 months, 95% CI 57.Zero to 57.three months survival). CAR-T examine members could differ considerably from the overall inhabitants of sufferers with non-Hodgkin’s and B-cell lymphoma. Effectiveness of CAR-T therapies within the basic inhabitants of lymphoma sufferers could differ from effectiveness demonstrated in trials. Newly created CAR-T affected person registries are important to establishing population-level effectiveness of the therapies.

Recombinant Human ITGB1 Protein, His, E.coli-2ug

QP12462-HIS-2ug 2ug
EUR 155

Recombinant Human ITGB1 Protein, His, E.coli-5ug

QP12462-HIS-5ug 5ug
EUR 155

Recombinant Human ITGB1 Protein, His, E.coli-1mg

QP12462-HIS-EC-1mg 1mg
EUR 2757

ITGB1 protein (His tag)

80R-3617 100 ug
EUR 327
Description: Purified recombinant ITGB1 protein (His tag)

Human Integrin Beta 1 (ITGb1) ELISA Kit

DLR-ITGb1-Hu-48T 48T
EUR 498
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Beta 1 (ITGb1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Integrin Beta 1 (ITGb1) ELISA Kit

DLR-ITGb1-Hu-96T 96T
EUR 647
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Beta 1 (ITGb1) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Integrin Beta 1 (ITGb1) ELISA Kit

RDR-ITGb1-Hu-48Tests 48 Tests
EUR 522

Human Integrin Beta 1 (ITGb1) ELISA Kit

RDR-ITGb1-Hu-96Tests 96 Tests
EUR 724

Human Integrin Beta 1 (ITGb1) ELISA Kit

RD-ITGb1-Hu-48Tests 48 Tests
EUR 500

Human Integrin Beta 1 (ITGb1) ELISA Kit

RD-ITGb1-Hu-96Tests 96 Tests
EUR 692

Recombinant Human ITGB1 Protein, His, Insect-1mg

QP12462-HIS-INSECT-1mg 1mg
EUR 5251

XMIR-21 RNA oligo miRNA-21-5p with Xmotif

XMIR-21 10 rxn
EUR 438

Recombinant (E.coli) Human CD40 (aa: 21-193, His Tag, >95% Pure)

HCD4015-N-10 10 ug
EUR 286

AXMIR-21 RNA oligo anti-miRNA-21-5p with Xmotif

AXMIR-21 10 reactions
EUR 438

Recombinant (E.Coli, His-tag) Human Syndecan-4, His-tag

RP-993 10 ug
EUR 225

Recombinant (E.coli) Rat CD40 (aa: 21-193, His Tag, >95% Pure)

RCD4015-N-10 10 ug
EUR 213

FGF-21 Fibroblast Growth Factor-21 Human Recombinant Protein, His Tag

PROTQ9NSA1 Regular: 50ug
EUR 317
Description: Fibroblast Growth Factor -21 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 202 amino acids (29-209) and having a molecular mass of 21.6 kDa (molecular weight on SDS-PAGE will appear higher). ;The FGF-21 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Recombinant Human Fibroblast Growth Factor-21, His Tag

7-00385 10µg Ask for price

Recombinant Human Fibroblast Growth Factor-21, His Tag

7-00386 50µg Ask for price

Recombinant Human Fibroblast Growth Factor-21, His Tag

7-00387 1mg Ask for price

XMIRXpress lentivector miRNA-21-5p with Xmotif

XMIRXP-21 10 ug
EUR 677

Recombinant (E.Coli, His-tag) Human HTRA2

RP-413 10 ug
EUR 225

Recombinant (E.Coli, His-tag) Human STAT1

RP-722 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human S100b

RP-774 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human Osteocrin

RP-868 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human CD29

RP-915 2 ug
EUR 347

Recombinant (E.Coli, His-tag) Human Geminin

RP-989 5 ug
EUR 164

FGF-21 Fibroblast Growth Factor-21 Mouse Recombinant Protein, His Tag

PROTQ9JJN1-1 Regular: 10ug
EUR 317
Description: Fibroblast Growth Factor -21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 192 amino acids and having a molecular mass of 21.2 kDa. The amino acid sequence of the recombinant human FGF21 is 100% homologous to the amino acid sequence of the Mouse FGF21 without signal sequence and contains 10 a.a. His tag at N-terminal.;The FGF-21 is purified by proprietary chromatographic techniques.

Human ITGA1&ITGB1 Heterodimer Protein (Phe 29-Pro 1141 (ITGA1)&Gln 21-Asp 728 (ITGB1))

VAng-1839Lsx-100g 100 µg
EUR 1178
Description: Human ITGA1&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P56199-1 (ITGA1)&P05556-1 (ITGB1))

Human ITGA1&ITGB1 Heterodimer Protein (Phe 29-Pro 1141 (ITGA1)&Gln 21-Asp 728 (ITGB1))

VAng-1839Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA1&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P56199-1 (ITGA1)&P05556-1 (ITGB1))

Human ITGA10&ITGB1 Heterodimer Protein (Phe 23-Ser 1122 (ITGA10)&Gln 21-Asp 728 (ITGB1))

VAng-1840Lsx-100g 100 µg
EUR 1178
Description: Human ITGA10&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: O75578-1 (ITGA10)&P05556-1 (ITGB1))

Human ITGA10&ITGB1 Heterodimer Protein (Phe 23-Ser 1122 (ITGA10)&Gln 21-Asp 728 (ITGB1))

VAng-1840Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA10&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: O75578-1 (ITGA10)&P05556-1 (ITGB1))

Human ITGA11&ITGB1 Heterodimer Protein (Phe 23-Ser 1122 (ITGA10)&Gln 21-Asp 728 (ITGB1))

VAng-1841Lsx-100g 100 µg
EUR 1178
Description: Human ITGA11&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: Q9UKX5-1 (L524R) (ITGA11)&P05556-1 (ITGB1))

Human ITGA11&ITGB1 Heterodimer Protein (Phe 23-Ser 1122 (ITGA10)&Gln 21-Asp 728 (ITGB1))

VAng-1841Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA11&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: Q9UKX5-1 (L524R) (ITGA11)&P05556-1 (ITGB1))

Human ITGA4&ITGB1 Heterodimer Protein (Tyr 34-Thr 977 (ITGA4)&Gln 21-Asp 728 (ITGB1))

VAng-1842Lsx-100g 100 µg
EUR 1178
Description: Human ITGA4&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P13612-1 (ITGA4)&P05556-1 (ITGB1))

Human ITGA4&ITGB1 Heterodimer Protein (Tyr 34-Thr 977 (ITGA4)&Gln 21-Asp 728 (ITGB1))

VAng-1842Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA4&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P13612-1 (ITGA4)&P05556-1 (ITGB1))

Human ITGA5&ITGB1 Heterodimer Protein (Phe 42-Tyr 995 (ITGA5)&Gln 21-Asp 728 (ITGB1))

VAng-1844Lsx-100g 100 µg
EUR 1178
Description: Human ITGA5&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P08648-1 (ITGA5)&P05556-1 (ITGB1))

Human ITGA5&ITGB1 Heterodimer Protein (Phe 42-Tyr 995 (ITGA5)&Gln 21-Asp 728 (ITGB1))

VAng-1844Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA5&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P08648-1 (ITGA5)&P05556-1 (ITGB1))

Human ITGA7X2B&ITGB1 Heterodimer Protein (Phe 34-Trp 1038 (ITGA7X2B)&Gln 21-Asp 728 (ITGB1))

VAng-1846Lsx-100g 100 µg
EUR 1178
Description: Human ITGA7X2B&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: Q13683-7 (ITGA7X2B)&P05556-1 (ITGB1))

Human ITGA7X2B&ITGB1 Heterodimer Protein (Phe 34-Trp 1038 (ITGA7X2B)&Gln 21-Asp 728 (ITGB1))

VAng-1846Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA7X2B&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: Q13683-7 (ITGA7X2B)&P05556-1 (ITGB1))

Human ITGA8&ITGB1 Heterodimer Protein (Phe 39-Leu 1012 (ITGA8)&Gln 21-Asp 728 (ITGB1))

VAng-1847Lsx-100g 100 µg
EUR 1178
Description: Human ITGA8&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P53708-1 (ITGA8)&P05556-1 (ITGB1))

Human ITGA8&ITGB1 Heterodimer Protein (Phe 39-Leu 1012 (ITGA8)&Gln 21-Asp 728 (ITGB1))

VAng-1847Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA8&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: P53708-1 (ITGA8)&P05556-1 (ITGB1))

Human ITGA9&ITGB1 Heterodimer Protein (Phe 39-Leu 1012 (ITGA8)&Gln 21-Asp 728 (ITGB1))

VAng-1848Lsx-100g 100 µg
EUR 1178
Description: Human ITGA9&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: Q13797-1 (ITGA9)&P05556-1 (ITGB1))

Human ITGA9&ITGB1 Heterodimer Protein (Phe 39-Leu 1012 (ITGA8)&Gln 21-Asp 728 (ITGB1))

VAng-1848Lsx-1mg 1 mg
EUR 7969
Description: Human ITGA9&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: Q13797-1 (ITGA9)&P05556-1 (ITGB1))

Human ITGAV&ITGB1 Heterodimer Protein (Phe 31-Val 992 (ITGAV)&Gln 21-Asp 728 (ITGB1))

VAng-1852Lsx-100g 100 µg
EUR 1178
Description: Human ITGAV&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: NP_002201.1 (ITGAV)&P05556-1 (ITGB1))

Human ITGAV&ITGB1 Heterodimer Protein (Phe 31-Val 992 (ITGAV)&Gln 21-Asp 728 (ITGB1))

VAng-1852Lsx-200g 200 µg
EUR 7969
Description: Human ITGAV&ITGB1 Heterodimer protein, expressed in human 293 cells. (Uniprot ID: NP_002201.1 (ITGAV)&P05556-1 (ITGB1))

Recombinant (E.Coli, His-tag) Human Ubiquitin Conjugating enzyme 7, His-tag

RP-425 10 ug
EUR 225

Recombinant E.coli LACTB Protein, His, E.coli-20ug

QP12522-HIS-20ug 20ug
EUR 201

Recombinant E.coli LACTB Protein, His, E.coli-5ug

QP12522-HIS-5ug 5ug
EUR 155

Histidine-tag (poly-His/Hisx6) Protein (His-tag-fusion protein) ELISA Kit, 96 tests, Quantitative

800-440-HIS 1 kit
EUR 895

Recombinant (E.Coli) Human Eotaxin (CCL11), His-tag

RP-1045 5 ug
EUR 164

Recombinant (E.Coli, His-tag) Human AminoAcylase-1

RP-382 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human Paraoxonase-1

RP-385 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human Paraoxonase-2

RP-386 10 ug
EUR 286

Recombinant (E.Coli, His-tag) )Human Chorionic Gonadotropin

RP-599 10 ug
EUR 225

Recombinant (E.Coli, His-tag) Human Beta-Trace

RP-783 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human L-Selectin

RP-835 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human P-Selectin

RP-836 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human Annexin 7

RP-890 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human Annexin 9

RP-891 10 ug
EUR 286

Recombinant (E.Coli, His-tag) Human Ephrin A1

RP-936 2 ug
EUR 347

Recombinant (E.Coli, His-tag) Human Ephrin B1

RP-937 2 ug
EUR 347

Recombinant (E.Coli, His-tag) Human Ephrin B3

RP-938 2 ug
EUR 347

Recombinant (E.Coli, His-tag) Human Fyn-p59

RP-946 2 ug
EUR 347

Recombinant (E.Coli, His-tag) Human Melanoma (gp100)

RP-949 2 ug
EUR 347

Recombinant (E.Coli, His-tag) Human Mammaglobin-A

RP-952 2 ug
EUR 347

Recombinant (E.Coli, His-tag) Human Synaptobrevin-1

RP-987 20 ug
EUR 164

Recombinant (E.Coli, His-tag) Human Synaptobrevin-2

RP-988 5 ug
EUR 164

Recombinant Mouse Fibroblast Growth Factor-21, His Tag

7-00391 2µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-21, His Tag

7-00392 10µg Ask for price

Recombinant Mouse Fibroblast Growth Factor-21, His Tag

7-00393 1mg Ask for price

Recombinant Human ACPP Protein, His, E.coli-100ug

QP10946-HIS-100ug 100ug
EUR 1261

Recombinant Human ACPP Protein, His, E.coli-10ug

QP10946-HIS-10ug 10ug
EUR 201

Recombinant Human ACPP Protein, His, E.coli-1mg

QP10946-HIS-1mg 1mg
EUR 3655

Recombinant Human ACPP Protein, His, E.coli-20ug

QP10946-HIS-20ug 20ug
EUR 201

Recombinant Human ACPP Protein, His, E.coli-2ug

QP10946-HIS-2ug 2ug
EUR 155

Recombinant Human ACPP Protein, His, E.coli-5ug

QP10946-HIS-5ug 5ug
EUR 155

Recombinant Human ADAM10 Protein, His, E.coli-10ug

QP10961-HIS-10ug 10ug
EUR 201

Recombinant Human ADAM10 Protein, His, E.coli-1mg

QP10961-HIS-1mg 1mg
EUR 4851

Recombinant Human ADAM10 Protein, His, E.coli-1ug

QP10961-HIS-1ug 1ug
EUR 155

Recombinant Human ADAM10 Protein, His, E.coli-2ug

QP10961-HIS-2ug 2ug
EUR 155

Recombinant Human ADAM10 Protein, His, E.coli-50ug

QP10961-HIS-50ug 50ug
EUR 1261

Recombinant Human ADAM10 Protein, His, E.coli-5ug

QP10961-HIS-5ug 5ug
EUR 201

Recombinant Human ADH1A Protein, His, E.coli-10ug

QP10966-HIS-10ug 10ug
EUR 201

Recombinant Human ADH1A Protein, His, E.coli-20ug

QP10966-HIS-20ug 20ug
EUR 201

Recombinant Human ADH1A Protein, His, E.coli-2ug

QP10966-HIS-2ug 2ug
EUR 155

Recombinant Human ADH1A Protein, His, E.coli-5ug

QP10966-HIS-5ug 5ug
EUR 155

Recombinant Human Adipsin Protein, His, E.coli-10ug

QP10969-HIS-10ug 10ug
EUR 201

Recombinant Human Adipsin Protein, His, E.coli-20ug

QP10969-HIS-20ug 20ug
EUR 201

Recombinant Human Adipsin Protein, His, E.coli-2ug

QP10969-HIS-2ug 2ug
EUR 155

Recombinant Human Adipsin Protein, His, E.coli-5ug

QP10969-HIS-5ug 5ug
EUR 155

Recombinant Human AKR1D1 Protein, His, E.coli-20ug

QP10995-HIS-20ug 20ug
EUR 201

Recombinant Human AKR1D1 Protein, His, E.coli-5ug

QP10995-HIS-5ug 5ug
EUR 155

Recombinant Human AMBP Protein, His, E.coli-10ug

QP11009-HIS-10ug 10ug
EUR 201

Recombinant Human AMBP Protein, His, E.coli-1mg

QP11009-HIS-1mg 1mg
EUR 5251

Recombinant Human AMBP Protein, His, E.coli-2ug

QP11009-HIS-2ug 2ug
EUR 155

Recombinant Human ANGPTL3 Protein, His, E.coli-100ug

QP11018-HIS-100ug 100ug
EUR 1261

Recombinant Human ANGPTL3 Protein, His, E.coli-1mg

QP11018-HIS-1mg 1mg
EUR 4851

Leave a Reply

Your email address will not be published.